Gdnf

Summary

Gene Symbol: Gdnf
Description: glial cell derived neurotrophic factor
Alias: gndf, glial cell line-derived neurotrophic factor, ATF, Glial cell line derived neutrophic factor, astrocyte-derived trophic factor
Species: rat
Products:     Gdnf

Top Publications

  1. Hashimoto M, Nitta A, Fukumitsu H, Nomoto H, Shen L, Furukawa S. Inflammation-induced GDNF improves locomotor function after spinal cord injury. Neuroreport. 2005;16:99-102 pubmed
    ..improved locomotor function greater than low-dose LPS, being consistent with the expression of neurotrophic factor (GDNF) in microglia/macrophages...
  2. Blesch A, Tuszynski M. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. J Comp Neurol. 2003;467:403-17 pubmed
    Glial cell line-derived neurotrophic factor (GDNF) is the prototypical member of a growth factor family that signals via the cognate receptors ret and GDNF-receptor alpha-1...
  3. Sanchez M, Silos Santiago I, Frisen J, He B, Lira S, Barbacid M. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996;382:70-3 pubmed
    Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for dopaminergic neurons and motor neurons in culture...
  4. Johnston D, Olivas E, DiCandeloro P, Wright W. Stage-specific changes in GDNF expression by rat Sertoli cells: a possible regulator of the replication and differentiation of stem spermatogonia. Biol Reprod. 2011;85:763-9 pubmed publisher
    ..and differentiation result from changes in the expression of glial cell-line derived neurotrophic factor (GDNF) by Sertoli cells...
  5. Sun Y, Huang X, Liu M, Cao J, Chen J, Wang H, et al. A new alternative NF-?B pathway mediated the neuroprotection of GDNF on 6-OHDA-induced DA neurons neurotoxicity. Brain Res. 2012;1437:38-49 pubmed publisher
    Glial cell line-derived neurotrophic factor (GDNF) is a potent protective factor for dopaminergic (DA) neurons, but the signaling mechanisms underlying the effect of GDNF on these neurons remain obscure...
  6. Michael L, Sweeney D, Davies J. The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system. J Anat. 2007;210:89-97 pubmed
    ..kidneys is inhibited in organ culture, by blocking the kidney's endogenous glial cell-derived neurothrophic factor (GDNF)-based branch-promoting signals, the DBA-binding zone extends to the very end of the tip but is lost from there ..
  7. Basson M, Akbulut S, Watson Johnson J, Simon R, Carroll T, Shakya R, et al. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005;8:229-39 pubmed
    ..These defects are due to increased sensitivity of the Wolffian duct to GDNF/RET signaling, and reducing Gdnf gene dosage correspondingly rescues the Spry1 null phenotype...
  8. Salvatore M, Gerhardt G, Dayton R, Klein R, Stanford J. Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system. Exp Neurol. 2009;219:197-207 pubmed publisher
    ..We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased ..
  9. Moore M, Klein R, Farinas I, Sauer H, Armanini M, Phillips H, et al. Renal and neuronal abnormalities in mice lacking GDNF. Nature. 1996;382:76-9 pubmed
    Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for embryonic midbrain dopaminergic, spinal motor, cranial sensory, sympathetic, and hindbrain noradrenergic neurons, and is available to these cells in vivo...

More Information

Publications62

  1. Cheng H, Wu J, Tzeng S. Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury. J Neurosci Res. 2002;69:397-405 pubmed
    Glial cell line-derived neurotrophic factor (GDNF) acts as a potent survival factor for many neuronal populations, including spinal motoneurons, indicating the therapeutic promise of GDNF for neurological disorders...
  2. Pichel J, Shen L, Sheng H, Granholm A, Drago J, Grinberg A, et al. Defects in enteric innervation and kidney development in mice lacking GDNF. Nature. 1996;382:73-6 pubmed
    Glial-lial-cell-line-derived neurotrophic factor (GDNF) has been isolated as neurotrophic factor for midbrain dopaminergic neurons...
