Gria1

Summary

Gene Symbol: Gria1
Description: glutamate receptor, ionotropic, AMPA 1
Alias: GluA1, gluR-A, AMPA-selective glutamate receptor 1, GluR1, gluR-1, gluR-K1, glutamate receptor 1, glutamate receptor A, glutamate receptor subunit GluR1, glutamate receptor, ionotropic, AMPA1 (alpha 1)
Species: rat

Top Publications

  1. ncbi Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor
    Shinji Matsuda
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Biol Chem 280:20021-9. 2005
  2. pmc Sustained hypertension increases the density of AMPA receptor subunit, GluR1, in baroreceptive regions of the nucleus tractus solitarii of the rat
    Sam M Hermes
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1187:125-36. 2008
  3. pmc Crystal structure of the glutamate receptor GluA1 N-terminal domain
    Guorui Yao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Fujian, China
    Biochem J 438:255-63. 2011
  4. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
  5. pmc Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit
    Heng Ye Man
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:3579-84. 2007
  6. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
  7. ncbi Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
    Michael C Oh
    Vollum Institute, Oregon Health and Sciences University, Portland, 97239, USA
    J Biol Chem 281:752-8. 2006
  8. pmc The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex
    Wenhua Liu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 285:6101-8. 2010
  9. ncbi Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
  10. ncbi Postsynaptic receptor trafficking underlying a form of associative learning
    Simon Rumpel
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 308:83-8. 2005

Research Grants

Scientific Experts

Detail Information

Publications102 found, 100 shown here

  1. ncbi Roles of the N-terminal domain on the function and quaternary structure of the ionotropic glutamate receptor
    Shinji Matsuda
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Biol Chem 280:20021-9. 2005
    ..Here, we developed a new approach to address these issues. The LIVBP domain of the GluR1 subunit of AMPA receptors was replaced by leucine-zipper peptides designed to form stable symmetric dimers, ..
  2. pmc Sustained hypertension increases the density of AMPA receptor subunit, GluR1, in baroreceptive regions of the nucleus tractus solitarii of the rat
    Sam M Hermes
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1187:125-36. 2008
    ..Within NTS, the GluR1 subunit of the AMPA receptor is found primarily in dendritic spines...
  3. pmc Crystal structure of the glutamate receptor GluA1 N-terminal domain
    Guorui Yao
    Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, College of Medicine, Xiamen University, Fujian, China
    Biochem J 438:255-63. 2011
    ..We report in the present study a 2.5 Å (1 Å=0.1 nm) resolution crystal structure of the ATD of GluA1. Comparative analyses of the structure of GluA1-ATD and other subunits sheds light on our understanding of how ATD ..
  4. ncbi Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS
    B Sommer
    Laboratory of Molecular Neuroendocrinology, Center for Molecular Biology, University of Heidelberg, F R G
    Science 249:1580-5. 1990
    ..These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing...
  5. pmc Regulation of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking through PKA phosphorylation of the Glu receptor 1 subunit
    Heng Ye Man
    Howard Hughes Medical Institute and Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:3579-84. 2007
    ..studies have shown that activation of PKA regulates the membrane trafficking of the AMPA receptor Glu receptor 1 (GluR1) subunit, but the role of direct phosphorylation of GluR1 in regulating receptor redistribution is not clear...
  6. pmc Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons
    Hisaaki Namba
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Mol Cell Neurosci 31:628-41. 2006
    ..growth factor alpha (TGFalpha), EGF, or heparin-binding EGF (HB-EGF) down-regulated protein expression of the GluR1 AMPA receptor subunit in cultured neocortical neurons...
  7. ncbi Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
    Michael C Oh
    Vollum Institute, Oregon Health and Sciences University, Portland, 97239, USA
    J Biol Chem 281:752-8. 2006
    ..Using a quantitative assay of net serine 845 (Ser-845) phosphorylation in the GluR1 subunit of AMPARs, we investigated the relationship between phospho-Ser-845, GluR1 surface expression, and ..
  8. pmc The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex
    Wenhua Liu
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 285:6101-8. 2010
    ..It provides a potential mechanism underlying the role of corticosteroid stress hormone in up-regulating excitatory synaptic efficacy in cortical neurons...
  9. ncbi Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking
    Hailan Hu
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 131:160-73. 2007
    ..Toward this aim, we have examined the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-..
  10. ncbi Postsynaptic receptor trafficking underlying a form of associative learning
    Simon Rumpel
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 308:83-8. 2005
    ..Thus, the encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking, is widely distributed, and displays little redundancy...
  11. ncbi Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    S Shi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 105:331-43. 2001
    ..In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms...
  12. pmc Surface mobility of postsynaptic AMPARs tunes synaptic transmission
    Martin Heine
    CNRS, UMR 5091, Universite Bordeaux, Bordeaux, France
    Science 320:201-5. 2008
    ..Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses...
