Gene Symbol: Gpr183
Description: G protein-coupled receptor 183
Alias: Ebi2, G-protein coupled receptor 183, EBV-induced G-protein coupled receptor 2, Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor), epstein-Barr virus-induced G-protein coupled receptor 2
Species: rat
Products:     Gpr183

Top Publications

  1. Pereira J, Kelly L, Xu Y, Cyster J. EBI2 mediates B cell segregation between the outer and centre follicle. Nature. 2009;460:1122-6 pubmed publisher
    ..a role for the orphan G-protein-coupled receptor, Epstein-Barr virus induced molecule-2 (EBI2, also known as GPR183), in this process...
  2. Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira J, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011;475:524-7 pubmed publisher
    Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) is a G-protein-coupled receptor that is required for humoral immune responses; polymorphisms in the receptor have been associated with inflammatory autoimmune diseases...
  3. Benned Jensen T, Rosenkilde M. Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist. Mol Pharmacol. 2008;74:1008-21 pubmed publisher
    The Epstein-Barr induced receptor 2 (EBI2) is a lymphocyte-expressed orphan seven transmembrane-spanning (7TM) receptor that signals constitutively through Galphai, as shown, for instance by guanosine 5'-O-(3-thio)triphosphate ..
  4. Benned Jensen T, Smethurst C, Holst P, Page K, Sauls H, Sivertsen B, et al. Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J Biol Chem. 2011;286:29292-302 pubmed publisher
    The Epstein-Barr virus-induced receptor 2 (EBI2) is a constitutively active seven-transmembrane receptor, which was recently shown to orchestrate the positioning of B cells in the follicle...
  5. Liu C, Yang X, Wu J, Kuei C, Mani N, Zhang L, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011;475:519-23 pubmed publisher
    EBI2 (also called GPR183) is an orphan G-protein-coupled receptor that is highly expressed in spleen and upregulated upon Epstein-Barr-virus infection...
  6. Gatto D, Wood K, Caminschi I, Murphy Durland D, Schofield P, Christ D, et al. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol. 2013;14:446-53 pubmed publisher
    ..Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regulated the positioning and homeostasis of DCs in the spleen...
  7. Wang X, Sumida H, Cyster J. GPR18 is required for a normal CD8αα intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014;211:2351-9 pubmed publisher
    ..These findings establish a requirement for GPR18 in CD8αα and CD8αβ IELs, and we suggest the receptor has a role in augmenting the accumulation of CD8 T cells in the intraepithelial versus lamina propria compartment. ..
  8. Benned Jensen T, Norn C, Laurent S, Madsen C, Larsen H, Arfelt K, et al. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). J Biol Chem. 2012;287:35470-83 pubmed publisher
    ..Specifically, the Epstein-Barr virus-induced gene 2 (EBI2 or GPR183) was shown to be activated by several oxysterols, most potently by 7?,25-dihydroxycholesterol (7?,25-OHC)...
  9. Gessier F, Preuss I, Yin H, Rosenkilde M, Laurent S, Endres R, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014;57:3358-68 pubmed publisher
    Oxysterols have recently been identified as natural ligands for a G protein-coupled receptor called EBI2 (aka GPR183) ( Nature 2011 , 475 , 524 ; 519 ). EBI2 is highly expressed in immune cells ( J. Biol. Chem...

More Information


  1. Rutkowska A, Preuss I, Gessier F, Sailer A, Dev K. EBI2 regulates intracellular signaling and migration in human astrocyte. Glia. 2015;63:341-51 pubmed publisher
    The G protein-coupled receptor EBI2 (Epstein-Barr virus-induced gene 2) is activated by 7α, 25-dihydroxycholesterol (7α25HC) and plays a role in T cell-dependant antibody response and B cell migration...
  2. Yi T, Cyster J. EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture. elife. 2013;2:e00757 pubmed publisher
    ..Here we show that CD4(+) DCs highly express EBI2 and migrate to its oxysterol ligand, 7?,25-OHC...
  3. Zhang L, Shih A, Yang X, Kuei C, Wu J, Deng X, et al. Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site. Mol Pharmacol. 2012;82:1094-103 pubmed publisher
    Epstein-Barr virus-induced molecule 2 (EBI2) (also known as G-protein-coupled receptor 183) is a G-protein-coupled receptor (GPCR) that is best known for its role in B cell migration and localization...
  4. Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz M, et al. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. J Exp Med. 2015;212:1931-46 pubmed publisher
    ..Here, we show that the Gαi protein-coupled receptor (GPCR) EBI2 is expressed in mouse monocyte/OC precursors (OCPs) and its oxysterol ligand 7α,25-dihydroxycholesterol (7α,..
  5. Li J, Lu E, Yi T, Cyster J. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533:110-4 pubmed publisher
    ..Here we show that the G-protein-coupled receptor EBI2 (GPR183) and its ligand 7?,25-dihydroxycholesterol mediate positioning of activated CD4 T cells at the interface of the ..