Gata3

Summary

Gene Symbol: Gata3
Description: GATA binding protein 3
Alias: trans-acting T-cell-specific transcription factor GATA-3
Species: rat
Products:     Gata3

Top Publications

  1. Nakamura Y, Ghaffar O, Olivenstein R, Taha R, Soussi Gounni A, Zhang D, et al. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol. 1999;103:215-22 pubmed
    ..These findings support a causal association between augmented GATA-3 expression and dysregulated IL-5 expression in atopic asthma. ..
  2. Van Esch H, Groenen P, Nesbit M, Schuffenhauer S, Lichtner P, Vanderlinden G, et al. GATA3 haplo-insufficiency causes human HDR syndrome. Nature. 2000;406:419-22 pubmed
    ..deletion-mapping studies in two HDR patients, and here we define a critical 200-kilobase region which contains the GATA3 gene...
  3. Fang T, Yashiro Ohtani Y, Del Bianco C, Knoblock D, Blacklow S, Pear W. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 2007;27:100-10 pubmed
    ..In the absence of Notch signals, Gata3 expression was markedly diminished...
  4. Pai S, Truitt M, Ting C, Leiden J, Glimcher L, Ho I. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 2003;19:863-75 pubmed
    ..Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells. ..
  5. Kaufman C, Zhou P, Pasolli H, Rendl M, Bolotin D, Lim K, et al. GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev. 2003;17:2108-22 pubmed
    ..This newfound function for GATA-3 in skin development strengthens the parallels between the differentiation programs governing hair follicle and lymphocyte differentiation. ..
  6. Lim K, Lakshmanan G, Crawford S, Gu Y, Grosveld F, Engel J. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet. 2000;25:209-12 pubmed
    Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin...
  7. Grote D, Souabni A, Busslinger M, Bouchard M. Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 2006;133:53-61 pubmed
    ..screen for genes specifically expressed in the pro/mesonephros and regulated by Pax proteins, we identified Gata3, a transcription factor gene associated with hypoparathyroidism, deafness and renal anomaly (HDR) syndrome...
  8. George K, Leonard M, Roth M, Lieuw K, Kioussis D, Grosveld F, et al. Embryonic expression and cloning of the murine GATA-3 gene. Development. 1994;120:2673-86 pubmed
    ..Furthermore, this same region of the locus confers developmentally appropriate expression in transgenic mice, but only in a subset of the tissues that naturally express the gene. ..
  9. Wang L, Wildt K, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, et al. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008;9:1122-30 pubmed publisher
    ..Here we show that, contrary to previous findings, Gata3 disruption blocked differentiation into the CD4(+) T cell lineage before commitment to the CD4(+) lineage and in ..

More Information

Publications81

  1. Grote D, Boualia S, Souabni A, Merkel C, Chi X, Costantini F, et al. Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet. 2008;4:e1000316 pubmed publisher
    ..Here, we show that the nephric duct-specific inactivation of the transcription factor gene Gata3 leads to massive ectopic ureter budding...
  2. Ko L, Yamamoto M, Leonard M, George K, Ting P, Engel J. Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. Mol Cell Biol. 1991;11:2778-84 pubmed
    ..We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation. ..
  3. Taghon T, Yui M, Rothenberg E. Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3. Nat Immunol. 2007;8:845-55 pubmed
    ..Our results suggest a close relationship between the pro-T cell and mast cell programs and a previously unknown function for Notch in T lineage fidelity. ..
  4. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-50 pubmed
    ..in the second intron was essential and sufficient for the TAL1- and LMO-dependent transcriptional activation, and GATA3 binds to this site...
  5. Ting C, Olson M, Barton K, Leiden J. Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 1996;384:474-8 pubmed
    ..These findings suggest that GATA-3 is an essential and specific regulator of early thymocyte development. ..
  6. Pandolfi P, Roth M, Karis A, Leonard M, Dzierzak E, Grosveld F, et al. Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis. Nat Genet. 1995;11:40-4 pubmed
    ..Mice heterozygous for the GATA3 mutation are fertile and appear in all respects to be normal, whereas homozygous mutant embryos die between days ..