  13. pmc Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression
    Hussam Jourdi
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States of America
    PLoS ONE 8:e57124. 2013
    ..Our results show that acute BDNF treatment upregulates the interactions between AMPAr subunits (GluR1 and GluR2) with their scaffold proteins SAP97 and GRIP1, respectively, leading to prolonged increased accumulation ..
  14. pmc PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons
    Rebecca M Dixon
    Medical Research Council MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 284:14230-5. 2009
    ....
  15. pmc PKCλ is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP
    Si Qiang Ren
    Department of Neurobiology, Nanjing Medical University, Nanjing, People s Republic of China
    EMBO J 32:1365-80. 2013
    Direct phosphorylation of GluA1 by PKC controls α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor (AMPAR) incorporation into active synapses during long-term potentiation (LTP)...
  16. pmc SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons
    Nadia Jaafari
    School of Biochemistry, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e52345. 2013
    ..Here we demonstrate that protein SUMOylation is required for insertion of the GluA1 AMPAR subunit following transient glycine-evoked increase in AMPA receptor surface expression (ChemLTP) in ..
  17. doi Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
    ..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse...
  18. doi Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats
    Hsien Yu Peng
    Department of Medicine, Mackay Medical College, New Taipei, Taiwan
    Pain 153:2380-92. 2012
    ..SGK1) and downstream glutamate receptor interacting protein (GRIP)-associated protein-1 (GRASP-1)/Rab4-dependent GluR1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) recycling play a role in ..
  19. pmc Identification of a novel signaling pathway and its relevance for GluA1 recycling
    Guiscard Seebohm
    Department of Biochemistry I Cation Channel Group, Ruhr University Bochum, Bochum, Germany
    PLoS ONE 7:e33889. 2012
    ..showed that the serum- and glucocorticoid-inducible kinase 3 (SGK3) increases the AMPA-type glutamate receptor GluA1 protein in the plasma membrane...
  20. doi Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF
    Midori Ninomiya
    Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo, Japan
    Neurosci Lett 476:104-9. 2010
    ..Expression of glutamate receptors such as GluA1 and GluN2A was also suppressed in IUGR-rat cultures...
  21. doi Increased synaptic GluR1 subunits in the anterior cingulate cortex of rats with peripheral inflammation
    Bihua Bie
    Department of General Anesthesiology, Institute of Anesthesiology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Eur J Pharmacol 653:26-31. 2011
    ..Furthermore, an increased distribution of the synaptic GluR1 subunit was observed in the ACC neurons...
  22. pmc Acute stress induces contrasting changes in AMPA receptor subunit phosphorylation within the prefrontal cortex, amygdala and hippocampus
    Dorian Caudal
    INSERM U894, Physiopathologie des Maladies Psychiatriques, Centre de psychiatrie et Neurosciences, Paris, France
    PLoS ONE 5:e15282. 2010
    ..After stress, the phosphorylation of Ser831-GluA1 was markedly decreased in the mPFC and DH, whereas the phosphorylation of Ser845-GluA1 was increased in the ..
  23. doi Role of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR1 in spinal dorsal horn in inflammatory nociception and neuropathic nociception in rat
    Yue Lu
    Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China
    Brain Res 1200:19-26. 2008
    The present study aims to investigate changes of spinal cord AMPA receptor GluR1 and its phosphorylation in inflammatory and neuropathic pain...
  24. pmc Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation
    Dongdong Li
    Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurochem 118:237-47. 2011
    ..Consistent with these findings, preventing GluR1 phosphorylation with the alanine mutant GluR1(S845A) reduces glutamate-evoked currents in cultured medium spiny ..
  25. ncbi Characterization of alternatively spliced isoforms of AMPA receptor subunits encoding truncated receptors
    André R Gomes
    Centre for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Largo Marques de Pombal, 3004 517 Coimbra, Portugal
    Mol Cell Neurosci 37:323-34. 2008
    ..AMPA receptors form heterotetramers of four homologous subunits (GluR1-4), which exist in two functionally different isoforms, flip and flop, generated by alternative splicing...
  26. pmc Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations
    Ahmed H Ahmed
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:35257-66. 2011
    ..The results are consistent the hypothesis that the efficacy is determined at least in part by the stability of the state in which the lobes are fully closed...
  27. ncbi Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus
    Kentaro Matsuzaki
    Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6 3 Aoba, Aramaki, Aoba ku, Sendai 980 8578, Japan
    Eur J Pharmacol 578:194-200. 2008
    ..combined methods of biochemistry and electrophysiology, we examined the effects of nobiletin on phosphorylation of GluR1 receptor, the subunit of alpha-amino-3-hydroxy-5-methyl-D-aspartate (AMPA) receptors, and the receptor-mediated ..
  28. doi Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate
    Yusuke Nakatsu
    Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3, Kasumi, Minami Ku, Hiroshima, 734 8553, Japan
    Toxicol Appl Pharmacol 240:292-8. 2009
    ..Long-term exposure to 20 nM TBT decreased the mRNA expression of glutamate receptors NR1, NR2A, GluR1 and GluR2, and increased that of NR2B, GluR3 and GluR4...
  29. ncbi Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions
    Clotilde Lecrux
    University of Caen, CNRS UMR 6185, Cyceron, Caen, France
    Stroke 38:3007-15. 2007
    ....
  30. pmc Regulation of AMPA receptor trafficking and function by glycogen synthase kinase 3
    Jing Wei
    Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, Jiangsu Province, China
    J Biol Chem 285:26369-76. 2010
    ..Treatment with GSK-3 inhibitors also decreased surface and synaptic GluR1 clusters on dendrites and increased internalized GluR1 in cortical cultures...
  31. ncbi Differential regulation of AMPA receptor trafficking by neurabin-targeted synaptic protein phosphatase-1 in synaptic transmission and long-term depression in hippocampus
    Xiao Dong Hu
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 27:4674-86. 2007
    ..Instead, NrbI-targeted PP1 facilitates LTD by dephosphorylating GluR1 at both serine 845 and serine 831, with GluR2 serine 880 phosphorylation unaltered...
  32. pmc Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguous of F344 rats
    Binbin Yan
    Biomolecular Science Center, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 4000 Central Florida Parkway, Orlando, FL 32816, USA
    Am J Physiol Regul Integr Comp Physiol 296:R299-308. 2009
    ..CIH -238 +/- 27 beats/min, P < 0.05); and 3) the number of NMDAR1, AMPA GluR1, and AMPA GluR2/3-immunoreactive cells in the NA was reduced (P < 0.05)...
  33. pmc Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus
    Pascal Ravassard
    UMR 5167 CNRS, Physio pathologie des reseaux neuronaux du cycle veille sommeil, Institut Feddratifdes Neurosciences de Lyon IFNL, IFR 19, Universite Lyon, Lyon, France
    Sleep 32:227-40. 2009
    ..We examined whether PS modulated the excitatory transmission and expression of glutamate receptor subtypes and phosphorylated extracellular signal-regulated kinases (p-ERK1/2)...
  34. doi Activation of group I metabotropic glutamate receptors increases serine phosphorylation of GluR1 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in the rat dorsal striatum
    Sung Min Ahn
    Department of Biological Sciences, Pusan National University, 30 Jangjeon dong, Kumjeong gu, Pusan 609 735, Korea
    J Pharmacol Exp Ther 329:1117-26. 2009
    ..study, we investigated the regulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor GluR1 subunit phosphorylation by the stimulation of group I metabotropic glutamate receptors (mGluRs) in the rat dorsal ..
  35. pmc Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein
    Charu Misra
    Department of Biochemistry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Mol Cell Neurosci 43:341-52. 2010
    ..viral expression of pABP-L increased AMPAR mediated mEPSC amplitude and frequency and elevated surface levels of GluR1 and GluR2, suggesting an increase in AMPA receptors at individual synapses...
  36. ncbi [Effect of behavioral training on learning and memory capacity and changes of hippocampal NR2B and GluR1 expressions in FGR offspring rats]
    Pu Huang
    Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi an Jiaotong University Coolege of Medicine, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:708-11. 2010
    To study the effect of behavioral training on the learning and memory abilities and changes of NR2B and GluR1 expressions in the hippocampus of offspring rats with fetal growth retardation (FGR).
  37. ncbi Immunohistochemistry of GluR1 subunits of AMPA receptors of rat cerebellar nerve cells
    Orlando J Castejon
    Institute of Biological Investigations, Faculty of Medicine, University of Zulia, PO Box 526, Maracaibo, Venezuela
    Biocell 33:71-80. 2009
    The localization of GluR1 subunits of ionotropic glutamate receptors in the glial cells and inhibitory neurons of cerebellar cortex and their association with the climbing and parallel fibers, and basket cell axons were studied...
  38. pmc Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activity
    Yelyzaveta A Nikandrova
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 285:923-34. 2010
    Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) promotes trafficking and activation of the GluR1 subunit of alpha-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) during synaptic plasticity...
  39. pmc C-terminal domains of transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor regulatory proteins not only facilitate trafficking but are major modulators of AMPA receptor function
    Charlotte Sager
    Department of Biochemistry I Receptor Biochemistry, Ruhr University Bochum, Germany
    J Biol Chem 284:32413-24. 2009
    ..We analyzed the impact of the resulting chimeras on GluR1 functional properties in Xenopus oocytes and HEK293 cells...
  40. doi Fast, quantitative in situ hybridization of rare mRNAs using 14C-standards and phosphorus imaging
    Christian M Cremer
    Institute for Neuroscience and Medicine INM 2, Research Center Julich, Julich, Germany
    J Neurosci Methods 185:56-61. 2009
    ..We used this approach as an example for applications to quantify the expression of GluR1 and GluR2 subunit mRNAs of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor in the ..
  41. pmc Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone
    Robert M Sears
    Department of Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 30:8263-73. 2010
    ..A reduction of phosphorylation of GluR1 at serine 845 (pSer(845)) is shown to occur after both pharmacological and genetic manipulations of MCHR1 activity...
