Gene Symbol: Gdf7
Description: growth differentiation factor 7
Alias: growth/differentiation factor 7
Species: rat
Products:     Gdf7

Top Publications

  1. Butler S, Dodd J. A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron. 2003;38:389-401 pubmed
    ..Of three Bmps expressed in the roof plate, BMP7, but not BMP6 or GDF7, mimics the roof plate activity in vitro...
  2. Settle S, Marker P, Gurley K, Sinha A, Thacker A, Wang Y, et al. The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation. Dev Biol. 2001;234:138-50 pubmed
    ..Here, we show that a member of the BMP family, Gdf7, is required for normal seminal vesicle development...
  3. Lo L, Dormand E, Anderson D. Late-emigrating neural crest cells in the roof plate are restricted to a sensory fate by GDF7. Proc Natl Acad Sci U S A. 2005;102:7192-7 pubmed
    ..Using Cre recombinase-based fate mapping, we show that GDF7, which is exclusively expressed in the roof plate, marks neural crest cells with a 10-fold higher bias to the ..
  4. Li W, Cogswell C, LoTurco J. Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP. J Neurosci. 1998;18:8853-62 pubmed
  5. Nef S, Lush M, Shipman T, Parada L. Neurotrophins are not required for normal embryonic development of olfactory neurons. Dev Biol. 2001;234:80-92 pubmed
    ..Our data indicate that Trk signaling is not required for normal embryonic development of the olfactory system. ..
  6. Sena K, Morotome Y, Baba O, Terashima T, Takano Y, Ishikawa I. Gene expression of growth differentiation factors in the developing periodontium of rat molars. J Dent Res. 2003;82:166-71 pubmed
    ..GDF expression in these cells were down-regulated after completion of root formation. Our results appeared to suggest the involvement of GDF-5, -6, and -7 in the formation of the dental attachment apparatus. ..
  7. Mazerbourg S, Sangkuhl K, Luo C, Sudo S, Klein C, Hsueh A. Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. J Biol Chem. 2005;280:32122-32 pubmed
    ..We characterized the dimeric nature of recombinant GDF6 (also known as BMP13), GDF7 (also known as BMP12), and BMP10...
  8. Lee J, Zhou Z, Taub P, Ramcharan M, Li Y, Akinbiyi T, et al. BMP-12 treatment of adult mesenchymal stem cells in vitro augments tendon-like tissue formation and defect repair in vivo. PLoS ONE. 2011;6:e17531 pubmed publisher
    ..This strategy of pretreating BM-MSCs with BMP-12 prior to in vivo transplantation may be useful in MSC-based tendon reconstruction or tissue engineering. ..
  9. Jelinsky S, Li L, Ellis D, Archambault J, Li J, St Andre M, et al. Treatment with rhBMP12 or rhBMP13 increase the rate and the quality of rat Achilles tendon repair. J Orthop Res. 2011;29:1604-12 pubmed publisher

More Information


  1. Lee K, Dietrich P, Jessell T. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature. 2000;403:734-40 pubmed
    ..These results reveal that the roof plate is essential for specifying multiple classes of neurons in the mammalian central nervous system. ..
  2. Akbar M, Lundberg A, Liu K, Vidyadaran S, Wells K, Dolatshad H, et al. The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. J Biol Chem. 2003;278:19956-65 pubmed