Gene Symbol: Grm1
Description: glutamate receptor, metabotropic 1
Alias: Gprc1a, metabotropic glutamate receptor 1, G protein coupled receptor family C group 1 member A, mGluR1
Species: rat
Products:     Grm1

Top Publications

  1. Ray K, Hauschild B. Cys-140 is critical for metabotropic glutamate receptor-1 dimerization. J Biol Chem. 2000;275:34245-51 pubmed
    b>Metabotropic glutamate receptor 1 (mGluR1) expresses at the cell surface as disulfide-linked dimers and can be reduced to monomers with sulfhydryl reagents...
  2. Kammermeier P. Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins. BMC Neurosci. 2006;7:1 pubmed
    Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites...
  3. Neugebauer V, Li W, Bird G, Bhave G, Gereau R. Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J Neurosci. 2003;23:52-63 pubmed
    ..of the arthritic condition induced in vivo on synaptic transmission and group I metabotropic glutamate receptor (mGluR1 and mGluR5) function was examined in vitro using whole-cell voltage-clamp recordings of neurons in the central ..
  4. Galante M, Diana M. Group I metabotropic glutamate receptors inhibit GABA release at interneuron-Purkinje cell synapses through endocannabinoid production. J Neurosci. 2004;24:4865-74 pubmed
    ..Our results reveal a mechanism with potential physiological importance, by which glutamatergic synapses induce an endocannabinoid-mediated inhibition of the GABAergic inputs onto Purkinje cells. ..
  5. Brakeman P, Lanahan A, O Brien R, Roche K, Barnes C, Huganir R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386:284-8 pubmed
    ..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling. ..
  6. Xiao B, Tu J, Petralia R, Yuan J, Doan A, Breder C, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21:707-16 pubmed
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties. ..
  7. Wu H, Wang C, Gregory K, Han G, Cho H, Xia Y, et al. Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science. 2014;344:58-64 pubmed publisher
    ..A combination of crystallography, structure-activity relationships, mutagenesis, and full-length dimer modeling provides insights about the allosteric modulation and activation mechanism of class C GPCRs. ..
  8. Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 2000;288:1832-5 pubmed
    Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum...
  9. Rives M, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub M, et al. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. EMBO J. 2009;28:2195-208 pubmed publisher
    ..Such a mechanism helps explain specific properties of cells expressing two different Gi- and Gq-coupled receptors activated by a single transmitter, or properties of GPCRs naturally coupled to both types of the G protein. ..

More Information


  1. Ansah O, Gonçalves L, Almeida A, Pertovaara A. Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals. Exp Neurol. 2009;216:66-74 pubmed publisher
  2. Chong Z, Li F, Maiese K. Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress. Curr Neurovasc Res. 2006;3:107-17 pubmed
    ..Further insight into the cellular mechanisms that determine neuronal protection by the metabotropic glutamate system will foster the successful therapeutic development of mGluRs for neurodegenerative disorders. ..
  3. San Gabriel A, Uneyama H, Yoshie S, Torii K. Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli. Chem Senses. 2005;30 Suppl 1:i25-6 pubmed
  4. Mitrano D, Arnold C, Smith Y. Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats. Neuroscience. 2008;154:653-66 pubmed publisher
    ..These results provide valuable information on the neuroadaptive mechanisms of accumbens group I mGluRs in response to cocaine administration. ..
  5. Wu M, Hajszan T, Xu C, Leranth C, Alreja M. Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons. J Neurophysiol. 2004;92:1216-25 pubmed
    ..1 microM. Pharmacologically, the effects of DHPG were partially/completely reduced by the mGluR1 antagonists, 7-hydrox-iminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester and (+)-2-methyl-4-..
  6. Yang B, Rajput P, Kumar U, Sastry B. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS ONE. 2015;10:e0138215 pubmed publisher
    ..While blockade of mGluR1 or mGluR5 alone could interfere with TBS-induced shifts in EGABA in neonates, only a combined blockade could do ..