  42. doi Differential roles of phosphorylated AMPA receptor GluR1 subunits at Serine-831 and Serine-845 sites in spinal cord dorsal horn in a rat model of post-operative pain
    Yun Wang
    Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, no 8, Gongtinan Road, Chaoyang District, 100020 Beijing, China
    Neurochem Res 36:170-6. 2011
    ..that the enhanced levels of phosphorylated α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are ..
  43. pmc Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
    Da Ting Lin
    Department of Neuroscience and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 12:879-87. 2009
    ..By directly visualizing individual insertion events of the AMPAR subunit GluR1 in rodents, we found that the protein 4.1N was required for activity-dependent GluR1 insertion...
  44. pmc The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors
    Nael Nadif Kasri
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Genes Dev 23:1289-302. 2009
    ..Thus, our findings link genetic deficits in OPHN1 to glutamatergic dysfunction and suggest that defects in early circuitry development are an important contributory factor to this form of MR...
  45. pmc Activity level-dependent synapse-specific AMPA receptor trafficking regulates transmission kinetics
    J Julius Zhu
    Departments of Pharmacology and Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 29:6320-35. 2009
    ..Moreover, GluR1-containing AMPA-Rs traffic selectively into intracortical synapses, and this process requires sensory experience-..
  46. doi Physical exercise improves learning by modulating hippocampal mossy fiber sprouting and related gene expression in a developmental rat model of penicillin-induced recurrent epilepticus
    Hong Ni
    Neurology Laboratory, Soochow University Affiliated Children s Hospital, Laboratory of Aging and Nervous Diseases, Soochow University, Suzhou 215003, PR China
    Toxicol Lett 191:26-32. 2009
    ..Both EXP1 and EXP2 rats had a higher amount of glutamate receptor 1 (GluR1) and lower amount of the ratio of GluR2/GluR1 in hippocampus when compared with CONT rats...
  47. doi Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
    Jochen Schwenk
    Institute of Physiology II, University of Freiburg, Engesserstrasse 4, 79108 Freiburg, Germany
    Science 323:1313-9. 2009
    ..These results demonstrate that cornichons are intrinsic auxiliary subunits of native AMPARs and provide previously unknown molecular determinants for glutamatergic neurotransmission in the central nervous system...
  48. doi The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene
    Jonathan M Levenson
    Galenea, Corp, Cambridge, MA 02139, USA
    Biochim Biophys Acta 1779:422-31. 2008
    ....
  49. ncbi Differential phosphorylation at serine sites in glutamate receptor-1 within neonatal rat hippocampus
    Ai Jun Li
    Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 341:41-4. 2003
    ..of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid (AMPA)-receptor glutamate receptor-1 (GluR1) and related protein kinases in rat hippocampus on postnatal days (PND) 1-28...
  50. ncbi Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo
    M Wyszynski
    Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 19:6528-37. 1999
    ..Collectively, these findings support a role for GRIP in the synaptic anchoring of AMPA receptors but also suggest that GRIP has additional functions unrelated to the binding of AMPA receptors...
  51. pmc Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex
    Robert B Levy
    New York University Center for Neural Science, New York, New York 10003, USA
    J Neurosci 22:5001-15. 2002
    ..we used dual immunolabeling and electron microscopy to examine the distribution of alpha7nAChR relative to AMPAR (GluR1, GluR2, and GluR3 subunits combined) at excitatory synapses in somatosensory cortex of adult and 1-week-old rats...
  52. ncbi A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors
    Houhui Xia
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94304, USA
    J Biol Chem 277:47765-9. 2002
    ..assembly and surface expression, we have epitope-tagged the N-terminal domain of the AMPA receptor subunit, GluR1, and expressed it in human embryonic kidney 293 cells and hippocampal neurons...
  53. ncbi Control of excitatory and inhibitory synapse formation by neuroligins
    Ben Chih
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 307:1324-8. 2005
    ..Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons...
  54. ncbi Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 45:269-77. 2005
    ..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory...
  55. ncbi Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals
    Fumino Fujiyama
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Japan
    Eur J Neurosci 20:3322-30. 2004
    ..Immunoreactive gold particles for AMPA receptor subunits GluR1 and GluR2/3 were frequently found not only on postsynaptic but also on presynaptic profiles immunopositive for ..
  56. ncbi Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression
    Jing Du
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:6578-89. 2004
    ..dissimilar, antimanic agents lithium and valproate regulate synaptic expression of AMPA receptor subunit glutamate receptor 1 (GluR1)...
  57. ncbi Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons
    Sang Hyoung Lee
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Neuron 43:221-36. 2004
    ..The intracellular accumulation of GluR2 and GluR3 but not GluR1 is enhanced by AMPA, NMDA, or synaptic activity...
  58. ncbi Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses
    Susumu Tomita
    Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 2140, USA
    Science 303:1508-11. 2004
    ..This did not require ion flux or intracellular second messengers. This allosteric mechanism for AMPA receptor dissociation from TARPs may participate in glutamate-mediated internalization of receptors in synaptic plasticity...