  7. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 2007;27:89-99 pubmed
    ..GATA-3 was necessary for Notch-induced Th2 differentiation, and we identified an upstream Gata3 promoter as a direct target for Notch signaling...
  8. Duncan J, Lim K, Engel J, Fritzsch B. Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3. Int J Dev Biol. 2011;55:297-303 pubmed publisher
    Haploinsufficiency of Gata3 causes hypoparathyroidism, deafness and renal dysplasia (HDR) syndrome in mice and humans. Gata3 null mutation leads to early lethality around embryonic day (E)11...
  9. Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, et al. Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009;238:2280-91 pubmed publisher
    ..expression of E-cadherin, a premature lens vesicle marker, is abnormally prolonged in the posterior region of Gata3 homozygous mutant lenses...
  10. Li Y, Chen D, Li T, Wen W, Shi J, He X. [Kinetic expression of T-bet and GATA-3 genes in rat allergic rhinitis models]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;25:791-5 pubmed
  11. Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim K, et al. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009;206:2987-3000 pubmed publisher
    ..We provide multiple lines of in vivo evidence through the analysis of T cell development in Gata3 hypomorphic mutant embryos, in irradiated mice reconstituted with Gata3 mutant hematopoietic cells, and in mice ..
  12. Diaz Y, Rojas R, Valderrama L, Saravia N. T-bet, GATA-3, and Foxp3 expression and Th1/Th2 cytokine production in the clinical outcome of human infection with Leishmania (Viannia) species. J Infect Dis. 2010;202:406-15 pubmed publisher
    ..Regulation of the inflammatory response rather than biased Th1/Th2 response distinguished asymptomatic and recalcitrant outcomes of infection with Leishmnania viannia species. ..
  13. Yang C, Li C, Luo G, Luo Y, Liu Y. [Expression of transcription factors T-bet and GATA-3 and relationship to the numbers of eosinophils in rat model of allergic rhinitis]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011;25:1090-3 pubmed
    ..The imbalance of transcription factor GATA-3 and T-bet has a close correlation with the eosinophil count, and may play a key role in the formation of allergic rhinitis. ..
  14. Tsarovina K, Reiff T, Stubbusch J, Kurek D, Grosveld F, Parlato R, et al. The Gata3 transcription factor is required for the survival of embryonic and adult sympathetic neurons. J Neurosci. 2010;30:10833-43 pubmed publisher
    The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells...
  15. Chia I, Grote D, Marcotte M, Batourina E, Mendelsohn C, Bouchard M. Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development. 2011;138:2089-97 pubmed publisher
    ..We find a similar set of malformations in mutants lacking either Gata3 or Raldh2. We show that these factors act in parallel to regulate ND insertion via Ret...
  16. Yamashita M, Ukai Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, et al. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem. 2004;279:26983-90 pubmed
    b>GATA3 expression is essential for type-2 helper T (Th2) cell differentiation...
  17. Wang L, Carr T, Xiong Y, Wildt K, Zhu J, Feigenbaum L, et al. The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol. 2010;40:2385-90 pubmed publisher
    ..We previously showed that the sequential activity of two zinc finger transcription factors, Gata3 and Thpok, promotes the differentiation of conventional, MHC II-restricted thymocytes into CD4(+) T cells...
  18. Oliver C, Khaled W, Frend H, Nichols J, Watson C. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev. 2012;26:1086-97 pubmed publisher
    ..These data suggest that the luminal alveolar compartment of the mammary gland is comprised of a number of distinct cell populations that, although interdependant, exhibit considerable cell fate plasticity. ..
  19. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel R, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008;9:1347-55 pubmed publisher
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation. ..
  20. Ruest L, Xiang X, Lim K, Levi G, Clouthier D. Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development. 2004;131:4413-23 pubmed
    ..Together, our results suggest that the establishment of a 'mandibular identity' during lower jaw development requires both Ednra-dependent and -independent signaling pathways. ..
