Gldn

Summary

Gene Symbol: Gldn
Description: gliomedin
Alias: Colm, Crgl2, gliomedin, collomin, olfactomedin-related protein
Species: rat
Products:     Gldn

Top Publications

  1. Graveel C, Harkins Perry S, Acevedo L, Farnham P. Identification and characterization of CRG-L2, a new marker for liver tumor development. Oncogene. 2003;22:1730-6 pubmed
    ..Its restricted expression in normal tissues and unique early upregulation during tumor development make CRG-L2 an excellent candidate as a new clinical marker of HCC. ..
  2. Eshed Y, Feinberg K, Poliak S, Sabanay H, Sarig Nadir O, Spiegel I, et al. Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. Neuron. 2005;47:215-29 pubmed
    ..We report the identification of gliomedin, a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated ..
  3. Maertens B, Hopkins D, Franzke C, Keene D, Bruckner Tuderman L, Greenspan D, et al. Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation. J Biol Chem. 2007;282:10647-59 pubmed
    b>Gliomedin, which has been implicated as a major player in genesis of the nodes of Ranvier, contains two collagenous domains and an olfactomedin-like domain and belongs to the group of type II transmembrane collagens that includes ..
  4. Feinberg K, Eshed Eisenbach Y, Frechter S, Amor V, Salomon D, Sabanay H, et al. A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier. Neuron. 2010;65:490-502 pubmed publisher
    ..Here, we show that initial clustering of Na(+) channels at heminodes requires glial NrCAM and gliomedin, as well as their axonal receptor neurofascin 186 (NF186)...
  5. Devaux J. Antibodies to gliomedin cause peripheral demyelinating neuropathy and the dismantling of the nodes of Ranvier. Am J Pathol. 2012;181:1402-13 pubmed publisher
    ..In particular, GBS patients have antibodies against gliomedin and neurofascin, two adhesion molecules that play a crucial role in the formation of nodes of Ranvier...
  6. Han H, Kursula P. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin. Acta Crystallogr F Struct Biol Commun. 2014;70:1536-9 pubmed publisher
    b>Gliomedin (GLDN) is one of the essential proteins in the development of the nodes of Ranvier in the vertebrate peripheral nervous system...