Gene Symbol: Gmcl1
Description: germ cell-less, spermatogenesis associated 1
Alias: Gcl, germ cell-less protein-like 1, germ cell-less homolog 1
Species: rat
Products:     Gmcl1

Top Publications

  1. Leatherman J, Kaestner K, Jongens T. Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Mech Dev. 2000;92:145-53 pubmed
    Drosophila Germ cell-less (Gcl) has previously been shown to be important in early events during the formation of pole cells, which are the germ cell precursors in the fly...
  2. Kimura T, Ito C, Watanabe S, Takahashi T, Ikawa M, Yomogida K, et al. Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol. 2003;23:1304-15 pubmed
  3. Masuhara M, Nagao K, Nishikawa M, Kimura T, Nakano T. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem Biophys Res Commun. 2003;308:927-32 pubmed
    ..In addition, the amount of p53 was increased and transactivation by p53 was enhanced by mGCL-1. Thus, mGCL-1 turned out to be a factor modulating MDM2-p53 axis by enhanced degradation of MDM2. ..
  4. Kleiman S, Yogev L, Gal Yam E, Hauser R, Gamzu R, Botchan A, et al. Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. J Androl. 2003;24:670-5 pubmed
    Germ cell-less (GCL) protein is a nuclear envelope protein highly conserved between the mammalian and Drosophila orthologues. In Drosophila, maternal GCL protein is required to establish the germ lineage during embryonic development...
  5. Maekawa M, Ito C, Toyama Y, Suzuki Toyota F, Kimura T, Nakano T, et al. Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility. Arch Histol Cytol. 2004;67:335-47 pubmed
    ..These observations provide important insights into the mechanisms regulating the nuclear architecture and causes of human infertility. ..
  6. Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
    ..protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein...