Gene Symbol: Gpx2
Description: glutathione peroxidase 2
Alias: GPX-GI, GSHPx-2, GSHPx-GI, glutathione peroxidase 2, GPx-2, glutathione peroxidase-gastrointestinal
Esworthy R, Swiderek K, Ho Y, Chu F. Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the mucosal epithelium of rodent intestine. Biochim Biophys Acta. 1998;1381:213-26 pubmed
b>Gpx2 mRNA, encoding a selenium-dependent glutathione peroxidase (GPX-GI), has been found to be highly expressed in the gastrointestinal tract (GI) mucosal epithelium...
Drew J, Farquharson A, Arthur J, Morrice P, Duthie G. Novel sites of cytosolic glutathione peroxidase expression in colon. FEBS Lett. 2005;579:6135-9 pubmed
..This study reports evidence of both common sites of Gpx1 and Gpx2 expression in rat colon and sites that are exclusive to each isoform...
Esworthy R, Aranda R, Martin M, Doroshow J, Binder S, Chu F. Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol. 2001;281:G848-55 pubmed
Glutathione peroxidase (GPX)-1 and gastrointestinal (GI) epithelium-specific GPX (GPX-GI), encoded by Gpx1 and Gpx2, provide most GPX activity in GI epithelium...
Bartel J, Bartz T, Wolf C, Charkiewicz E, Kuhbacher M, Pohl T, et al
. Activity of the glutathione peroxidase-2. Differences in the selenium-dependent expression between colon and small intestine. Cancer Genomics Proteomics. 2007;4:369-72 pubmed
..This finding might explain the different susceptibility of the colon and the small intestine to cancer and support the theory of the protective effect of selenium in the gastrointestinal tract. ..
Suzuki S, Pitchakarn P, Ogawa K, Naiki Ito A, Chewonarin T, Punfa W, et al
. Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis. Toxicology. 2013;311:115-23 pubmed publisher
..inoculation into the tail vein of nude mice, the most metastatic featured particular overexpression of glutathione peroxidase 2 (GPX2)...
Esworthy R, Binder S, Doroshow J, Chu F. Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol Chem. 2003;384:597-607 pubmed
..germ-free GPX-DKO mice developed severe acute colitis while their littermates with at least one wild-type Gpx1 or Gpx2 gene remained virtually symptom-free. Microflora also affected Gpx2 gene expression...
Naiki Ito A, Asamoto M, Hokaiwado N, Takahashi S, Yamashita H, Tsuda H, et al
. Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens. Cancer Res. 2007;67:11353-8 pubmed
..DNA microarray analysis revealed that glutathione peroxidase 2 (Gpx2) was commonly up-regulated in the mammary carcinomas induced by the three different carcinogens, ..
Maseko T, Dunshea F, Howell K, Cho H, Rivera L, Furness J, et al
. Selenium-enriched Agaricus bisporus mushroom protects against increase in gut permeability ex vivo and up-regulates glutathione peroxidase 1 and 2 in hyperthermally-induced oxidative stress in rats. Nutrients. 2014;6:2478-92 pubmed publisher
..05). Thus, dietary Se-enriched A. bisporus protected against increase in ileum permeability and up-regulated GPx-1 and GPx-2 expression, selenoenzymes relevant to mitigating oxidative stress. ..
Herlan L, Schulz A, Schulte L, Schulz H, HÃ¼bner N, Kreutz R. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Clin Exp Pharmacol Physiol. 2015;42:1051-8 pubmed publisher
..Seven genes including Abcg5, Ab1-233, Efcab11, Fntb, Gpx2, Lrrn3, and Rtn1 were assigned on RNO6 and their differential expression was confirmed...