  59. ncbi Co-localization of AMPA receptor subunits in the nucleus of the solitary tract in the rat
    Sue A Aicher
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Brain Res 958:454-8. 2002
    ..GluR2/3 was found at pre- and postsynaptic sites, and in astrocytic glia; while GluR1 was found primarily in small dendrites and spines...
  60. pmc Characterization of the intracellular transport of GluR1 and GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons
    Pavel V Perestenko
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:43525-32. 2003
    ..Here, using virally expressed green fluorescent protein (GFP)-GluR1 and GFP-GluR2 and confocal photobleach techniques we show near real-time movement of these subunits in living ..
  61. pmc Regulated delivery of AMPA receptor subunits to the presynaptic membrane
    Ursula Schenk
    CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Center of Excellence for Neurodegenerative Diseases, Department of Medical Pharmacology, Via Vanvitelli 32, 20129 Milano, Italy
    EMBO J 22:558-68. 2003
    ..We demonstrate that the AMPA receptor subunits GluR1 and GluR2 are expressed and organized in functional receptors in axonal growth cones of hippocampal neurons...
  62. ncbi Experience strengthening transmission by driving AMPA receptors into synapses
    Takuya Takahashi
    Jones Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Science 299:1585-8. 2003
    ..In vivo gene delivery was combined with in vitro recordings to show that experience drives recombinant GluR1, an AMPA-R subunit, into synapses formed between layer 4 and layer 2/3 neurons...
  63. ncbi The structure and function of glutamate receptor ion channels
    Dean R Madden
    Ion Channel Structure Research Group, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Nat Rev Neurosci 3:91-101. 2002
    ....
  64. ncbi The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway
    Tomoyuki Nishizaki
    Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, 663 8501, Nishinomiya, Japan
    Brain Res Mol Brain Res 98:130-4. 2002
    ..on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, heteromerically formed of GluR1,2 (GluR1 and GluR2), GluR1,3 (GluR1 and GluR3), and GluR1,2,3 (GluR1, GluR2, and GluR3), expressed in Xenopus ..
  65. ncbi Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs
    Rebeca Martinez-Turrillas
    Division of Neurosciences, CIMA, School of Medicine, University of Navarra, Av Pio XII, 55, 31008 Pamplona, Spain
    Biochem Biophys Res Commun 353:750-5. 2007
    ..Both antidepressants increased the interaction of GluR1 subunit with stargazin and of GluR2/3 with NSF...
  66. ncbi Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity
    Jannic Boehm
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Learn Mem 13:562-5. 2006
    The regulated trafficking of GluR1 contributes significantly to synaptic plasticity, but studies addressing the function of the GluR1 C-terminal PDZ-ligand domain in this process have produced conflicting results...
  67. ncbi Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
    ..were associated with parallel alterations in expression levels and/or phosphorylation changes in the NR2B and GluR1 subunits of the respective NMDA and AMPA receptors...
  68. ncbi Molecular cloning and functional expression of glutamate receptor subunit genes
    J Boulter
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138
    Science 249:1033-7. 1990
    Three closely related genes, GluR1, GluR2, and GluR3, encode receptor subunits for the excitatory neurotransmitter glutamate...
  69. ncbi Ischemia-induced alterations of AMPA-type glutamate receptor subunit. Expression patterns in the rat retina--an immunocytochemical study
    Frederike Dijk
    Glaucoma Research Group, Netherlands Ophthalmic Research Institute KNAW, Graduate School for the Neurosciences Amsterdam, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Brain Res 997:207-21. 2004
    ..ischemia/reperfusion leads to alterations in the expression of AMPA-type glutamate receptor (AMPAR) subunits GluR1-4...
  70. ncbi Cloning by functional expression of a member of the glutamate receptor family
    M Hollmann
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037
    Nature 342:643-8. 1989
    ....
  71. ncbi Antibody specific for phosphorylated AMPA-type glutamate receptors at GluR2 Ser-696
    K Nakazawa
    Laboratory for Synaptic Function, Institute of Physical and Chemical Research RIKEN, Saitama, Japan
    Neurosci Res 24:75-86. 1995
    ..Another peptide containing Thr-692 of a rat GluRA, clone almost identical to GluR1, was phosphorylated by PKC but not by PKG...
  72. ncbi Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II
    A L Mammen
    Howard Hughes Medical Institute, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:32528-33. 1997
    ..generated two phosphorylation site-specific antibodies to analyze the phosphorylation of the glutamate receptor GluR1 subunit. These antibodies recognize GluR1 only when it is phosphorylated on serine residues 831 or 845...
  73. ncbi Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin
    Pieter H Anborgh
    Cell Biology Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Biol Chem 280:34840-8. 2005
    ..Taken together, these studies identify a novel mechanism for mGluR desensitization and an additional biochemical link between altered glutamate receptor signaling and Huntington disease...