  3. Iannotti C, Li H, Yan P, Lu X, Wirthlin L, Xu X. Glial cell line-derived neurotrophic factor-enriched bridging transplants promote propriospinal axonal regeneration and enhance myelination after spinal cord injury. Exp Neurol. 2003;183:379-93 pubmed
    Glial cell line-derived neurotrophic factor (GDNF), a distant member of the transforming growth factor-beta (TGF-beta) family, is widely expressed in the developing and adult central nervous system (CNS)...
  4. Hung S, Liou H, Fu W. The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression. Neuropharmacology. 2010;58:321-9 pubmed publisher
    ..Bilirubin is a potent antioxidant and neuroprotectant. Neurotrophic factors of BDNF and GDNF also play important roles in survival and morphological differentiation of dopaminergic neurons...
  5. Lin L, Doherty D, Lile J, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 1993;260:1130-2 pubmed
    ..Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-..
  6. Grieshammer U, Le Ma -, Plump A, Wang F, Tessier Lavigne M, Martin G. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell. 2004;6:709-17 pubmed
    ..It begins when a single ureteric bud emerges from the nephric duct in response to GDNF secreted by the adjacent nephrogenic mesenchyme...
  7. Llado J, Haenggeli C, Maragakis N, Snyder E, Rothstein J. Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Mol Cell Neurosci. 2004;27:322-31 pubmed
    ..ELISA revealed that the NSCs secrete glial cell-line-derived factor (GDNF) and nerve growth factor (NGF)...
  8. Cheng Q, Di Liberto V, Caniglia G, Mudo G. Time-course of GDNF and its receptor expression after brain injury in the rat. Neurosci Lett. 2008;439:24-9 pubmed publisher
    ..to perform, by in situ hybridization, a time-course analysis of the glial cell line-derived neurotrophic factor (GDNF) and its receptor mRNA expression in two models of brain injury in the rat: (a) excitotoxic lesion by ibotenic acid ..
  9. Cao J, Yu J, Li C, Sun Y, Yuan H, Wang H, et al. Integrin beta1 is involved in the signaling of glial cell line-derived neurotrophic factor. J Comp Neurol. 2008;509:203-10 pubmed publisher
    Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor for the substantia nigra (SN) dopamine (DA) neurons...
  10. Kramer F, Stover T, Warnecke A, Diensthuber M, Lenarz T, Wissel K. BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. J Neurooncol. 2010;98:31-9 pubmed publisher
    The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-beta1/beta2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular ..
  11. Gurley G, Jelaso A, Ide C, Spitsbergen J. Effects of polychlorinated biphenyls (PCBs) on expression of neurotrophic factors in C6 glial cells in culture. Neurotoxicology. 2007;28:1264-71 pubmed
    ..1% dimethyl sulfoxide (DMSO=vehicle), or normal culture medium. Glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) protein were measured by enzyme-linked immunosorbant assay...
  12. Rind H, Butowt R, von Bartheld C. Synaptic targeting of retrogradely transported trophic factors in motoneurons: comparison of glial cell line-derived neurotrophic factor, brain-derived neurotrophic factor, and cardiotrophin-1 with tetanus toxin. J Neurosci. 2005;25:539-49 pubmed
    Glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and cardiotrophin-1 (CT-1) are the most potent neurotrophic factors for motoneurons, but their fate after retrograde axonal transport is not ..
  13. Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, Hsiao L, et al. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol. 2003;13:1625-9 pubmed
    ..The contribution of PlGF toward stromal signals that regulate epithelial differentiation suggests novel functions for a growth factor previously implicated in reactive angiogenesis. ..
