Grm5

Summary

Gene Symbol: Grm5
Description: glutamate metabotropic receptor 5
Alias: mGluR5, mGlur5, metabotropic glutamate receptor 5, glutamate receptor, metabotropic 5, metabotropic glutamate receptor (mGluR5), metabotropic glutamate receptor 5b
Species: rat
Products:     Grm5

Top Publications

  1. Cho K, Brown M, Bashir Z. Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex. J Physiol. 2002;540:895-906 pubmed
    ..Similar mechanisms of synergistic interaction may also be important in other physiological processes dependent on mGlu receptors. ..
  2. Sourdet V, Russier M, Daoudal G, Ankri N, Debanne D. Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5. J Neurosci. 2003;23:10238-48 pubmed
    ..We report here that synaptic or pharmacological activation of the metabotropic glutamate receptor subtype 5 (mGluR5) induces long-term potentiation of intrinsic excitability (LTP-IE) in layer V pyramidal neurons...
  3. Scheggi S, Raone A, De Montis M, Tagliamonte A, Gambarana C. Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway. J Neurochem. 2007;103:1168-83 pubmed
    ..and modifications in the DARPP-32 phosphorylation pattern, cAMP-dependent protein kinase (PKA) activity, and mGluR5 tone in the medial prefrontal cortex and nucleus accumbens...
  4. Bortolotto Z, Collett V, Conquet F, Jia Z, van der Putten H, Collingridge G. The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors. Neuropharmacology. 2005;49 Suppl 1:13-25 pubmed
    ..In addition, the mGlu5 selective agonist CHPG ((RS)-2-chloro-5-hydroxyphenylglycine) sets the molecular switch. These data demonstrate that the operation of the molecular switch requires activation of mGlu5 receptors. ..
  5. Xiao B, Tu J, Petralia R, Yuan J, Doan A, Breder C, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21:707-16 pubmed
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties. ..
  6. Popkirov S, Manahan Vaughan D. Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses. Cereb Cortex. 2011;21:501-9 pubmed publisher
    ..The metabotropic glutamate receptor subtype 5 (mGluR5) is critically involved in enabling the persistency of multiple forms of hippocampal synaptic plasticity...
  7. Rodrigues S, Bauer E, Farb C, Schafe G, LeDoux J. The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. J Neurosci. 2002;22:5219-29 pubmed
    The group I metabotropic glutamate receptor subtype mGluR5 has been shown to play a key role in the modulation of synaptic plasticity...
  8. Mao L, Yang L, Tang Q, Samdani S, Zhang G, Wang J. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci. 2005;25:2741-52 pubmed
    ..We found that selective activation of mGluR5, but not mGluR1, increased ERK1/2 phosphorylation...
  9. Gravius A, Barberi C, Schafer D, Schmidt W, Danysz W. The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison. Neuropharmacology. 2006;51:1146-55 pubmed
    ..The purpose of the present study was to evaluate the contribution of mGluR1 and mGluR5 to both acquisition and expression of behaviours in contextual and auditory fear conditioning models...

More Information

Publications62

  1. Schiefer J, Sprünken A, Puls C, Lüesse H, Milkereit A, Milkereit E, et al. The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease. Brain Res. 2004;1019:246-54 pubmed
    ..release through stimulation of presynaptic metabotropic glutamate receptor (mGluR) 2 and blockade of postsynaptic mGluR5 have been demonstrated to be neuroprotective against excitotoxicity...
  2. Simonyi A, Serfozo P, Shelat P, Dopheide M, Coulibaly A, Schachtman T. Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning. Neurobiol Learn Mem. 2007;88:305-11 pubmed
    ..These findings indicate a selective participation of hippocampal group I mGlu receptors in memory processing in this task. ..
  3. Simonyi A, Serfozo P, Parker K, Ramsey A, Schachtman T. Metabotropic glutamate receptor 5 in conditioned taste aversion learning. Neurobiol Learn Mem. 2009;92:460-3 pubmed publisher
    ..b>Metabotropic glutamate receptor 5 (mGlu5) has been implicated in learning and memory processes and is necessary for CTA...
