Gene Symbol: Glra3
Description: glycine receptor, alpha 3
Alias: glycine receptor subunit alpha-3, glycine receptor, alpha 3 subunit
Esmaeili A, Zaker S. Differential expression of glycine receptor subunit messenger RNA in the rat following spinal cord injury. Spinal Cord. 2011;49:280-4 pubmed publisher
..Therefore, control of GlyR expression could represent a novel therapeutic avenue for the development of new painkiller agents in SCI. ..
Huang X, Chen H, Michelsen K, Schneider S, Shaffer P. Crystal structure of human glycine receptor-Î±3 bound to antagonist strychnine. Nature. 2015;526:277-80 pubmed publisher
Meier J, Henneberger C, Melnick I, Racca C, Harvey R, Heinemann U, et al
. RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency. Nat Neurosci. 2005;8:736-44 pubmed
..Conditional regulation of GlyR alpha3(P185L) is thus likely to be part of a post-transcriptional adaptive mechanism in neurons with enhanced excitability. ..
Marabelli A, Moroni M, Lape R, Sivilotti L. The kinetic properties of the ?3 rat glycine receptor make it suitable for mediating fast synaptic inhibition. J Physiol. 2013;591:3289-308 pubmed publisher
..These currents had fast deactivation, with a time constant of decay of 9 ms. Thus, if native synaptic currents can be mediated by ?3 glycine receptors, they are likely to be very close in their kinetics to ?1-mediated synaptic events. ..
Raltschev C, Hetsch F, Winkelmann A, Meier J, Semtner M. Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels. J Biol Chem. 2016;291:18030-40 pubmed publisher
Kuhse J, Schmieden V, Betz H. Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor. J Biol Chem. 1990;265:22317-20 pubmed
..These data indicate alpha subunit heterogeneity of the inhibitory glycine receptor in adult rats that may result in pharmacologically distinct receptor subtypes. ..
Nikolic Z, Laube B, Weber R, Lichter P, Kioschis P, Poustka A, et al
. The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcripts. J Biol Chem. 1998;273:19708-14 pubmed
..Using P1 artificial chromosome (PAC) clones, the structure of the GLRA3 gene was elucidated and its locus assigned to human chromosomal bands 4q33-q34 by fluorescence in situ ..
Chen X, Webb T, Lynch J. The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors. Mol Membr Biol. 2009;26:321-32 pubmed publisher
..This strong influence of M4 primary structure on partial agonist efficacy suggests that the relatively poorly conserved alpha3 GlyR M4 segment may be a promising domain to target in the search for alpha3 GlyR-specific modulators. ..
Eichler S, Förstera B, Smolinsky B, Jüttner R, Lehmann T, Fähling M, et al
. Splice-specific roles of glycine receptor alpha3 in the hippocampus. Eur J Neurosci. 2009;30:1077-91 pubmed publisher
..GlyR) alpha3 is involved in vision, and processing of acoustic and nociceptive signals, and RNA editing of GLRA3 transcripts was associated with hippocampal pathophysiology of mesial temporal lobe epilepsy (TLE)...