Genomes and Genes
Gene Symbol: Gnrh1
Description: gonadotropin releasing hormone 1
Alias: Gnrh, Gnrha, Lhrh, Rgnrhg1, SH-4, progonadoliberin-1, Putative protein SH, gonadotropin-releasing hormone 1 (luteinizing-releasing hormone), luteinizing hormone-releasing hormone, progonadoliberin I
- Episodic activation of the rat GnRH promoter: role of the homeoprotein oct-1Rafael Vazquez-Martinez
Laboratory of Molecular Dynamics F R B, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Mol Endocrinol 16:2093-100. 2002Recent reports demonstrate that the rat GnRH promoter is activated in an episodic fashion in immortalized GnRH neurons, but little information is available on molecular processes that contribute to this phenomenon...
- Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levelsAndrea C Gore
Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
Mol Cell Endocrinol 256:40-8. 2006..Rats were treated either chronically or acutely with glucocorticoids, and circulating gonadotropins, GnRH mRNA levels, and gonadotropin subunit mRNAs levels were measured...
- Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutationJerome Bouligand
Universite Paris Sud, Faculté de Médecine Paris Sud and Assistance Publique Hôpitaux de Paris, Hopital de Bicetre, INSERM UMR S693, Paris, France
N Engl J Med 360:2742-8. 2009We investigated whether mutations in the gene encoding gonadotropin-releasing hormone 1 (GNRH1) might be responsible for idiopathic hypogonadotropic hypogonadism (IHH) in humans...
- GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadismYee Ming Chan
Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 106:11703-8. 2009..be mutated in patients with IHH, yet to date no mutations have been identified in the most obvious candidate gene, GNRH1 itself, which encodes the preprohormone that is ultimately processed to produce GnRH...
- Nonmammalian gonadotropin-releasing hormone molecules in the brain of promoter transgenic ratsIshwar S Parhar
Department of Physiology, Nippon Medical School, Tokyo 113 8602, Japan
Proc Natl Acad Sci U S A 102:5880-5. 2005Mammalian gonadotropin-releasing hormone (GnRH1) and nonmammalian immunoreactive GnRH subtypes were examined in transgenic rats carrying an enhanced GFP (EGFP) reporter gene driven by a rat GnRH1 promoter...
- Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female ratJames S Kinsey-Jones
Division of Reproduction and Endocrinology, 2 36D New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
Endocrinology 149:1004-8. 2008..are extraordinarily potent in stimulating gonadotropic hormone secretion via an action on the hypothalamic GnRH neural system...
- Delayed puberty in prenatally glucocorticoid administered female rats occurs independently of the hypothalamic Kiss1-Kiss1r-GnRH systemTakeshi Iwasa
Department of Obstetrics and Gynecology, The University of Tokushima Graduate School, Institute of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
Int J Dev Neurosci 29:183-8. 2011..We have previously reported that decreased action of hypothalamic kisspeptin, which is a positive regulator of GnRH, contributes to the delayed onset of puberty in undernutrition-induced IUGR rats...
- Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkageFerenc G Rick
Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Miami, Florida 33125, USA
J Urol 187:1498-504. 2012..We investigated the influence of a combination of antagonists of growth hormone-releasing hormone and luteinizing hormone-releasing hormone on animal models of benign prostatic hyperplasia...
- Differential expression of gonadotropin-releasing hormone (GnRH) in pancreas during rat pregnancyLi Wang
Department of Endocrinology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
Endocrine 36:538-45. 2009Many studies have shown that there is a relationship between gonadotropin-releasing hormone (GnRH) and glucose metabolism, but little is known about the effects of GnRH on the pancreas...
- Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibersRebecca E Campbell
Department of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
Endocrinology 144:1542-8. 2003..Using double- and triple-label immunofluorescence coupled with confocal microscopy, we found that 75-85% of GnRH neurons were contacted by orexin fibers, and triple labeling with synaptophysin provided additional confirmation of ..