  21. Yagi R, Junttila I, Wei G, Urban J, Zhao K, Paul W, et al. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity. 2010;32:507-17 pubmed publisher
    The transcription factor GATA3 is crucial for the differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells...
  22. Pata I, Studer M, van Doorninck J, Briscoe J, Kuuse S, Engel J, et al. The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4. Development. 1999;126:5523-31 pubmed
    In this paper, we show that the transcription factor GATA3 is dynamically expressed during hindbrain development. Function of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1...
  23. Fu T, Yang P, Huang X, Huang Q, Zhou H, Li B, et al. GATA-3 expression in the development of anterior chamber associated immune deviation. Chin Med J (Engl). 2005;118:2000-4 pubmed
    ..The expression of GATA-3 is increased during ACAID, suggesting that GATA-3 may be involved in the development of ACAID. ..
  24. Horiuchi S, Onodera A, Hosokawa H, Watanabe Y, Tanaka T, Sugano S, et al. Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J Immunol. 2011;186:6378-89 pubmed publisher
    ..IL-4-mediated STAT6 activation induces high levels of transcription of GATA3, a master regulator of Th2 cell differentiation, and enforced expression of GATA3 induces Th2 cytokine expression...
  25. Rivolta M, Holley M. GATA3 is downregulated during hair cell differentiation in the mouse cochlea. J Neurocytol. 1998;27:637-47 pubmed
    b>GATA3 is a transcription factor expressed in the inner ear during the early stages of development...
  26. Jack B, Crossley M. GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis. J Biol Chem. 2010;285:32405-14 pubmed publisher
    ..In mammals, both GATA2 and GATA3 have been shown to be present in preadipocytes, and their silencing allows the onset of adipogenesis...
  27. Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gerard D, et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J Exp Med. 2010;207:2141-56 pubmed publisher
    ..Finally, TAL1 or NKX3.1 knockdown abrogates the ability of human T-ALL cells to efficiently induce leukemia development in mice. These results suggest that tumor suppressor or oncogenic activity of NKX3.1 depends on tissue expression. ..
  28. Tsarovina K, Pattyn A, Stubbusch J, Muller F, van der Wees J, Schneider C, et al. Essential role of Gata transcription factors in sympathetic neuron development. Development. 2004;131:4775-86 pubmed
    ..Here, we have studied the function of Gata2 and Gata3 zinc-finger transcription factors in autonomic neuron development...
  29. Nakata Y, Brignier A, Jin S, Shen Y, Rudnick S, Sugita M, et al. c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development. Blood. 2010;116:1280-90 pubmed publisher
    ..Therefore, c-Myb, GATA-3, and Menin form a core transcription complex that regulates GATA-3 expression and, with the recruitment of MLL, Th2 cell maturation in primary human peripheral blood T cells...
  30. Zou M, Cao J, Liu Z, Huh S, Polyak K, Yan Q. Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. J Biol Chem. 2014;289:17620-33 pubmed publisher
    ..Mechanistically, JARID1B was required for GATA3 recruitment to the Foxa1 promoter to activate Foxa1 expression...
  31. Cao L, Wang J, Zhu Y, Tseu I, Post M. Maternal endotoxin exposure attenuates allergic airway disease in infant rats. Am J Physiol Lung Cell Mol Physiol. 2010;298:L670-7 pubmed publisher
    ..e., increased T-bet and T(H)1 cytokine expression while expression of T(H)2-associated transcription factors (GATA3 and STAT6) and cytokines was decreased]...
  32. Boualia S, Gaitan Y, Murawski I, Nadon R, Gupta I, Bouchard M. Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2. PLoS ONE. 2011;6:e21529 pubmed publisher
    ..As both genes are located on human chromosome 10q, which is lost in a proportion of VUR patients, these findings may help understand VUR and CAKUT in humans. ..
  33. Hossain M, Hosokawa H, Hasegawa A, Watarai H, Taniguchi M, Yamashita M, et al. Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells. Immunology. 2008;125:377-86 pubmed publisher
    ..These results suggest that LEF-1 is involved in the GATA-3 complex, while also regulating the GATA-3 function, such as the induction of Th2 cytokine expression via the inhibition of the DNA-binding activity of GATA-3. ..
