Gnrh1

Summary

Gene Symbol: Gnrh1
Description: gonadotropin releasing hormone 1
Alias: Gnrh, Gnrha, Lhrh, Rgnrhg1, SH-4, progonadoliberin-1, Putative protein SH, gonadotropin-releasing hormone 1 (luteinizing-releasing hormone), luteinizing hormone-releasing hormone, progonadoliberin I
Species: rat

Top Publications

  1. ncbi Episodic activation of the rat GnRH promoter: role of the homeoprotein oct-1
    Rafael Vazquez-Martinez
    Laboratory of Molecular Dynamics F R B, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Mol Endocrinol 16:2093-100. 2002
  2. ncbi Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels
    Andrea C Gore
    Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
    Mol Cell Endocrinol 256:40-8. 2006
  3. doi Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation
    Jerome Bouligand
    Universite Paris Sud, Faculté de Médecine Paris Sud and Assistance Publique Hôpitaux de Paris, Hopital de Bicetre, INSERM UMR S693, Paris, France
    N Engl J Med 360:2742-8. 2009
  4. pmc GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:11703-8. 2009
  5. pmc Nonmammalian gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats
    Ishwar S Parhar
    Department of Physiology, Nippon Medical School, Tokyo 113 8602, Japan
    Proc Natl Acad Sci U S A 102:5880-5. 2005
  6. ncbi Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female rat
    James S Kinsey-Jones
    Division of Reproduction and Endocrinology, 2 36D New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Endocrinology 149:1004-8. 2008
  7. doi Delayed puberty in prenatally glucocorticoid administered female rats occurs independently of the hypothalamic Kiss1-Kiss1r-GnRH system
    Takeshi Iwasa
    Department of Obstetrics and Gynecology, The University of Tokushima Graduate School, Institute of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Dev Neurosci 29:183-8. 2011
  8. doi Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage
    Ferenc G Rick
    Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Miami, Florida 33125, USA
    J Urol 187:1498-504. 2012
  9. doi Differential expression of gonadotropin-releasing hormone (GnRH) in pancreas during rat pregnancy
    Li Wang
    Department of Endocrinology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Endocrine 36:538-45. 2009
  10. ncbi Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers
    Rebecca E Campbell
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Endocrinology 144:1542-8. 2003

Research Grants

  1. Neuroendocrine outcomes of prenatal PCB exposures
    ANDREA GORE; Fiscal Year: 2005
  2. Neuromodulation of reproduction during aging
    Lynnette Gerhold; Fiscal Year: 2004
  3. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
  4. Forum on Endocrine-Disrupting Chemicals
    ANDREA GORE; Fiscal Year: 2005
  5. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications87

  1. ncbi Episodic activation of the rat GnRH promoter: role of the homeoprotein oct-1
    Rafael Vazquez-Martinez
    Laboratory of Molecular Dynamics F R B, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Mol Endocrinol 16:2093-100. 2002
    Recent reports demonstrate that the rat GnRH promoter is activated in an episodic fashion in immortalized GnRH neurons, but little information is available on molecular processes that contribute to this phenomenon...
  2. ncbi Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels
    Andrea C Gore
    Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
    Mol Cell Endocrinol 256:40-8. 2006
    ..Rats were treated either chronically or acutely with glucocorticoids, and circulating gonadotropins, GnRH mRNA levels, and gonadotropin subunit mRNAs levels were measured...
  3. doi Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation
    Jerome Bouligand
    Universite Paris Sud, Faculté de Médecine Paris Sud and Assistance Publique Hôpitaux de Paris, Hopital de Bicetre, INSERM UMR S693, Paris, France
    N Engl J Med 360:2742-8. 2009
    We investigated whether mutations in the gene encoding gonadotropin-releasing hormone 1 (GNRH1) might be responsible for idiopathic hypogonadotropic hypogonadism (IHH) in humans...
  4. pmc GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism
    Yee Ming Chan
    Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 106:11703-8. 2009
    ..be mutated in patients with IHH, yet to date no mutations have been identified in the most obvious candidate gene, GNRH1 itself, which encodes the preprohormone that is ultimately processed to produce GnRH...
  5. pmc Nonmammalian gonadotropin-releasing hormone molecules in the brain of promoter transgenic rats
    Ishwar S Parhar
    Department of Physiology, Nippon Medical School, Tokyo 113 8602, Japan
    Proc Natl Acad Sci U S A 102:5880-5. 2005
    Mammalian gonadotropin-releasing hormone (GnRH1) and nonmammalian immunoreactive GnRH subtypes were examined in transgenic rats carrying an enhanced GFP (EGFP) reporter gene driven by a rat GnRH1 promoter...
  6. ncbi Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin-releasing hormone pulse generator activity in the female rat
    James S Kinsey-Jones
    Division of Reproduction and Endocrinology, 2 36D New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Endocrinology 149:1004-8. 2008
    ..are extraordinarily potent in stimulating gonadotropic hormone secretion via an action on the hypothalamic GnRH neural system...
