Gene Symbol: Grm7
Description: glutamate metabotropic receptor 7
Alias: metabotropic glutamate receptor 7, glutamate receptor, metabotropic 7, mGluR7, metabotropic glutamate receptor mGluR7, metabotropic glutamate receptor subtype 7b
Species: rat
Products:     Grm7

Top Publications

  1. Somogyi P, Dalezios Y, Lujan R, Roberts J, Watanabe M, Shigemoto R. High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. Eur J Neurosci. 2003;17:2503-20 pubmed
    ..Using immunocytochemistry, we investigated whether one of the receptors, mGluR7, whose level of expression is governed by the postsynaptic target, was present in GABAergic terminals and whether ..
  2. Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, et al. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. J Neurosci. 2001;21:8734-45 pubmed
    To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7(-/-))...
  3. Nakajima Y. Ca2+-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors. Biochem Biophys Res Commun. 2011;412:602-5 pubmed publisher
  4. Saugstad J, Kinzie J, Mulvihill E, Segerson T, Westbrook G. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol Pharmacol. 1994;45:367-72 pubmed
    ..A full length cDNA clone encoding a metabotropic receptor (mGluR7) whose sequence was 69% identical to that of mGluR4 was isolated...
  5. Brandstätter J, Koulen P, Kuhn R, van Der Putten H, Wassle H. Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse. J Neurosci. 1996;16:4749-56 pubmed
    The distribution of the metabotropic glutamate receptor 7 (mGluR7) was studied in the rat retina using a specific antiserum...
  6. Millán C, Lujan R, Shigemoto R, Sánchez Prieto J. The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. J Biol Chem. 2002;277:14092-101 pubmed
    ..terminals that were immunopositive to synaptophysin were also immunoreactive to the low affinity L-AP4-sensitive mGluR7. Then, mGluR7 mediates the inhibition of glutamate release caused by 1 mm L-AP4, primarily by a strong inhibition ..
  7. Kahl E, Fendt M. Metabotropic Glutamate Receptors 7 within the Nucleus Accumbens are Involved in Relief Learning in Rats. Curr Neuropharmacol. 2016;14:405-12 pubmed
    ..Since the nucleus accumbens mediates relief learning and accumbal metabotropic glutamate receptors 7 (mGluR7) modulate appetitive-like processes, we hypothesized that accumbal mGluR7 may be involved in the modulation of ..
  8. Caldwell J, Herin G, Nagel G, Bamberg E, Scheschonka A, Betz H. Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7. J Biol Chem. 2008;283:24300-7 pubmed publisher
  9. Tang Z, El Far O, Betz H, Scheschonka A. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. J Biol Chem. 2005;280:38153-9 pubmed
    ..Our results are consistent with post-translational sumoylation providing a novel mechanism of group III mGluR regulation. ..

More Information


  1. Martín R, Durroux T, Ciruela F, Torres M, Pin J, Sánchez Prieto J. The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. J Biol Chem. 2010;285:17907-17 pubmed publisher
    At synaptic boutons, metabotropic glutamate receptor 7 (mGlu7 receptor) serves as an autoreceptor, inhibiting glutamate release...
  2. Suh Y, Park J, Park S, Jou I, Roche P, Roche K. Regulation of metabotropic glutamate receptor 7 (mGluR7) internalization and surface expression by Ser/Thr protein phosphatase 1. J Biol Chem. 2013;288:17544-51 pubmed publisher
    The metabotropic glutamate receptor type 7 (mGluR7) is the predominant group III mGluR in the presynaptic active zone, where it serves as an autoreceptor to inhibit neurotransmitter release...
  3. Friedman R, Van Laer L, Huentelman M, Sheth S, Van Eyken E, Corneveaux J, et al. GRM7 variants confer susceptibility to age-related hearing impairment. Hum Mol Genet. 2009;18:785-96 pubmed publisher
    ..We performed histochemical studies in human and mouse and showed that mGluR7 is expressed in hair cells and in spiral ganglion cells of the inner ear...
  4. Phillips T, Makoff A, Murrison E, Mimmack M, Waldvogel H, Faull R, et al. Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies. Brain Res Mol Brain Res. 1998;57:132-41 pubmed
    ..To characterise the protein expression of the two mGluR7 receptor splice variants in human and rat cerebellar cortex, antibodies specific to mGluR7 were generated...
  5. Wang W, Wu X, Jia L, Zhang H, Cai F, Mao H, et al. Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. Neuroscience. 2016;313:199-212 pubmed publisher
    ..In the previous study, we have shown that metabotropic glutamate receptor 7 (mGluR7) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling may be involved in the ..