  7. Wittmann M, Hubert G, Smith Y, Conn P. Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata. Neuroscience. 2001;105:881-9 pubmed
    ..This effect is selectively mediated by presynaptic activation of the group I mGluR subtype, mGluR1. Consistent with these data, electron microscopic immunocytochemical studies demonstrate the localization of ..
  8. Dong H, Hayar A, Callaway J, Yang X, Nai Q, Ennis M. Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells. J Neurosci. 2009;29:11943-53 pubmed publisher
  9. Brown J, Booth C, Randall A. Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. Eur J Neurosci. 2011;33:879-89 pubmed publisher
    ..This ADP was persistently depressed following a short application of (S)-DHPG. This effect was blocked by the mGluR1 antagonist, (S)-(+)-?-amino-4-carboxy-2-methylbenzeneacetic acid (LY367385)...
  10. Doumazane E, Scholler P, Zwier J, Trinquet E, Rondard P, Pin J. A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors. FASEB J. 2011;25:66-77 pubmed publisher
    ..In addition to describing a new method to analyze cell-surface receptor complexes, our data reveal a new level of complexity within the mGluR family. ..
  11. Poisik O, Smith Y, Conn P. D1- and D2-like dopamine receptors regulate signaling properties of group I metabotropic glutamate receptors in the rat globus pallidus. Eur J Neurosci. 2007;26:852-62 pubmed
    ..receptors is necessary to maintain signaling properties of group I metabotropic glutamate receptor subtypes, mGluR1 and 5, in the rat globus pallidus (GP), one of the nuclei in the BG circuit...
  12. Sun L, Gu L, Wang S, Yuan J, Yang H, Zhu J, et al. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. PLoS ONE. 2012;7:e32503 pubmed publisher
    ..The study also suggests that NAC might be a potential therapeutics targeting for group I mGlus activation in the treatment of PD. ..
  13. Jung C, Lee S, Choi H, Lim E, Lee M, Yang G, et al. Participation of peripheral group I and II metabotropic glutamate receptors in the development or maintenance of IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats. Neurosci Lett. 2006;409:173-8 pubmed
    ..chromen-1a-carboxylate ethyl ester (CPCCOEt) or 2-methyl-6-(phenylethynyl)-pyridine hydrochloride (MPEP), a mGluR1 or mGluR5 antagonist, blocked IL-1beta-induced mechanical allodynia and mirror-image mechanical allodynia produced ..
  14. Jin D, Guo M, Xue B, Fibuch E, Choe E, Mao L, et al. Phosphorylation and feedback regulation of metabotropic glutamate receptor 1 by calcium/calmodulin-dependent protein kinase II. J Neurosci. 2013;33:3402-12 pubmed publisher
    The metabotropic glutamate receptor 1 (mGluR1) is a G?(q)-protein-coupled receptor and is distributed in broad regions of the mammalian brain...
  15. Sevastyanova T, Kammermeier P. Cooperative signaling between homodimers of metabotropic glutamate receptors 1 and 5. Mol Pharmacol. 2014;86:492-504 pubmed publisher
    Metabotropic glutamate receptors (mGluRs) function as dimers. Recent work suggests that mGluR1 and mGluR5 may physically interact, but the nature and functional consequences of this relationship have not been addressed...
  16. Nakamura M, Sato K, Fukaya M, Araishi K, Aiba A, Kano M, et al. Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain. Eur J Neurosci. 2004;20:2929-44 pubmed
    ..This close molecular relationship might provide PLCbeta4 with a high-fidelity effector function to mediate various neuronal responses under physiological and pathophysiological conditions. ..
  17. Buratta S, Mambrini R, Miniaci M, Tempia F, Mozzi R. Group I metabotropic glutamate receptors mediate the inhibition of phosphatidylserine synthesis in rat cerebellar slices: a possible role in physiology and pathology. J Neurochem. 2004;89:730-8 pubmed
    ..CPCCOEt, an antagonist of metabotropic glutamate receptors type 1 (mGluR1) counteracted the effect, whereas antagonists of NMDA or AMPA receptors were ineffective...
