Gene Symbol: Grpel1
Description: GrpE-like 1, mitochondrial
Alias: GrpE#1, GrpE1, grpE protein homolog 1, mitochondrial, mt-GrpE#1, stress-inducible chaperone mt-GrpE#1
Species: rat
Products:     Grpel1

Top Publications

  1. Tamura S, Kinouchi H, Izaki K, Okubo A, Sugawara T, Kunizuka H, et al. Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat. Brain Res. 2003;960:277-81 pubmed
    ..These results demonstrate the synergic induction of HSP70 molecular chaperone machinery in cerebral ischemia. ..
  2. Naylor D, Hoogenraad N, Hoj P. Isolation and characterisation of a cDNA encoding rat mitochondrial GrpE, a stress-inducible nucleotide-exchange factor of ubiquitous appearance in mammalian organs. FEBS Lett. 1996;396:181-8 pubmed
    ..Furthermore, members of the GrpE family exhibit a much lower degree of sequence identity than do the well studied members of the Hsp70, Hsp60 and Hsp10 families. ..
  3. Naylor D, Stines A, Hoogenraad N, Høj P. Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. J Biol Chem. 1998;273:21169-77 pubmed
  4. Choglay A, Chapple J, Blatch G, Cheetham M. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. Gene. 2001;267:125-34 pubmed
  5. Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
    ..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..