  6. Gillard S, Tzaferis J, Tsui H, Kingston A. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. J Comp Neurol. 2003;461:317-32 pubmed
    ..In contrast, mGluR1 alpha, mGluR2/3, mGluR4a, and mGluR7 were expressed in leptomeninges from adult rats...
  7. El Far O, Airas J, Wischmeyer E, Nehring R, Karschin A, Betz H. Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1. Eur J Neurosci. 2000;12:4215-21 pubmed
    ..Here, we used the yeast two-hybrid system to identify a direct interaction of the C-terminal tail region of mGluR7 with the rat homologue of the protein kinase C substrate PICK1...
  8. Gu Z, Liu W, Wei J, Yan Z. Regulation of N-methyl-D-aspartic acid (NMDA) receptors by metabotropic glutamate receptor 7. J Biol Chem. 2012;287:10265-75 pubmed publisher
    ..significantly reduced NMDAR-mediated synaptic and ionic currents in PFC pyramidal neurons, which was mediated by mGluR7 localized at postsynaptic neurons and involved the ?-arrestin/ERK signaling pathway...
  9. Dütting E, Schröder Kress N, Sticht H, Enz R. SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b. Biochem J. 2011;435:365-71 pubmed publisher
    ..In summary, the results of the present study show in vivo SUMOylation of the complete mGluR8b and co-localize proteins of the SUMOylation machinery in the retina. ..
  10. Enz R. The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. FEBS Lett. 2002;514:184-8 pubmed
    ..Domain mapping revealed that alternative splicing of mGluR4, mGluR7 and mGluR8 C-termini regulated the interaction...
  11. Lavezzari G, Roche K. Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent. Neuropharmacology. 2007;52:100-7 pubmed
    ..We describe here for the first time a distinct endocytic and intracellular sorting pathway utilized by mGluR7. We show that mGluR7 constitutively internalizes via a non-clathrin mediated pathway in heterologous cells and in ..
  12. Croci C, Sticht H, Brandstätter J, Enz R. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem. 2003;278:50682-90 pubmed
    ..In summary, these results provide a molecular description of the interaction between protein phosphatase 1C and metabotropic glutamate receptors and thereby increase our understanding of glutamatergic signal transduction. ..
  13. Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, et al. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J Biol Chem. 1994;269:1231-6 pubmed
    A cDNA clone for a new rat metabotropic glutamate receptor termed mGluR7 was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic receptor (mGluR) family and by ..
  14. Bertaso F, Lill Y, Airas J, Espeut J, Blahos J, Bockaert J, et al. MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels. J Neurochem. 2006;99:288-98 pubmed
    We have previously shown that the interaction of Ca2+/calmodulin with the metabotropic glutamate receptor type 7 (mGluR7) promotes the G-protein-mediated inhibition of voltage-sensitive Ca2+ channels (VSCCs) seen upon agonist activation...
  15. Muto T, Tsuchiya D, Morikawa K, Jingami H. Expression, purification, crystallization and preliminary X-ray analysis of the ligand-binding domain of metabotropic glutamate receptor 7. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:627-30 pubmed
    ..The ligand-binding domain (LBD) of mGluR subtype 7 (mGluR7) was produced using the baculovirus expression system and purified from the culture medium...
  16. Li J, Wang X, Ji P, Li X, Guan G, Jiang X, et al. Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons. Neurosci Lett. 2012;531:52-6 pubmed publisher
    ..Previous pharmacological evidences show that activation of mGluR7 could inhibit nociceptive reception...
  17. Kammermeier P. Constitutive activity of metabotropic glutamate receptor 7. BMC Neurosci. 2015;16:17 pubmed publisher
    ..b>mGluR7 is a member of this family that has been implicated in numerous physiological and pathological processes, but the ..
  18. Liu X, Han M, Zhu J, Sun N, Tang J, Huo F, et al. Metabotropic glutamate subtype 7 and 8 receptors oppositely modulate cardiac nociception in the rat nucleus tractus solitarius. Neuroscience. 2012;220:322-9 pubmed publisher
    ..The present study examined the roles of group III mGluRs and their subtype 7 and 8 receptors (mGluR7 and mGluR8) in modulating the cardiac-somatic reflex induced by pericardial capsaicin, which was monitored by ..
  19. Saugstad J, Yang S, Pohl J, Hall R, Conn P. Interaction between metabotropic glutamate receptor 7 and alpha tubulin. J Neurochem. 2002;80:980-8 pubmed
    ..Here, we describe the interaction of mGluR7, a group-III mGluR and presynaptic autoreceptor, with the cytoskeletal protein, alpha tubulin...
