Gene Symbol: Gpd1
Description: glycerol-3-phosphate dehydrogenase 1
Alias: GPDH, Gpd3, glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic, GPD-C, GPDH-C, glycerol 3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1 (soluble), glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Species: rat
Products:     Gpd1

Top Publications

  1. Dobson D, Groves D, Spiegelman B. Nucleotide sequence and hormonal regulation of mouse glycerophosphate dehydrogenase mRNA during adipocyte and muscle cell differentiation. J Biol Chem. 1987;262:1804-9 pubmed
    ..These results indicate that GPD gene expression is linked to cell differentiation in both fat and muscle cells, and suggest certain similarities in hormonal modulation in both cell types. ..
  2. Rauchova H, ZACHAROVA G, Soukup T. Influence of chronically altered thyroid status on the activity of liver mitochondrial glycerol-3-phosphate dehydrogenase in female inbred lewis rats. Horm Metab Res. 2004;36:286-90 pubmed
    The activity of liver mitochondrial flavoprotein-dependent glycerol-3-phosphate dehydrogenase (GPDH) is considered a reliable marker of thyroid status in acute and short-lasting experiments...
  3. Tan C, Tuch B, Tu J, Brown S. Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells. Diabetes. 2002;51:2989-96 pubmed
    ..We concluded that the immaturity of the NADH shuttles contributes to the inability of fetal beta-cells to secrete insulin in response to glucose. ..
  4. Rauchova H, Mracek T, Novak P, Vokurkova M, Soukup T. Glycerol-3-phosphate dehydrogenase expression and oxygen consumption in liver mitochondria of female and male rats with chronic alteration of thyroid status. Horm Metab Res. 2011;43:43-7 pubmed publisher
    ..chronic experiments (over several months), the activity and protein amount of glycerol-3-phosphate dehydrogenase (GPDH) in mitochondria isolated from the liver of adult male and female inbred Lewis strain euthyroid (EU), hyperthyroid (..
  5. Rumberger J, Wu T, Hering M, Marshall S. Role of hexosamine biosynthesis in glucose-mediated up-regulation of lipogenic enzyme mRNA levels: effects of glucose, glutamine, and glucosamine on glycerophosphate dehydrogenase, fatty acid synthase, and acetyl-CoA carboxylase mRNA levels. J Biol Chem. 2003;278:28547-52 pubmed
    ..A ribonuclease protection assay was used to quantitate mRNA levels for FAS, ACC, and glycerol-3-P dehydrogenase (GPDH)...
  6. McKenna M, Waagepetersen H, Schousboe A, Sonnewald U. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. Biochem Pharmacol. 2006;71:399-407 pubmed
    ..This report evaluates the evidence for each shuttle in brain cells and the drugs that can be used as pharmacological tools to study these shuttles. ..
  7. Preston S, McMorris F. Normal myelin composition and phospholipid synthesis in adrenalectomized rats with reduced brain myelin and glycerol 3-phosphate dehydrogenase activity. J Neurochem. 1985;45:1771-8 pubmed
  8. Shillabeer G, Kumar V, Tibbo E, Lau D. Arachidonic acid metabolites of the lipoxygenase as well as the cyclooxygenase pathway may be involved in regulating preadipocyte differentiation. Metabolism. 1998;47:461-6 pubmed
    ..Differentiation was determined by assay of glycerol-3-phosphate dehydrogenase (GPDH)...
  9. Orr A, Quinlan C, Perevoshchikova I, Brand M. A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase. J Biol Chem. 2012;287:42921-35 pubmed publisher
    ..These results clarify the maximum rate and mechanism of superoxide production by mGPDH. ..

More Information


  1. MacDonald M, Marshall L. Mouse lacking NAD+-linked glycerol phosphate dehydrogenase has normal pancreatic beta cell function but abnormal metabolite pattern in skeletal muscle. Arch Biochem Biophys. 2000;384:143-53 pubmed
    ..Glycerol kinase is also absent in the pancreatic insulin cell, but this cell's function is essentially normal probably because of redundancy of NAD(H) shuttles. ..
  2. Mracek T, Pecinova A, Vrbacky M, Drahota Z, Houstek J. High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria. Arch Biochem Biophys. 2009;481:30-6 pubmed publisher
    ..Our results demonstrate high efficiency of mGPDH-dependent ROS production in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT. ..
  3. Brown L, Koza R, Marshall L, Kozak L, MacDonald M. Lethal hypoglycemic ketosis and glyceroluria in mice lacking both the mitochondrial and the cytosolic glycerol phosphate dehydrogenases. J Biol Chem. 2002;277:32899-904 pubmed
  4. Daikoku T, Shinohara Y, Shima A, Yamazaki N, Terada H. Dramatic enhancement of the specific expression of the heart-type fatty acid binding protein in rat brown adipose tissue by cold exposure. FEBS Lett. 1997;410:383-6 pubmed
    ..Thus, the expressions of H-FABP and UCP may be controlled by the same mechanism. ..
  5. Brand I, Heinickel A. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). J Biol Chem. 1991;266:20984-9 pubmed
    ..The behavior of glucose-6-phosphate dehydrogenase and glycerol-3-phosphate dehydrogenase from this tissue could not be followed. A possible function of ZnBP in supramolecular organization of carbohydrate metabolism is proposed. ..
  6. Punkt K, Naupert A, Wellner M, Asmussen G, Schmidt C, Buchwalow I. Nitric oxide synthase II in rat skeletal muscles. Histochem Cell Biol. 2002;118:371-9 pubmed
    ..Our findings suggest that the NOS II may be designated both as constitutive and inducible. ..
  7. Weitzel J, Shiryaeva N, Middendorff R, Balvers M, Radtke C, Ivell R, et al. Testis-specific expression of rat mitochondrial glycerol-3-phosphate dehydrogenase in haploid male germ cells. Biol Reprod. 2003;68:699-707 pubmed
    ..Our results indicate that rat mGPDH is expressed by a testis-specific promoter from haploid male germ cells in a stage-specific manner. ..
  8. Ying W. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal. 2008;10:179-206 pubmed
    ..Future investigation into the metabolism and biological functions of NAD and NADP may expose fundamental properties of life, and suggest new strategies for treating diseases and slowing the aging process. ..
  9. Kozak L, Ratner P. Genetic regulation of translatable mRNA levels for mouse sn-glycerol-3-phosphate dehydrogenase during development of the cerebellum. J Biol Chem. 1980;255:7589-94 pubmed