- Mechanisms of prostate atrophy after LHRH antagonist cetrorelix injection: an experimental study in a rat model of benign prostatic hyperplasiaDong Yang
Department of Urology, Huazhong University of Science and Technology, Wuhan, China
J Huazhong Univ Sci Technolog Med Sci 32:389-95. 2012..Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment...
- Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transitionJ Donato
Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
Neuroscience 241:67-79. 2013..18% in the control group). Notably, lesions of the PMV disrupted the physiologic fluctuations of Kiss1 and GnRH mRNA expression characteristic of the proestrus-to-estrus transition...
- Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanismsDebolina Ray
Department of Medicine, Texas A and M Health Science Center College of Medicine, Temple, Texas
Am J Pathol 185:1061-72. 2015..Gonadotropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and proliferation in many cell types...
- Hypothalamic molecular changes underlying natural reproductive senescence in the female ratBailey A Kermath
Institute for Neuroscience B A K, A C G, Division of Pharmacology and Toxicology P D R, A C G, and Institute for Cell and Molecular Biology A C G, The University of Texas at Austin, Austin, Texas 78712 Department of Biology M J W, University of Wisconsin Whitewater, Whitewater, Wisconsin 53190 and Department of Pediatrics A W, Johns Hopkins University School of Medicine, Baltimore Maryland 21287
Endocrinology 155:3597-609. 2014..Esr2, Pgr, Ar), steroidogenic enzymes (Sts, Hsd17b8), growth factors (Igf1, Tgfa), and neuropeptides (Kiss1, Tac2, Gnrh1). Bionetwork analysis revealed region-specific correlations between genes and hormones...
- The Pro-LHRH system of the rat brain. Effects of changes in the endocrine backgroundI Merchenthaler
Department of Anatomy, University Medical School, Pecs, Hungary
Brain Res Bull 20:713-20. 1988The gonadotropin-releasing hormone-associated peptide (GAP) and luteinizing hormone-releasing hormone (LHRH) portions of the LHRH precursor were localized by immunocytochemistry in prepubertal female rats, in adult female rats at ..
- Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activationM M Valenca
Reproductive Neuroendrocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
Mol Cell Endocrinol 55:95-100. 1988ProLHRH contains the luteinizing hormone-releasing hormone (LHRH) decapeptide and a 56 amino acid peptide designated gonadotropin-releasing hormone-associated peptide (GAP)...
- Neurokinin B signaling in the female rat: a novel link between stress and reproductionP Grachev
Division of Women s Health P G, X F L, M H H, S Y L, K T O, School of Medicine, King s College London, United Kingdom Mammal Research Institute R P M, University of Pretoria, Pretoria, South Africa Medical Research Council Receptor Biology Unit, University of Cape Town, Cape Town, South Africa Centre for Integrative Physiology, University of Edinburgh, Scotland and Henry Wellcome Laboratory for Integrative Neuroscience and Endocrinology S L L, University of Bristol, Bristol, United Kingdom
Endocrinology 155:2589-601. 2014..The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which is considered to be the hypothalamic arcuate nucleus kisspeptin/..
- Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in femalesCadence True
Divisions of Diabetes, Obesity, and Metabolism, and Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
Endocrinology 154:2821-32. 2013..The current study characterized CART's regulatory influence on GnRH and kisspeptin (Kiss1) cells and determined the sensitivity of different CART populations to negative energy ..
- Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expressionT M Wilson
Department of Pediatrics, Wells Center for Pediatric Research, Indianapolis, Indiana, USA
Mol Endocrinol 9:44-53. 1995..One of these genes, LHRH, has not previously been reported to respond in this manner, although we and others have reported its presence in ..
- Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional levelR E Nappi
CHUL Research Center and Laval University, Quebec, Canada
Endocrinology 138:1374-84. 1997..to investigate the influence of immune (systemic endotoxin administration) and metabolic (fasting) challenges on LHRH neuronal activity and transcription in the organum vasculosum of the lamina terminalis/medial preoptic area as well ..
