Grin2a

Summary

Gene Symbol: Grin2a
Description: glutamate ionotropic receptor NMDA type subunit 2A
Alias: GluN2A, NMDAR2A, NR2A, glutamate receptor ionotropic, NMDA 2A, N-methyl D-aspartate receptor subtype 2A, N-methyl-D-aspartate receptor subunit 2A, glutamate [NMDA] receptor subunit epsilon-1, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Species: rat
Products:     Grin2a

Top Publications

  1. Massey P, Johnson B, Moult P, Auberson Y, Brown M, Molnar E, et al. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J Neurosci. 2004;24:7821-8 pubmed
    ..We also find that de novo LTD requires the activation of NR2B-containing NMDAR, whereas LTP requires activation of NR2A-containing NMDARs. Surprisingly another form of LTD, depotentiation, requires activation of NR2A-containing NMDARs...
  2. Kornau H, Schenker L, Kennedy M, Seeburg P. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995;269:1737-40 pubmed
    ..The interaction of these proteins may affect the plasticity of excitatory synapses. ..
  3. Chen J, Miao Y, Wang X, Wang Z. Elevation of p-NR2A(S1232) by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model. Neurobiol Dis. 2011;43:455-64 pubmed publisher
    ..001), whereas that of p35 displayed a marked increase on D14 (P<0.01) and D21 (P<0.001). Meanwhile, both NR2A and p-NR2A(S1232) increased from D14 onwards (P<0.01 to 0.001)...
  4. Lee C, Gouaux E. Amino terminal domains of the NMDA receptor are organized as local heterodimers. PLoS ONE. 2011;6:e19180 pubmed publisher
    ..Here we studied the organization of the amino terminal domain (ATD) of the rat GluN1/GluN2A and GluN1/GluN2B NMDA receptors by cysteine-directed, disulfide bond-mediated cross-linking...
  5. Puddifoot C, Chen P, Schoepfer R, Wyllie D. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol. 2009;156:509-18 pubmed publisher
    ..This study determines to what extent characteristic pharmacological properties of NR2A-containing NMDARs are influenced by this key functional domain...
  6. Yang W, Zheng C, Song Q, Yang X, Qiu S, Liu C, et al. A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit. J Biol Chem. 2007;282:9269-78 pubmed
  7. Bartlett T, Bannister N, Collett V, Dargan S, Massey P, Bortolotto Z, et al. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology. 2007;52:60-70 pubmed
    ..Against recombinant receptors in HEK293 cells NVP-AAM077 (NVP) was approximately 14-fold selective for NR2A vs NR2B receptors, whilst Ro 25-6981 (Ro) was highly selective for NR2B receptors...
  8. Zhao M, Toyoda H, Lee Y, Wu L, Ko S, Zhang X, et al. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005;47:859-72 pubmed
    ..In particular, it has been suggested that NR2A-containing NMDA receptors are involved in LTP induction, whereas NR2B-containing receptors are involved in LTD ..
  9. Köhr G, Jensen V, Koester H, Mihaljevic A, Utvik J, Kvello A, et al. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci. 2003;23:10791-9 pubmed
    ..CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits...
  10. Niethammer M, Kim E, Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996;16:2157-63 pubmed
    ..library and by in vitro binding assays, we have identified an interaction between NMDA receptor subunits 2A and 2B (NR2A and NR2B) and three distinct members of the PSD-95/SAP90 family of membrane-associated putative guanylate kinases...

Detail Information

Publications62

  1. Massey P, Johnson B, Moult P, Auberson Y, Brown M, Molnar E, et al. Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J Neurosci. 2004;24:7821-8 pubmed
    ..We also find that de novo LTD requires the activation of NR2B-containing NMDAR, whereas LTP requires activation of NR2A-containing NMDARs. Surprisingly another form of LTD, depotentiation, requires activation of NR2A-containing NMDARs...
