Grp

Summary

Gene Symbol: Grp
Description: gastrin releasing peptide
Alias: gastrin-releasing peptide
Species: rat
Products:     Grp

Top Publications

  1. Lebacq Verheyden A, Kasprzyk P, Raum M, van Wyke Coelingh K, Lebacq J, Battey J. Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor. Mol Cell Biol. 1988;8:3129-35 pubmed
    ..The major pro-GRP hormone (isoform I) contains both GRP1-27 and a novel C-terminal extension peptide termed pro-GRP31-125...
  2. Pereira P, Machado G, Danesi G, Canevese F, Reddy V, Pereira T, et al. GRPR/PI3Kγ: Partners in Central Transmission of Itch. J Neurosci. 2015;35:16272-81 pubmed publisher
    The gastrin-releasing peptide (GRP) and its receptor (GRPR) are important components of itch transmission. Upstream, but not downstream, aspects of GRPR signaling have been investigated extensively...
  3. Sakamoto H, Arii T, Kawata M. High-voltage electron microscopy reveals direct synaptic inputs from a spinal gastrin-releasing peptide system to neurons of the spinal nucleus of bulbocavernosus. Endocrinology. 2010;151:417-21 pubmed publisher
    ..We recently found that a sexually dimorphic expression of gastrin-releasing peptide (GRP) in the lumbar spinal cord regulates male copulatory reflexes...
  4. Takanami K, Sakamoto H, Matsuda K, Satoh K, Tanida T, Yamada S, et al. Distribution of gastrin-releasing peptide in the rat trigeminal and spinal somatosensory systems. J Comp Neurol. 2014;522:1858-73 pubmed publisher
    Gastrin-releasing peptide (GRP) has recently been identified as an itch-specific neuropeptide in the spinal sensory system in mice, but there are no reports of the expression and distribution of GRP in the trigeminal sensory system in ..
  5. Bedard T, Mountney C, Kent P, Anisman H, Merali Z. Role of gastrin-releasing peptide and neuromedin B in anxiety and fear-related behavior. Behav Brain Res. 2007;179:133-40 pubmed
    ..investigation was to assess the effects of two mammalian BB-related peptides, namely gastrin-releasing peptide (GRP) and neuromedin B (NMB), in paradigms thought to reflect fear and anxiety-related behaviors...
  6. Dumesny C, Whitley J, Baldwin G, Giraud A, Shulkes A. Developmental expression and biological activity of gastrin-releasing peptide and its receptors in the kidney. Am J Physiol Renal Physiol. 2004;287:F578-85 pubmed
    Mammalian gastrin-releasing peptide (GRP) has a widespread distribution and multiple stimulating effects on metabolism, release of regulatory peptides, gastrointestinal and pancreatic secretions, and behavior...
  7. Abramov A, Kolesnik Y. Morphofunctional characteristics of the gastrin-releasing peptide-synthesizing system of the hypothalamus in normal conditions and in experimental diabetes in rats. Neurosci Behav Physiol. 2002;32:567-72 pubmed
  8. Merali Z, Anisman H, James J, Kent P, Schulkin J. Effects of corticosterone on corticotrophin-releasing hormone and gastrin-releasing peptide release in response to an aversive stimulus in two regions of the forebrain (central nucleus of the amygdala and prefrontal cortex). Eur J Neurosci. 2008;28:165-72 pubmed publisher
    ..Like CRH, gastrin-releasing peptide (GRP) appears to be involved in mediation of the stress response and is released at the CeA during exposure to an acute ..
  9. Mountney C, Anisman H, Merali Z. In vivo levels of corticotropin-releasing hormone and gastrin-releasing peptide at the basolateral amygdala and medial prefrontal cortex in response to conditioned fear in the rat. Neuropharmacology. 2011;60:410-7 pubmed publisher
    ..modulatory effect of exogenously administered corticotropin-releasing hormone (CRH) and gastrin-releasing peptide (GRP) on conditioned fear, the present study sought to measure the fear-induced endogenous release of CRH and GRP at the ..