  7. doi Delayed puberty in prenatally glucocorticoid administered female rats occurs independently of the hypothalamic Kiss1-Kiss1r-GnRH system
    Takeshi Iwasa
    Department of Obstetrics and Gynecology, The University of Tokushima Graduate School, Institute of Health Biosciences, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    Int J Dev Neurosci 29:183-8. 2011
    ..We have previously reported that decreased action of hypothalamic kisspeptin, which is a positive regulator of GnRH, contributes to the delayed onset of puberty in undernutrition-induced IUGR rats...
  8. doi Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage
    Ferenc G Rick
    Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education, Miami, Florida 33125, USA
    J Urol 187:1498-504. 2012
    ..We investigated the influence of a combination of antagonists of growth hormone-releasing hormone and luteinizing hormone-releasing hormone on animal models of benign prostatic hyperplasia...
  9. doi Differential expression of gonadotropin-releasing hormone (GnRH) in pancreas during rat pregnancy
    Li Wang
    Department of Endocrinology, Xijing Hospital, The Fourth Military Medical University, Xi an, China
    Endocrine 36:538-45. 2009
    Many studies have shown that there is a relationship between gonadotropin-releasing hormone (GnRH) and glucose metabolism, but little is known about the effects of GnRH on the pancreas...
  10. ncbi Gonadotropin-releasing hormone neurons coexpress orexin 1 receptor immunoreactivity and receive direct contacts by orexin fibers
    Rebecca E Campbell
    Department of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Endocrinology 144:1542-8. 2003
    ..Using double- and triple-label immunofluorescence coupled with confocal microscopy, we found that 75-85% of GnRH neurons were contacted by orexin fibers, and triple labeling with synaptophysin provided additional confirmation of ..
  11. doi Mechanisms of prostate atrophy after LHRH antagonist cetrorelix injection: an experimental study in a rat model of benign prostatic hyperplasia
    Dong Yang
    Department of Urology, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 32:389-95. 2012
    ..Our findings strongly suggest that the TGF-β signaling pathway may be one of the major causes responsible for prostate volume reduction in BPH rats after cetrorelix treatment...
  12. pmc Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition
    J Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Neuroscience 241:67-79. 2013
    ..18% in the control group). Notably, lesions of the PMV disrupted the physiologic fluctuations of Kiss1 and GnRH mRNA expression characteristic of the proestrus-to-estrus transition...
  13. pmc Gonadotropin-releasing hormone stimulates biliary proliferation by paracrine/autocrine mechanisms
    Debolina Ray
    Department of Medicine, Texas A and M Health Science Center College of Medicine, Temple, Texas
    Am J Pathol 185:1061-72. 2015
    ..Gonadotropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and proliferation in many cell types...
  14. pmc Hypothalamic molecular changes underlying natural reproductive senescence in the female rat
    Bailey A Kermath
    Institute for Neuroscience B A K, A C G, Division of Pharmacology and Toxicology P D R, A C G, and Institute for Cell and Molecular Biology A C G, The University of Texas at Austin, Austin, Texas 78712 Department of Biology M J W, University of Wisconsin Whitewater, Whitewater, Wisconsin 53190 and Department of Pediatrics A W, Johns Hopkins University School of Medicine, Baltimore Maryland 21287
    Endocrinology 155:3597-609. 2014
    ..Esr2, Pgr, Ar), steroidogenic enzymes (Sts, Hsd17b8), growth factors (Igf1, Tgfa), and neuropeptides (Kiss1, Tac2, Gnrh1). Bionetwork analysis revealed region-specific correlations between genes and hormones...
  15. ncbi The Pro-LHRH system of the rat brain. Effects of changes in the endocrine background
    I Merchenthaler
    Department of Anatomy, University Medical School, Pecs, Hungary
    Brain Res Bull 20:713-20. 1988
    The gonadotropin-releasing hormone-associated peptide (GAP) and luteinizing hormone-releasing hormone (LHRH) portions of the LHRH precursor were localized by immunocytochemistry in prepubertal female rats, in adult female rats at ..
  16. ncbi Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation
    M M Valenca
    Reproductive Neuroendrocrinology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Mol Cell Endocrinol 55:95-100. 1988
    ProLHRH contains the luteinizing hormone-releasing hormone (LHRH) decapeptide and a 56 amino acid peptide designated gonadotropin-releasing hormone-associated peptide (GAP)...
