Gene Symbol: Grb10
Description: growth factor receptor bound protein 10
Alias: RGD1566234, growth factor receptor-bound protein 10, GRB10 adapter protein
Species: rat
Products:     Grb10

Top Publications

  1. Tezuka N, Brown A, Yanagawa S. GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway. Biochem Biophys Res Commun. 2007;356:648-54 pubmed
    ..We show here that growth factor receptor-bound protein10 (GRB10), a multi-modular adaptor protein that is known to associate with several transmembrane tyrosine kinase receptors, ..
  2. Laviola L, Giorgino F, Chow J, Baquero J, Hansen H, Ooi J, et al. The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Clin Invest. 1997;99:830-7 pubmed
    ..Multiple receptor-interactive clones encoding the SH2 domain of the adapter protein Grb10 were isolated...
  3. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland K, Smith R. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003;278:31564-73 pubmed
    ..have identified two members of a novel protein family, which become transiently linked to IGF-I receptors by the Grb10 adapter protein following IGF-I stimulation. Grb10 and GIGYFs may act cooperatively to regulate receptor signaling.
  4. Murdaca J, Treins C, Monthouël Kartmann M, Pontier Bres R, Kumar S, Van Obberghen E, et al. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chem. 2004;279:26754-61 pubmed
    ..In a previous work, we have shown that the adaptor protein Grb10 is a positive regulator of the VEGF signaling pathway...
  5. Youngren J. Regulation of insulin receptor function. Cell Mol Life Sci. 2007;64:873-91 pubmed
    ..The impact of these processes on the conformational changes and phosphorylation events required for full signaling activity, as well as the role of these mechanisms in human disease, is reviewed in this article. ..
  6. Ajiro M, Nishidate T, Katagiri T, Nakamura Y. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Int J Oncol. 2010;37:1085-93 pubmed
    We previously reported an important role of RQCD1 in mammary carcinogenesis through the interaction with Grb10 interacting GYF protein 1 (GIGYF1), Grb10 interacting GYF protein 2 (GIGYF2) and growth factor receptor binding protein 10 (..
  7. Mori K, Giovannone B, Smith R. Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling. Mol Cell Endocrinol. 2005;230:39-50 pubmed
    The adapter protein Grb10 binds to phosphotyrosine residues in insulin receptors via its C-terminal region and regulates insulin signaling...
  8. Depetris R, Wu J, Hubbard S. Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Nat Struct Mol Biol. 2009;16:833-9 pubmed publisher
    Growth factor receptor-binding proteins Grb7, Grb10 and Grb14 are adaptor proteins containing a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region and a C-terminal Src-..
  9. Mounier C, Lavoie L, Dumas V, Mohammad Ali K, Wu J, Nantel A, et al. Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway. Mol Cell Endocrinol. 2001;173:15-27 pubmed
    b>Grb10 is a member of a family of adapter proteins that binds to tyrosine-phosphorylated receptors including the insulin receptor kinase (IRK)...

More Information


  1. Ma L, Wei Q, Deng H, Zhang Q, Li G, Tang N, et al. Growth factor receptor-bound protein 10-mediated negative regulation of the insulin-like growth factor-1 receptor-activated signalling pathway results in cognitive disorder in diabetic rats. J Neuroendocrinol. 2013;25:626-34 pubmed publisher
    Growth factor receptor-bound protein 10 (Grb10) is a Src homology 2 domain-containing protein and one of the binding partners for several transmembrane tyrosine kinase receptors, including insulin receptor (IR) and insulin-like growth ..
  2. Xia H, Cao J, Jin X, Ma X. MiR199a is implicated in embryo implantation by regulating Grb10 in rat. Reproduction. 2014;147:91-9 pubmed publisher
    ..a significant inverse association between the expression of miR199a and growth factor receptor-bound protein 10 (Grb10), an imprinted gene, and miR199a could bind to the 3'UTR of Grb10 to inhibit Grb10 translation...