Gipr

Summary

Gene Symbol: Gipr
Description: gastric inhibitory polypeptide receptor
Alias: Gippr, RATGIPPR, GIP-R, gastric inhibitory peptide receptor, glucose-dependent insulinotropic polypeptide receptor
Species: rat

Top Publications

  1. ncbi Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
    Inke Nitz
    Department of Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University, Kiel, Germany
    Mol Nutr Food Res 51:1046-52. 2007
  2. ncbi A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells
    Francis C Lynn
    Department of Physiology, University of British Columbia, Vancouver Canada, V6T 1Z3
    FASEB J 17:91-3. 2003
  3. ncbi A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice
    Norio Harada
    Dept Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Physiol Endocrinol Metab 294:E61-8. 2008
  4. ncbi Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892
    Endocrinology 133:2861-70. 1993
  5. ncbi Inhibition of gastric inhibitory polypeptide signaling prevents obesity
    Kazumasa Miyawaki
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 8:738-42. 2002
  6. ncbi Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat
    Shalea Piteau
    University of British Columbia, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, BC, Canada
    Biochem Biophys Res Commun 362:1007-12. 2007
  7. pmc Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
    K Miyawaki
    Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 96:14843-7. 1999
  8. ncbi Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist
    J T Lewis
    Department of Physiology and Medicine, Heritage Medical Research Centre, University of Alberta, Edmonton, Canada
    Endocrinology 141:3710-6. 2000
  9. pmc Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
    C C Tseng
    Gastroenterology Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 98:2440-5. 1996
  10. doi Pax6 is a key component of regulated glucagon secretion
    Yvan Gosmain
    Diabetes Unit, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 153:4204-15. 2012

Scientific Experts

  • Nadja Herbach
  • Yvan Gosmain
  • Jenny Nyberg
  • Natalia Rudovich
  • Carla I G Vogel
  • Christopher H S McIntosh
  • Peter Ravn
  • C C Tseng
  • Dhananjay Gupta
  • Luan Shu
  • Bettina A Buhren
  • Norio Harada
  • Shalea Piteau
  • Gang Xu
  • Inke Nitz
  • Jie Zhou
  • Michael O Boylan
  • Raymond A Pederson
  • Yutaka Seino
  • Yuichiro Yamada
  • Katsushi Tsukiyama
  • T J Kieffer
  • Francis C Lynn
  • Kazumasa Miyawaki
  • Gyeong Jae Cho
  • Monika Papworth
  • Lambertus Benthem
  • Maria Fritsch-Fredin
  • Susan Kunze
  • Andie Collinson
  • Siobhan O'Brien
  • Chaithanya Madhurantakam
  • Markus Gruetter
  • Ronald H Jackson
  • Evelyn Matthews
  • Lutz Jermutus
  • Claire Priest
  • F C Lynn
  • Navjot Monga
  • Thomas L Jetton
  • Mina Peshavaria
  • J T Lewis
  • Jack L Leahy
  • Aleksey V Matveyenko
  • Jae Hyoung Cho
  • Kathrin Maedler
  • Bernard Thorens
  • Hans Werner Müller
  • Marcia Gasis
  • Frank Bosse
  • Julie Kerr-Conte
  • Chizumi Yamada
  • K Miyawaki
  • T B Usdin
  • Nobuya Inagaki
  • Akihiro Hamasaki
  • Kentaro Toyoda
  • Yasuhiko Nakamura
  • Eri Mukai
  • Xibao Liu
  • Stuart Maudsley
  • Yun Li
  • Nitin Trivedi
  • Cornelia Weikert
  • Olga D Carlson
  • Dariush Elahi
  • Madeleine Speck
  • Kyle Winter
  • Gordon C Weir
  • Susanne Manhart
  • Jurgen Schrezenmeir
  • Su Jin Kim
  • Matthias Mohlig
  • Heiner Boeing
  • Mauren F A Livak
  • Michel Bernier
  • Amy Olver
  • Susan Bonner-Weir
  • Frank Döring
  • Francis Lynn
  • Denis C Muller
  • Eva Fisher
  • Kiyoshi Suzuma
  • Josephine M Egan
  • Hideaki Kaneto
  • Stefan Schreiber
  • D Ross Laybutt
  • John Andrew Pospisilik
  • Hans Ulrich Demuth
  • Barbara Burwinkel