  17. doi Neurokinin B signaling in the female rat: a novel link between stress and reproduction
    P Grachev
    Division of Women s Health P G, X F L, M H H, S Y L, K T O, School of Medicine, King s College London, United Kingdom Mammal Research Institute R P M, University of Pretoria, Pretoria, South Africa Medical Research Council Receptor Biology Unit, University of Cape Town, Cape Town, South Africa Centre for Integrative Physiology, University of Edinburgh, Scotland and Henry Wellcome Laboratory for Integrative Neuroscience and Endocrinology S L L, University of Bristol, Bristol, United Kingdom
    Endocrinology 155:2589-601. 2014
    ..The underlying mechanism involves stress-induced suppression of the GnRH pulse generator, the functional unit of which is considered to be the hypothalamic arcuate nucleus kisspeptin/..
  18. pmc Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females
    Cadence True
    Divisions of Diabetes, Obesity, and Metabolism, and Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Endocrinology 154:2821-32. 2013
    ..The current study characterized CART's regulatory influence on GnRH and kisspeptin (Kiss1) cells and determined the sensitivity of different CART populations to negative energy ..
  19. ncbi Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression
    T M Wilson
    Department of Pediatrics, Wells Center for Pediatric Research, Indianapolis, Indiana, USA
    Mol Endocrinol 9:44-53. 1995
    ..One of these genes, LHRH, has not previously been reported to respond in this manner, although we and others have reported its presence in ..
  20. ncbi Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level
    R E Nappi
    CHUL Research Center and Laval University, Quebec, Canada
    Endocrinology 138:1374-84. 1997
    ..to investigate the influence of immune (systemic endotoxin administration) and metabolic (fasting) challenges on LHRH neuronal activity and transcription in the organum vasculosum of the lamina terminalis/medial preoptic area as well ..
  21. pmc R31C GNRH1 mutation and congenital hypogonadotropic hypogonadism
    Luigi Maione
    Universite Paris Sud, Faculté de Médecine Paris Sud Unité mixte de Recherche en Santé 693, Le Kremlin Bicetre, France
    PLoS ONE 8:e69616. 2013
    ..Loss-of-function mutations of GNRH1 gene are a very rare cause of autosomal recessive nCHH...
  22. pmc Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides
    J K Hiney
    Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4458, USA
    Proc Natl Acad Sci U S A 99:2386-91. 2002
    ..hormone release, is coexpressed in neurons containing mammalian luteinizing hormone-releasing hormone (m-LHRH)...
  23. doi Intercellular communications within the rat anterior pituitary. XVI: postnatal changes of distribution of S-100 protein positive cells, connexin 43 and LH-RH positive sites in the pars tuberalis of the rat pituitary gland. An immunohistochemical and elect
    Ikuo Wada
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan Electronic address
    Tissue Cell 46:33-9. 2014
    ..It is suggested that the folliculo-stellate cell system including the LH-RH neurons in the pars tuberalis participates in the control of LH secretion along with the portal vein system. ..
  24. pmc Direct evidence for the co-expression of URP and GnRH in a sub-population of rat hypothalamic neurones: anatomical and functional correlation
    Johann Günther Egginger
    Laboratoire de Neurobiologie des Signaux Intercellulaires, CNRS UMR 7101 Université Pierre et Marie Curie, Paris, France
    PLoS ONE 6:e26611. 2011
    ..with immunohistochemistry, we showed that cell bodies of the rat anterior hypothalamus contained both URP mRNA and GnRH peptide...
  25. ncbi [Experimental study on therapeutic effect of Dabuyin Wan on true precocious puberty in female rats]
    Min Cheng
    Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
    Zhongguo Zhong Yao Za Zhi 38:386-90. 2013
    ..To study the therapeutic effect of Dabuyin Wan on true precocious puberty of female rats and its possible mechanism...
  26. pmc Combination of a GnRH agonist with an antagonist prevents flare-up effects and protects primordial ovarian follicles in the rat ovary from cisplatin-induced toxicity: a controlled experimental animal study
    Xiaoyan Li
    Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Reprod Biol Endocrinol 11:16. 2013
    ..Thus far, gonadotropin releasing hormone (GnRH) agonist (GnRHa) and antagonist (GnRHant) are reported to act as protective agents of the ovary in chemotherapy through the ..
  27. ncbi Immunohistochemical evidence for the relationship between microglia and GnRH neurons in the preoptic area of ovariectomized rats with and without steroid replacement
    Hitomi Fujioka
    Department of Physiology, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
    Endocr J 60:191-6. 2013
    ..COX-1 and COX-2, are among the important mediators involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion. However, the cellular origin of PGs remains obscure in terms of its relationship to GnRH neurons...
  28. doi Somatostatin inhibition of GnRH neuronal activity and the morphological relationship between GnRH and somatostatin neurons in rats
    Makiko Koyama
    Department of Physiology, Nippon Medical School, 1 Sendagi, Bunkyo, Tokyo 113 8602, Japan
    Endocrinology 153:806-14. 2012
    In rodents, GnRH neurons are diffusely distributed from the medial septum through to the medial preoptic area and control gonadal functions through the pituitary...