  2. Kornau H, Schenker L, Kennedy M, Seeburg P. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science. 1995;269:1737-40 pubmed
    ..The interaction of these proteins may affect the plasticity of excitatory synapses. ..
  3. Chen J, Miao Y, Wang X, Wang Z. Elevation of p-NR2A(S1232) by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model. Neurobiol Dis. 2011;43:455-64 pubmed publisher
    ..001), whereas that of p35 displayed a marked increase on D14 (P<0.01) and D21 (P<0.001). Meanwhile, both NR2A and p-NR2A(S1232) increased from D14 onwards (P<0.01 to 0.001)...
  4. Lee C, Gouaux E. Amino terminal domains of the NMDA receptor are organized as local heterodimers. PLoS ONE. 2011;6:e19180 pubmed publisher
    ..Here we studied the organization of the amino terminal domain (ATD) of the rat GluN1/GluN2A and GluN1/GluN2B NMDA receptors by cysteine-directed, disulfide bond-mediated cross-linking...
  5. Puddifoot C, Chen P, Schoepfer R, Wyllie D. Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed in Xenopus laevis oocytes. Br J Pharmacol. 2009;156:509-18 pubmed publisher
    ..This study determines to what extent characteristic pharmacological properties of NR2A-containing NMDARs are influenced by this key functional domain...
  6. Yang W, Zheng C, Song Q, Yang X, Qiu S, Liu C, et al. A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit. J Biol Chem. 2007;282:9269-78 pubmed
  7. Bartlett T, Bannister N, Collett V, Dargan S, Massey P, Bortolotto Z, et al. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology. 2007;52:60-70 pubmed
    ..Against recombinant receptors in HEK293 cells NVP-AAM077 (NVP) was approximately 14-fold selective for NR2A vs NR2B receptors, whilst Ro 25-6981 (Ro) was highly selective for NR2B receptors...
  8. Zhao M, Toyoda H, Lee Y, Wu L, Ko S, Zhang X, et al. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005;47:859-72 pubmed
    ..In particular, it has been suggested that NR2A-containing NMDA receptors are involved in LTP induction, whereas NR2B-containing receptors are involved in LTD ..
  9. Köhr G, Jensen V, Koester H, Mihaljevic A, Utvik J, Kvello A, et al. Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction. J Neurosci. 2003;23:10791-9 pubmed
    ..CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality assemble from NR1 with NR2A and/or NR2B subunits...
  10. Niethammer M, Kim E, Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996;16:2157-63 pubmed
    ..library and by in vitro binding assays, we have identified an interaction between NMDA receptor subunits 2A and 2B (NR2A and NR2B) and three distinct members of the PSD-95/SAP90 family of membrane-associated putative guanylate kinases...
  11. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science. 1992;256:1217-21 pubmed
    ..Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence...
  12. Li B, Sun M, Zhang L, Takahashi S, Ma W, Vinade L, et al. Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci U S A. 2001;98:12742-7 pubmed
    ..Here, we demonstrate that cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at Ser-1232 in vitro and in intact cells...
  13. Wang J, Liu S, Fu Y, Wang J, Lu Y. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci. 2003;6:1039-47 pubmed
    ..Inhibiting endogenous Cdk5, or perturbing interactions between Cdk5 and NR2A subunits, abolished NR2A phosphorylation at Ser1232 and protected CA1 pyramidal neurons from ischemic insult...
  14. Liu Y, Zhang G, Gao C, Hou X. NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Brain Res. 2001;909:51-8 pubmed
    ..In this study, effect of ischemia and reperfusion (I/R) on tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) and the interaction of two tyrosine kinases, Src and Pyk2, with NR2A was investigated...
  15. Berberich S, Jensen V, Hvalby Ø, Seeburg P, Köhr G. The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology. 2007;52:77-86 pubmed
    ..For high frequency afferent stimulation (HFS), we found that genetic impairment of NR2A or pharmacological block of NR2A- or NR2B-type NMDARs can reduce field LTP...