- R31C GNRH1 mutation and congenital hypogonadotropic hypogonadismLuigi Maione
Universite Paris Sud, Faculté de Médecine Paris Sud Unité mixte de Recherche en Santé 693, Le Kremlin Bicetre, France
PLoS ONE 8:e69616. 2013..Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH...
- Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptidesJ K Hiney
Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4458, USA
Proc Natl Acad Sci U S A 99:2386-91. 2002..hormone release, is coexpressed in neurons containing mammalian luteinizing hormone-releasing hormone (m-LHRH)...
- Intercellular communications within the rat anterior pituitary. XVI: postnatal changes of distribution of S-100 protein positive cells, connexin 43 and LH-RH positive sites in the pars tuberalis of the rat pituitary gland. An immunohistochemical and electIkuo Wada
Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan Electronic address
Tissue Cell 46:33-9. 2014..It is suggested that the folliculo-stellate cell system including the LH-RH neurons in the pars tuberalis participates in the control of LH secretion along with the portal vein system. ..
- Direct evidence for the co-expression of URP and GnRH in a sub-population of rat hypothalamic neurones: anatomical and functional correlationJohann Günther Egginger
Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101 Université Pierre et Marie Curie, Paris, France
PLoS ONE 6:e26611. 2011..with immunohistochemistry, we showed that cell bodies of the rat anterior hypothalamus contained both URP mRNA and GnRH peptide...
- [Experimental study on therapeutic effect of Dabuyin Wan on true precocious puberty in female rats]Min Cheng
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
Zhongguo Zhong Yao Za Zhi 38:386-90. 2013..To study the therapeutic effect of Dabuyin Wan on true precocious puberty of female rats and its possible mechanism...
- Combination of a GnRH agonist with an antagonist prevents flare-up effects and protects primordial ovarian follicles in the rat ovary from cisplatin-induced toxicity: a controlled experimental animal studyXiaoyan Li
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Reprod Biol Endocrinol 11:16. 2013..Thus far, gonadotropin releasing hormone (GnRH) agonist (GnRHa) and antagonist (GnRHant) are reported to act as protective agents of the ovary in chemotherapy through the ..
- Immunohistochemical evidence for the relationship between microglia and GnRH neurons in the preoptic area of ovariectomized rats with and without steroid replacementHitomi Fujioka
Department of Physiology, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Endocr J 60:191-6. 2013..COX-1 and COX-2, are among the important mediators involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion. However, the cellular origin of PGs remains obscure in terms of its relationship to GnRH neurons...
- Somatostatin inhibition of GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in ratsMakiko Koyama
Department of Physiology, Nippon Medical School, 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
Endocrinology 153:806-14. 2012In rodents, GnRH neurons are diffusely distributed from the medial septum through to the medial preoptic area and control gonadal functions through the pituitary...
- Regulation of intracellular signaling cascades by GNRH pulse frequency in the rat pituitary: roles for CaMK II, ERK, and JNK activationLaura L Burger
Division of Endocrinology and Metabolism, Department of Medicine, and the Center for Research in Reproduction, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
Biol Reprod 79:947-53. 2008Pulsatile GnRH (GNRH) differentially regulates LH and FSH subunit genes, with faster frequencies favoring Lhb transcription and slower favoring Fshb...
- Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female ratsSatoshi Ohkura
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
Peptides 30:49-56. 2009..to unravel the physiological role of metastin/kisspeptin in the control of gonadotropin-releasing hormone (GnRH) release...
- Converse regulatory functions of estrogen receptor-alpha and -beta subtypes expressed in hypothalamic gonadotropin-releasing hormone neuronsLian Hu
Endocrinology and Reproduction Research Branch, PDEGEN, National Institue of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
Mol Endocrinol 22:2250-9. 2008Estradiol (E(2)) acts as a potent feedback molecule between the ovary and hypothalamic GnRH neurons, and exerts both positive and negative regulatory actions on GnRH synthesis and secretion...
- Leptin indirectly regulates gonadotropin-releasing hormone neuronal functionJanette H Quennell
Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
Endocrinology 150:2805-12. 2009The adipose-derived hormone leptin communicates information about metabolic status to the hypothalamic GnRH neuronal system. It is unclear whether leptin can act directly on GnRH neurons. To examine this, we used three approaches...
- Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systemsJuan Pablo Prestifilippo
Center of Pharmacological and Botanical Studies CEFyBO CONICET UBA, Facultad de Medicina, UBA, Paraguay 2155, piso 16, Buenos Aires, Argentina
Toxicol Sci 105:295-302. 2008Manganese chloride (MnCl2) is capable of stimulating luteinizing hormone releasing hormone (LHRH) secretion in adult male Sprague-Dawley rats through the activation of the hypothalamic nitric oxide/cyclic guanosine monophosphate (cGMP)/..
- The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antagonistJoelle E Taylor
Reproductive Biology and Medicine Branch, National Institutes of Health, Bethesda, Maryland 20814, USA
Fertil Steril 93:1668-75. 2010To elucidate the physiologic mechanism responsible for the supraphysiologic gonadotropin release from the pituitary induced by gonadotropin-releasing hormone (GnRH) agonist in female rats primed with GnRH antagonist.
- Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH systemL Pinilla
Medical Research Council Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh, United Kingdom
Endocrinology 150:2889-97. 2009..We analyze herein in female SH rats: 1) possible alterations in the expression and function of KiSS-1/GPR54 and GnRH/GnRH-receptor systems, 2) the integrity of feedback mechanisms governing the hypothalamic-pituitary-ovarian axis, ..
- Characterization of the cDNAs encoding three GnRH forms in the pejerrey fish Odontesthes bonariensis (Atheriniformes) and the evolution of GnRH precursorsLeonardo G Guilgur
Laboratorio de Ictiofisiología y Acuicultura, Instituto de Investigaciones Biotecnologicas, Instituto Tecnológico de Chascomús CONICET UNSAM, C C 164 B7130IWA, Chascomús, Provincia de Buenos Aires, Argentina
J Mol Evol 64:614-27. 2007Most vertebrates express two gonadotropin releasing hormone (GnRH) variants in brain tissue but there is an increasing number of fish species for which a third GnRH form has been detected...
- A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta geneNick A Ciccone
Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 0211, USA
Mol Endocrinol 22:1908-23. 2008..remains poorly understood, but is known to involve the complex interplay of multiple endocrine factors including GnRH. We have identified a GnRH-responsive element within the rat FSHbeta promoter containing an E-box and partial cAMP ..
- Hormonal regulation of GnRH and LHbeta mRNA expression in cultured rat granulosa cellsNaomi Litichever
Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
J Mol Neurosci 39:78-85. 2009..In the present report, we studied the regulation of LHbeta and of gonadotropin-releasing hormone (GnRH) mRNA expression in granulosa cells that were isolated from immature rats treated with either estrogen or pregnant ..
- Expression of the GABAA receptor associated protein Gec1 is circadian and dependent upon the cellular clock machinery in GnRH secreting GnV-3 cellsVirginie Mansuy
Services of Endocrinology, Diabetology, and Metabolism of the University Hospital of Lausanne, Switzerland
Mol Cell Endocrinol 307:68-76. 2009The timely regulation of gonadotropin-releasing hormone (GnRH) secretion requires a GABAergic signal. We hypothesized that GEC1, a protein promoting the transport of GABA(A) receptors, could represent a circadian effector in GnRH neurons...
- Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old ratsWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
J Comp Neurol 517:284-95. 2009The decapeptide gonadotropin-releasing hormone (GnRH), which regulates reproduction in all vertebrates, is stored in, and secreted from, large dense-core secretory vesicles in nerve terminals in the median eminence...
- Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatmentWeiling Yin
Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
Endocrinology 150:5498-508. 2009The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is a convergence of numerous nerve terminals and glial cells...
- Pulsatile gonadotropin-releasing hormone release from hypothalamic explants of male marmoset monkeys compared with male ratsMichael J Woller
Biological Sciences, Univ of Wisconsin Whitewater, Whitewater, WI 53190 1790, USA
Am J Physiol Regul Integr Comp Physiol 298:R70-8. 2010The present study was conducted to quantify in vitro gonadotropin-releasing hormone (GnRH) release parameters in the male marmoset...
- Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the ratXiao Feng Li
Division of Reproduction and Endocrinology, King s College London, London, United Kingdom
PLoS ONE 4:e8334. 2009..As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses.
- An immunohistochemical study on the expressional dynamics of kisspeptin neurons relevant to GnRH neurons using a newly developed anti-kisspeptin antibodyNorio Iijima
Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
J Mol Neurosci 43:146-54. 2011..antibody for the investigation of the interaction between kisspeptin fibers and gonadotropin-releasing hormone (GnRH) neurons...
- Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of gonadotrophin-releasing hormone (GnRH), its analogues and melatoninE Boczek-Leszczyk
Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Lodz, Lodz, Poland
J Physiol Pharmacol 61:459-66. 2010The influence of gonadotrophin-releasing hormone (GnRH) and its analogues (i.e., agonist and antagonist) on vasopressin (VP) release from the rat hypothalamo-neurohypophysial (H-N) system was studied both in vitro and in vivo...
- Phenotypic and molecular characterization of proliferating and differentiated GnRH-expressing GnV-3 cellsVirginie Mansuy
Service of Endocrinology, Diabetology and Metabolism, University Hospital and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
Mol Cell Endocrinol 332:97-105. 2011b>GnRH neurons provide the primary driving force upon the neuroendocrine reproductive axis...
- Further evaluation of the biological activity of the unique gonadotropin-releasing hormone peptide in the guinea pig brainChang Qing Gao
Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium
Neurosci Lett 487:246-9. 2011In this study we compared the biological activity of a unique form of gonadotropin-releasing hormone (GnRH) in the brain of the guinea pig (gpGnRH) with mammalian GnRH (mGnRH)...
- Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic ratsSreenivasan Paruthiyil
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 99:17191-6. 2002Experiments in the GT1 gonadotropin-releasing hormone (GnRH) cell line have shown that the cAMP signaling pathway plays a central role in regulating the excitability of the cells...
- Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signalingRakel Lopez de Maturana
Ardana Bioscience, Edinburgh, UK
Mol Endocrinol 22:1711-22. 2008b>GnRH and its receptor are expressed in human reproductive tract cancers, and direct antiproliferative effects of GnRH analogs have been demonstrated in cancer cell lines...
- Prolactin inhibits annexin 5 expression and apoptosis in the corpus luteum of pseudopregnant rats: involvement of local gonadotropin-releasing hormoneMitsumori Kawaminami
Veterinary Physiology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
Endocrinology 144:3625-31. 2003..the expression of annexin 5 and prolactin in the corpus luteum of pseudopregnant rats, with particular interest in GnRH and apoptosis of luteal cells...
- Mast cells in the rat brain synthesize gonadotropin-releasing hormoneMona H Khalil
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Neurobiol 56:113-24. 2003..has been suggested that brain mast cells contain the mammalian hypothalamic form of gonadotropin-releasing hormone (GnRH-I), it is not known whether mast cells synthesize GnRH-I de novo...
- Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumorAstrid Chamson-Reig
Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Medicina, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Endocrinology 144:2957-66. 2003Previous results showed that GnRH signaling is altered in cells from rat luteinized ovarian tumors (tumor group) because it did not activate the phospholipase C pathway, in contrast to control ovarian cells from superovulated prepubertal ..
- Gonadotropin-releasing hormone stimulation of gonadotropin subunit transcription: evidence for the involvement of calcium/calmodulin-dependent kinase II (Ca/CAMK II) activation in rat pituitariesD J Haisenleder
Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Aurbach Medical Research Building, PO Box 801412, Charlottesville, VA 22908, USA
Endocrinology 144:2768-74. 2003The intracellular pathways mediating GnRH regulation of gonadotropin subunit transcription remain to be fully characterized, and the present study examined whether calcium/calmodulin-dependent kinase II (Ca/CAMK II) plays a role in the ..