  14. Balaszczuk V, Bender C, Pereno G, Beltramino C. Binge alcohol-induced alterations in BDNF and GDNF expression in central extended amygdala and pyriform cortex on infant rats. Int J Dev Neurosci. 2013;31:287-96 pubmed publisher
    ..Our goal was to study whether brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) expression were affected by alcohol in central extended amygdala (CEXA) and pyriform cortex (Pyr), structures ..
  15. Eggers R, Hendriks W, Tannemaat M, van Heerikhuize J, Pool C, Carlstedt T, et al. Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots. Mol Cell Neurosci. 2008;39:105-17 pubmed publisher
    ..show in a rat model that lentiviral vector-mediated overexpression of glial cell line-derived neurotrophic factor (GDNF) in reimplanted nerve roots completely prevents motoneuron atrophy after ventral root avulsion and stimulates ..
  16. Chao C, Ma Y, Chu K, Lee E. Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats. Neurobiol Aging. 2003;24:105-16 pubmed
    Glial cell line-derived neurotrophic factor (GDNF) is a specific neurotrophic factor for midbrain dopamine (DA) neurons, but the mechanism underlying the neurotrophic action of GDNF is not well known...
  17. Maeshima A, Sakurai H, Choi Y, Kitamura S, Vaughn D, Tee J, et al. Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct. J Am Soc Nephrol. 2007;18:3147-55 pubmed
  18. Deng X, Liang Y, Lu H, Yang Z, Liu R, Wang J, et al. Co-transplantation of GDNF-overexpressing neural stem cells and fetal dopaminergic neurons mitigates motor symptoms in a rat model of Parkinson's disease. PLoS ONE. 2013;8:e80880 pubmed publisher
    ..co-transplantation of mesencephalic NSCs stably overexpressing human glial-derived neurotrophic factor (GDNF-mNSCs) together with fetal DA neurons in the 6-OHDA rat model of PD...
  19. Impellizzeri D, Esposito E, Mazzon E, Paterniti I, Di Paola R, Bramanti P, et al. The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice. Biochem Pharmacol. 2012;83:1413-26 pubmed publisher
    ..peroxidation, (9) nitrotyrosine and poly-ADP-ribose (PAR) formation, (10) glial cell-derived neurotrophic factor (GDNF) levels, (11) apoptosis (TUNEL staining, FAS ligand expression, Caspase 3, Bax and Bcl-2 expression)...
  20. Xiao H, Hirata Y, Isobe K, Kiuchi K. Glial cell line-derived neurotrophic factor up-regulates the expression of tyrosine hydroxylase gene in human neuroblastoma cell lines. J Neurochem. 2002;82:801-8 pubmed
    The role of glial cell line-derived neurotrophic factor (GDNF) in the survival of dopaminergic neurons has been well documented, but its effect on dopamine biosynthesis remains to be elucidated...
  21. Salimi K, Moser K, Marksteiner J, Reindl M, Humpel C. GDNF and TGF-beta1 promote cell survival in serum-free cultures of primary rat microglia. Cell Tissue Res. 2003;312:135-9 pubmed
    Recent evidence indicates that glial cell line-derived neurotrophic factor (GDNF) may influence microglial survival, proliferation, and activation, but this has not yet been tested on isolated primary microglia...
  22. Zhang B, Ni H, Liu J, Lei Y, Li H, Xiong Y, et al. Egr-1 participates in abnormally high gdnf gene transcription mediated by histone hyperacetylation in glioma cells. Biochim Biophys Acta. 2014;1839:1161-9 pubmed publisher
    Abnormally high transcription of the glial cell-line derived neurotrophic factor (gdnf) gene in glioma cells is related to the hyperacetylation of histone H3 lysine 9 (H3K9) in its promoter region II, but the mechanism remains unclear...
  23. Wang J, Yang Z, Liu C, Zhao Y, Chen Y. Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-? secretion after subacute cerebral ischemia. Int J Mol Med. 2013;31:172-8 pubmed publisher
    ..of CD11b (a marker of microglial activation), glial cell line-derived neurotrophic factor (GDNF) and tumor necrosis factor-? (TNF-?) at 1, 3 and 7 days after treatment...