Detail Information

Publications27

  1. ncbi Association analyses of GIP and GIPR polymorphisms with traits of the metabolic syndrome
    Inke Nitz
    Department of Molecular Nutrition, Institute of Human Nutrition and Food Science, Christian Albrechts University, Kiel, Germany
    Mol Nutr Food Res 51:1046-52. 2007
    ..polypeptide (GIP) stimulates insulin release via interaction with its pancreatic receptor (GIP receptor (GIPR)). GIP also acts as vasoactive protein...
  2. ncbi A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells
    Francis C Lynn
    Department of Physiology, University of British Columbia, Vancouver Canada, V6T 1Z3
    FASEB J 17:91-3. 2003
    ..Here, we describe a novel pathway for the regulation of GIP receptor (GIPR) expression within clonal beta-cell lines, pancreatic islets, and in vivo...
  3. ncbi A novel GIP receptor splice variant influences GIP sensitivity of pancreatic beta-cells in obese mice
    Norio Harada
    Dept Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Physiol Endocrinol Metab 294:E61-8. 2008
    ..GIP) is an incretin that potentiates insulin secretion from pancreatic beta-cells by binding to GIP receptor (GIPR) and subsequently increasing the level of intracellular adenosine 3',5'-cyclic monophosphate (cAMP)...
  4. ncbi Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    T B Usdin
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892
    Endocrinology 133:2861-70. 1993
    ..This suggests that a novel peptide may be present in the brain...
  5. ncbi Inhibition of gastric inhibitory polypeptide signaling prevents obesity
    Kazumasa Miyawaki
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Nat Med 8:738-42. 2002
    ..In contrast, mice lacking the GIP receptor (Gipr(-/-)) fed a high-fat diet were clearly protected from both the obesity and the insulin resistance...
  6. ncbi Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat
    Shalea Piteau
    University of British Columbia, Department of Cellular and Physiological Sciences, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver, BC, Canada
    Biochem Biophys Res Commun 362:1007-12. 2007
    ..These findings support the proposal that GIP receptor down-regulation in rodent T2DM is secondary to chronic hyperglycemia and that normalization of glycemia can restore GIP sensitivity...
  7. pmc Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
    K Miyawaki
    Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 96:14843-7. 1999
    Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to pancreatic beta cells...
  8. ncbi Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist
    J T Lewis
    Department of Physiology and Medicine, Heritage Medical Research Centre, University of Alberta, Edmonton, Canada
    Endocrinology 141:3710-6. 2000
    ..Antisera to an extracellular epitope of the GIP receptor (GIPR) detected immunoreactive GIPR on rat pancreatic beta-cells...
  9. pmc Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat
    C C Tseng
    Gastroenterology Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 98:2440-5. 1996
    ..It is concluded that GIP (7-30)-NH2 is a GIP-specific receptor antagonist and that GIP plays a dominant role in mediating postprandial insulin release...
  10. doi Pax6 is a key component of regulated glucagon secretion
    Yvan Gosmain
    Diabetes Unit, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 153:4204-15. 2012
    ..involved in glucagon secretion such as the glucokinase (GCK), G protein-coupled receptor (GPR40), and GIP receptor (GIPR) as well as the corresponding proteins were significantly decreased whereas the insulin receptor (IR) Kir6...
  11. ncbi Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes
    Gang Xu
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 56:1551-8. 2007
    ..Gene expression of incretin receptors, GLP-1R and GIPR, were significantly decreased in islets of 90% pancreatectomized (Px) hyperglycemic rats, with recovery when ..
  12. pmc Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor
    Peter Ravn
    Department of Antibody Discovery and Protein Engineering, MedImmune, Milstein Building, Granta Park, Cambridge CB21 6GH, United Kingdom
    J Biol Chem 288:19760-72. 2013
    ..insulinotropic polypeptide (GIP) is an endogenous hormonal factor (incretin) that, upon binding to its receptor (GIPr; a class B G-protein-coupled receptor), stimulates insulin secretion by beta cells in the pancreas...
  13. pmc Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function
    Luan Shu
    Islet Biology Laboratory, Centre for Biomolecular Interactions Bremen, University of Bremen, Bremen, Germany
    Hum Mol Genet 18:2388-99. 2009
    ..Our findings suggest that beta-cell function and survival are regulated through an interplay between TCF7L2 and GLP-1R/GIP-R expression and signaling in T2DM...
  14. ncbi Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
    F C Lynn
    Department of Physiology, University of British Columbia, Vancouver, Canada
    Diabetes 50:1004-11. 2001
    ..These data suggest that the decreased effectiveness of GIP in the VDF rat and in type 2 diabetes may be a result of a decreased receptor expression in the islet...
  15. pmc Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:19. 2009