  16. Popescu G, Robert A, Howe J, Auerbach A. Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature. 2004;430:790-3 pubmed
    ..by examining the kinetics of transmitter binding and channel gating in single-channel currents from recombinant NR1/NR2A receptors, that the synaptic response to trains of impulses is determined by the molecular reaction mechanism of ..
  17. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A. 1999;96:435-40 pubmed
    ..Results showed that tyrosine phosphorylation of NR2A, one of the NMDA receptor subunits, was reduced in fyn-mutant mice...
  18. Mallon A, Auberson Y, Stone T. Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices. Exp Brain Res. 2005;162:374-83 pubmed
    ..Each receptor includes at least two NR2 subunits. Here, we have examined the effects of selective antagonists of NR2A and NR2B subunits (NVP-AAM07 and Ro25-6981 respectively) on the effects of NMDA in the CA1 field of rat hippocampal ..
  19. Kim M, Dunah A, Wang Y, Sheng M. Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron. 2005;46:745-60 pubmed
    ..In mature cultured neurons, NR2A-NMDARs promote, whereas NR2B-NMDARs inhibit, the surface expression of GluR1, primarily by regulating its surface ..
  20. Qiu S, Hua Y, Yang F, Chen Y, Luo J. Subunit assembly of N-methyl-d-aspartate receptors analyzed by fluorescence resonance energy transfer. J Biol Chem. 2005;280:24923-30 pubmed
    ..The results showed that NR1, NR2A, and NR2B subunits could form homodimers when they were expressed alone in HEK293 cells...
  21. Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, et al. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem. 1993;268:2836-43 pubmed
    cDNA clones for four different N-methyl-D-aspartate (NMDA) receptor subunits (NMDAR2A-NMDAR2D) were isolated through polymerase chain reactions followed by molecular screening of a rat brain cDNA library...
  22. Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, et al. Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell. 1998;92:279-89 pubmed
    ..Mice expressing the NR2B subunit in a C-terminally truncated form (NR2B(deltaC/deltaC) mice) die perinatally. NR2A(deltaC/deltaC) mice are viable but exhibit impaired synaptic plasticity and contextual memory...
  23. Furukawa H, Singh S, Mancusso R, Gouaux E. Subunit arrangement and function in NMDA receptors. Nature. 2005;438:185-92 pubmed
    ..Here we report crystal structures of the ligand-binding core of NR2A with glutamate and that of the NR1-NR2A heterodimer with glutamate and glycine...
  24. Waxman E, Lynch D. N-methyl-D-aspartate receptor subtype mediated bidirectional control of p38 mitogen-activated protein kinase. J Biol Chem. 2005;280:29322-33 pubmed
    ..The ability of NMDAR subtype-specific mechanisms to regulate p38 has implications for NMDAR-mediated synaptic plasticity, gene regulation, and excitotoxicity. ..
  25. Wu H, Yuen E, Lu Y, Matsushita M, Matsui H, Yan Z, et al. Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons. J Biol Chem. 2005;280:21588-93 pubmed
    ..Immunoblotting analysis showed that the NR2A and NR2B subunits of NMDARs were markedly degraded in cultured cortical neurons treated with glutamate, and the ..
  26. Sakimura K, Kutsuwada T, Ito I, Manabe T, Takayama C, Kushiya E, et al. Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature. 1995;373:151-5 pubmed
    ..On the basis of the Mg2+ sensitivity and expression patterns, we have proposed that the epsilon 1 (NR2A) and epsilon 2 (NR2B) subunits play a role in synaptic plasticity...
  27. Foster K, McLaughlin N, Edbauer D, Phillips M, Bolton A, Constantine Paton M, et al. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. J Neurosci. 2010;30:2676-85 pubmed publisher
    ..receptors (NMDARs) are critical mediators of activity-dependent synaptic plasticity, but the differential roles of NR2A- versus NR2B-containing NMDARs have been controversial...