  20. Masugi M, Yokoi M, Shigemoto R, Muguruma K, Watanabe Y, Sansig G, et al. Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion. J Neurosci. 1999;19:955-63 pubmed
    ..We examined the fear response of freezing after electric shock in wild-type and mGluR7(-/-) knockout littermates. Wild-type mice displayed freezing immediately after and 1 d after footshock...
  21. Corti C, Restituito S, Rimland J, Brabet I, Corsi M, Pin J, et al. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8. Eur J Neurosci. 1998;10:3629-41 pubmed
    ..out-of-frame insertion in the carboxyl-terminus that results in the replacement of the last 16 amino acids of mGluR7 and mGluR8 by 23 and 16 different amino acids, respectively...
  22. Callaerts Vegh Z, Beckers T, Ball S, Baeyens F, Callaerts P, Cryan J, et al. Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice. J Neurosci. 2006;26:6573-82 pubmed
    b>Metabotropic glutamate receptor 7 (mGluR7), a receptor with a distinct brain distribution and a putative role in anxiety, emotional responding, and spatial working memory, could be an interesting therapeutic target for fear and anxiety ..
  23. Li J, Ohishi H, Kaneko T, Shigemoto R, Neki A, Nakanishi S, et al. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR7, in ganglion neurons of the rat; with special reference to the presence in glutamatergic ganglion neurons. Neurosci Lett. 1996;204:9-12 pubmed
    Immunoreactivity for the metabotropic glutamate receptor 7 (mGluR7) and that for phosphate-activated glutaminase (PAG) were examined in the trigeminal (TG), dorsal root (DRG), nodose (NG), superior cervical, celiac, and pelvic ganglia of ..
  24. Bahi A. Viral-mediated knockdown of mGluR7 in the nucleus accumbens mediates excessive alcohol drinking and increased ethanol-elicited conditioned place preference in rats. Neuropsychopharmacology. 2013;38:2109-19 pubmed publisher
    Whether metabotropic glutamate 7 (mGluR7) -activation enhances or diminishes the reinforcing properties of psychostimulants remains unclear...
  25. Holscher C, Schmid S, Pilz P, Sansig G, van der Putten H, Plappert C. Lack of the metabotropic glutamate receptor subtype 7 selectively modulates Theta rhythm and working memory. Learn Mem. 2005;12:450-5 pubmed
    ..We have previously shown that mGluR7 deletion in mice produces a selective working memory (WM) impairment, while other types of memory such as ..
  26. Kobayashi Y, Akiyoshi J, Kanehisa M, Ichioka S, Tanaka Y, Tsuru J, et al. Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. Psychiatr Genet. 2007;17:9 pubmed
  27. Konieczny J, Lenda T. Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082. Pharmacol Rep. 2013;65:1194-203 pubmed
    ..N,N'-dibenzhydryl-ethane-1,2-diamine dihydrochloride (AMN082) is a potent, brain penetrating mGluR7 agonist, selective over other mGluRs...
  28. Xi Z, Shen H, Baker D, Kalivas P. Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens. J Neurochem. 2003;87:1204-12 pubmed
    ..high affinity for mGluR4/6/8, reduced extracellular glutamate only at high concentrations capable of binding to mGluR7. The increase in extracellular glutamate by MSOP was tetrodotoxin-independent, and resistant to both the L-type ..
  29. Cryan J, Kelly P, Neijt H, Sansig G, Flor P, van der Putten H. Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7. Eur J Neurosci. 2003;17:2409-17 pubmed
    ..Of all glutamate receptors, the role of group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, mGluR8) in such disorders is the least investigated because of the lack of specific pharmacological tools...
  30. Perroy J, Gutierrez G, Coulon V, Bockaert J, Pin J, Fagni L. The C terminus of the metabotropic glutamate receptor subtypes 2 and 7 specifies the receptor signaling pathways. J Biol Chem. 2001;276:45800-5 pubmed
    ..These results show that the C terminus of mGlu2 and mGlu7 receptors is a key structural determinant that allows these receptors to select a specific signaling pathway in neurons. ..
  31. Dev K, Nakajima Y, Kitano J, Braithwaite S, Henley J, Nakanishi S. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. J Neurosci. 2000;20:7252-7 pubmed
    ..We show a relationship between these three proteins using recombinant PICK1, mGluR7, and PKCalpha, where they were co-immunoprecipitated as a complex from COS-7 cells...
  32. Lidwell K, Dillon J, Sihota A, O CONNOR V, Pilkington B. Determining calmodulin binding to metabotropic glutamate receptors with distinct protein-interaction methods. Biochem Soc Trans. 2004;32:868-70 pubmed
    ..This illustrates that certain Ca(2+)-dependent interactions are not recapitulated in yeast. Moreover, it highlights the necessity for supporting biochemical data to substantiate interactions identified with Y2H methods. ..