  29. pmc Regulation of intracellular signaling cascades by GNRH pulse frequency in the rat pituitary: roles for CaMK II, ERK, and JNK activation
    Laura L Burger
    Division of Endocrinology and Metabolism, Department of Medicine, and the Center for Research in Reproduction, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 79:947-53. 2008
    Pulsatile GnRH (GNRH) differentially regulates LH and FSH subunit genes, with faster frequencies favoring Lhb transcription and slower favoring Fshb...
  30. doi Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats
    Satoshi Ohkura
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Peptides 30:49-56. 2009
    ..to unravel the physiological role of metastin/kisspeptin in the control of gonadotropin-releasing hormone (GnRH) release...
  31. pmc Converse regulatory functions of estrogen receptor-alpha and -beta subtypes expressed in hypothalamic gonadotropin-releasing hormone neurons
    Lian Hu
    Endocrinology and Reproduction Research Branch, PDEGEN, National Institue of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    Mol Endocrinol 22:2250-9. 2008
    Estradiol (E(2)) acts as a potent feedback molecule between the ovary and hypothalamic GnRH neurons, and exerts both positive and negative regulatory actions on GnRH synthesis and secretion...
  32. pmc Leptin indirectly regulates gonadotropin-releasing hormone neuronal function
    Janette H Quennell
    Department of Anatomy and Structural Biology, Centre for Neuroendocrinology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 150:2805-12. 2009
    The adipose-derived hormone leptin communicates information about metabolic status to the hypothalamic GnRH neuronal system. It is unclear whether leptin can act directly on GnRH neurons. To examine this, we used three approaches...
  33. pmc Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: involvement of specific neurotransmitter systems
    Juan Pablo Prestifilippo
    Center of Pharmacological and Botanical Studies CEFyBO CONICET UBA, Facultad de Medicina, UBA, Paraguay 2155, piso 16, Buenos Aires, Argentina
    Toxicol Sci 105:295-302. 2008
    Manganese chloride (MnCl2) is capable of stimulating luteinizing hormone releasing hormone (LHRH) secretion in adult male Sprague-Dawley rats through the activation of the hypothalamic nitric oxide/cyclic guanosine monophosphate (cGMP)/..
  34. pmc The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antagonist
    Joelle E Taylor
    Reproductive Biology and Medicine Branch, National Institutes of Health, Bethesda, Maryland 20814, USA
    Fertil Steril 93:1668-75. 2010
    To elucidate the physiologic mechanism responsible for the supraphysiologic gonadotropin release from the pituitary induced by gonadotropin-releasing hormone (GnRH) agonist in female rats primed with GnRH antagonist.
  35. doi Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system
    L Pinilla
    Medical Research Council Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Endocrinology 150:2889-97. 2009
    ..We analyze herein in female SH rats: 1) possible alterations in the expression and function of KiSS-1/GPR54 and GnRH/GnRH-receptor systems, 2) the integrity of feedback mechanisms governing the hypothalamic-pituitary-ovarian axis, ..
  36. ncbi Characterization of the cDNAs encoding three GnRH forms in the pejerrey fish Odontesthes bonariensis (Atheriniformes) and the evolution of GnRH precursors
    Leonardo G Guilgur
    Laboratorio de Ictiofisiología y Acuicultura, Instituto de Investigaciones Biotecnologicas, Instituto Tecnológico de Chascomús CONICET UNSAM, C C 164 B7130IWA, Chascomús, Provincia de Buenos Aires, Argentina
    J Mol Evol 64:614-27. 2007
    Most vertebrates express two gonadotropin releasing hormone (GnRH) variants in brain tissue but there is an increasing number of fish species for which a third GnRH form has been detected...
  37. pmc A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene
    Nick A Ciccone
    Brigham and Women s Hospital, Division of Endocrinology, Diabetes and Hypertension, 221 Longwood Avenue, Boston, Massachusetts 0211, USA
    Mol Endocrinol 22:1908-23. 2008
    ..remains poorly understood, but is known to involve the complex interplay of multiple endocrine factors including GnRH. We have identified a GnRH-responsive element within the rat FSHbeta promoter containing an E-box and partial cAMP ..
  38. doi Hormonal regulation of GnRH and LHbeta mRNA expression in cultured rat granulosa cells
    Naomi Litichever
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, 76100, Israel
    J Mol Neurosci 39:78-85. 2009
    ..In the present report, we studied the regulation of LHbeta and of gonadotropin-releasing hormone (GnRH) mRNA expression in granulosa cells that were isolated from immature rats treated with either estrogen or pregnant ..
  39. doi Expression of the GABAA receptor associated protein Gec1 is circadian and dependent upon the cellular clock machinery in GnRH secreting GnV-3 cells
    Virginie Mansuy
    Services of Endocrinology, Diabetology, and Metabolism of the University Hospital of Lausanne, Switzerland
    Mol Cell Endocrinol 307:68-76. 2009
    The timely regulation of gonadotropin-releasing hormone (GnRH) secretion requires a GABAergic signal. We hypothesized that GEC1, a protein promoting the transport of GABA(A) receptors, could represent a circadian effector in GnRH neurons...
