Gene Symbol: Gpr107
Description: G protein-coupled receptor 107
Alias: protein GPR107
Yosten G, Redlinger L, Samson W. Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. Am J Physiol Regul Integr Comp Physiol. 2012;303:R941-9 pubmed publisher
..Four orphan GPCRs were expressed by all cell types, including GPR56 and GPR107. Knockdown of GPR107, but not GPR56 or GPR146, led to a loss of responsiveness to neuronostatin by KATOIII cells...
Zhou G, Na S, Niedra R, Seed B. Deficits in receptor-mediated endocytosis and recycling in cells from mice with Gpr107 locus disruption. J Cell Sci. 2014;127:3916-27 pubmed publisher
b>GPR107 is a type III integral membrane protein that was initially predicted to be a member of the family of G-protein-coupled receptors...
Elrick M, Samson W, Corbett J, Salvatori A, Stein L, Kolar G, et al
. Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic Î±-cells. Am J Physiol Regul Integr Comp Physiol. 2016;310:R143-55 pubmed publisher
..cellular activities, including the phosphorylation of PKA following activation of the G protein-coupled receptor, GPR107. GPR107 is abundantly expressed in the pancreas, particularly, in rodent and human Î±-cells...