Gene Symbol: Gnb1
Description: G protein subunit beta 1
Alias: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein beta 1, guanine nucleotide binding protein (G protein), beta 1, guanine nucleotide binding protein (G protein), beta polypeptide 1, guanine nucleotide binding protein, beta 1, guanine nucleotide-binding protein, beta-1 subunit, transducin beta chain 1
Species: rat
Products:     Gnb1

Top Publications

  1. Hill C, Goddard A, Ladds G, Davey J. The cationic region of Rhes mediates its interactions with specific Gbeta subunits. Cell Physiol Biochem. 2009;23:1-8 pubmed publisher
    ..Possible implications of this interaction for the activity of Rhes are discussed. ..
  2. Spiegelberg B, Hamm H. G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. J Biol Chem. 2005;280:41769-76 pubmed
    ..Taken together, these data imply that HDAC5 and possibly other class II HDACs can be added to the growing list of G betagamma effectors. ..
  3. Agler H, Evans J, Tay L, Anderson M, Colecraft H, Yue D. G protein-gated inhibitory module of N-type (ca(v)2.2) ca2+ channels. Neuron. 2005;46:891-904 pubmed
    ..Thus, an NT module, acting via interactions with the I-II loop, appears fundamental to such modulation. ..
  4. Macrez Leprêtre N, Kalkbrenner F, Morel J, Schultz G, Mironneau J. G protein heterotrimer Galpha13beta1gamma3 couples the angiotensin AT1A receptor to increases in cytoplasmic Ca2+ in rat portal vein myocytes. J Biol Chem. 1997;272:10095-102 pubmed
  5. Arshavsky V, Burns M. Photoreceptor signaling: supporting vision across a wide range of light intensities. J Biol Chem. 2012;287:1620-6 pubmed publisher
  6. Fresco P, Oliveira J, Kunc F, Soares A, Rocha Pereira C, Goncalves J, et al. A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and betagamma subunits formed after alpha2-adrenoceptor activation. Neurochem Int. 2007;51:47-56 pubmed
  7. Sokolov M, Lyubarsky A, Strissel K, Savchenko A, Govardovskii V, Pugh E, et al. Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation. Neuron. 2002;34:95-106 pubmed
  8. Huang L, Shanker Y, Dubauskaite J, Zheng J, Yan W, Rosenzweig S, et al. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci. 1999;2:1055-62 pubmed
    ..We conclude that gustducin heterotrimers transduce responses to bitter and sweet compounds via alpha-gustducin's regulation of phosphodiesterase (PDE) and Gbetagamma's activation of phospholipase C (PLC). ..
  9. Liang J, Cockett M, Khawaja X. Immunohistochemical localization of G protein beta1, beta2, beta3, beta4, beta5, and gamma3 subunits in the adult rat brain. J Neurochem. 1998;71:345-55 pubmed
    ..In conclusion, despite the widespread overlapping distributions of Gbeta1-beta5 with Ggamma3, specific dimeric associations in situ were observed within discrete brain regions. ..

More Information


  1. von Weizsäcker E, Strathmann M, Simon M. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA. Biochem Biophys Res Commun. 1992;183:350-6 pubmed
    ..The predicted amino acid sequence of G beta 4 is 79% to 89% identical to the three previously known beta subunits. The diversity of beta gene products may be an important corollary to the functional diversity of G proteins. ..
  2. Hippe H, Lutz S, Cuello F, Knorr K, Vogt A, Jakobs K, et al. Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Specific activation of Gsalpha by an NDPK B.Gbetagamma complex in H10 cells. J Biol Chem. 2003;278:7227-33 pubmed
    ..Gbetagamma complexes and which appears to contribute to the receptor-independent activation of heterotrimeric G proteins. ..
  3. Betty M, Harnish S, Rhodes K, Cockett M. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Neuroscience. 1998;85:475-86 pubmed
    ..The localizations of the G-protein beta and gamma subunits, and their potential coupling to various receptor/effector systems, are discussed. ..
  4. Lobanova E, Finkelstein S, Herrmann R, Chen Y, Kessler C, Michaud N, et al. Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability. J Neurosci. 2008;28:3510-20 pubmed publisher
    ..They further suggest that the production of transducin beta-subunit without its constitutive gamma-subunit partner sufficiently stresses the cellular biosynthetic and/or chaperone machinery to induce cell death. ..
  5. Bowers M, Hopf F, Chou J, Guillory A, Chang S, Janak P, et al. Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A. 2008;105:12533-8 pubmed publisher
    ..AGS3 up-regulation during abstinence may be a key determinant of the transition from social consumption to compulsion-like seeking during relapse. ..
  6. Wang X, Funada M, Imai Y, Revay R, Ujike H, Vandenbergh D, et al. rGbeta1: a psychostimulant-regulated gene essential for establishing cocaine sensitization. J Neurosci. 1997;17:5993-6000 pubmed
    ..Full, regulated rGbeta1 expression is a biochemical component essential to the establishment of a key consequence of repeated cocaine administrations, sensitization. ..
  7. Sato M, Jiao Q, Honda T, Kurotani R, Toyota E, Okumura S, et al. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). J Biol Chem. 2009;284:31431-40 pubmed publisher
    ..Under hypoxic stress, this unrecognized response program plays a critical role in the fate of NCM. ..
  8. Aoyama C, Sugimoto H, Ando H, Yamashita S, Horibata Y, Sugimoto S, et al. The heterotrimeric G protein subunits G?(q) and G?(1) have lysophospholipase D activity. Biochem J. 2011;440:241-50 pubmed publisher
    ..Clarification of the physiological relevance of lysoPLD activity of these proteins will need further studies. ..
  9. Sanada K, Tsai L. G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors. Cell. 2005;122:119-31 pubmed
    ..Furthermore, our observations indicate that the cell-fate decision of daughter cells is coupled to mitotic-spindle orientation in progenitors. ..
  10. Song K, Peterson Y, Freidman A, Blumer J, Sato M, Lanier S. Identification and characterization of a G-protein regulatory motif in WAVE1. FEBS Lett. 2006;580:1993-8 pubmed
    ..The docking of Gialpha within a WAVE1 scaffolding complex may facilitate dynamic cycling and/or targeting for efficient and localized control of actin polymerization. ..
  11. Stott J, Povstyan O, Carr G, Barrese V, Greenwood I. G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. Proc Natl Acad Sci U S A. 2015;112:6497-502 pubmed publisher
    ..These results reveal that Gβγ subunits are fundamental for Kv7.4 activation and crucial for vascular Kv7 channel activity, which has major consequences for the regulation of arterial tone. ..