    ..It exerts its function through its receptor, GIPR. We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index ..
  16. doi Glucose-dependent insulinotropic polypeptide (GIP) and its receptor (GIPR): cellular localization, lesion-affected expression, and impaired regenerative axonal growth
    Bettina A Buhren
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    J Neurosci Res 87:1858-70. 2009
    ..To gain more insight into the lesion-induced expression of GIP and its receptor (GIPR), expression profiles of the mRNAs were studied after rat sciatic nerve crush injury in 1) affected lumbar dorsal ..
  17. pmc Physiologic and pharmacologic modulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta-cells by peroxisome proliferator-activated receptor (PPAR)-gamma signaling: possible mechanism for the GIP resistance in type 2 diab
    Dhananjay Gupta
    Division of Endocrinology, Diabetes, and Metabolism and the Department of Medicine, University of Vermont, Burlington, Vermont, USA
    Diabetes 59:1445-50. 2010
    ..Gene Bank blast for a homologous nucleotide sequence revealed the same PPRE within the rat glucose-dependent insulinotropic polypeptide receptor (GIP-R) promoter sequence. We investigated the role of PPARgamma in GIP-R transcription...
  18. doi Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
    Am J Physiol Renal Physiol 296:F819-29. 2009
    ..In the present study, we characterize the age-related sequence of diabetes-associated kidney lesions in GIPR(dn) transgenic mice, a novel mouse model of early-onset diabetes mellitus...
  19. pmc Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets
    Jie Zhou
    Diabetes Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Endocrinol Metab 293:E538-47. 2007
    ..These results suggest that the GIP-R is ubiquitated, resulting in downregulation of the actions of GIP...
  20. ncbi GIP receptor mRNA expression in different fat tissue depots in postmenopausal non-diabetic women
    Natalia Rudovich
    Department of Endocrinology, Diabetes and Nutrition, Campus B Franklin, Charite Medicine University of Berlin, Germany
    Regul Pept 142:138-45. 2007
    ..Despite evidence for GIP effects on fat metabolism in humans, the GIP receptor (GIPR) has not been identified in fat tissues...
  21. ncbi Sp1/Sp3 binding is associated with cell-specific expression of the glucose-dependent insulinotropic polypeptide receptor gene
    Michael O Boylan
    Section of Gastroenterology, Boston Medical Center, 650 Albany St, Boston, MA 02118, USA
    Am J Physiol Endocrinol Metab 290:E1287-95. 2006
    ..Because aberrant GIP receptor (GIPR) expression has been implicated in abnormal GIP responses associated with type 2 diabetes mellitus and food-induced ..
  22. ncbi Glucose-dependent insulinotropic polypeptide is expressed in adult hippocampus and induces progenitor cell proliferation
    Jenny Nyberg
    The Arvid Carlsson Institute for Neuroscience at the Institute of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    J Neurosci 25:1816-25. 2005
    ..This investigation demonstrates the presence of GIP in the brain for the first time and provides evidence for a regulatory function for GIP in progenitor cell proliferation...
  23. ncbi Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstrasse 13, 80539 Munich, Germany
    Regul Pept 125:103-17. 2005
    ..This study aims to gain further insight into the effect of the expression of a dominant negative GIPR on glucose homeostasis and postnatal development of the endocrine pancreas...
  24. ncbi Upregulation of glucose-dependent insulinotropic polypeptide and its receptor in the retina of streptozotocin-induced diabetic rats
    Gyeong Jae Cho
    Department of Anatomy and Neurobiology, College of Medicine, Gyeongsang National University, Chinju, Kyungnam, South Korea
    Curr Eye Res 25:381-8. 2002
    ..However, the expression of GIP and its receptor (GIPR) has not been previously noted in the rat retina...
  25. ncbi The cysteine of the cytoplasmic tail of glucose-dependent insulinotropic peptide receptor mediates its chronic desensitization and down-regulation
    C C Tseng
    Section of Gastroenterology, Boston VA Medical Center and Boston University School of Medicine, MA 02118, USA
    Mol Cell Endocrinol 139:179-86. 1998
    ..The data suggest that chronic desensitization and down-regulation of the GIP-R may be mediated by similar mechanisms, and that the cysteine in the carboxyl terminus plays an essential role in regulating both processes...
  26. ncbi Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats
    C C Tseng
    Harvard Digestive Disease Center, Division of Gastroenterology, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol 270:E661-6. 1996
    ..The results of these studies indicate that GIP gene expression is enhanced in diabetic animals and that elevated serum GIP level induces chronic desensitization of the GIP receptor in vivo and in a stably transfected cell line...
  27. ncbi Ultrastructural identification of neurofibrillary tangles in the spinal cords in Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia complex on Guam
    S Kato
    Department of Pathology, Montefiore Medical Center, NY 10467
    Acta Neuropathol 83:277-82. 1992
    ..This is the first demonstration of the fine structure of the spinal cord NFTs...