Gene Symbol: GLUT3
Description: solute carrier family 2 (facilitated glucose transporter), member 3
Alias: GLUT3, solute carrier family 2, facilitated glucose transporter member 3, GLUT-3, Solute carrier family 2 A3 (neuron glucose transporter), glucose transporter type 3, brain, solute carrier family 2, member 2, solute carrier family 2, member 3
Species: rat
Products:     GLUT3

Top Publications

  1. Yu S, Zhao T, Guo M, Fang H, Ma J, Ding A, et al. Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes. Brain Res. 2008;1211:22-9 pubmed publisher
    ..on glucose transport activity and the gene expression of two major forms of glucose transporters (GLUT1 and GLUT3) in the brain were investigated in cultured rat hippocampal neurons and astrocytes...
  2. Vavaiya K, Briski K. Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol. J Mol Neurosci. 2008;34:121-9 pubmed
    ..Neuronal glucose (GLUT3, GLUT4) and monocarboxylate (MCT2) transporter genes are expressed in both sites, suggesting that glucose and ..
  3. Zhang W, Zhang L, Hou W, Xu Y, Xu H, Lou F, et al. Dynamic expression of glucose transporters 1 and 3 in the brain of diabetic rats with cerebral ischemia reperfusion. Chin Med J (Engl). 2009;122:1996-2001 pubmed
    ..The present study aimed to explore the expression of brain-type glucose transporters (GLUT1 and GLUT3) in cerebral ischemic penumbra at different blood glucose levels and different ischemic-reperfusion time in ..
  4. Cidad P, Almeida A, Bolanos J. Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase. Biochem J. 2004;384:629-36 pubmed
    ..specifically to this effect, we have now investigated the possible role of NO in modulating glucose uptake through GLUT3, a facilitative high-affinity glucose carrier that has been suggested to afford cytoprotection against ..
  5. Thoidis G, Kupriyanova T, Cunningham J, Chen P, Cadel S, Foulon T, et al. Glucose transporter Glut3 is targeted to secretory vesicles in neurons and PC12 cells. J Biol Chem. 1999;274:14062-6 pubmed
    In rat brain and cultured neuroendocrine PC12 cells, Glut3 is localized at the cell surface and, also, in a distinct population of homogenous synaptic-like vesicles...
  6. Seatter M, De la Rue S, Porter L, Gould G. QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry. 1998;37:1322-6 pubmed
    The liver-type (GLUT2) and brain-type (GLUT3) human facilitative glucose transporters exhibit distinct kinetics (Km values for deoxyglucose transport of approximately 11 mM and approximately 1...
  7. Campbell I, Dominiczak A, Livingstone C, Gould G. Analysis of the glucose transporter compliment of metabolically important tissues from the Milan hypertensive rat. Biochem Biophys Res Commun. 1995;211:780-91 pubmed
    ..Patterns of expression of GLUT1, GLUT3 and GLUT4 as determined by immunoblot analysis were profoundly altered in certain brain regions in the ..
  8. Angulo C, Castro M, Rivas C, Segretain D, Maldonado R, Yañez A, et al. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. J Cell Physiol. 2008;217:708-16 pubmed publisher
    ..OMG) transport by 42GPA9 Sertoli cells correspond to facilitative hexose transporters GLUT1, GLUT2 and GLUT3 expressed in these cells...
  9. Rodriguez Enriquez S, Marin Hernandez A, Gallardo Pérez J, Moreno Sanchez R. Kinetics of transport and phosphorylation of glucose in cancer cells. J Cell Physiol. 2009;221:552-9 pubmed publisher
    ..To understand why they are the main controlling steps, the GLUT and HK kinetics and the contents of GLUT1, GLUT2, GLUT3, GLUT4, HKI, and HKII were analyzed in rat hepatocarcinoma AS-30D and HeLa human cervix cancer...

More Information


  1. Merriman Smith B, Krushinsky A, Kistler J, Donaldson P. Expression patterns for glucose transporters GLUT1 and GLUT3 in the normal rat lens and in models of diabetic cataract. Invest Ophthalmol Vis Sci. 2003;44:3458-66 pubmed
    ..used to detect changes in GLUT1 and -3 transcript levels, and Western blot analysis was used to monitor changes in GLUT3 protein expression levels in diabetic rats...
  2. Li D, Han H. [Effect of progesterone on the expression of GLUT in the brain following hypoxic-ischemia in newborn rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008;24:353-5 pubmed
    To investigate the expression of GLUT1 and GLUT3 in the hippocampus after cerebral hypoxic-ischemia (HI) in newborn rats and the effect of progesterone (PROG) on them...
