Gene Symbol: Gpha2
Description: glycoprotein hormone alpha 2
Alias: Gpa2, Zsig51, glycoprotein hormone alpha-2, cysteine knot protein, glycoprotein-alpha 2, thyrostimulin subunit alpha
Nakabayashi K, Matsumi H, Bhalla A, Bae J, Mosselman S, Hsu S, et al
. Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor. J Clin Invest. 2002;109:1445-52 pubmed
Hsu S, Nakabayashi K, Bhalla A. Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. Mol Endocrinol. 2002;16:1538-51 pubmed
..sequence similarity to the alpha- and beta-subunits of glycoprotein hormones, they were named glycoprotein-alpha2 (GPA2) and glycoprotein-beta5 (GPB5), respectively...
Li C, Hirooka Y, Habu S, Takagi J, Gotoh M, Nogimori T. Distribution of thyrostimulin in the rat: an immunohistochemical study. Endocr Regul. 2004;38:131-42 pubmed
..These findings suggest that thyrostimulin is widely distributed and that the method used is valuable in studying the distribution of thyrostimulin in rats. ..
Nagasaki H, Wang Z, Jackson V, Lin S, Nothacker H, Civelli O. Differential expression of the thyrostimulin subunits, glycoprotein alpha2 and beta5 in the rat pituitary. J Mol Endocrinol. 2006;37:39-50 pubmed
Two glycoprotein hormone subunits, (glycoprotein hormone alpha2-subunit GPA2) and (glycoprotein hormone beta5-subunit GPB5) have been recently discovered which, when expressed in vitro, heterodimerize to form a new hormone called ..
Sun S, Hsu P, Wu F, Li S, Lu C, Luo C. Thyrostimulin, but not thyroid-stimulating hormone (TSH), acts as a paracrine regulator to activate the TSH receptor in mammalian ovary. J Biol Chem. 2010;285:3758-65 pubmed publisher
..Thus, this study demonstrates that oocyte-derived thyrostimulin and granulosa cell-expressed TSHR compose a novel paracrine system in the ovary, where the activity is tightly controlled by gonadotropins. ..