  24. Yang L, Nelson P. Glia cell line-derived neurotrophic factor regulates the distribution of acetylcholine receptors in mouse primary skeletal muscle cells. Neuroscience. 2004;128:497-509 pubmed
    It was recently reported that glia cell line-derived neurotrophic factor (GDNF) facilitates presynaptic axonal growth and neurotransmitter release at neuromuscular synapses...
  25. Garcia R, Aguiar J, Alberti E, de la Cuétara K, Pavon N. Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. Biochem Biophys Res Commun. 2004;316:753-4 pubmed
    ..The objective of this work was determine whether rat BMSC express NGF and GDNF, in order to study its potential application for treatment of neurodegenerative diseases...
  26. Martinelli P, Camargos E, Azevedo A, Chiari E, Morel G, Machado C. Cardiac NGF and GDNF expression during Trypanosoma cruzi infection in rats. Auton Neurosci. 2006;130:32-40 pubmed
    ..The present work shows the cardiac levels of glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF), and their cellular sources during T. cruzi infection in rats...
  27. Sun M, Kong L, Wang X, Lu X, Gao Q, Geller A. Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease. Brain Res. 2005;1052:119-29 pubmed
    Both glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) can protect nigrostriatal dopaminergic neurons from neurotoxins in rodent and monkey models of Parkinson's disease (PD)...
  28. Obara Y, Nemoto W, Kohno S, Murata T, Kaneda N, Nakahata N. Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. Cell Signal. 2011;23:666-72 pubmed publisher
    ..factors and cytokines, bFGF induced significant gene expression of glial cell-derived neurotrophic factor (GDNF)...
  29. Jiang L, Yan S, Wang J, Liang Q. Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. Pharm Biol. 2013;51:1188-95 pubmed publisher
    ..whether DHA supplementation affects lipid peroxidation and activates the glial-derived neurotrophic factor (GDNF)-mitogen-activated protein kinase pathway (MAPK pathway) in hippocampus of natural aged rat...
  30. Ahmadiantehrani S, Ron D. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via G??-Erk1/2-dependent induction of Zif268. J Neurochem. 2013;125:193-204 pubmed publisher
    Glial cell line-derived neurotrophic factor (GDNF) is a potent growth factor essential to the development, survival, and function of dopaminergic neurons (Airaksinen and Saarma 2002)...
  31. Marquardt L, Ee X, Iyer N, Hunter D, Mackinnon S, Wood M, et al. Finely Tuned Temporal and Spatial Delivery of GDNF Promotes Enhanced Nerve Regeneration in a Long Nerve Defect Model. Tissue Eng Part A. 2015;21:2852-64 pubmed publisher
    The use of growth factors, such as glial cell line-derived neurotrophic factor (GDNF), for the treatment of peripheral nerve injury has been useful in promoting axon survival and regeneration...
  32. Takarada T, Nakamichi N, Kawagoe H, Ogura M, Fukumori R, Nakazato R, et al. Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes. J Neurosci Res. 2012;90:2074-85 pubmed publisher
    ..Exposure to nicotine predominantly induced mRNA expression of glial cell line-derived neurotrophic factor (GDNF) among the different neurotrophic factors examined in cultured astrocytes, in a manner sensitive to nAChR ..
  33. Nosheny R, Bachis A, Aden S, De Bernardi M, Mocchetti I. Intrastriatal administration of human immunodeficiency virus-1 glycoprotein 120 reduces glial cell-line derived neurotrophic factor levels and causes apoptosis in the substantia nigra. J Neurobiol. 2006;66:1311-21 pubmed
    ..Because glial cell line-derived neurotrophic factor (GDNF) and BDNF are neurotrophic factors crucial for the survival of dopaminergic neurons of the SN, we investigated ..