  34. Marine J, Winoto A. The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements. Proc Natl Acad Sci U S A. 1991;88:7284-8 pubmed
    ..find a common TCR regulatory element, we have studied the ability of the newly described enhancer-binding protein Gata3 to bind to the sequence motif (A/T)GATA(G/A) shared between enhancer elements of all four TCR genes...
  35. van Hamburg J, de Bruijn M, Ribeiro de Almeida C, Van Zwam M, van Meurs M, de Haas E, et al. Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology. Eur J Immunol. 2008;38:2573-86 pubmed publisher
    The zinc-finger transcription factor GATA3 serves as a master regulator of T-helper-2 (Th2) differentiation by inducing expression of the Th2 cytokines IL-4, IL-5 and IL-13 and by suppressing Th1 development...
  36. Grigorieva I, Mirczuk S, Gaynor K, Nesbit M, Grigorieva E, Wei Q, et al. Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2. J Clin Invest. 2010;120:2144-55 pubmed publisher
    Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia...
  37. Lawoko Kerali G, Rivolta M, Lawlor P, Cacciabue Rivolta D, Langton Hewer C, van Doorninck J, et al. GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear. Mech Dev. 2004;121:287-99 pubmed
    The function of the zinc finger transcription factor GATA3 was studied in a newly established, conditionally immortal cell line derived to represent auditory sensory neuroblasts migrating from the mouse otic vesicle at embryonic day E10...
  38. Son D, Li L, Katsuyama H, Komatsu N, Saito M, Tanii H, et al. Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene. 2009;436:121-7 pubmed publisher
    ..and DNA footprinting confirmed the binding of NHEK nuclear protein to these motifs that were supershifted by anti-GATA3 antibody. Among GATA isoforms, GATA3 alone could be amplified in RNA obtained from NHEK...
  39. Stellato C, Gubin M, Magee J, Fang X, Fan J, Tartar D, et al. Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J Immunol. 2011;187:441-9 pubmed publisher
    ..A better understanding of HuR-mediated control of Th2 polarization may have utility in altering allergic airway inflammation in human asthmatic patients. ..
  40. Gross J, Stute K, Fuchs J, Angerstein M, Amarjargal N, Mazurek B. Effects of retinoic acid and butyric acid on the expression of prestin and Gata-3 in organotypic cultures of the organ of corti of newborn rats. Dev Neurobiol. 2011;71:650-61 pubmed publisher
    ..The data indicate that retinoid nuclear transcription factors, GATA-3 and histone acetylation/deacetylation processes may have a regulatory role to play in prestin expression...
  41. Jenner R, Townsend M, Jackson I, Sun K, Bouwman R, Young R, et al. The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A. 2009;106:17876-81 pubmed publisher
  42. Hwang S, Lee S, Lee W, Lee G. GATA-binding protein-3 regulates T helper type 2 cytokine and ifng loci through interaction with metastasis-associated protein 2. Immunology. 2010;131:50-8 pubmed publisher
    ..These results suggest that GATA-3 interacts with MTA-2 to co-ordinately regulate Th2 cytokine and ifng loci during T helper cell differentiation. ..
  43. Bull R, Orner G, Cheng R, Stillwell L, Stauber A, Sasser L, et al. Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol Appl Pharmacol. 2002;182:55-65 pubmed
    ..These data are not consistent with the hypothesis that all liver tumors induced by TRI were produced by TCA...
  44. Bonin F, Molina M, Malet C, Ginestet C, Berthier Vergnes O, Martin M, et al. GATA3 is a master regulator of the transcriptional response to low-dose ionizing radiation in human keratinocytes. BMC Genomics. 2009;10:417 pubmed publisher
    ..The present study investigated the role of GATA3 protein in the control of the cellular and molecular response of human keratinocytes exposed to a 1 cGy dose of X-..
  45. Bates D, Chen Y, Kim G, Guo L, Chen L. Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. J Mol Biol. 2008;381:1292-306 pubmed publisher
    ..Here we determined the crystal structures of the C-terminal zinc finger of mouse GATA3 bound to DNA containing two variously arranged GATA binding sites...
