Gene Symbol: Gipc1
Description: GIPC PDZ domain containing family, member 1
Alias: Gipc, Rgs19, Rgs19ip1, PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, GLUT1 C-terminal-binding protein, GLUT1CBP, RGS-GAIP interacting protein, C-terminus, RGS-GAIP-interacting protein, RGS19-interacting protein 1, regulator of G-protein signaling 19 interacting protein 1, synectin
Species: rat
Products:     Gipc1

Top Publications

  1. Lou X, Yano H, Lee F, Chao M, Farquhar M. GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Mol Biol Cell. 2001;12:615-27 pubmed
    ..Here we describe a novel interaction between TrkA and GIPC, a PDZ domain protein. GIPC binds to the juxtamembrane region of TrkA through its PDZ domain...
  2. He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, et al. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem. 2006;281:2820-7 pubmed
    ..screens confirmed beta1AR associations with several previously identified PDZ partners, such as PSD-95, MAGI-2, GIPC, and CAL. Moreover, two novel beta1AR-interacting proteins, SAP97 and MAGI-3, were also identified...
  3. Bohlson S, Zhang M, Ortiz C, Tenner A. CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis. J Leukoc Biol. 2005;77:80-9 pubmed
    ..Fifteen of 34 positive clones contained a splice variant or a partial cDNA encoding GIPC, a PSD-95/Dlg/ZO-1 (PDZ) domain-containing protein, shown previously to regulate cytoskeletal dynamics...
  4. Kato H, Ohno K, Hashimoto K, Sato K. Synectin in the nervous system: expression pattern and potential as a binding partner of neurotrophin receptors. FEBS Lett. 2004;572:123-8 pubmed
    To assess the potential for functional interaction between synectin and neurotrophin receptors (Trk receptors) in the nervous system, we characterized synectin expression in the rat brain...
  5. Zhang X, Bedigian A, Wang W, Eggert U. G protein-coupled receptors participate in cytokinesis. Cytoskeleton (Hoboken). 2012;69:810-8 pubmed publisher
    ..the downstream components that transmit GPCR signals during cytokinesis will be the next step and we show that GIPC1 (GIPC PDZ domain containing family, member 1), an adaptor protein for GPCRs, may play a part...
  6. Naccache S, Hasson T, Horowitz A. Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci U S A. 2006;103:12735-40 pubmed
    ..Although there is evidence suggesting that the PDZ adaptor protein GIPC/synectin is involved in the association of myo6 with UCV, the recruitment mechanism is unknown...
  7. Lou X, McQuistan T, Orlando R, Farquhar M. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. J Am Soc Nephrol. 2002;13:918-27 pubmed
    ..By immunofluorescence GIPC and GAIP, components of G protein-mediated signaling pathways, are also concentrated in the brush border region of ..
  8. Blobe G, Liu X, Fang S, How T, Lodish H. A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J Biol Chem. 2001;276:39608-17 pubmed
    ..While expression cloning signaling molecules downstream of TGF-beta, we cloned GIPC (GAIP-interacting protein, C terminus), a PDZ domain-containing protein...
  9. Jeanneteau F, Diaz J, Sokoloff P, Griffon N. Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Mol Biol Cell. 2004;15:696-705 pubmed
    ..dopamine D(3) receptor (D(3)R) as bait, we characterized a new interaction with the PDZ domain-containing protein, GIPC (GAIP interacting protein, C terminus)...

More Information


  1. de Vries L, Lou X, Zhao G, Zheng B, Farquhar M. GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. Proc Natl Acad Sci U S A. 1998;95:12340-5 pubmed
    We have identified a mammalian protein called GIPC (for GAIP interacting protein, C terminus), which has a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain...
  2. Yano H, Ninan I, Zhang H, Milner T, Arancio O, Chao M. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci. 2006;9:1009-18 pubmed
    ..Here we report that Myo6 and a Myo6-binding protein, GIPC1, form a complex that can engage TrkB...
  3. Cai H, Reed R. Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J Neurosci. 1999;19:6519-27 pubmed
    ..NIP has been independently cloned as RGS-GAIP-interacting protein (GIPC), where it was identified by virtue of its interaction with the C terminus of RGS-GAIP and suggested to participate ..
  4. Yi Z, Petralia R, Fu Z, Swanwick C, Wang Y, Prybylowski K, et al. The role of the PDZ protein GIPC in regulating NMDA receptor trafficking. J Neurosci. 2007;27:11663-75 pubmed
    ..We identified a novel NMDA receptor-interacting protein, GIPC (GAIP-interacting protein, C terminus), that associates with surface as well as internalized NMDA receptors when ..
  5. Bunn R, Jensen M, Reed B. Protein interactions with the glucose transporter binding protein GLUT1CBP that provide a link between GLUT1 and the cytoskeleton. Mol Biol Cell. 1999;10:819-32 pubmed
    ..This report describes the identification and characterization of a protein, GLUT1 C-terminal binding protein (GLUT1CBP), that binds via a PDZ domain to the C terminus of GLUT1...
  6. Fischer T, De Vries L, Meerloo T, Farquhar M. Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. Proc Natl Acad Sci U S A. 2003;100:8270-5 pubmed
    ..RGS-GAIP functions as a bifunctional adaptor that binds to G alpha subunits through its RGS domain and to GIPN through its cysteine string motif. ..
  7. Elfenbein A, Rhodes J, Meller J, Schwartz M, Matsuda M, Simons M. Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol. 2009;186:75-83 pubmed publisher
    ..Previous work has shown that genetic deletion of S4 or its adapter, synectin, leads to depolarized Rac activation, decreased endothelial migration, and other physiological defects...
  8. Aschenbrenner L, Lee T, Hasson T. Myo6 facilitates the translocation of endocytic vesicles from cell peripheries. Mol Biol Cell. 2003;14:2728-43 pubmed
    ..b>GIPC, a putative myo6 tail binding protein, was also present...
  9. Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P. CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. Brain Res Mol Brain Res. 2003;117:47-57 pubmed
    ..partial cDNAs encoding, respectively, for the MUPP1 multi-PDZ protein, for the N-terminal region of radixin, for GIPC and for a 160-amino acid open reading frame sharing high homology with the human CLIC6, also identified as ..
  10. Reed B, Cefalu C, Bellaire B, Cardelli J, Louis T, Salamon J, et al. GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell. 2005;16:4183-201 pubmed
    We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it might function to couple vesicle-bound proteins to myosin VI movement...
  11. Liu M, Horowitz A. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol Biol Cell. 2006;17:1880-7 pubmed
    ..The PDZ adaptor protein synectin bound the longer splice variant, Syx1, which was targeted to the plasma membrane in a synectin-dependent manner...