Gene Symbol: Gps1
Description: G protein pathway suppressor 1
Alias: MFH, COP9 signalosome complex subunit 1, GPS-1, JAB1-containing signalosome subunit 1, MFH protein, SGN1, signalosome subunit 1
Spain B, Bowdish K, Pacal A, Staub S, Koo D, Chang C, et al
. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol. 1996;16:6698-706 pubmed
We have isolated two novel human cDNAs, gps1-1 and gps2, that suppress lethal G-protein subunit-activating mutations in the pheromone response pathway of the yeast Saccharomyces cerevisiae...
Nitz B, Ivell R, Hartung S, Middendorff R, Olcese J. A fusca gene homologue in mammalian tissues: Developmental regulation in the rat testes. Mol Cell Endocrinol. 1998;144:131-8 pubmed
..homology and a 45% amino acid identity with a plant fusca-gene (fus6) to which a corresponding human sequence (gps1) has recently been reported...
Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher
..This suggests that the propensity of the CSN complex to change and adapt its subunit composition might underlie its ability to perform multiple functions in vivo. ..
Lu H, Liang X, Issaenko O, Hallstrom T. Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets. Cell Cycle. 2011;10:3317-26 pubmed publisher
..We explored the link between increased Jab1 levels and PI3K function in tumors and detected a highly significant correlation between elevated Jab1/CSN5 levels and PI3K activity in breast, ovarian, lung and prostate cancers. ..
Kang S, Shin Y, Shim Y, Jeong S, Park I, Min B. Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Exp Cell Res. 2005;309:305-15 pubmed
..Taken together, these results suggest that the clusterin interacts with SCLIP and the interaction may act as an important modulator during neuronal differentiation. ..
Cheng X, Zhou Z, Xu G, Zhao J, Wu H, Long L, et al
. Dynamic changes of Jab1 and p27kip1 expression in injured rat sciatic nerve. J Mol Neurosci. 2013;51:148-58 pubmed publisher
..Thus, these results suggested that Jab1 and p27kip1 may be involved in the pathophysiology of sciatic nerve after SNC. ..
Chen Y, Chen X, Yu J, Xu X, Wei X, Gu X, et al
. JAB1 is Involved in Neuropathic Pain by Regulating JNK and NF-ÎºB Activation After Chronic Constriction Injury. Neurochem Res. 2016;41:1119-29 pubmed publisher
..Taken together, these results suggested that JAB1 promotes neuropathic pain via positively regulating JNK and NF-ÎºB activation. ..
Cayli S, Ocakli S, Senel U, Eyerci N, Delibasi T. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. J Mol Histol. 2016;47:91-100 pubmed publisher
..These finding suggest that p97/VCP and Jab1/CSN5 provide a novel signaling pathway for testicular ischaemia and may play an important role in IR injury induced cell death in rat testis. ..