  4. Izumi Y, Zorumski C. NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. Neuropsychopharmacology. 2012;37:609-17 pubmed publisher
    In the CA1 region of the rat hippocampus, metabotropic glutamate receptor-5 (mGluR5) and cannabinoid-1 receptors (CB1Rs) are believed to participate in long-term synaptic depression (LTD)...
  5. Jin D, Guo M, Xue B, Mao L, Wang J. Differential regulation of CaMKII? interactions with mGluR5 and NMDA receptors by Ca(2+) in neurons. J Neurochem. 2013;127:620-31 pubmed publisher
    Two glutamate receptors, metabotropic glutamate receptor 5 (mGluR5), and ionotropic NMDA receptors (NMDAR), functionally interact with each other to regulate excitatory synaptic transmission in the mammalian brain...
  6. Tsanov M, Manahan Vaughan D. Synaptic plasticity in the adult visual cortex is regulated by the metabotropic glutamate receptor, mGluR5. Exp Brain Res. 2009;199:391-9 pubmed publisher
    ..Given its intrinsic role in hippocampal plasticity, we investigated the eVects of pharmacological antagonism of mGluR5 on synaptic plasticity and receptor expression in the VC of freely moving adult pigmented rats, and compared this ..
  7. Wang H, Westin L, Nong Y, Birnbaum S, Bendor J, Brismar H, et al. Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling. Science. 2009;326:1554-7 pubmed publisher
    b>Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous system (CNS)...
  8. Kammermeier P, Worley P. Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors. Proc Natl Acad Sci U S A. 2007;104:6055-60 pubmed
    ..This modulation occurred postsynaptically, was mediated primarily by mGluR5, and was inositol triphosphate receptor-dependent...
  9. FONTANEZ NUIN D, Santini E, Quirk G, Porter J. Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons. Cereb Cortex. 2011;21:727-35 pubmed publisher
    ..Previous studies have shown that systemic blockade of metabotropic glutamate receptor type 5 (mGluR5) reduces bursting in the mPFC and mGluR5 agonists enhance NMDA receptor currents in vitro, suggesting that mGluR5 ..
  10. Harney S, Rowan M, Anwyl R. Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering. J Neurosci. 2006;26:1128-32 pubmed
    ..We also identified a role for metabotropic glutamate receptor 5 (mGluR5) in NMDAR plasticity...
  11. Brakeman P, Lanahan A, O Brien R, Roche K, Barnes C, Huganir R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386:284-8 pubmed
    ..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling. ..
  12. Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. J Biol Chem. 1992;267:13361-8 pubmed
    A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by ..
  13. Yang L, Mao L, Tang Q, Samdani S, Liu Z, Wang J. A novel Ca2+-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons. J Neurosci. 2004;24:10846-57 pubmed
    ..Here we investigated the interaction between NMDA receptors and metabotropic glutamate receptor 5 (mGluR5) in the integral regulation of extracellular signal-regulated protein kinase (ERK) and gene ..
  14. Lu Y, Jia Z, Janus C, Henderson J, Gerlai R, Wojtowicz J, et al. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci. 1997;17:5196-205 pubmed
    ..To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other glutamate receptors. The CNS revealed normal development of gross anatomical features...
  15. Tu J, Xiao B, Naisbitt S, Yuan J, Petralia R, Brakeman P, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23:583-92 pubmed
    ..Moreover, Shank clusters mGluR5 in heterologous cells in the presence of Homer and mediates the coclustering of Homer with PSD-95/GKAP...
  16. Elmenhorst D, Mertens K, Kroll T, Oskamp A, Ermert J, Elmenhorst E, et al. Circadian variation of metabotropic glutamate receptor 5 availability in the rat brain. J Sleep Res. 2016;25:754-761 pubmed publisher
    The metabotrophic subtype 5 glutamate receptor (mGluR5) plays a critical role in synaptic plasticity besides its involvement in numerous neurological disorders, such as depression...