More Information

Publications25

  1. Washington M, Aglan A, Sayegh A. The stomach and/or upper duodenum contain sites of action that control meal size and intermeal interval length by exogenous rat gastrin releasing peptide. Peptides. 2014;55:41-6 pubmed publisher
    ..normal rat chow) and intermeal interval length (IMI) by the mammalian homologues of Bn gastrin releasing peptides (GRP-10, GRP-27 and GRP-29, 0.01, 0.05, 0.1, 0.2 and 0...
  2. Katayama N, Oti T, Takanami K, Sakamoto T, Sakamoto H. Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats. Proc Jpn Acad Ser B Phys Biol Sci. 2016;92:69-75 pubmed publisher
    A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats...
  3. Lu F, Jin T, Drucker D. Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line. Endocrinology. 1996;137:3710-6 pubmed
    ..We show here that gastrin-releasing peptide (GRP) induces proglucagon messenger RNA transcripts in STC-1 enteroendocrine cells...
  4. Reeve J, Washington M, Park K, Johnson T, Hunt J, Shively J, et al. Sequence analysis and feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat GRP-29. Peptides. 2014;59:1-8 pubmed publisher
    ..phase high performance liquid chromatography (HPLC) steps have resulted in the purification of two rat gastrin releasing peptide (GRP) forms suitable for microsequence and mass spectral analysis...
  5. Lebacq Verheyden A, Krystal G, Sartor O, Way J, Battey J. The rat prepro gastrin releasing peptide gene is transcribed from two initiation sites in the brain. Mol Endocrinol. 1988;2:556-63 pubmed
    The gastrin-releasing peptide (GRP) is a gastrointestinal hormone, a neuropeptide, and a growth factor...
  6. Washington M, Wright S, Sayegh A. Gastrin releasing peptide-29 evokes feeding responses in the rat. Peptides. 2011;32:241-5 pubmed publisher
    In mammals, gastrin releasing peptide (GRP) 10 and 27 reduce food intake...
  7. Wright S, Washington M, Garcia C, Sayegh A. Gastrin releasing peptide-29 requires vagal and splanchnic neurons to evoke satiation and satiety. Peptides. 2012;33:125-31 pubmed publisher
    We have shown that gastrin-releasing peptide-29 (GRP-29), the large molecular form of GRP in rats, reduces meal size (MS, intake of 10% sucrose solution) and prolongs the intermeal interval (IMI)...
  8. Fekete E, Vigh J, Bagi E, Lenard L. Gastrin-releasing peptide microinjected into the amygdala inhibits feeding. Brain Res. 2002;955:55-63 pubmed
    Bombesin (BN)-like peptides including gastrin-releasing peptide (GRP) are known to inhibit feeding. In the amygdaloid body BN receptors have been found in moderate to high densities...
  9. Garrido M, Fuentes J, Manzanares J. Gastrin-releasing peptide mediated regulation of 5-HT neuronal activity in the hypothalamic paraventricular nucleus under basal and restraint stress conditions. Life Sci. 2002;70:2953-66 pubmed
    The purpose of this study was to examine the gastrin-releasing peptide (GRP) mediated regulation of 5-HT neuronal activity in the paraventricular nucleus of the hypothalamus under basal and restraint stress conditions...
  10. Hermes M, Kolaj M, Coderre E, Renaud L. Gastrin-releasing peptide acts via postsynaptic BB2 receptors to modulate inward rectifier K+ and TRPV1-like conductances in rat paraventricular thalamic neurons. J Physiol. 2013;591:1823-39 pubmed publisher
    Gastrin-releasing peptide (GRP) is a bombesin-like peptide with a widespread distribution in mammalian CNS, where it has a role in food intake, circadian rhythm generation, fear memory, itch sensation and sexual behaviour...
  11. Ladenheim E, Behles R, Bi S, Moran T. Gastrin-releasing peptide messenger ribonucleic acid expression in the hypothalamic paraventricular nucleus is altered by melanocortin receptor stimulation and food deprivation. Endocrinology. 2009;150:672-8 pubmed publisher
    Gastrin-releasing peptide (GRP) is a bombesin-like peptide widely distributed in the gastrointestinal tract and central nervous system...
  12. Washington M, Salyer S, Aglan A, Sayegh A. Intravenous infusion of gastrin-releasing peptide-27 and bombesin in rats reveals differential effects on meal size and intermeal interval length. Peptides. 2014;51:145-9 pubmed publisher
    We have previously shown that the intraperitoneal (i.p.) administration of gastrin-releasing peptide-27 (GRP-27) or bombesin (BN) (at 0.21, 0.41 and 1.03nmol/kg) reduces meal size (MS) and prolongs the intermeal interval (IMI)...
  13. Sakamoto H, Takanami K, Zuloaga D, Matsuda K, Jordan C, Breedlove S, et al. Androgen regulates the sexually dimorphic gastrin-releasing peptide system in the lumbar spinal cord that mediates male sexual function. Endocrinology. 2009;150:3672-9 pubmed publisher
    ..lumbar spinal cord of male rats projects to the lower lumbar spinal cord, releasing gastrin-releasing peptide (GRP) onto somatic and autonomic centers known to regulate male sexual reflexes such as erection and ejaculation...
  14. Sakamoto H, Matsuda K, Zuloaga D, Nishiura N, Takanami K, Jordan C, et al. Stress affects a gastrin-releasing peptide system in the spinal cord that mediates sexual function: implications for psychogenic erectile dysfunction. PLoS ONE. 2009;4:e4276 pubmed publisher
    ..Recently, we identified a gastrin-releasing peptide (GRP) system in the lumbar spinal cord that is a primary mediator for male reproductive functions...
  15. Yu Y, Barry D, Hao Y, Liu X, Chen Z. Molecular and neural basis of contagious itch behavior in mice. Science. 2017;355:1072-1076 pubmed publisher
    ..in the SCN abolished contagious scratching behavior, which was recapitulated by chemogenetic inhibition of SCN GRP neurons. Activation of SCN GRP/GRPR neurons evoked scratching behavior...
  16. Washington M, Park K, Sayegh A. Obese and lean Zucker rats respond similarly to intraperitoneal administration of gastrin-releasing peptides. Peptides. 2014;58:36-41 pubmed publisher
    ..Here, we hypothesized that intraperitoneal (i.p) administration of gastrin-releasing peptides-10, -27 and -29 (GRP-10, GRP-27, GRP-29), which are the mammalian forms of Bn, would reduce first meal size (MS, 10% sucrose) and ..