  28. Papadakis M, Hawkins L, Stephenson F. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors. J Biol Chem. 2004;279:14703-12 pubmed
    ..NR1-2a(c-Myc) /NR2A receptors when expressed in mammalian cells are not trafficked to the cell surface nor do they yield cell ..
  29. Wang W, Hu S, Li C, Zhou C, Qi S, Zhang G. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Brain Res. 2010;1328:162-70 pubmed publisher
    ..We recently reported that the triplicate complex NR2A-PSD-95-Src is a signaling module to facilitate NMDA receptor over-activation...
  30. Kussius C, Popescu G. NMDA receptors with locked glutamate-binding clefts open with high efficacy. J Neurosci. 2010;30:12474-9 pubmed publisher
    ..We found that locking GluN1 domains had no observable consequences on receptor activity, whereas locking GluN2A domains increased channel activity without reducing the number of resolvable kinetic states...
  31. Toyoda H, Zhao M, Zhuo M. Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur J Neurosci. 2005;22:485-94 pubmed
    ..In the hippocampus, the NR2A subunit is believed to be involved in the induction of LTP, whereas the NR2B subunit contributes to the formation ..
  32. Liu L, Wong T, Pozza M, Lingenhoehl K, Wang Y, Sheng M, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 2004;304:1021-4 pubmed
    ..In contrast, preferential inhibition of NR2A-containing NMDARs prevents the induction of LTP without affecting LTD production...
  33. Cousins S, Stephenson F. Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95. J Biol Chem. 2012;287:13465-76 pubmed publisher
    ..We previously challenged this dogma to demonstrate a second non-ES(E/D)V PSD-95-binding site in both NMDA receptor NR2A and NR2B subunits...
  34. Riou M, Stroebel D, Edwardson J, Paoletti P. An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors. PLoS ONE. 2012;7:e35134 pubmed publisher
    ..a combination of electrophysiological and cross-linking experiments, we provide evidence that functional GluN1/GluN2A receptors adopt the 1/2/1/2 arrangement in which like subunits are diagonal to one another...
  35. Fan J, Vasuta O, Zhang L, Wang L, George A, Raymond L. N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95. J Neurochem. 2010;115:1045-56 pubmed publisher
    ..Tat-NR2B9c, a membrane-permeant peptide that disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95...
  36. Shi M, Wu X, Wei C, Yang M, Liu Z, Ren W. Effects of NR2A and NR2B-containing N-methyl-D-aspartate receptors on neuronal-firing properties. Neuroreport. 2011;22:762-6 pubmed publisher
    ..Furthermore, selective activation of NR2A-containing NMDARs mediated the enhancement of spike adaptation, whereas selective activation of NR2B-containing ..
  37. Staples M, Somkuwar S, Mandyam C. Developmental effects of wheel running on hippocampal glutamate receptor expression in young and mature adult rats. Neuroscience. 2015;305:248-56 pubmed publisher
    ..In contrast, mature adult runners demonstrated a reduction in total GluN2A expression in the DH, without producing alterations in the VH compared to age-matched sedentary controls...
  38. Wrighton D, Baker E, Chen P, Wyllie D. Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol. 2008;586:211-25 pubmed
    ..and memantine at the two NMDARs displaying the largest differences in sensitivity to these blockers, namely NR1/NR2A and NR1/NR2D NMDARs...
  39. Lebel D, Sidhu N, Barkai E, Quinlan E. Learning in the absence of experience-dependent regulation of NMDAR composition. Learn Mem. 2006;13:566-70 pubmed
    ..in the composition and function of NMDARs at synapses in the piriform cortex, resulting in a high level of the NR2a subunit relative to NR2b...
  40. Wyllie D, Johnston A, Lipscombe D, Chen P. Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit. J Physiol. 2006;574:477-89 pubmed
    We have examined the function of a conserved serine residue (Ser670) in the S2 ligand-binding region of the NR2A N-methyl-d-aspartate (NMDA) receptor subunit, using recombinant NR1/NR2A receptors expressed in Xenopus laevis oocytes...