  18. Semenov D, Belyakov A, Glushchenko T, Samoilov M, Salinska E, Lazarewicz J. Hypobaric Preconditioning Modifies Group I mGluRs Signaling in Brain Cortex. Neurochem Res. 2015;40:2200-10 pubmed publisher
    The study assessed involvement of Ca(2+) signaling mediated by the metabotropic glutamate receptors mGluR1/5 in brain tolerance induced by hypoxic preconditioning...
  19. Mori M, Gerber U. Slow feedback inhibition in the CA3 area of the rat hippocampus by synergistic synaptic activation of mGluR1 and mGluR5. J Physiol. 2002;544:793-9 pubmed
    ..Synergistic activation of mGluR1 and mGluR5 was required to induce the full inhibitory response...
  20. Shin J, Kim Y, Linden D. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2008;105:746-50 pubmed publisher
    ..This depolarization-induced slow current (DISC) is attenuated by antagonists of mGluR1 or TRP channels...
  21. Croci C, Sticht H, Brandstätter J, Enz R. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. J Biol Chem. 2003;278:50682-90 pubmed
    ..In summary, these results provide a molecular description of the interaction between protein phosphatase 1C and metabotropic glutamate receptors and thereby increase our understanding of glutamatergic signal transduction. ..
  22. Gillard S, Tzaferis J, Tsui H, Kingston A. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. J Comp Neurol. 2003;461:317-32 pubmed
    ..In contrast, mGluR1 alpha, mGluR2/3, mGluR4a, and mGluR7 were expressed in leptomeninges from adult rats...
  23. Bakshi K, Parihar R, Goswami S, Walsh M, Friedman E, Wang H. Prenatal cocaine exposure uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE. 2014;9:e91671 pubmed publisher
    ..neurotransmission and in utero cocaine exposure negatively affects metabotropic glutamate receptor-type 1 (mGluR1) activity, the effect of prenatal cocaine exposure on mGluR1 signaling and the underlying mechanism responsible ..
  24. Agassandian K, Cassell M. Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Brain Res. 2008;1226:39-55 pubmed publisher
    ..subcellular distribution of Cd and Cp in the amygdala and their possible relationship to metabotropic glutamate (mGluR1 alpha and 5) and TrkB receptors which interact with inputs from the cortex and are involved in associative ..
  25. Tadavarty R, Rajput P, Wong J, Kumar U, Sastry B. Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression. PLoS ONE. 2011;6:e24933 pubmed publisher
  26. Techlovská Å, Chambers J, Dvořáková M, Petralia R, Wang Y, Hájková A, et al. Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo. Neuropharmacology. 2014;86:329-336 pubmed publisher
    The assembly of two covalently linked monomers into dimeric complexes is a prerequisite for metabotropic glutamate receptor 1 (mGluR1) function...
  27. Ji G, Neugebauer V. Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. J Neurophysiol. 2011;106:2642-52 pubmed publisher
    ..mPFC neurons to determine the role of GABA(A) receptors and metabotropic glutamate receptor (mGluR) subtypes, mGluR1 and mGluR5, in pain-related activity changes of mPFC neurons...
  28. Le Duigou C, Holden T, Kullmann D. Short- and long-term depression at glutamatergic synapses on hippocampal interneurons by group I mGluR activation. Neuropharmacology. 2011;60:748-56 pubmed publisher
    ..Selective blockers revealed a link from mGluR1 to reversible, and mGluR5 to long-lasting, depression...
  29. Sánchez Fuentes A, Marichal Cancino B, Méndez Díaz M, Becerril Meléndez A, Ruiz Contreras A, Prospero Garcia O. mGluR1/5 activation in the lateral hypothalamus increases food intake via the endocannabinoid system. Neurosci Lett. 2016;631:104-8 pubmed publisher
    ..Stimulation of hypothalamic mGluR1/5 and CB1 receptors induces hyperphagia suggesting a possible interaction between these systems to control food ..