  40. pmc Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old rats
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    J Comp Neurol 517:284-95. 2009
    The decapeptide gonadotropin-releasing hormone (GnRH), which regulates reproduction in all vertebrates, is stored in, and secreted from, large dense-core secretory vesicles in nerve terminals in the median eminence...
  41. pmc Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatment
    Weiling Yin
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
    Endocrinology 150:5498-508. 2009
    The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is a convergence of numerous nerve terminals and glial cells...
  42. pmc Pulsatile gonadotropin-releasing hormone release from hypothalamic explants of male marmoset monkeys compared with male rats
    Michael J Woller
    Biological Sciences, Univ of Wisconsin Whitewater, Whitewater, WI 53190 1790, USA
    Am J Physiol Regul Integr Comp Physiol 298:R70-8. 2010
    The present study was conducted to quantify in vitro gonadotropin-releasing hormone (GnRH) release parameters in the male marmoset...
  43. pmc Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat
    Xiao Feng Li
    Division of Reproduction and Endocrinology, King s College London, London, United Kingdom
    PLoS ONE 4:e8334. 2009
    ..As the ARC is known to be the site of the gonadotropin-releasing hormone (GnRH) pulse generator we explored whether kisspeptin-GPR54 signalling in the ARC regulates GnRH pulses.
  44. doi An immunohistochemical study on the expressional dynamics of kisspeptin neurons relevant to GnRH neurons using a newly developed anti-kisspeptin antibody
    Norio Iijima
    Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Mol Neurosci 43:146-54. 2011
    ..antibody for the investigation of the interaction between kisspeptin fibers and gonadotropin-releasing hormone (GnRH) neurons...
  45. ncbi Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of gonadotrophin-releasing hormone (GnRH), its analogues and melatonin
    E Boczek-Leszczyk
    Department of Pathophysiology and Experimental Neuroendocrinology, Medical University of Lodz, Lodz, Poland
    J Physiol Pharmacol 61:459-66. 2010
    The influence of gonadotrophin-releasing hormone (GnRH) and its analogues (i.e., agonist and antagonist) on vasopressin (VP) release from the rat hypothalamo-neurohypophysial (H-N) system was studied both in vitro and in vivo...
  46. doi Phenotypic and molecular characterization of proliferating and differentiated GnRH-expressing GnV-3 cells
    Virginie Mansuy
    Service of Endocrinology, Diabetology and Metabolism, University Hospital and Faculty of Biology and Medicine, 1011 Lausanne, Switzerland
    Mol Cell Endocrinol 332:97-105. 2011
    b>GnRH neurons provide the primary driving force upon the neuroendocrine reproductive axis...
  47. doi Further evaluation of the biological activity of the unique gonadotropin-releasing hormone peptide in the guinea pig brain
    Chang Qing Gao
    Department of Endocrinology, Ghent University Hospital, 9000 Ghent, Belgium
    Neurosci Lett 487:246-9. 2011
    In this study we compared the biological activity of a unique form of gonadotropin-releasing hormone (GnRH) in the brain of the guinea pig (gpGnRH) with mammalian GnRH (mGnRH)...
  48. pmc Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats
    Sreenivasan Paruthiyil
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 99:17191-6. 2002
    Experiments in the GT1 gonadotropin-releasing hormone (GnRH) cell line have shown that the cAMP signaling pathway plays a central role in regulating the excitability of the cells...
  49. doi Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling
    Rakel Lopez de Maturana
    Ardana Bioscience, Edinburgh, UK
    Mol Endocrinol 22:1711-22. 2008
    b>GnRH and its receptor are expressed in human reproductive tract cancers, and direct antiproliferative effects of GnRH analogs have been demonstrated in cancer cell lines...
  50. ncbi Prolactin inhibits annexin 5 expression and apoptosis in the corpus luteum of pseudopregnant rats: involvement of local gonadotropin-releasing hormone
    Mitsumori Kawaminami
    Veterinary Physiology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034 8628, Japan
    Endocrinology 144:3625-31. 2003
    ..the expression of annexin 5 and prolactin in the corpus luteum of pseudopregnant rats, with particular interest in GnRH and apoptosis of luteal cells...
  51. pmc Mast cells in the rat brain synthesize gonadotropin-releasing hormone
    Mona H Khalil
    Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurobiol 56:113-24. 2003
    ..has been suggested that brain mast cells contain the mammalian hypothalamic form of gonadotropin-releasing hormone (GnRH-I), it is not known whether mast cells synthesize GnRH-I de novo...