  17. Takagi N, Besshoh S, Marunouchi T, Takeo S, Tanonaka K. Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats. Neurosci Lett. 2012;530:91-6 pubmed publisher
  18. Patel S, Hamill T, Connolly B, Jagoda E, Li W, Gibson R. Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB. Nucl Med Biol. 2007;34:1009-17 pubmed
    ..1-0.15 nM, n> or =3) to a saturable site previously shown to be metabotropic glutamate receptor 5 (mGluR5; Patel S, Ndubizu O, Hamill T, Chaudhary A, Burns HD, Hargreaves RJ, Gibson RE...
  19. Rodrigues R, Alfaro T, Rebola N, Oliveira C, Cunha R. Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J Neurochem. 2005;92:433-41 pubmed
    The anti-Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine A(2A) receptor antagonists is believed to result from their ability to postsynaptically control the responsiveness of the indirect pathway that is ..
  20. Tu J, Xiao B, Yuan J, Lanahan A, Leoffert K, Li M, et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21:717-26 pubmed
    ..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function. ..
  21. Yim Y, Lee J, Kim G, Song T, Kim C, Kim D. Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress. Neurosci Lett. 2012;519:62-6 pubmed publisher
    ..In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress...
  22. Goudet C, Gaven F, Kniazeff J, Vol C, Liu J, Cohen Gonsaud M, et al. Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors. Proc Natl Acad Sci U S A. 2004;101:378-83 pubmed
    ..Here, we show that the HD of metabotropic glutamate receptor 5 (mGlu(5)) displays the same agonist-independent constitutive activity as the wild-type receptor...
  23. Yang B, Rajput P, Kumar U, Sastry B. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS ONE. 2015;10:e0138215 pubmed publisher
    ..While blockade of mGluR1 or mGluR5 alone could interfere with TBS-induced shifts in EGABA in neonates, only a combined blockade could do the same in ..
  24. Sevastyanova T, Kammermeier P. Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5. Mol Pharmacol. 2014;86:492-504 pubmed publisher
    Metabotropic glutamate receptors (mGluRs) function as dimers. Recent work suggests that mGluR1 and mGluR5 may physically interact, but the nature and functional consequences of this relationship have not been addressed...
  25. Swaminathan S, Huentelman M, Corneveaux J, Myers A, Faber K, Foroud T, et al. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. PLoS ONE. 2012;7:e50640 pubmed publisher
    ..006, odds ratio = 3.986 (95% confidence interval 1.490-10.667)). A novel APP gene duplication was observed in one case sample. Further investigation of the identified genes in independent and larger samples is warranted. ..
  26. Hsu J, Cheng S, Yang H, Wang H, Chiu T, Min M, et al. Bidirectional synaptic plasticity induced by conditioned stimulations with different number of pulse at hippocampal CA1 synapses: roles of N-methyl-D-aspartate and metabotropic glutamate receptors. Synapse. 2011;65:795-803 pubmed publisher
    ..The PP-induced LTD (PP-LTD) was blocked by the metabotropic glutamate receptors subtype 5 (mGluR5) antagonist MPEP, suggesting that the PP-LTD relied on the activation of GluR5...
  27. Calcinaghi N, Jolivet R, Wyss M, Ametamey S, Gasparini F, Buck A, et al. Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response. J Cereb Blood Flow Metab. 2011;31:e1-10 pubmed publisher
    Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of ..
  28. Kumar V, Fahey P, Jong Y, Ramanan N, O Malley K. Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem. 2012;287:5412-25 pubmed publisher
    The G-protein coupled receptor, metabotropic glutamate receptor 5 (mGluR5), is expressed on both cell surface and intracellular membranes in striatal neurons...
  29. Semenov D, Belyakov A, Glushchenko T, Samoilov M, Salinska E, Lazarewicz J. Hypobaric Preconditioning Modifies Group I mGluRs Signaling in Brain Cortex. Neurochem Res. 2015;40:2200-10 pubmed publisher
    ..We suggest that enhanced expression of mGluR5 and PLC?1 and potentiation of Ca(2+) signaling may represent pro-survival upregulation of Ca(2+)-dependent genomic ..
  30. Liang S, Alger B, McCarthy M. Developmental increase in hippocampal endocannabinoid mobilization: role of metabotropic glutamate receptor subtype 5 and phospholipase C. J Neurophysiol. 2014;112:2605-15 pubmed publisher
    ..Western blotting revealed significant increases in both metabotropic type glutamate receptor 5 (mGluR5) and PLCβ1 proteins in juveniles compared with neonates...