  30. Shaffer C, Guo M, Fibuch E, Mao L, Wang J. Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo. Brain Res. 2010;1326:184-92 pubmed publisher
    ..Group I mGluRs (mGluR1 and mGluR5 subtypes) are expressed in striatal medium spiny output neurons and are believed to play an important ..
  31. Clement J, Randall A, Brown J. Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. Eur J Neurosci. 2009;29:2347-62 pubmed publisher
    ..DHPG-LDE was blocked by (S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid (LY367385), an antagonist of mGluR1, but not 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP), an mGluR5 inhibitor...
  32. Poisik O, Mannaioni G, Traynelis S, Smith Y, Conn P. Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. J Neurosci. 2003;23:122-30 pubmed
    ..Here, we report that group I mGluR1 and mGluR5 have distinct functional roles in type II neurons of the rat globus pallidus (GP)...
  33. Jung K, Mangieri R, Stapleton C, Kim J, Fegley D, Wallace M, et al. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Mol Pharmacol. 2005;68:1196-202 pubmed
    ..The results suggest that 2-AG is a primary endocannabinoid mediator of mGlu receptor-dependent neuronal plasticity. ..
  34. Jin Y, Kim S, Kim J, Worley P, Linden D. Long-term depression of mGluR1 signaling. Neuron. 2007;55:277-87 pubmed
    ..Burst stimulation of parallel fibers releases glutamate, which activates perisynaptic mGluR1 in the dendritic spines of cerebellar Purkinje cells...
  35. Houamed K, Kuijper J, Gilbert T, Haldeman B, O Hara P, Mulvihill E, et al. Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. Science. 1991;252:1318-21 pubmed
    ..Activation is blocked by Bordella pertussis toxin. These properties are typical of some metabotropic glutamate receptors. ..
  36. Watson L, Bamber E, Schnekenberg R, Williams J, Bettencourt C, Lickiss J, et al. Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44. Am J Hum Genet. 2017;101:451-458 pubmed publisher
    The metabotropic glutamate receptor 1 (mGluR1) is abundantly expressed in the mammalian central nervous system, where it regulates intracellular calcium homeostasis in response to excitatory signaling...
  37. Hsu W, Chung H, Wu C, Wu H, Lee Y, Chen E, et al. Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors. J Biol Chem. 2015;290:20748-60 pubmed publisher
    ..local translation in axons begins with the binding of glutamate to the ionotropic AMPA receptors and metabotropic glutamate receptor 1 and members of group 2 metabotropic glutamate receptors on the plasma membrane...
  38. Kushmerick C, Price G, Taschenberger H, Puente N, Renden R, Wadiche J, et al. Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. J Neurosci. 2004;24:5955-65 pubmed
  39. Moore S, Cooper D, Spruston N. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors. Neuron. 2009;61:287-300 pubmed publisher
    ..These results indicate that the output of subiculum can be strongly and bidirectionally regulated by activation of glutamatergic inputs within the hippocampus and cholinergic afferents from the medial septum. ..
  40. Hainmueller T, Krieglstein K, Kulik A, Bartos M. Joint CP-AMPA and group I mGlu receptor activation is required for synaptic plasticity in dentate gyrus fast-spiking interneurons. Proc Natl Acad Sci U S A. 2014;111:13211-6 pubmed publisher
    ..We found that mGluRs1/5 are located perisynaptically and that pharmacological block of mGluR1 or mGluR5 abolished MF-LTP...
  41. Mitrano D, Pare J, Smith Y. Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens. J Comp Neurol. 2010;518:1315-29 pubmed publisher
  42. Sun H, Neugebauer V. mGluR1, but not mGluR5, activates feed-forward inhibition in the medial prefrontal cortex to impair decision making. J Neurophysiol. 2011;106:960-73 pubmed publisher
    ..An mGluR1/5 agonist [(S)-3,5-dihydroxyphenylglycine, DHPG] increased synaptic inhibition more strongly than excitatory ..
