Gene Symbol: Gpsm2
Description: G-protein signaling modulator 2
Alias: RGD1560967, G-protein-signaling modulator 2, G-protein signaling modulator 2 (AGS3-like, C. elegans), G-protein signalling modulator 2 (AGS3-like, C. elegans)
Species: rat
Products:     Gpsm2

Top Publications

  1. Du Q, Macara I. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell. 2004;119:503-16 pubmed
    ..We propose that a related switch mechanism might operate in asymmetric cell divisions in the fly and nematode. ..
  2. Kiyomitsu T, Cheeseman I. Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. Nat Cell Biol. 2012;14:311-7 pubmed publisher
    ..We propose that these chromosome- and spindle-pole-derived gradients generate an intrinsic code to control spindle position and orientation. ..
  3. Du Q, Stukenberg P, Macara I. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat Cell Biol. 2001;3:1069-75 pubmed
    ..Thus, we have identified a mammalian Pins homologue as a key regulator of spindle organization during mitosis. ..
  4. Izaki T, Kamakura S, Kohjima M, Sumimoto H. Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3. Biochem Biophys Res Commun. 2006;341:1001-6 pubmed
  5. Walsh T, Shahin H, Elkan Miller T, Lee M, Thornton A, Roeb W, et al. Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. Am J Hum Genet. 2010;87:90-4 pubmed publisher
    ..The nonsense mutation leads to an early truncation of the G protein signaling modulator GPSM2, a protein that is essential for maintenance of cell polarity and spindle orientation...
  6. Doherty D, Chudley A, Coghlan G, Ishak G, Innes A, Lemire E, et al. GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Am J Hum Genet. 2012;90:1088-93 pubmed publisher
    ..deletions, a nonsense mutation, and a canonical splice-site mutation) in the G protein-signaling modulator 2 gene, GPSM2, that underlie CMS...
  7. Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W. Crystal structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from G?i. J Biol Chem. 2012;287:36766-76 pubmed publisher
    ..Together with the sequence alignment, we suggest that the LGN GL/G?(i) interaction represents a general binding mode between GL motifs and G?(i). We also show that LGN GLs are potent guanine nucleotide dissociation inhibitors. ..
  8. Kotak S, Busso C, G nczy P. Cortical dynein is critical for proper spindle positioning in human cells. J Cell Biol. 2012;199:97-110 pubmed publisher
    ..Overall, we propose a model in which the ternary complex serves to anchor dynein at the plasma membrane to ensure correct spindle positioning...
  9. Kiyomitsu T, Cheeseman I. Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase. Cell. 2013;154:391-402 pubmed publisher
    ..Our results reveal the anaphase-specific spindle centering systems that achieve equal-sized cell division. ..

More Information


  1. Yariz K, Walsh T, Akay H, Duman D, Akkaynak A, King M, et al. A truncating mutation in GPSM2 is associated with recessive non-syndromic hearing loss. Clin Genet. 2012;81:289-93 pubmed publisher
    ..By analysis of a consanguineous Palestinian family, GPSM2 was recently discovered to be the cause of autosomal recessive non-syndromic hearing loss DFNB82...
  2. Zhu J, Wen W, Zheng Z, Shang Y, Wei Z, Xiao Z, et al. LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G?i/LGN/NuMA pathways. Mol Cell. 2011;43:418-31 pubmed publisher
    ..Our results suggest that the Par3/mInsc/LGN and NuMA/LGN/G?i complexes play sequential and partially overlapping roles in asymmetric cell division. ..
  3. Yuzawa S, Kamakura S, Iwakiri Y, Hayase J, Sumimoto H. Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN). Proc Natl Acad Sci U S A. 2011;108:19210-5 pubmed publisher
    ..We also demonstrate, using mutant proteins, that mInsc-LGN interaction is vital for stabilization of LGN and for intracellular localization of mInsc. ..
  4. Bird S, Heald R, Weis K. RanGTP and CLASP1 cooperate to position the mitotic spindle. Mol Biol Cell. 2013;24:2506-14 pubmed publisher
    ..Together our data suggest a model for mitotic spindle positioning in which RanGTP and CLASP1 cooperate to align the spindle along the long axis of the dividing cell. ..
  5. Chiu C, Monat C, Robitaille M, Lacomme M, Daulat A, Macleod G, et al. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Dev Cell. 2016;36:50-62 pubmed publisher
    ..These results uncover SAPCD2 as a key regulator of the ternary complex controlling spindle orientation during morphogenesis and asymmetric cell divisions. ..