  52. ncbi Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumor
    Astrid Chamson-Reig
    Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Medicina, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Endocrinology 144:2957-66. 2003
    Previous results showed that GnRH signaling is altered in cells from rat luteinized ovarian tumors (tumor group) because it did not activate the phospholipase C pathway, in contrast to control ovarian cells from superovulated prepubertal ..
  53. ncbi Gonadotropin-releasing hormone stimulation of gonadotropin subunit transcription: evidence for the involvement of calcium/calmodulin-dependent kinase II (Ca/CAMK II) activation in rat pituitaries
    D J Haisenleder
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Aurbach Medical Research Building, PO Box 801412, Charlottesville, VA 22908, USA
    Endocrinology 144:2768-74. 2003
    The intracellular pathways mediating GnRH regulation of gonadotropin subunit transcription remain to be fully characterized, and the present study examined whether calcium/calmodulin-dependent kinase II (Ca/CAMK II) plays a role in the ..
  54. ncbi A study on the localization and distribution of GnRH and its receptor in rat submaxillary glands by immunohistochemical, in situ hybridization and RT-PCR
    Bing Yao
    Department of Reproduction of Nanjing Jingling Hospital, Clinical School of Medical College, Nanjing University, No 305 East Zhongshan Road, 210002, Nanjing, People s Republic of China
    Life Sci 72:2895-904. 2003
    We investigated the rat submaxillary gland for the presence of GnRH and GnRH receptors, the localization and colocalization of GnRH, GnRH receptor and their mRNA, and studied the sequence of GnRH receptor complementary DNA (cDNA) by ..
  55. ncbi Gonadotropin-releasing hormone attenuates pregnancy-associated thymic involution and modulates the expression of antiproliferative gene product prohibitin
    Vishwa Deep Dixit
    Department of Physiology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Endocrinology 144:1496-505. 2003
    ..In the present study, we examined the effects of GnRH on pregnancy-induced thymic involution by characterizing the expression patterns of prohibitin (PHB), an ..
  56. pmc Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland
    Jonathan D Johnston
    School of Biological Sciences, University of Aberdeen, Aberdeen AB24 5UA, United Kingdom
    Proc Natl Acad Sci U S A 100:2831-5. 2003
    ..the transcription factor, early growth response factor-1, which is induced by gonadotrophin-releasing hormone (GnRH) and trans-activates LH beta expression, attenuated Pitx-1-induced MT(1)-luciferase activity...
  57. ncbi Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus
    Sebastien Bouret
    Institut National de la Santé et de la Recherche Médicale Unité 422, Lille, France
    Endocrinology 145:1794-801. 2004
    ..immortalized GT1 cells suggest that hypothalamic astrocytes employ TGFbeta(1) to directly regulate the secretion of GnRH, the neurohormone that controls sexual maturation and adult reproductive function...
  58. ncbi Proestrous surge of gonadotropin-releasing hormone secretion inhibits apoptosis of anterior pituitary cells in cycling female rats
    Ping Yin
    Department of Physiology, Yamanashi Medical University, Yamanashi, Japan
    Neuroendocrinology 76:272-82. 2002
    ..was reduced by simultaneous treatment with an ovulation-inducing dose of gonadotropin-releasing hormone (GnRH), but not with progesterone, an ovarian steroid also released after GnRH treatment...
  59. pmc Leptin directly acts within the hypothalamus to stimulate gonadotropin-releasing hormone secretion in vivo in rats
    Hajime Watanobe
    Division of Internal Medicine, Clinical Research Center, International University of Health and Welfare, Otawara, Tochigi, Japan
    J Physiol 545:255-68. 2002
    ..adipocyte-derived hormone, acts directly within the hypothalamus to stimulate the gonadotropin-releasing hormone (GnRH)-luteinizing hormone (LH) system...
  60. pmc Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements
    Carolyn G Kelley
    Department of Reproductive Medicine, Center for the Study of Reproductive Biology and Disease, University of California, San Diego, La Jolla, California 92093 0674, USA
    Mol Endocrinol 16:2413-25. 2002
    b>GnRH gene expression is restricted to a tiny population of neurons scattered throughout the mediobasal hypothalamus...
  61. ncbi Age-related changes in hypothalamic gonadotropin-releasing hormone and N-methyl-D-aspartate receptor gene expression, and their regulation by oestrogen, in the female rat
    A C Gore
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY, USA
    J Neuroendocrinol 14:300-9. 2002
    ..in rodents are believed to involve changes in hypothalamic neurones, including gonadotropin-releasing hormone (GnRH) cells and their afferent inputs...
  62. ncbi Neuron-specific expression in vivo by defined transcription regulatory elements of the GnRH gene
    Mark A Lawson
    Department of Reproductive Medicine and Center for the Study of Reproductive Biology and Disease, University of California San Diego, La Jolla, California 92093 0674, USA
    Endocrinology 143:1404-12. 2002
    The GnRH-expressing neurons are the ultimate regulator of reproductive function. GnRH gene expression is limited to this small population of neurons in the hypothalamus...