  74. pmc A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing
    P J Aruscavage
    Department of Biochemistry Howard Hughes Medical Institute, University of Utah, Salt Lake City 84132, USA
    RNA 6:257-69. 2000
    ..The approximately 600-nt intron 13 of gluR-C was particularly remarkable, showing >94% nucleotide identity between human and chicken, organisms estimated to have diverged 310 million years ago...
  75. ncbi Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex
    M Colledge
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Neuron 27:107-19. 2000
    ..studies indicate that phosphorylation of AMPA receptors is enhanced by a SAP97-AKAP79 complex that directs PKA to GluR1 via a PDZ domain interaction...
  76. ncbi A family of AMPA-selective glutamate receptors
    K Keinanen
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, F R G
    Science 249:556-60. 1990
    ....
  77. ncbi Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
    Michael A Sutton
    Division of Molecular Psychiatry and the Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 421:70-5. 2003
    ..training during withdrawal from chronic cocaine self-administration induces experience-dependent increases in the GluR1 and GluR2/3 subunits of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) glutamate receptors in the ..
  78. ncbi The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs
    Hélène Hirbec
    Department of Anatomy, Medical Research Council Centre of Synaptic Plasticity, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:15221-4. 2002
    ..syntenin with mGluR7a, mGluR4a, and mGluR6; (ii) PICK1 and GRIP with mGluR3; and (iii) syntenin with all forms of GluR1-4 and mGluR7b...
  79. ncbi Chemokine receptor CXCR2 regulates the functional properties of AMPA-type glutamate receptor GluR1 in HEK cells
    P Lax
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma, Piazzale Aldo Moro 5, I00185, Rome, Italy
    J Neuroimmunol 129:66-73. 2002
    ..cells and cerebellar neurons to investigate whether CXC chemokine receptor 2 (CXCR2) is functionally coupled to GluR1. The co-expression of CXCR2 with GluR1 in HEK cells increased (i) the GluR1 "apparent" affinity for the ..
  80. ncbi Benzodiazepine withdrawal-induced glutamatergic plasticity involves up-regulation of GluR1-containing alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in Hippocampal CA1 neurons
    Jun Song
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus Formerly Medical University of Ohio, Toledo, OH 43614, USA
    J Pharmacol Exp Ther 322:569-81. 2007
    ..As GluR1-containing AMPARs are critical for activity-dependent alterations in excitatory strength, we sought to determine ..
  81. ncbi Glutamate receptor GluR-K1: structure, function, and expression in the brain
    M Hollmann
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California
    Cold Spring Harb Symp Quant Biol 55:41-55. 1990
  82. pmc Integrin-linked kinase is involved in cocaine sensitization by regulating PSD-95 and synapsin I expression and GluR1 Ser845 phosphorylation
    Qiang Chen
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3870, Durham, NC 27710, USA
    J Mol Neurosci 40:284-94. 2010
    ..with enhanced PSD-95 and synapsin I protein expression as well as enhanced Ser(845) phosphorylation of the GluR1 subunit on withdrawal day. Silencing ILK expression under both paradigms prevented or reversed these changes...
  83. ncbi Synapse-specific regulation of AMPA receptor subunit composition by activity
    Kimberly J Harms
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:6379-88. 2005
    ..However, silenced neurons could not recruit the AMPA-type glutamate receptor subunit GluR1 as efficiently when competing with active neighbors...
  84. pmc Homeostatic regulation of AMPA receptor expression at single hippocampal synapses
    Qingming Hou
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:775-80. 2008
    ..These results demonstrate the existence of synaptic specificity and the crucial role of AMPAR-gated calcium in homeostatic plasticity in central neurons...
  85. pmc Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats
    Miklos Antal
    Department of Anatomy, Histology, and Embryology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012 Debrecen, Hungary
    J Neurosci 28:9692-701. 2008
    ..99%) glutamatergic postsynaptic membranes expressed GluR2, and most of them (87%) were also immunoreactive for GluR1. The numbers of gold particles for pan-AMPA, NR1, and GluR2 subunits showed a linear correlation with the size of ..
  86. ncbi Differential regulation of dendrite complexity by AMPA receptor subunits GluR1 and GluR2 in motor neurons
    Ranjini Prithviraj
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Neurobiol 68:247-64. 2008
    ..of activation of AMPA receptors in dendritic outgrowth of spinal motor neurons by overexpression of two subunits, GluR1 and GluR2, and find that dendrite outgrowth is differentially controlled by expression of these subunits...
  87. ncbi Additive regulation of GluR1 by stargazin and serum- and glucocorticoid-inducible kinase isoform SGK3
    Nathalie Strutz-Seebohm
    Department of Physiology I, University of Tuebingen, 72076, Tuebingen, Germany
    Pflugers Arch 452:276-82. 2006
    ..kinase isoform 3 (SGK3) and stargazin have both been shown to enhance the synaptic expression level of GluR1. The present study was performed to elucidate whether SGK3 and stargazin interact or are effective through ..
  88. ncbi AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, UK
    Neuropsychopharmacology 32:343-53. 2007
    ..Here, we examine the consequences of targeted deletion of the gene encoding GluR1 subunits of AMPA receptors (gria1 knockouts (KO)) on cocaine self-administration and on the ability of cocaine-..