  41. Hawkins L, Chazot P, Stephenson F. Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors. J Biol Chem. 1999;274:27211-8 pubmed
    ..Thus, human embryonic kidney 293 cells were transfected with the NR1-1a and NR2A NMDA receptor subunits in combination with both FLAG- and c-Myc epitope-tagged NR2B subunits...
  42. Williams S, Chen L, Savignac H, Tzortzis G, Anthony D, Burnet P. Neonatal prebiotic (BGOS) supplementation increases the levels of synaptophysin, GluN2A-subunits and BDNF proteins in the adult rat hippocampus. Synapse. 2016;70:121-4 pubmed publisher
    ..or a control solution, alters the levels of hippocampal N-Methyl-D-Aspartate receptor (NMDAR) subunits (GluN1, GluN2A, GluN2B), synaptic proteins (synaptophysin, MAP2, and GAP43) and brain-derived-neurotrophic factor (BDNF), at post-..
  43. Miao Y, Dong L, Chen J, Hu X, Yang X, Wang Z. Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons. PLoS ONE. 2012;7:e42318 pubmed publisher
    ..Glutamate treatment for less than 9 h also considerably enhanced the ratio of the Cdk5-phosphorylated NMDAR subunit NR2A at Ser1232 site (p-NR2A(S1232)) and NR2A (p-NR2A(S1232)/NR2A), and caused a translocation of p-NR2A(S1232) from the ..
  44. Takagi N, Besshoh S, Marunouchi T, Takeo S, Tanonaka K. Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats. Neurosci Lett. 2012;530:91-6 pubmed publisher
    ..Tyrosine phosphorylation of the NR2A subunit, but not that of the NR2B one, was inhibited by the mGlu5 receptor antagonist...
  45. Choo A, Geddes Klein D, Hockenberry A, Scarsella D, Mesfin M, Singh P, et al. NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult. Neurochem Int. 2012;60:506-16 pubmed publisher
    ..b>NR2A- and NR2B-containing NMDARs differentially mediated acute changes in cytosolic calcium, alterations in ..
  46. Bigford G, Chaudhry N, Keane R, Holohean A. 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 2012;287:11049-59 pubmed publisher
    ..Co-immunoprecipitation of synaptosomal fractions showed that GluN2A, 5HT2C receptors, and Src tyrosine kinase form protein associations in synaptosomes...
  47. Tang J, Chen X, Xu X, Wu R, Zhao J, Hu Z, et al. Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia. Neurosci Lett. 2006;409:80-2 pubmed
    ..identified a variable (GT)n polymorphism in the promoter region of the N-methyl-d-aspartate (NMDA) subunit gene (GRIN2A), and showed its association with schizophrenia in a case-control study, together with a correlation between the ..
  48. Jin S, Feig L. Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling. PLoS ONE. 2010;5:e11732 pubmed publisher
    ..A majority of studies show that both NR2A and NR2B-containing NMDARs can contribute to LTP, but their unique contributions to this form of synaptic ..
  49. Shmelkov S, Hormigo A, Jing D, Proenca C, Bath K, Milde T, et al. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med. 2010;16:598-602, 1p following 602 pubmed publisher
    ..Thus, our studies identify Slitrk5 as an essential molecule at corticostriatal synapses and provide a new mouse model of OCD-like behaviors. ..
  50. Suckow S, Caudle R. NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity. Mol Pain. 2009;5:54 pubmed publisher
    ..Therefore, these data suggest that CANs contribute to visceral hypersensitivity during inflammation. ..
  51. Liu W, Wang X, Zhang R, Zhou Y. Effects of postnatal exposure to methylmercury on spatial learning and memory and brain NMDA receptor mRNA expression in rats. Toxicol Lett. 2009;188:230-5 pubmed publisher
    ..In hippocampus, the mRNA expression of NR2A and NR2B decreased, but the NR2C expression increased in PND14 group following MMC-treatment (p<0.01)...