  63. ncbi Two mammalian genes transcribed from opposite strands of the same DNA locus
    J P Adelman
    Science 235:1514-7. 1987
    ..One gene (strand) encodes gonadotropin-releasing hormone (GnRH). A second gene, SH, is transcribed from the other DNA strand to produce RNA of undefined function...
  64. pmc Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat
    J P Adelman
    Proc Natl Acad Sci U S A 83:179-83. 1986
    ..Genomic analyses revealed the presence of a single Gn-RH-PIF gene in human and rat containing sequences corresponding to the cDNA distributed across four exons...
  65. ncbi The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression
    C T Bond
    Department of Cell Biology, Oregon Health Sciences University, Portland 97201
    Mol Endocrinol 3:1257-62. 1989
    The rat GnRH gene as expressed in the central nervous system is comprised of four exons and three introns and spans 4.5 kilobases of genomic DNA...
  66. pmc Calcium influx and DREAM protein are required for GnRH gene expression pulse activity
    Gilles M Leclerc
    Laboratory of Molecular Dynamics, Department of Cell Biology and Anatomy Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Mol Cell Endocrinol 267:70-9. 2007
    Recent evidence using GT1-7 cells indicates that GnRH pulsatility depends on exocytotic-release and gene transcription events...
  67. pmc Gonadotropin-releasing hormone regulates spine density via its regulatory role in hippocampal estrogen synthesis
    Janine Prange-Kiel
    Institute of Anatomy I Cellular Neurobiology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    J Cell Biol 180:417-26. 2008
    ..In view of the abundant gonadotropin-releasing hormone receptor (GnRH-R) messenger RNA expression in the hippocampus and the direct effect of GnRH on estradiol (E2) synthesis in gonadal ..
  68. ncbi Mechanisms of interaction of endocrine-disrupting chemicals with glutamate-evoked secretion of gonadotropin-releasing hormone
    Gregory Rasier
    Developmental Neuroendocrinology Unit, Centre for Cellular and Molecular Neurobiology, University of Liege, University Hospital, Belgium
    Toxicol Sci 102:33-41. 2008
    ..Recently, we reported that DDT stimulated pulsatile gonadotropin-releasing hormone (GnRH) secretion and sexual maturation in the female rat...
  69. ncbi Presence of immunoreactive gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) in rat ovary during pregnancy
    Anamika Sengupta
    Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Mol Reprod Dev 75:1031-44. 2008
    The present study aims at quantification of gonadotropin releasing hormone (GnRH) by radioimmunoassay, relative expression of its mRNA by real-time PCR accompanied by its cellular localization in the rat ovary by immunonohistochemistry (..
  70. pmc GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Breast Cancer Res 9:R51. 2007
    ..Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis...
  71. ncbi Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA
    C C Maier
    Department of Physiology and Biophysics, University of Alamaba, Birmingham 35294 0005
    Cell Mol Neurobiol 12:447-54. 1992
    1. A luteinizing hormone-releasing hormone (LHRH)-like molecule produced by thymocytes is similar to hypothalamic LHRH in both bioactivity and antigenicity. 2...
  72. ncbi Localization of immunoreactive gonadotropin-releasing hormone and relative expression of its mRNA in the oviduct during pregnancy in rats
    Anamika Sengupta
    Department of Physiology, Morehouse School of Medicine, Atlanta, GA 30310 1495, USA
    J Histochem Cytochem 55:525-34. 2007
    ..was designed to determine the cellular and ultrastructural distribution of the gonadotropin-releasing hormone (GnRH) and the relative expression of its mRNA in the oviduct of rats during different time points (days 7, 9, 16, and 20)..
  73. ncbi Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty
    M C Lebrethon
    Developmental Neuroendocrinology Unit, Center of Cellular and Molecular Neurobiology, Division of Ambulatory Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Liege, CHU Sart Tilman, Liege, Belgium
    J Neuroendocrinol 19:181-8. 2007
    ..aimed to investigate the effects of leptin and ghrelin on pulsatile pulsatile gonadotrophin-releasing hormone (GnRH) secretion in vitro with emphasis on neuropeptide mediators and changes between prepuberty (15 days) and sexual ..
  74. ncbi Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice
    Sudha Srinivasan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 145:2023-34. 2004
    ..infertility of Cpe(fat/fat) mice has not been systematically investigated, it is thought to be due to a deficit in GnRH processing...
  75. ncbi Daily GnRH and GnRH-receptor mRNA expression in the ovariectomized and intact rat
    Tamar D Schirman-Hildesheim
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell Endocrinol 252:120-5. 2006
    We recently described patterns of GnRH and GnRH receptor (GnRH-R) expression in the hypothalamus, pituitary and ovary throughout the rat estrus cycle...