  3. Sciullo E, Cardellini G, Baroni M, Torresi P, Buongiorno A, Pozzilli P, et al. Glucose transporter (Glut1, Glut3) mRNA in human placenta of diabetic and non-diabetic pregnancies. Early Pregnancy. 1997;3:172-82 pubmed
    Transport of glucose into the cell is catalyzed by glucose transporters (Glut). Glut1 and Glut3 are expressed at various levels in many human tissues, including the placenta...
  4. Iasevoli F, Latte G, Avvisati L, Sarappa C, Aloj L, de Bartolomeis A. The expression of genes involved in glucose metabolism is affected by N-methyl-D-aspartate receptor antagonism: a putative link between metabolism and an animal model of psychosis. J Neurosci Res. 2012;90:1756-67 pubmed publisher
    ..Here, we explored the gene expression of hexokinase 1 (Hk1) and glucose transporter 3 (GLUT3) after the administration of a subanesthetic or a subconvulsant dose of ketamine in rats, considered to provide an ..
  5. Maher F, Davies Hill T, Simpson I. Substrate specificity and kinetic parameters of GLUT3 in rat cerebellar granule neurons. Biochem J. 1996;315 ( Pt 3):827-31 pubmed
    ..catalytic-centre activity ("turnover number') and stereospecificity of the neuronal glucose transporter GLUT3 in primary cultured cerebellar granule neurons...
  6. Scheepers A, Joost H, Schurmann A. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr. 2004;28:364-71 pubmed
    ..In addition, a malfunction of glucose transporter expression or regulation (GLUT4) appears to contribute to the insulin resistance syndrome. ..
  7. Natalicchio A, De Stefano F, Perrini S, Laviola L, Cignarelli A, Caccioppoli C, et al. Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts. Am J Physiol Endocrinol Metab. 2009;296:E228-37 pubmed publisher
    ..GLUT1 and GLUT3 transporter proteins were sevenfold and fourfold more abundant, respectively, and were localized throughout the ..
  8. Nagamatsu S, Sawa H, Kamada K, Nakamichi Y, Yoshimoto K, Hoshino T. Neuron-specific glucose transporter (NSGT): CNS distribution of GLUT3 rat glucose transporter (RGT3) in rat central neurons. FEBS Lett. 1993;334:289-95 pubmed
    ..In the present study we have isolated the GLUT3 (RGT3) cDNA and produced anti RGT3 polyclonal antibody allowing us to investigate the cellular localization and ..
  9. Ganguly A, McKnight R, Raychaudhuri S, Shin B, Ma Z, Moley K, et al. Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction. Am J Physiol Endocrinol Metab. 2007;292:E1241-55 pubmed
    Glucose transporter isoform-3 (GLUT3) is the trophoblastic facilitative glucose transporter...
  10. Santalucia T, Palacin M, Zorzano A. T3 strongly regulates GLUT1 and GLUT3 mRNA in cerebral cortex of hypothyroid rat neonates. Mol Cell Endocrinol. 2006;251:9-16 pubmed
    ..Because of this, we hypothesised that the expression of GLUT1 and GLUT3, glucose transporters expressed in brain cortex, may be altered in congenital hypothyroidism...
  11. Krishnan S, Haddad G. Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain. Life Sci. 1995;56:1193-7 pubmed
    Using PCR, glucose transporter-3 (GLUT3) was cloned in its entirety from rat brain. The similarity between human, murine and rodent glucose transporter-3 proteins exceeds 90%...
  12. Shin B, Fujikura K, Suzuki T, Tanaka S, Takata K. Glucose transporter GLUT3 in the rat placental barrier: a possible machinery for the transplacental transfer of glucose. Endocrinology. 1997;138:3997-4004 pubmed the transplacental transfer of glucose, we investigated the localization of glucose transporters GLUT1 and GLUT3 immunohistochemically in the rat placenta...
  13. Fattoretti P, Bertoni Freddari C, Casoli T, Di Stefano G, Giorgetti G, Solazzi M. Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age. Ann N Y Acad Sci. 2003;1010:500-3 pubmed
    We measured the effect of chronic ethanol administration on the expression of Glut3 in the cerebellum and hippocampus of adult and old rats. Glut3 expression significantly decreased in aging, in ethanol-treated rats vs...