  34. Davies J, Yates E, Turnbull J. Structural determinants of heparan sulphate modulation of GDNF signalling. Growth Factors. 2003;21:109-19 pubmed
    Glial cell line-derived neurotrophic factor (GDNF) has many functions including regulation of kidney morphogenesis and of neuron growth and survival in the enteric, sensory and central nervous systems...
  35. Wehrwein E, Roskelley E, Spitsbergen J. GDNF is regulated in an activity-dependent manner in rat skeletal muscle. Muscle Nerve. 2002;26:206-11 pubmed
    Glial cell line-derived neurotrophic factor (GDNF) is produced by skeletal muscle and affects peripheral motor neurons...
  36. Carmillo P, Dagø L, Day E, Worley D, Rossomando A, Walus L, et al. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. 2005;44:2545-54 pubmed
    To clarify whether glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFRalpha1), the glycosylphosphatidylinositol (GPI)-linked coreceptor for GDNF, is also a functional coreceptor for artemin (ART), we have studied ..
  37. Han T, Lourenssen S, Miller K, Blennerhassett M. Intestinal smooth muscle phenotype determines enteric neuronal survival via GDNF expression. Neuroscience. 2015;290:357-68 pubmed publisher
    ..We recently showed that expression of glial cell-derived neurotrophic factor (GDNF), the critical neurotrophin for the post-natal enteric nervous system (ENS) is upregulated in ISMC by inflammatory ..
  38. Jung W, Kim H, Shon J, Lee M, Lee S, Sul D, et al. Intervertebral disc degeneration-induced expression of pain-related molecules: glial cell-derived neurotropic factor as a key factor. J Neurosurg Anesthesiol. 2011;23:329-34 pubmed publisher
    ..factor-? did not significantly increase in the DRG or thalamus, whereas glial cell line-derived neurotropic factor (GDNF) was significantly increased at 2 weeks and was sustained through 8 weeks in both the DRG and thalamus...
  39. Madhavan L, Daley B, Davidson B, Boudreau R, Lipton J, Cole Strauss A, et al. Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration. PLoS ONE. 2015;10:e0137136 pubmed publisher
    ..study investigated the roles of two donor NPC molecules, namely glial cell-line derived neurotrophic factor (GDNF) and sonic hedgehog (SHH), in the protection of substantia nigra dopamine neurons in rats treated with 6-..
  40. Oo T, Kholodilov N, Burke R. Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo. J Neurosci. 2003;23:5141-8 pubmed
    ..We showed in vitro that glial cell line-derived neurotrophic factor (GDNF) is able to suppress apoptotic death in DA neurons in postnatal primary culture...
  41. Du F, Wang L, Qian W, Liu S. Loss of enteric neurons accompanied by decreased expression of GDNF and PI3K/Akt pathway in diabetic rats. Neurogastroenterol Motil. 2009;21:1229-e114 pubmed publisher
    To investigate the enteric neuropathy in diabetic rats and the role of glia cell line-derived neurotrophic factor (GDNF) and its signalling pathway PI3K/Akt in regulating enteric neurons survival...
  42. Tumer N, Scarpace P, Dogan M, Broxson C, Matheny M, Yurek D, et al. Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Neurobiol Aging. 2006;27:459-70 pubmed
    Intraventricular delivery of glial cell line-derived neurotrophic factor (GDNF) results in weight loss. We hypothesized that this effect of GDNF was likely mediated via its effects on dopaminergic neurons in the hypothalamus...
  43. Iravani M, Sadeghian M, Leung C, Jenner P, Rose S. Lipopolysaccharide-induced nigral inflammation leads to increased IL-1? tissue content and expression of astrocytic glial cell line-derived neurotrophic factor. Neurosci Lett. 2012;510:138-42 pubmed publisher
    ..Astrocyte derived glial cell line-derived neurotrophic factor (GDNF) promotes the survival and growth of dopaminergic neurones and it protects against or reverses nigral degeneration ..