  43. Simonyi A, Ngomba R, Storto M, Catania M, Miller L, Youngs B, et al. Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging. Brain Res. 2005;1043:95-106 pubmed
    ..These results demonstrate region- and subtype-specific, including splice variant specific changes in the expression of mGlu receptors in the brain with increasing age. ..
  44. Volk L, Daly C, Huber K. Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression. J Neurophysiol. 2006;95:2427-38 pubmed
    Although metabotropic glutamate receptors (mGluRs) mGluR1 and mGluR5 are often found to have similar functions, there is considerable evidence that the two receptors also serve distinct functions in neurons...
  45. Xie F, Yi S, Hao L, Zhang Y, Zhong J. Role of group I metabotropic glutamate receptors, mGluR1/mGluR5, in connexin43 phosphorylation and inhibition of gap junctional intercellular communication in H9c2 cardiomyoblast cells. Mol Cell Biochem. 2015;400:213-22 pubmed publisher
    Group I metabotropic glutamate receptors, mGluR1 and mGluR5, are associated with sympathetic nerve activity...
  46. Tashiro A, Nishida Y, Bereiter D. Local group I mGluR antagonists reduce TMJ-evoked activity of trigeminal subnucleus caudalis neurons in female rats. Neuroscience. 2015;299:125-33 pubmed publisher
    Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are functionally linked to estrogen receptors and play a key role in the plasticity of central neurons...
  47. San Gabriel A, Maekawa T, Uneyama H, Yoshie S, Torii K. mGluR1 in the fundic glands of rat stomach. FEBS Lett. 2007;581:1119-23 pubmed
    ..We used RT-PCR, western blotting, and immunohistochemistry to demonstrate that mGluR1 is located in glandular stomach...
  48. Prisco S, Natoli S, Bernardi G, Mercuri N. Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons. Neuropharmacology. 2002;42:289-96 pubmed
    ..These results suggest that both the activation of glutamate metabotropic type 1 and NMDA ionotropic receptors induce burst firing in the dopaminergic cells of the ventral midbrain when the activity of the SK-channels is reduced...
  49. Gierke P, Zhao C, Bernstein H, Noack C, Anand R, Heinemann U, et al. Implication of neuronal Ca2+ -sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia. Neurobiol Dis. 2008;32:162-75 pubmed publisher
  50. Fan W. Group I metabotropic glutamate receptors modulate late phase long-term potentiation in hippocampal CA1 pyramidal neurons: comparison of apical and basal dendrites. Neurosci Lett. 2013;553:132-7 pubmed publisher
    ..My results show that mGlu1 receptor modulates late-LTP in apical dendrites and basal dendrites, whereas mGlu5 receptor modulates late-LTP only in apical dendrites. ..
  51. Hardingham N, Bannister N, Read J, Fox K, Hardingham G, Jack J. Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors. J Neurosci. 2006;26:6337-45 pubmed
    ..Therefore, physiologically relevant changes in extracellular Ca2+ can regulate information transfer at cortical synapses via both presynaptic and postsynaptic mechanisms. ..
  52. Soloviev M, Ciruela F, Chan W, McIlhinney R. Identification, cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR1 mRNA1. Biochim Biophys Acta. 1999;1446:161-6 pubmed
    ..applied quantitative RT-PCR analysis to characterise relative levels of expression of the alternatively spliced mGluR1 mRNAs. This has also allowed us to identify and clone a new alternatively spliced form of the mGluR1 mRNA...
  53. Kramer P, Williams J. Calcium Release from Stores Inhibits GIRK. Cell Rep. 2016;17:3246-3255 pubmed publisher
    ..This inhibition of GABAB IPSCs through release of calcium from stores is a postsynaptic mechanism that may broadly reduce GIRK-dependent inhibition of many central neurons. ..