Gene Symbol: Grm6
Description: glutamate metabotropic receptor 6
Alias: mGluR6, metabotropic glutamate receptor 6, glutamate receptor, metabotropic 6
Takao M, Morigiwa K, Sasaki H, Miyoshi T, Shima T, Nakanishi S, et al
. Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice. Neuroscience. 2000;97:779-87 pubmed
..This study clearly demonstrates that the dysfunction of the ON visual pathway in metabotropic glutamate receptor subtype 6-deficient mice impairs their behavioral responsiveness to light and yet preserves their circadian system. ..
Valerio A, Ferraboli S, Paterlini M, Spano P, Barlati S. Identification of novel alternatively-spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina. Gene. 2001;262:99-106 pubmed
..Though generated by different patterns of alternative splicing, the inter-species conservation of truncated mGlu receptor molecules strongly suggest their relevance in the regulatory network of glutamatergic neurotransmission. ..
Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley J, et al
. The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs. J Biol Chem. 2002;277:15221-4 pubmed
..several receptor-protein interactions, strong ones include: (i) GRIP and syntenin with mGluR7a, mGluR4a, and mGluR6; (ii) PICK1 and GRIP with mGluR3; and (iii) syntenin with all forms of GluR1-4 and mGluR7b...
Tang Z, El Far O, Betz H, Scheschonka A. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. J Biol Chem. 2005;280:38153-9 pubmed
..Our results are consistent with post-translational sumoylation providing a novel mechanism of group III mGluR regulation. ..
Zeitz C, Forster U, Neidhardt J, Feil S, Kälin S, Leifert D, et al
. Night blindness-associated mutations in the ligand-binding, cysteine-rich, and intracellular domains of the metabotropic glutamate receptor 6 abolish protein trafficking. Hum Mutat. 2007;28:771-80 pubmed
Mutations in the GRM6 gene, which encodes the metabotropic glutamate receptor 6 (mGluR6), lead to autosomal recessive congenital stationary night blindness (CSNB), which is characterized by loss of night vision due to a defect in signal ..
Beqollari D, Kammermeier P. The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors. Eur J Pharmacol. 2008;589:49-52 pubmed publisher
..Conversely, PHCCC directly activates the mGlu(6) receptor and does not enhance activity of glutamate. Therefore, PHCCC is a direct mGlu(6) receptor agonist, but lacks allosteric modulatory properties. ..
Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, et al
. TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A. 2010;107:332-7 pubmed publisher
..Glutamate released from photoreceptors modulates the photoresponse of ON BCs via metabotropic glutamate receptor 6 (mGluR6) and G protein (Go) that regulates a cation channel...
Dütting E, Schröder Kress N, Sticht H, Enz R. SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b. Biochem J. 2011;435:365-71 pubmed publisher
..In summary, the results of the present study show in vivo SUMOylation of the complete mGluR8b and co-localize proteins of the SUMOylation machinery in the retina. ..
Cao Y, Posokhova E, Martemyanov K. TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner. J Neurosci. 2011;31:11521-6 pubmed publisher
..This process is mediated by the G-protein-coupled receptor pathway involving glutamate receptor mGluR6 and effector channel TRPM1...