  52. Garside M, Turner P, Austen B, Strehler E, Beesley P, Empson R. Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum. Neuroscience. 2009;162:383-95 pubmed publisher
    ..that PMCA2 interacts with the post-synaptic proteins PSD95 and the NMDA glutamate receptor subunits NR1 and NR2a, via its C-terminal PDZ (PSD95/Dlg/ZO-1) binding domain...
  53. Kitamura T, Mishina M, Sugiyama H. Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit. Neurosci Res. 2003;47:55-63 pubmed
    ..These results suggest that the wheel exercise may activate NMDA receptors in the hippocampus, which in turn may enhance BDNF production and neurogenesis. ..
  54. Fu Z, Washbourne P, Ortinski P, Vicini S. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J Neurophysiol. 2003;90:3950-7 pubmed
  55. Liu A, Zhuang Z, Hoffman P, Bai G. Functional analysis of the rat N-methyl-D-aspartate receptor 2A promoter: multiple transcription starts points, positive regulation by Sp factors, and translational regulation. J Biol Chem. 2003;278:26423-34 pubmed
    N-Methyl-d-aspartate (NMDA) receptor subunit 2A (NR2A) is an important modulatory component of the NMDA subtype of glutamate receptors...
  56. Ren H, Zhao Y, Wu M, Dwyer D, Peoples R. Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating. Neuropharmacology. 2017;114:20-33 pubmed publisher
  57. Zhu J, Shao C, Yang W, Zhang X, Wu Z, Zhou L, et al. Chronic zinc exposure decreases the surface expression of NR2A-containing NMDA receptors in cultured hippocampal neurons. PLoS ONE. 2012;7:e46012 pubmed publisher
    ..We reported that chronic zinc exposure reduced the numbers of NR1 and NR2A clusters in cultured hippocampal pyramidal neurons. Whole-cell and synaptic NR2A-mediated currents also decreased...
  58. Arning L, Saft C, Wieczorek S, Andrich J, Kraus P, Epplen J. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Hum Genet. 2007;122:175-82 pubmed
    ..g. variations in the NR2A and NR2B glutamate receptor subunit genes (GRIN2A, GRIN2B)...
  59. Xu Z, Chen R, Gu Q, Yan J, Wang S, Liu S, et al. Metaplastic regulation of long-term potentiation/long-term depression threshold by activity-dependent changes of NR2A/NR2B ratio. J Neurosci. 2009;29:8764-73 pubmed publisher
    ..priming stimulations (PSs) across a wide range of frequencies (1-100 Hz) could induce bidirectional changes in the NR2A/NR2B ratio, which governs the threshold for subsequent long-term potentiation/long-term depression (LTP/LTD)...
  60. Yuan H, Vance K, Junge C, Geballe M, Snyder J, Hepler J, et al. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem. 2009;284:12862-73 pubmed publisher
    Zinc is hypothesized to be co-released with glutamate at synapses of the central nervous system. Zinc binds to NR1/NR2A N-methyl-d-aspartate (NMDA) receptors with high affinity and inhibits NMDAR function in a voltage-independent manner...
  61. Abe M, Fukaya M, Yagi T, Mishina M, Watanabe M, Sakimura K. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. J Neurosci. 2004;24:7292-304 pubmed
    ..investigated the GluRzeta1 subunit in cerebellar granule cells lacking two major GluRepsilon subunits, GluRepsilon1/NR2A and GluRepsilon3/NR2C...
  62. Miller B, Gore A. N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat. Endocrinology. 2002;143:3568-74 pubmed
    ..Colocalization of the three NMDAR subunits that are most abundant in the hypothalamus (NR1, NR2A, or NR2B) with GnRH perikarya was determined in female rats at different stages of the reproductive life cycle: ..