  31. André M, Güntürkün O, Manahan Vaughan D. The metabotropic glutamate receptor, mGlu5, is required for extinction learning that occurs in the absence of a context change. Hippocampus. 2015;25:149-58 pubmed publisher
    ..This suggests that mGlu5 is intrinsically involved in enabling learning that once-relevant information is no longer valid. ..
  32. Arizono M, Bannai H, Mikoshiba K. Imaging mGluR5 dynamics in astrocytes using quantum dots. Curr Protoc Neurosci. 2014;66:Unit 2.21. pubmed publisher
    This unit describes the method that we have developed to clarify endogenous mGluR5 (metabotropic glutamate receptors 5) dynamics in astrocytes by single-particle tracking using quantum dots (QD-SPT)...
  33. Parelkar N, Wang J. mGluR5-dependent increases in immediate early gene expression in the rat striatum following acute administration of amphetamine. Brain Res Mol Brain Res. 2004;122:151-7 pubmed
    b>Metabotropic glutamate receptor 5 (mGluR5) is densely expressed in medium-sized spiny projection neurons of the rat striatum. Activation of mGluR5 increases intracellular Ca2+, resulting in Ca(2+)-dependent cellular responses...
  34. Alam M, Danysz W, Schmidt W, Dekundy A. Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. Toxicol Appl Pharmacol. 2009;240:198-207 pubmed publisher
    ..idazoxan (alpha2-adrenoceptor antagonist) or 2-methyl-6-(phenyl-ethyl)-pyrimidine (MPEP, metabotropic glutamate receptor 5 antagonist) prevents rotenone-induced parkinsonian-like behaviours and neurochemical changes in rats...
  35. Sahara Y, Kubota T, Ichikawa M. Cellular localization of metabotropic glutamate receptors mGluR1, 2/3, 5 and 7 in the main and accessory olfactory bulb of the rat. Neurosci Lett. 2001;312:59-62 pubmed
    ..These differences in the distribution of mGluRs in the MOB and AOB may reflect differences in synaptic transmission and sensitivity to neuromodulation in the two systems. ..
  36. Lin T, Lai C, Hsieh M, Wang H, Cheng J, Chau Y, et al. VPS26A-SNX27 Interaction-Dependent mGluR5 Recycling in Dorsal Horn Neurons Mediates Neuropathic Pain in Rats. J Neurosci. 2015;35:14943-55 pubmed publisher
    ..Moreover, SNL also increased membrane-bound and total mGluR5 abundance, VPS26A-bound SNX27 and mGluR5 and mGluR5-bound VPS26A and SNX27 coprecipitation, and mGluR5-positive ..
  37. Bradley S, Challiss R. Defining protein kinase/phosphatase isoenzymic regulation of mGlu? receptor-stimulated phospholipase C and Ca²? responses in astrocytes. Br J Pharmacol. 2011;164:755-71 pubmed publisher
    ..These data also highlight a potential alternative mechanism by which mGlu? receptor signalling might be therapeutically manipulated. ..
  38. Sinclair C, Cleva R, Hood L, Olive M, Gass J. mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. Pharmacol Biochem Behav. 2012;101:329-35 pubmed publisher
    Pharmacological blockade of the type 5 metabotropic glutamate receptor (mGluR5) attenuates cue-induced reinstatement of ethanol-seeking behavior, yet the brain regions involved in these effects are not yet known...
  39. Dong L, Quindlen J, Lipschutz D, Winkelstein B. Whiplash-like facet joint loading initiates glutamatergic responses in the DRG and spinal cord associated with behavioral hypersensitivity. Brain Res. 2012;1461:51-63 pubmed publisher
    ..Neuronal metabotropic glutamate receptor-5 (mGluR5) and protein kinase C-epsilon (PKC?) expression in the DRG and spinal cord were evaluated on days 1 and 7...
  40. Loane D, Stoica B, Pajoohesh Ganji A, Byrnes K, Faden A. Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem. 2009;284:15629-39 pubmed publisher
    ..We demonstrate that the group I receptor member mGluR5 is highly expressed in primary microglial cultures and the BV2 microglial cell line...