  14. Wu H, Sha J, Ren B, Wang H, Zhang G, Li M. [Expression of glucose transporter-3 in the cerebral cortex of aging rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1950-2 pubmed
    To observe the changes in the expression of glucose transporter-3 (GLUT3) in the cerebral cortex of rats during aging and investigate the role of GLUT3 in the aging process of the nervous system...
  15. Langdown M, Sugden M. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Mol Cell Endocrinol. 2001;185:109-17 pubmed
    ..Two glucose transporters, GLUT1 and GLUT3, are expressed in placenta. In rodent placenta, GLUT1 is replaced by GLUT3 during late gestation...
  16. Hamlin G, Cernak I, Wixey J, Vink R. Increased expression of neuronal glucose transporter 3 but not glial glucose transporter 1 following severe diffuse traumatic brain injury in rats. J Neurotrauma. 2001;18:1011-8 pubmed
    ..that increased glucose uptake after traumatic brain injury is primarily accounted for by increased neuronal Glut 3 glucose transporter expression and that this increased expression after trauma is part of a neuronal stress ..
  17. Beltrán F, Acuña A, Miró M, Angulo C, Concha I, Castro M. Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism. J Cell Physiol. 2011;226:3286-94 pubmed publisher
    ..Since this observation was valid only for cells expressing glucose transporter 3 (GLUT3), we evaluated the importance of this transporter on the inhibitory effect of ascorbic acid on glucose transport...
  18. Yu J, Li J, Zhang S, Xu X, Zheng M, Jiang G, et al. IGF-1 induces hypoxia-inducible factor 1?-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells. Brain Res. 2012;1430:18-24 pubmed publisher
    ..neurons, and the passage of glucose across cell membranes is mainly facilitated by glucose transporter 3 (GLUT3)...
  19. Iwabuchi S, Kawahara K. Extracellular ATP-prinoceptor signaling and AMP-activated protein kinase regulate astrocytic glucose transporter 3 in an in vitro ischemia. Neurochem Int. 2013;63:259-68 pubmed publisher
    ..Under the physiological conditions, cultured astrocytes primarily express glucose transporter1 (GLUT1), and GLUT3 is only detected at extremely low levels...
  20. Wu H, Sha J, Wang H, Ren B, Zhang G, Li M. [Expression of GLUT 3 in different brain regions of aged rats]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010;39:43-8 pubmed
    To examine the distribution of glucose transport 3 (GLUT 3) in different brain regions of aged rats and to investigate its role in ageing process of the nervous system...
  21. Kelly S, Harrell C, Neigh G. Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner. Physiol Behav. 2014;126:39-49 pubmed publisher
    ..Given the importance of appropriate metabolic balance within the brain, further assessment of the functional implications of life stage and environmentally-induced changes in GLUTs are warranted. ..
  22. Kipmen Korgun D, Bilmen Sarikcioglu S, Altunbas H, Demir R, Korgun E. Type-2 diabetes down-regulates glucose transporter proteins and genes of the human blood leukocytes. Scand J Clin Lab Invest. 2009;69:350-8 pubmed publisher
    ..b>GLUT 3 was decreased in granulocytes, lymphocytes and monocytes from diabetic patients...
  23. Rauch M, Ocampo M, Bohle J, Amthauer R, Yañez A, Rodríguez Gil J, et al. Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells. J Cell Physiol. 2006;207:397-406 pubmed
    ..We analyzed the expression and function of GLUT1 and GLUT3 in isolated spermatocytes and spermatids...
  24. Zoidis E, Ghirlanda Keller C, Schmid C. Triiodothyronine stimulates glucose transport in bone cells. Endocrine. 2012;41:501-11 pubmed publisher
    ..glucose (2DG) uptake and looked for expression of the high-affinity glucose transporters GLUT1 and GLUT3 by northern and western analysis. T? did not influence the cell number but slightly (1...
  25. Hou W, Xian Y, Zhang L, Lai H, Hou X, Xu Y, et al. Influence of blood glucose on the expression of glucose trans-porter proteins 1 and 3 in the brain of diabetic rats. Chin Med J (Engl). 2007;120:1704-9 pubmed
    ..The downregulation of GLUT(1) and GLUT(3) expression might be the adaptive reaction of the body to prevent excessive glucose entering the cell that may lead to cell damage. ..
  26. Rumsey S, Daruwala R, Al Hasani H, Zarnowski M, Simpson I, Levine M. Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes. J Biol Chem. 2000;275:28246-53 pubmed
    Dehydroascorbic acid (DHA), the first stable oxidation product of vitamin C, was transported by GLUT1 and GLUT3 in Xenopus laevis oocytes with transport rates similar to that of 2-deoxyglucose (2-DG), but due to inherent difficulties ..