  46. Zhang D, Yang L, Cohn L, Parkyn L, Homer R, Ray P, et al. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity. 1999;11:473-82 pubmed
    ..Thus, targeting GATA-3 activity alone is sufficient to blunt Th2 responses in vivo, thereby establishing GATA-3 as a potential therapeutic target in the treatment of asthma and allergic diseases. ..
  47. Liu C, Maejima T, Wyler S, Casadesus G, Herlitze S, Deneris E. Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010;13:1190-8 pubmed publisher
    ..These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription. ..
  48. Blanchard A, Page K, Watkin H, Hayward P, Wong T, Bartholomew M, et al. Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Eur J Immunol. 2000;30:3100-10 pubmed
    ..This result was confirmed using clones of EL4 cells stably expressing an inducible form of SKAT-2, thus SKAT-2 is a novel Th2-specific gene that may play a role in selective regulation of cytokine genes in T cells. ..
  49. Wei G, Abraham B, Yagi R, Jothi R, Cui K, Sharma S, et al. Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types. Immunity. 2011;35:299-311 pubmed publisher
    The transcription factor GATA3 plays an essential role during T cell development and T helper 2 (Th2) cell differentiation...
  50. Ma G, Roth M, Groskopf J, Tsai F, Orkin S, Grosveld F, et al. GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development. 1997;124:907-14 pubmed
  51. Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, et al. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol. 2011;12:178-85 pubmed publisher
    ..Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression. ..
  52. Gremy O, Benderitter M, Linard C. Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation. World J Gastroenterol. 2008;14:7075-85 pubmed
    ..Colorectal irradiation induces Th2 polarization, defective IL-10/STAT3 pathway activation and SOCS3 overexpression. These changes, in turn, maintain a immunological imbalance that persists in the long term. ..
  53. Garcia Frigola C, Shi Y, Evans S. Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development. Gene Expr Patterns. 2003;3:777-83 pubmed
    ..The site of HCN4 expression in late embryonic heart coincided with the location of the SA node in postnatal and adult heart [Cardiovasc. Res. 52 (2001) 51]. Our results suggest that HCN4 may be a unique marker of the developing SA node. ..
  54. Tai T, Pai S, Ho I. Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. PLoS ONE. 2014;9:e96535 pubmed publisher
    ..Thus, functional redundancy between Itm2a and Itm2b may explain the minimal phenotype of Itm2a deficiency. ..
  55. Potvin E, Beuret L, Cadrin Girard J, Carter M, Roy S, Tremblay M, et al. Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Mol Cell Biol. 2010;30:5348-63 pubmed publisher
    ..The characterization of the branchial arch enhancer has revealed a specific role of the transcription factor GATA3 in the regulation of N-myc expression...
  56. Hwang E, Szabo S, Schwartzberg P, Glimcher L. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-3 pubmed
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell. ..
  57. Huber J, RAMOS H, Gill M, Farrar J. Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J Immunol. 2010;185:813-7 pubmed publisher
    ..IL-4 promotes Th2 development by inducing the expression of the GATA3 transcription factor, and the Th2 phenotype is stabilized by a GATA3-dependent autoregulatory loop...
  58. Gross J, Stute K, Moller R, Fuchs J, Amarjargal N, Pohl E, et al. Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture. Hear Res. 2010;261:9-21 pubmed publisher
    ..These observations suggest a regulatory role played by the Gata-3,-2 transcription factors in prestin expression. ..
  59. Dydensborg A, Rose A, Wilson B, Grote D, Paquet M, Giguere V, et al. GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. Oncogene. 2009;28:2634-42 pubmed publisher
    The loss of expression of the transcription factor GATA3 in breast tumors has been linked to aggressive tumor development and poor patient survival...
  60. Kidder B, Palmer S. Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 2010;20:458-72 pubmed publisher
    ..with DNA microarray hybridization (ChIP-chip) analysis to investigate targets of the TFs-TCFAP2C, EOMES, ETS2, and GATA3-and a chromatin remodeling factor, SMARCA4...
  61. Zhao G, Li Z, Zou H, Hu Z, Song N, Zheng M, et al. Expression of the transcription factor GATA3 in the postnatal mouse central nervous system. Neurosci Res. 2008;61:420-8 pubmed publisher
    GATA binding protein 3 (GATA3) is an important regulator of central nervous system (CNS) development, but its expression pattern in the postnatal CNS has not been studied...
  62. Labastie M, Bories D, Chabret C, Gregoire J, Chretien S, Romeo P. Structure and expression of the human GATA3 gene. Genomics. 1994;21:1-6 pubmed
    b>GATA3, a member of the GATA family that is abundantly expressed in the T-lymphocyte lineage, is thought to participate in T-cell receptor gene activation through binding to enhancers...
  63. Ng Y, George K, Engel J, Linzer D. GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development. 1994;120:3257-66 pubmed
  64. Yao X, Yang Y, He H, Wang M, Yin K, Huang M. GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells. Chin Med J (Engl). 2010;123:739-44 pubmed
    ..Transcription factors GATA3 and NFAT1 have been both implicated in the regulation of Th2 cytokines...
  65. Fu T, Yang P, Huang X, Zhou H, Zhong H, Li B, et al. [GATA-3 in the development of anterior chamber associated immune deviation]. Zhonghua Yan Ke Za Zhi. 2002;38:213-6 pubmed
    ..It was detected mainly in CD(4)(+) T cells in spleen. The expression of GATA-3 increases earlier than development of ACAID. It suggests that GATA-3 play an important role in Th2 commitment during ACAID development. ..
  66. Raid R, Krinka D, Bakhoff L, Abdelwahid E, Jokinen E, Karner M, et al. Lack of Gata3 results in conotruncal heart anomalies in mouse. Mech Dev. 2009;126:80-9 pubmed publisher
    The transcription factor Gata3 is an important regulator of the development of thymus, the nervous system, ear, kidney, and adrenal glands...
  67. Xiong L, Fang Z, Tao X, Bai M, Feng G. Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model. Am J Chin Med. 2007;35:1011-20 pubmed
    ..In conclusion, ligustrazine inhibits OVA induced airway inflammation by modulating key master switches GATA-3 and T-bet that result in reversing the Th2 cytokine patterns in asthma. ..
  68. Ling K, van Hamburg J, de Bruijn M, Kurek D, Dingjan G, Hendriks R. GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development. Eur J Immunol. 2007;37:1043-52 pubmed
    The transcription factor GATA3 is essential at multiple stages of T cell development, including the earliest double-negative stages, beta-selection and CD4 single-positive thymocytes...
  69. Manaia A, Lemarchandel V, Klaine M, Max Audit I, Romeo P, Dieterlen Lievre F, et al. Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites. Development. 2000;127:643-53 pubmed
    ..A combined in situ and immunocytological analysis strongly suggests that ventral mesodermal GATA-3 patches are involved in the process of intraembryonic stem cell generation. ..
  70. Ferraris S, Del Monaco A, Garelli E, Carando A, De Vito B, Pappi P, et al. HDR syndrome: a novel "de novo" mutation in GATA3 gene. Am J Med Genet A. 2009;149A:770-5 pubmed publisher
    Human GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness, and renal dysplasia) syndrome...
  71. Gaynor K, Grigorieva I, Nesbit M, Cranston T, Gomes T, Gortner L, et al. A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome. J Clin Endocrinol Metab. 2009;94:3897-904 pubmed publisher
    The hypoparathyroidism, deafness, renal dysplasia (HDR) syndrome is caused by mutations in the gene encoding GATA3, which belongs to a family of dual zinc-finger transcription factors that have a role in vertebrate embryonic development...
  72. Appler J, Lu C, Druckenbrod N, Yu W, Koundakjian E, Goodrich L. Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013;33:3679-91 pubmed publisher
    ..Here, we show that the transcription factor Gata3, which is expressed in SGNs throughout their development, is essential for formation of the intricately patterned ..