- A study on the localization and distribution of GnRH and its receptor in rat submaxillary glands by immunohistochemical, in situ hybridization and RT-PCRBing Yao
Department of Reproduction of Nanjing Jingling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, 210002, Nanjing, People s Republic of China
Life Sci 72:2895-904. 2003We investigated the rat submaxillary gland for the presence of GnRH and GnRH receptors, the localization and colocalization of GnRH, GnRH receptor and their mRNA, and studied the sequence of GnRH receptor complementary DNA (cDNA) by ..
- Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitinVishwa Deep Dixit
Department of Physiology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Endocrinology 144:1496-505. 2003..In the present study, we examined the effects of GnRH on pregnancy-induced thymic involution by characterizing the expression patterns of prohibitin (PHB), an ..
- Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary glandJonathan D Johnston
School of Biological Sciences, University of Aberdeen, Aberdeen AB24 5UA, United Kingdom
Proc Natl Acad Sci U S A 100:2831-5. 2003..the transcription factor, early growth response factor-1, which is induced by gonadotrophin-releasing hormone (GnRH) and trans-activates LH beta expression, attenuated Pitx-1-induced MT(1)-luciferase activity...
- Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamusSebastien Bouret
Institut National de la Santé et de la Recherche Médicale Unité 422, Lille, France
Endocrinology 145:1794-801. 2004..immortalized GT1 cells suggest that hypothalamic astrocytes employ TGFbeta(1) to directly regulate the secretion of GnRH, the neurohormone that controls sexual maturation and adult reproductive function...
- Proestrous surge of gonadotropin-releasing hormone secretion inhibits apoptosis of anterior pituitary cells in cycling female ratsPing Yin
Department of Physiology, Yamanashi Medical University, Yamanashi, Japan
Neuroendocrinology 76:272-82. 2002..was reduced by simultaneous treatment with an ovulation-inducing dose of gonadotropin-releasing hormone (GnRH), but not with progesterone, an ovarian steroid also released after GnRH treatment...
- Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in ratsHajime Watanobe
Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
J Physiol 545:255-68. 2002..adipocyte-derived hormone, acts directly within the hypothalamus to stimulate the gonadotropin-releasing hormone (GnRH)-luteinizing hormone (LH) system...
- Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elementsCarolyn G Kelley
Department of Reproductive Medicine, Center for the Study of Reproductive Biology and Disease, University of California, San Diego, La Jolla, California 92093 0674, USA
Mol Endocrinol 16:2413-25. 2002b>GnRH gene expression is restricted to a tiny population of neurons scattered throughout the mediobasal hypothalamus...
- Age-related changes in hypothalamic gonadotropin-releasing hormone and N-methyl-D-aspartate receptor gene expression, and their regulation by oestrogen, in the female ratA C Gore
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA
J Neuroendocrinol 14:300-9. 2002..in rodents are believed to involve changes in hypothalamic neurones, including gonadotropin-releasing hormone (GnRH) cells and their afferent inputs...
- Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH geneMark A Lawson
Department of Reproductive Medicine and Center for the Study of Reproductive Biology and Disease, University of California San Diego, La Jolla, California 92093 0674, USA
Endocrinology 143:1404-12. 2002The GnRH-expressing neurons are the ultimate regulator of reproductive function. GnRH gene expression is limited to this small population of neurons in the hypothalamus...
- Two mammalian genes transcribed from opposite strands of the same DNA locusJ P Adelman
Science 235:1514-7. 1987..One gene (strand) encodes gonadotropin-releasing hormone (GnRH). A second gene, SH, is transcribed from the other DNA strand to produce RNA of undefined function...
- Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and ratJ P Adelman
Proc Natl Acad Sci U S A 83:179-83. 1986..Genomic analyses revealed the presence of a single Gn-RH-PIF gene in human and rat containing sequences corresponding to the cDNA distributed across four exons...