  33. Xu J, Yan H, Yang B, Tong L, Zou Y, Tian Y. Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats. J Negat Results Biomed. 2009;8:5 pubmed publisher
    ..The relationship between mGluR3/mGluR7 and synaptic plasticity had been verified by many recent studies...
  34. Dalezios Y, Lujan R, Shigemoto R, Roberts J, Somogyi P. Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cereb Cortex. 2002;12:961-74 pubmed
    ..The enrichment of mGluR7a in the main GABAergic, as well as in the glutamatergic, innervation of mGluR1 alpha/somatostatin-expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate. ..
  35. Kinzie J, Shinohara M, Van den Pol A, Westbrook G, Segerson T. Immunolocalization of metabotropic glutamate receptor 7 in the rat olfactory bulb. J Comp Neurol. 1997;385:372-84 pubmed
    ..Mitral cells of the olfactory bulb express mRNA for several mGluRs, including mGluR7, which has been suggested as a presynaptic glutamate autoreceptor...
  36. Schwendt M, Reichel C, See R. Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats. PLoS ONE. 2012;7:e34299 pubmed publisher
    ..dSTR) were isolated and labeled with membrane-impermeable biotin in order to measure surface mGluR2/3 and mGluR7 receptors...
  37. Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S. A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7. J Biol Chem. 1999;274:27573-7 pubmed
    Metabotropic glutamate receptor subtype 7 (mGluR7) is coupled to the inhibitory cyclic AMP cascade and is selectively activated by a glutamate analogue, L-2-amino-4-phosphonobutyrate...
  38. Wei X, Yang D, Shi T, Wang J, Deng Y, Qiao X, et al. Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3 Region of Rats. CNS Neurol Disord Drug Targets. 2017;16:610-616 pubmed publisher
    ..However, whether the metabotropic glutamate receptor 7 (mGluR7) can modulate the pain-evoked electrical activities of pain-excited neurons and pain-..
  39. Flor P, van Der Putten H, Ruegg D, Lukic S, Leonhardt T, Bence M, et al. A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. Neuropharmacology. 1997;36:153-9 pubmed
    Two splice variants of the human metabotropic glutamate receptor 7, named hmGluR7a and hmGluR7b, were isolated from a human brain cDNA library...
  40. Holscher C, Schmid S, Pilz P, Sansig G, van der Putten H, Plappert C. Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory. Behav Brain Res. 2004;154:473-81 pubmed
    ..Here, we report the effect of mGluR7 gene ablation in different learning paradigms...
  41. Wu S, Wright R, Rockey P, Burgett S, Arnold J, Rosteck P, et al. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998;53:88-97 pubmed
    ..Complementary DNAs (cDNAs) encoding the human mGluR4, human mGluR7, and human mGluR8 were isolated from human cerebellum, fetal brain or retinal cDNA libraries...
  42. Millán C, Castro E, Torres M, Shigemoto R, Sánchez Prieto J. Co-expression of metabotropic glutamate receptor 7 and N-type Ca(2+) channels in single cerebrocortical nerve terminals of adult rats. J Biol Chem. 2003;278:23955-62 pubmed that, in cerebrocortical nerve terminals of adult rats, the inhibition of glutamate release is mediated by mGluR7. In this preparation, the major component of glutamate release is supported by P/Q-type Ca2+ channels (72.7%)...
  43. Mares P. AMN 082, an agonist of mGluR7, exhibits mixed anti- and proconvulsant effects in developing rats. Physiol Res. 2008;57:969-72 pubmed
    ..Possible anticonvulsant action of AMN 082, an agonist of mGluR7 subtype, was studied in immature rats using pentylenetetrazol (PTZ)-induced seizures as a model...
  44. Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley J, et al. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem. 2002;277:15221-4 pubmed
    ..These data also suggest that the structural determinants involved in PDZ interactions are more complex than originally envisaged. ..
  45. Sorensen S, Macek T, Cai Z, Saugstad J, Conn P. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Mol Pharmacol. 2002;61:1303-12 pubmed
    ..Recent investigations have begun to identify novel interactions of presynaptic mGluRs, especially mGluR7, with multiple protein kinases and putative regulatory proteins that probably serve to further shape the overall ..
  46. Perroy J, El Far O, Bertaso F, Pin J, Betz H, Bockaert J, et al. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. EMBO J. 2002;21:2990-9 pubmed
    ..These results indicate that the scaffolding protein, PICK1, plays an essential role in the control of synaptic transmission by the mGlu7a receptor complex. ..