  76. ncbi Vasoactive intestinal polypeptide regulates dynamic changes in astrocyte morphometry: impact on gonadotropin-releasing hormone neurons
    Lynnette M Gerhold
    Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, 95616, USA
    Endocrinology 147:2197-202. 2006
    Recent studies suggest that astrocytes modulate the GnRH-induced LH surge. In particular, we have shown that the surface area of astrocytes that ensheath GnRH neurons exhibits diurnal rhythms...
  77. ncbi Presence of delta opioid receptors on a subset of hypothalamic gonadotropin releasing hormone (GnRH) neurons
    Federica Pimpinelli
    Laboratory of Developmental Neuroendocrinology, Institute of Endocrinology, University of Milano, via G Balzaretti, 9 20133 Milan, Italy
    Brain Res 1070:15-23. 2006
    Opioid peptides exert an inhibitory effect on hypothalamic gonadotropin releasing hormone (GnRH) secretion mainly by interacting with mu-opioid receptors...
  78. ncbi Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity
    Gilles M Leclerc
    Laboratory of Molecular Dynamics, Department of Cell Biology and Anatomy, Medical University of South Carolina, 173 Ashley Avenue, Charleston, 29425, USA
    Mol Cell Endocrinol 245:86-92. 2005
    Recent evidence from our laboratory demonstrated that the OCT1 protein was necessary for GnRH gene promoter pulse activity through its interaction with a specific OCT1 binding site (OCT1BS-a, -1,774/-1,781)...
  79. pmc The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells
    Qingbo Tang
    Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Mol Endocrinol 19:2769-79. 2005
    The GnRH gene uses two well-defined regions to target expression to a small population of hypothalamic GnRH neurons: a 173-bp proximal promoter and a 300-bp enhancer localized at approximately -1800 to -1500 bp from the start site...
  80. ncbi Identification of Ser153 in ICL2 of the gonadotropin-releasing hormone (GnRH) receptor as a phosphorylation-independent site for inhibition of Gq coupling
    Sharon Shacham
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    J Biol Chem 280:28981-8. 2005
    Type I gonadotropin-releasing hormone (GnRH) receptor (GnRHR) is unique among mammalian G-protein-coupled receptors (GPCRs) in lacking a C-terminal tail, which is involved in desensitization in GPCRs...
  81. ncbi Decreased gonadotropin-releasing hormone neuronal activity is associated with decreased fertility and dysregulation of food intake in the female GPR-4 transgenic rat
    Francisca Gomez
    Department of Obstetrics, 513 Parnassus Avenue, HSW1475, Box 0556, University of California, San Francisco, California 94143, USA
    Endocrinology 146:3800-8. 2005
    Expression of a cAMP-specific phosphodiesterase in GnRH neurons in the GPR-4 transgenic rat resulted in decreased LH levels and pulse frequency and diminished fertility...
  82. ncbi Differential gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acid expression patterns in different tissues of the female rat across the estrous cycle
    Tamar D Schirman-Hildesheim
    Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    Endocrinology 146:3401-8. 2005
    b>GnRH, the main regulator of reproduction, is produced in a variety of tissues outside of the hypothalamus, its main site of synthesis and release...
  83. pmc TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1
    Naama Rave-Harel
    Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92903, USA
    J Biol Chem 279:30287-97. 2004
    Gonadotropin-releasing hormone (GnRH) is the central regulator of reproductive function. Expression of the GnRH gene is confined to a rare population of neurons scattered throughout the hypothalamus...
  84. ncbi Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway
    Melissa P Allen
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:38133-40. 2002
    Recent studies suggest that adhesion-related kinase (Ark) plays a role in gonadotropin-releasing hormone (GnRH) neuronal physiology...
  85. ncbi Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays
    A C Dalkin
    Division of Endocrinology, Department of Internal Medicine and the Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 142:139-46. 2001
    b>GnRH regulates the synthesis and secretion of the pituitary gonadotropins LH and FSH...

Research Grants5

  1. Neuroendocrine outcomes of prenatal PCB exposures
    ANDREA GORE; Fiscal Year: 2005
    ..The results should have important implications for understanding consequences of, and developing therapies for, exposures of wildlife and humans to EDCs such as PCBs. ..
  2. Neuromodulation of reproduction during aging
    Lynnette Gerhold; Fiscal Year: 2004
    ..The integrity of the suprachiasmatic nucleus (SCN) is essential in maintaining regular cyclic GnRH/LH release and regular estrous cycles in young animals...
  3. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
    ..Isolation of actively translated and total mRNA from treated and control cells will allow identification and quantification of global changes in gene expression. ..
  4. Forum on Endocrine-Disrupting Chemicals
    ANDREA GORE; Fiscal Year: 2005
    ..In order to limit future contaminations and to mitigate existing exposures, it is critical that we educate the endocrine community and make this subject a permanent part of the Endocrine Society's agenda. ..
  5. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006
    ..We will also identify the mechanism of convergent GnRH and insulin signaling...