  41. Park J, Hu J, Milshteyn A, Zhang P, Moore C, Park S, et al. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell. 2013;154:637-50 pubmed publisher
    ..signaling that is induced by drug administration, the glutamate-receptor protein metabotropic glutamate receptor 5 (mGluR5) is phosphorylated by microtubule-associated protein kinase (MAPK), which we show ..
  42. Zhao L, Jiao Q, Chen X, Yang P, Zhao B, Zheng P, et al. mGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of mitogen-activated protein kinase signaling pathway. J Neurosci Res. 2012;90:447-60 pubmed publisher
    ..We investigated the effects of metabotropic glutamate receptor 5 (mGluR5) on NPC proliferation under hypoxia, the expression of cyclin D1, and the activation of the ..
  43. Charles J, Hernandez E, Winter A, Yang C, Stanley B. Site selective activation of lateral hypothalamic mGluR1 and R5 receptors elicits feeding in rats. Physiol Behav. 2015;139:261-6 pubmed publisher
    ..These results, demonstrating that the LH mediates the eating elicited by low doses of DHPG, suggest that the LH may contain mGluR whose activation can produce eating behavior. ..
  44. Taketo M, Matsuda H. Modulation of intracellular calcium mobilization and GABAergic currents through subtype-specific metabotropic glutamate receptors in neonatal rat hippocampus. Brain Res Bull. 2010;81:73-80 pubmed publisher
    ..In hippocampal interneurons, several subclasses of mGluRs including mGluR1 and mGluR5 have been immunohistochemically identified...
  45. Mao L, Yang L, Arora A, Choe E, Zhang G, Liu Z, et al. Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem. 2005;280:12602-10 pubmed
    ..However, signaling mechanisms linking mGluR5 to ERK are poorly understood...
  46. Yan H, Wang B, Wang Y, Tian Y, Yu X, Huang Y. [Expression changes of metabotropic glutamate receptor 5 in neuropathic pain]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007;29:111-6 pubmed
    To investigate the expression changes of metabotropic glutamate receptor 5 (mGluR5) in neuropathic pain...
  47. Reichel C, Schwendt M, McGinty J, Olive M, See R. Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. Neuropsychopharmacology. 2011;36:782-92 pubmed publisher
    ..metabotropic glutamate receptor (mGluR) expression, and the possible reversal of cognitive impairments with the mGluR5 allosteric modulator, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB)...
  48. Kato H, Kassai H, Watabe A, Aiba A, Manabe T. Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells. J Physiol. 2012;590:3019-34 pubmed publisher
    ..In this study, using subtype-specific knockout mice, we have shown that mGluR5 induces facilitation of the depolarization-evoked calcium current...
  49. Dolan S, Nolan A. Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery. Eur J Pain. 2007;11:644-51 pubmed
    ..01 vs. vehicle treatment). MPEP had no effect on acute nociceptive thresholds in naïve animals. These data suggest that activity at mGlu5 receptors contributes to development of pain and hypersensitivity following surgery. ..
  50. Dai S, Qin N, Chen T, Luo P, Zhang L, Rao W, et al. Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells. Int J Mol Sci. 2014;15:10892-907 pubmed publisher
    ..In the present study, we investigated the role of mGluR5 in the regulation of N-methyl-D-aspartate (NMDA)-induced excitotoxicity in differentiated PC12 cells...
  51. Bashkatova V, Sudakov S, Prast H. Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures. Bull Exp Biol Med. 2015;159:1-3 pubmed publisher
    ..Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of ..
  52. Liu M, Lu D, Wang Y, Chen X, Li Z, Xu Y, et al. Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways. Neurosci Lett. 2012;507:38-42 pubmed publisher
    ..However, inhibition of mGluR5 by a selective antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) produced no spatial change from either of the ..
  53. Eyigor O, Minbay Z, Cavusoglu I, Jennes L. Localization of kainate receptor subunit GluR5-immunoreactive cells in the rat hypothalamus. Brain Res Mol Brain Res. 2005;136:38-44 pubmed