  89. ncbi Influence of environmental enrichment on steady-state mRNA levels for EAAC1, AMPA1 and NMDA2A receptor subunits in rat hippocampus
    Josefine Andin
    Department of Neuroscience and Locomotion, Division of Geriatric Medicine, Linkopings Universitet, SE 581 85 Linkoping, Sweden
    Brain Res 1174:18-27. 2007
    ....
  90. pmc Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats
    Y P Deng
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Chem Neuroanat 33:167-92. 2007
    ..We therefore used immunolabeling to assess the frequency and abundance of GluR1 and GluR2, the most common AMPA subunits in striatum, in the main striatal neuron types...
  91. ncbi Differential environmental exposure alters NMDA but not AMPA receptor subunit expression in nucleus accumbens core and shell
    David A Wood
    Program in Neural Science, Department of Psychology, Indiana University, 1101 E Tenth Street, Bloomington, IN 47405 7007, USA
    Brain Res 1042:176-83. 2005
    ..this brain region, we assessed expression of the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor and the GluR1 subunit of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor in the NAcc core and shell ..
  92. ncbi Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development
    Jessica Douyard
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 062693156, USA
    J Comp Neurol 502:141-56. 2007
    ..In this study we investigated by immunocytochemistry at the light and electron microscopy level the expression of GluR1 and its scaffolding proteins SAP97 (synapse-associated protein) and 4.1N during cerebellar development...
  93. ncbi AMPA, kainate, and NMDA receptor densities in the hippocampus of untreated male rats and females in estrus and diestrus
    Nicola Palomero-Gallagher
    Institute of Medicine, Research Center Julich, Germany
    J Comp Neurol 459:468-74. 2003
    ..These results further support that steroid hormones, through their modulation of AMPA and NMDA receptors, may be involved in the control of synaptic efficacy and, therefore, influence learning and memory...
  94. pmc Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization
    Kurtis D Davies
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    J Biol Chem 283:33138-46. 2008
    ..However, phosphorylation of Ser-845 on the AMPA receptor subunit GluR1 was significantly decreased throughout the neuron, including in the synaptic membrane-enriched fraction...
  95. pmc Role of GluR1 in activity-dependent motor system development
    Lei Zhang
    Department of Pediatrics, Division of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:9953-68. 2008
    ..In the spinal cord under normal circumstances, the AMPA receptor subunit GluR1 is expressed at high levels by motor neurons and surrounding interneurons during this critical developmental ..
  96. doi Global ischemia-induced modifications in the expression of AMPA receptors and inflammation in rat brain
    Severiano Dos-Anjos
    Area de Biología Celular, Instituto de Biomedicina, Universidad de Leon, 24071, Leon, Spain
    Brain Res 1287:20-7. 2009
    ..We found outstanding decreases in GluR1 and GluR2 mRNA levels after global ischemia and 48 h reperfusion (I/R) in all the areas studied, however, protein ..
  97. ncbi Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond
    Lotta von Ossowski
    Department of Biological and Environmental Sciences Division of Biochemistry, University of Helsinki, Helsinki, Finland
    Biochemistry 45:5567-75. 2006
    Synaptic delivery of GluR-A (GluR1) subunit-containing glutamate receptors depends on a C-terminal type I PDZ binding motif in GluR-A. Synapse-associated protein 97 (SAP97) is the only PDZ domain protein known to associate with GluR-A...
  98. pmc Expression of Group I metabotropic glutamate receptors on phenotypically different cells within the nucleus of the solitary tract in the rat
    J R Austgen
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
    Neuroscience 159:701-16. 2009
    ..1+/-0.08). Cells triple labeled for FG, nNOS, and Group I mGluRs were identified in the NTS. Thus, these data provide an anatomical substrate by which Group I mGluRs could modulate activity of CVLM projecting neurons in the NTS...
  99. ncbi Developmentally regulated expression of CaMKII and iGluRs in the rat retina
    Jin Xue
    Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 500 South Preston Street, Louisville, KY 40202, USA
    Brain Res Dev Brain Res 138:61-70. 2002
    ..The developmental pattern of AMPAR-GluR1 was similar to that of NMDAR-NR2B, with high expression at P5, and modest increases thereafter...
  100. pmc Increased AMPA receptor GluR1 subunit incorporation in rat hippocampal CA1 synapses during benzodiazepine withdrawal
    Paromita Das
    Department of Physiology and Pharmacology, University of Toledo College of Medicine, Health Science Campus, Toledo, Ohio 43614, USA
    J Comp Neurol 511:832-46. 2008
    ..is also associated with a shift toward inward rectification of synaptic currents and increased expression of GluR1, but not GluR2, subunits, suggesting augmented membrane incorporation of GluR1-containing, GluR2-lacking AMPARs...
  101. ncbi Functional organization of the GluR1 glutamate receptor promoter
    K Borges
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:25929-38. 2001
    The GluR1 glutamate receptor subunit is expressed in most brain areas and plays a major role in excitatory synaptic transmission...