  27. Rumsey S, Kwon O, Xu G, Burant C, Simpson I, Levine M. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997;272:18982-9 pubmed
    ..The apparent Km of DHA transport via GLUT1 and GLUT3 was 1.1 +/- 0.2 and 1.7 +/- 0.3 mM, respectively...
  28. Colville C, Seatter M, Jess T, Gould G, Thomas H. Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. Biochem J. 1993;290 ( Pt 3):701-6 pubmed
    We have expressed the human isoforms of the liver-type (GLUT2) and brain-type (GLUT3) facilitative glucose transporters in oocytes from Xenopus laevis via injection of in vitro transcribed mRNA...
  29. Simpson I, Chundu K, Davies Hill T, Honer W, Davies P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann Neurol. 1994;35:546-51 pubmed
    ..We measured the concentrations of two glucose transporters, GLUT1 and GLUT3, in six regions of brains from both control subjects and patients with Alzheimer's disease...
  30. Miranda P, Allaire A, Sosnik J, Visconti P. Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod. 2009;80:897-904 pubmed publisher
    ..Taking into consideration the requirement of the acrosome reaction for sperm to become fusogenic, these results suggest that membrane raft dynamics may have a role in sperm-egg membrane interaction. ..
  31. Vavaiya K, Paranjape S, Briski K. Testicular regulation of neuronal glucose and monocarboxylate transporter gene expression profiles in CNS metabolic sensing sites during acute and recurrent insulin-induced hypoglycemia. J Mol Neurosci. 2007;31:37-46 pubmed
    ..In the intact male rat DVC, MCT2, GLUT3, and GLUT4 gene expression was not altered by acute hypoglycemia but was enhanced by RIIH...
  32. Bouche C, Serdy S, Kahn C, Goldfine A. The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev. 2004;25:807-30 pubmed
    ..This review is focused on the cellular fate of glucose and relevance to human type 2 diabetes. ..
  33. Yu S, Fan M, Zhao T, Ding A, Wang F. [CoCl2-induced enhancement of glucose transport activity in mediating hypoxic tolerance in cultured hippocampal neurons]. Sheng Li Xue Bao. 2002;54:508-12 pubmed
    ..showed that the 2-deoxy-D-[1-(3)H ]glucose uptake rate and the mRNA expressions of glucose transporters (GLUT1 and GLUT3) in the hippocampal neurons were significantly increased after a 24-hour pretreatment with CoCl(2)...
  34. Stuart C, Wen G, Williamson M, Jiang J, Gilkison C, Blackwell S, et al. Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4: protein in muscle from patients with acanthosis nigricans and severe insulin resistance. Metabolism. 2001;50:771-7 pubmed
    ..Glucose uptake into muscle cells in the fasting state is mediated primarily by GLUT1 and GLUT3 glucose transporters, whereas postprandial (insulin-stimulated) and exercise-related increments in muscle glucose ..
  35. Leroy C, Pierre K, Simpson I, Pellerin L, Vannucci S, Nehlig A. Temporal changes in mRNA expression of the brain nutrient transporters in the lithium-pilocarpine model of epilepsy in the immature and adult rat. Neurobiol Dis. 2011;43:588-97 pubmed publisher
    ..studies of cerebral metabolic changes, here we explored the expression of transporters for glucose (GLUT1 and GLUT3) and monocarboxylates (MCT1 and MCT2) during and after status epilepticus (SE) induced by lithium-pilocarpine in ..
  36. Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, et al. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015;526:391-6 pubmed publisher
    ..Using lipidic cubic phase crystallization and microfocus X-ray diffraction, we determined the structure of human GLUT3 in complex with D-glucose at 1.5 Ã… resolution in an outward-occluded conformation...
  37. Fattoretti P, Bertoni Freddari C, Casoli T, Di Stefano G, Solazzi M, Giorgetti B. Decreased expression of glucose transport protein (Glut3) in aging and vitamin E deficiency. Ann N Y Acad Sci. 2002;973:293-6 pubmed
  38. Sato Y, Ito T, Udaka N, Kanisawa M, Noguchi Y, Cushman S, et al. Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets. Tissue Cell. 1996;28:637-43 pubmed
    ..By these methods, GLUT2 immunostaining was observed on the lateral membranes of pancreatic beta-cells, whereas GLUT3 immunoreaction was predominantly localized in the cytoplasm of beta-cells and was not found in alpha-cells...