- The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expressionC T Bond
Department of Cell Biology, Oregon Health Sciences University, Portland 97201
Mol Endocrinol 3:1257-62. 1989The rat GnRH gene as expressed in the central nervous system is comprised of four exons and three introns and spans 4.5 kilobases of genomic DNA...
- Calcium influx and DREAM protein are required for GnRH gene expression pulse activityGilles M Leclerc
Laboratory of Molecular Dynamics, Department of Cell Biology and Anatomy Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Mol Cell Endocrinol 267:70-9. 2007Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events...
- Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesisJanine Prange-Kiel
Institute of Anatomy I Cellular Neurobiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
J Cell Biol 180:417-26. 2008..In view of the abundant gonadotropin-releasing hormone receptor (GnRH-R) messenger RNA expression in the hippocampus and the direct effect of GnRH on estradiol (E2) synthesis in gonadal ..
- Mechanisms of interaction of endocrine-disrupting chemicals with glutamate-evoked secretion of gonadotropin-releasing hormoneGregory Rasier
Developmental Neuroendocrinology Unit, Centre for Cellular and Molecular Neurobiology, University of Liege, University Hospital, Belgium
Toxicol Sci 102:33-41. 2008..Recently, we reported that DDT stimulated pulsatile gonadotropin-releasing hormone (GnRH) secretion and sexual maturation in the female rat...
- Presence of immunoreactive gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) in rat ovary during pregnancyAnamika Sengupta
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
Mol Reprod Dev 75:1031-44. 2008The present study aims at quantification of gonadotropin releasing hormone (GnRH) by radioimmunoassay, relative expression of its mRNA by real-time PCR accompanied by its cellular localization in the rat ovary by immunonohistochemistry (..
- GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patientsDjura Piersma
Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
Breast Cancer Res 9:R51. 2007..Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis...
- Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNAC C Maier
Department of Physiology and Biophysics, University of Alamaba, Birmingham 35294 0005
Cell Mol Neurobiol 12:447-54. 19921. A luteinizing hormone-releasing hormone (LHRH)-like molecule produced by thymocytes is similar to hypothalamic LHRH in both bioactivity and antigenicity. 2...
- Localization of immunoreactive gonadotropin-releasing hormone and relative expression of its mRNA in the oviduct during pregnancy in ratsAnamika Sengupta
Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
J Histochem Cytochem 55:525-34. 2007..was designed to determine the cellular and ultrastructural distribution of the gonadotropin-releasing hormone (GnRH) and the relative expression of its mRNA in the oviduct of rats during different time points (days 7, 9, 16, and 20)..
- Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after pubertyM C Lebrethon
Developmental Neuroendocrinology Unit, Center of Cellular and Molecular Neurobiology, Division of Ambulatory Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Liege, CHU Sart Tilman, Liege, Belgium
J Neuroendocrinol 19:181-8. 2007..aimed to investigate the effects of leptin and ghrelin on pulsatile pulsatile gonadotrophin-releasing hormone (GnRH) secretion in vitro with emphasis on neuropeptide mediators and changes between prepuberty (15 days) and sexual ..
- Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat miceSudha Srinivasan
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
Endocrinology 145:2023-34. 2004..infertility of Cpe(fat/fat) mice has not been systematically investigated, it is thought to be due to a deficit in GnRH processing...
- Daily GnRH and GnRH-receptor mRNA expression in the ovariectomized and intact ratTamar D Schirman-Hildesheim
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Mol Cell Endocrinol 252:120-5. 2006We recently described patterns of GnRH and GnRH receptor (GnRH-R) expression in the hypothalamus, pituitary and ovary throughout the rat estrus cycle...
- Vasoactive intestinal polypeptide regulates dynamic changes in astrocyte morphometry: impact on gonadotropin-releasing hormone neuronsLynnette M Gerhold
Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, 95616, USA
Endocrinology 147:2197-202. 2006Recent studies suggest that astrocytes modulate the GnRH-induced LH surge. In particular, we have shown that the surface area of astrocytes that ensheath GnRH neurons exhibits diurnal rhythms...
- Presence of delta opioid receptors on a subset of hypothalamic gonadotropin releasing hormone (GnRH) neuronsFederica Pimpinelli
Laboratory of Developmental Neuroendocrinology, Institute of Endocrinology, University of Milano, via G Balzaretti, 9 20133 Milan, Italy
Brain Res 1070:15-23. 2006Opioid peptides exert an inhibitory effect on hypothalamic gonadotropin releasing hormone (GnRH) secretion mainly by interacting with mu-opioid receptors...
- Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activityGilles M Leclerc
Laboratory of Molecular Dynamics, Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, USA
Mol Cell Endocrinol 245:86-92. 2005Recent evidence from our laboratory demonstrated that the OCT1 protein was necessary for GnRH gene promoter pulse activity through its interaction with a specific OCT1 binding site (OCT1BS-a, -1,774/-1,781)...
- The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cellsQingbo Tang
Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Mol Endocrinol 19:2769-79. 2005The GnRH gene uses two well-defined regions to target expression to a small population of hypothalamic GnRH neurons: a 173-bp proximal promoter and a 300-bp enhancer localized at approximately -1800 to -1500 bp from the start site...
- Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq couplingSharon Shacham
Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
J Biol Chem 280:28981-8. 2005Type I gonadotropin-releasing hormone (GnRH) receptor (GnRHR) is unique among mammalian G-protein-coupled receptors (GPCRs) in lacking a C-terminal tail, which is involved in desensitization in GPCRs...
- Decreased gonadotropin-releasing hormone neuronal activity is associated with decreased fertility and dysregulation of food intake in the female GPR-4 transgenic ratFrancisca Gomez
Department of Obstetrics, 513 Parnassus Avenue, HSW1475, Box 0556, University of California, San Francisco, California 94143, USA
Endocrinology 146:3800-8. 2005Expression of a cAMP-specific phosphodiesterase in GnRH neurons in the GPR-4 transgenic rat resulted in decreased LH levels and pulse frequency and diminished fertility...
- Differential gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acid expression patterns in different tissues of the female rat across the estrous cycleTamar D Schirman-Hildesheim
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Endocrinology 146:3401-8. 2005b>GnRH, the main regulator of reproduction, is produced in a variety of tissues outside of the hypothalamus, its main site of synthesis and release...
- TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1Naama Rave-Harel
Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92903, USA
J Biol Chem 279:30287-97. 2004Gonadotropin-releasing hormone (GnRH) is the central regulator of reproductive function. Expression of the GnRH gene is confined to a rare population of neurons scattered throughout the hypothalamus...
- Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathwayMelissa P Allen
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 277:38133-40. 2002Recent studies suggest that adhesion-related kinase (Ark) plays a role in gonadotropin-releasing hormone (GnRH) neuronal physiology...
- Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assaysA C Dalkin
Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia 22908, USA
Endocrinology 142:139-46. 2001b>GnRH regulates the synthesis and secretion of the pituitary gonadotropins LH and FSH...
- Neuroendocrine outcomes of prenatal PCB exposuresANDREA GORE; Fiscal Year: 2005..The results should have important implications for understanding consequences of, and developing therapies for, exposures of wildlife and humans to EDCs such as PCBs. ..
- Neuromodulation of reproduction during agingLynnette Gerhold; Fiscal Year: 2004..The integrity of the suprachiasmatic nucleus (SCN) is essential in maintaining regular cyclic GnRH/LH release and regular estrous cycles in young animals...
- Mechanisms of Response to GnRH Receptor SignalingMARK LAWSON; Fiscal Year: 2005..Isolation of actively translated and total mRNA from treated and control cells will allow identification and quantification of global changes in gene expression. ..
- Forum on Endocrine-Disrupting ChemicalsANDREA GORE; Fiscal Year: 2005..In order to limit future contaminations and to mitigate existing exposures, it is critical that we educate the endocrine community and make this subject a permanent part of the Endocrine Society's agenda. ..
- Insulin Signaling in the Anterior PituitaryMARK LAWSON; Fiscal Year: 2006..We will also identify the mechanism of convergent GnRH and insulin signaling...