Research Grants74

  1. CRCNS: Quantitative description of initial biochemical steps in LTP
    John E Lisman; Fiscal Year: 2010
    ..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
  2. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  3. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  4. Role of NMDA receptors in awake-state thalamocortical slow waves
    John E Lisman; Fiscal Year: 2010
    ..The cellular and molecular causes of this dysrhythmia in the thalamus will be investigated. A major clue appears to be the ability of NMDA recent antagonists to mimic the dysrhythmia. ..
  5. CRCNS: Quantitative description of initial biochemical steps in LTP
    John E Lisman; Fiscal Year: 2010
    ..There are also medical implications: understanding the early steps of synaptic plasticity may give insight into learning disorders. Ng, one of the proteins to be studied, is a risk gene for schizophrenia. ..
  6. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2003
    ..Consistent with this view, preliminary results indicate that a microtubule-motor system and a vesicle fusion process is required for maintaining AMPA transmission. ..
  7. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 2009
    ..abstract_text> ..
  8. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  9. MECHANISMS OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1999
    ..The experiments are aimed at determining how phosphatases affect the synaptic response and how they contribute to the activity-dependent weakening of synapses. ..
  10. MECHANISM OF LONG-TERM POTENTIATION
    John Lisman; Fiscal Year: 1993
    ..These studies will provide the first systematic test of the most explicit model of neuronal information storage yet proposed. The information acquired may well be relevant to the general questions of memory storage...
  11. MECHANISMS OF ADAPTATION
    John Lisman; Fiscal Year: 1980
    ....
  12. Keeping CFTR in its Place: An Integrated Small-Molecule Approach
    DEAN MADDEN; Fiscal Year: 2009
    ..Lay summary: In CF, genetic mutation prevents the CFTR protein from functioning correctly, leading to chronic lung infection and death. We seek chemicals that can correct this functional defect. ..
  13. TRIGEMINAL PAIN PATHWAYS
    Sue Aicher; Fiscal Year: 2009
    ..Other sources of ocular pain include dry eye, uveitis, and contact lens use. The studies in this proposal are designed to understand the neural pathways involved in transmitting pain from the cornea to the brain. ..
  14. Keeping CFTR in its Place: An Integrated Small-Molecule Approach
    Dean R Madden; Fiscal Year: 2010
    ..Lay summary: In CF, genetic mutation prevents the CFTR protein from functioning correctly, leading to chronic lung infection and death. We seek chemicals that can correct this functional defect. ..
  15. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2010
    ..abstract_text> ..
  16. TRIGEMINAL PAIN PATHWAYS
    Sue A Aicher; Fiscal Year: 2010
    ..Other sources of ocular pain include dry eye, uveitis, and contact lens use. The studies in this proposal are designed to understand the neural pathways involved in transmitting pain from the cornea to the brain. ..
  17. Synapse-specific Regulation of Transmission and Integration in the Barrel Cortex
    J Julius Zhu; Fiscal Year: 2010
    ....
  18. Synapse-specific Regulation of Transmission and Integration in the Barrel Cortex
    J Julius Zhu; Fiscal Year: 2010
    ....
  19. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2009
    ..abstract_text> ..
  20. ANATOMICAL STUDIES OF BRAINSTEM CARDIOVASCULAR SYSTEMS
    Sue Aicher; Fiscal Year: 2007
    ..In our previous studies of AMPA receptors we made a surprising discovery: the number of GluR1 receptor subunits significantly increases in NTS following the development of hypertension...
  21. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  22. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  23. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  24. TRIGEMINAL PAIN PATHWAYS
    Sue Aicher; Fiscal Year: 2001
    ..abstract_text> ..
  25. ANATOMICAL STUDIES OF BRAINSTEM CARDIOVASCULAR SYSTEMS
    Sue Aicher; Fiscal Year: 2003
    ..The long-term goal of this project is to understand the cellular basis for receptor modulation of central autonomic neuronal activity. ..
  26. TRIGEMINAL PAIN PATHWAYS
    Sue Aicher; Fiscal Year: 2007
    ..Together the studies will determine the subcellular localization of glutamate receptors and MORs in trigeminal pathways that may be targets for new therapeutic strategies to control trigeminal pain. ..
  27. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2007
    ....
  28. Mechanisms of Synaptic Depression: Focus on Rap Signaling Pathways
    J Julius Zhu; Fiscal Year: 2007
    ..by examining electrophysiologically tagged recombinant AMPA-R-mediated currents, measuring synaptic responses in GluR1 and GluR2 knockout mice, as well as quantifying phosphorylated or active endogenous signaling molecules and ..
  29. Role of Rab proteins in AMPA receptor synaptic targeting
    Jose Esteban; Fiscal Year: 2007
    ..We believe that these basic studies on the molecular and cellular mechanisms of synaptic plasticity will contribute to further our understanding of the physiological processes and pathological alterations affecting cognitive function. ..