  44. Airavaara M, Pletnikova O, Doyle M, Zhang Y, Troncoso J, Liu Q. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem. 2011;286:45093-102 pubmed publisher
    ..Our bioinformatic analysis revealed that there are possibly five isoforms of human GDNF gene with different pre- and pro-regions by inter- and intra-exon splicing...
  45. Golan M, Schreiber G, Avissar S. Antidepressants elevate GDNF expression and release from C? glioma cells in a ?-arrestin1-dependent, CREB interactive pathway. Int J Neuropsychopharmacol. 2011;14:1289-300 pubmed publisher
    Glial cell line-derived neurotrophic factor (GDNF), essential for neuronal survival, plasticity and development, has been implicated in the mechanism of action of antidepressant drugs (ADs)...
  46. Lonka Nevalaita L, Lume M, Leppänen S, Jokitalo E, Peranen J, Saarma M. Characterization of the intracellular localization, processing, and secretion of two glial cell line-derived neurotrophic factor splice isoforms. J Neurosci. 2010;30:11403-13 pubmed publisher
    ..study, we characterize the processing and secretion mechanisms of the glial cell line-derived neurotrophic factor (GDNF)...
  47. Whitehead J, Keller Peck C, Kucera J, Tourtellotte W. Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development. Mech Dev. 2005;122:27-41 pubmed
    Glial cell-line derived neurotrophic factor (GDNF) is a potent survival factor for motor neurons...
  48. Katoh Semba R, Tsuzuki M, Miyazaki N, Yoshida A, Nakajima H, Nakagawa C, et al. Distribution and immunohistochemical localization of GDNF protein in selected neural and non-neural tissues of rats during development and changes in unilateral 6-hydroxydopamine lesions. Neurosci Res. 2007;59:277-87 pubmed
    The tissue distribution of glial cell line-derived neurotrophic factor (GDNF) during development and changes in GDNF levels by unilateral 6-hydroxydopamine lesions were investigated in rats using a newly established enzyme immunoassay ..
  49. Anastasia A, Wojnacki J, De Erausquin G, Mascó D. Glial cell-line derived neurotrophic factor is essential for electroconvulsive shock-induced neuroprotection in an animal model of Parkinson's disease. Neuroscience. 2011;195:100-11 pubmed publisher
    ..in order to shed light into its neuroprotective mechanism, we studied glial cell-line derived neurotrophic factor (GDNF) levels (the most efficient TF for dopaminergic neurons) in the substantia nigra (SN) and striatum of 6-OHDA-..
  50. Ciobanu C, Reid G, Babes A. Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons. Brain Res. 2009;1284:54-67 pubmed publisher
    ..Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological pain states, and exogenous BDNF and GDNF have multiple effects on pain behavior,..
  51. Kanter Schlifke I, Fjord Larsen L, Kusk P, Angehagen M, Wahlberg L, Kokaia M. GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus. Exp Neurol. 2009;216:413-9 pubmed publisher
    ..that direct in vivo viral vector-mediated overexpression of the glial cell line-derived neurotrophic factor (GDNF) in the rat hippocampus suppressed seizures in different animal models of epilepsy...
  52. Hernandez Morato I, Isseroff T, Sharma S, Pitman M. Differential expression of glial-derived neurotrophic factor in rat laryngeal muscles during reinnervation. Laryngoscope. 2014;124:2750-6 pubmed publisher
    ..Laboratory experiment. The expression of glial-derived neurotrophic factor (GDNF) was studied in the abductor and adductor muscles of the larynx in the rat utilizing real-time polymerase chain ..
  53. Maeshima A, Vaughn D, Choi Y, Nigam S. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2006;295:473-85 pubmed
    Development of metanephric kidney begins with ureteric bud outgrowth from the Wolffian duct (WD). GDNF is believed to be a crucial positive signal in the budding process, but the negative regulation of this process remains unclear...