Gapdh

Summary

Gene Symbol: Gapdh
Description: glyceraldehyde-3-phosphate dehydrogenase
Alias: BARS-38, Gapd, glyceraldehyde-3-phosphate dehydrogenase, 38 kDa BFA-dependent ADP-ribosylation substrate, peptidyl-cysteine S-nitrosylase GAPDH
Species: rat
Products:     Gapdh

Top Publications

  1. Hara M, Agrawal N, Kim S, Cascio M, Fujimuro M, Ozeki Y, et al. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol. 2005;7:665-74 pubmed
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating to the nucleus during apoptosis...
  2. Kornberg M, Sen N, Hara M, Juluri K, Nguyen J, Snowman A, et al. GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol. 2010;12:1094-100 pubmed publisher
    ..Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is physiologically nitrosylated at its Cys 150 residue...
  3. Sen N, Hara M, Ahmad A, Cascio M, Kamiya A, Ehmsen J, et al. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 2009;63:81-91 pubmed publisher
    ..a cell death cascade whereby cellular stressors activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus...
  4. Tisdale E, Artalejo C. A GAPDH mutant defective in Src-dependent tyrosine phosphorylation impedes Rab2-mediated events. Traffic. 2007;8:733-41 pubmed
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has multiple intracellular activities in addition to its role in gluconeogenesis...
  5. Tajima H, Tsuchiya K, Yamada M, Kondo K, Katsube N, Ishitani R. Over-expression of GAPDH induces apoptosis in COS-7 cells transfected with cloned GAPDH cDNAs. Neuroreport. 1999;10:2029-33 pubmed
    The cDNAs for glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12) were cloned from cerebellar neurons undergoing age-induced apoptosis and/or healthy cells...
  6. Yao L, Wang Y, Liu X, Zhou Y, Li N, Liu J, et al. Phenylephrine protects cardiomyocytes from starvation-induced apoptosis by increasing glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity. J Cell Physiol. 2012;227:3518-27 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is known to be a "housekeeping" protein; studies in non-cardiomyocytic cells have shown that GAPDH plays pro-apoptotic role by translocating from cytoplasm to the nucleus or to ..
  7. Chen J, Wu M, Sezate S, Matsumoto H, Ramsey M, McGinnis J. Interaction of glyceraldehyde-3-phosphate dehydrogenase in the light-induced rod alpha-transducin translocation. J Neurochem. 2008;104:1280-92 pubmed
    ..two-hybrid assay and the co-immunoprecipitation assay, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and rTalpha as interacting proteins...
  8. Zhai D, Chin K, Wang M, Liu F. Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage. Mol Brain. 2014;7:20 pubmed publisher
    Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is conventionally considered a critical enzyme that involves in glycolysis for energy production...
  9. Ishida A, Tada Y, Nimura T, Sueyoshi N, Katoh T, Takeuchi M, et al. Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction. Arch Biochem Biophys. 2005;435:134-46 pubmed
    ..To clarify the physiological significance of CaMKP, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and fructose bisphosphate aldolase as major binding partners of CaMKP in a soluble fraction of rat brain using ..

More Information

Publications62

  1. Arif A, Chatterjee P, Moodt R, Fox P. Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol Cell Biol. 2012;32:5046-55 pubmed publisher
    ..EPRS), NS1-associated protein 1 (NSAP1), ribosomal protein L13a, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)...
  2. Shalova I, Cechalova K, Rehakova Z, Dimitrova P, Ognibene E, Caprioli A, et al. Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease. Biochim Biophys Acta. 2007;1770:826-32 pubmed
    Recently, a relationship between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the beta-amyloid precursor protein (betaAPP) in relationship with the pathogenesis of Alzheimer's disease (AD) has been suggested...
  3. Wentzel P, Ejdesjö A, Eriksson U. Maternal diabetes in vivo and high glucose in vitro diminish GAPDH activity in rat embryos. Diabetes. 2003;52:1222-8 pubmed
    ..whether diabetic embryopathy may be associated with the inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) resulting from an excess of reactive oxygen species (ROS) in the embryo...
  4. Cueille C, Pidoux E, de Vernejoul M, Ventura Clapier R, Garel J. Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure. Biochem Biophys Res Commun. 2002;294:340-6 pubmed
    ..These findings support a functional role for CGRP and ADM receptors to compensate the chronic heart failure in rats. ..
  5. Chen J, Ruan R. Identifying stable reference genes for evaluation of antioxidative enzyme gene expression in auditory cortex and cochlea of young and old Fischer 344 rats. Acta Otolaryngol. 2009;129:644-50 pubmed publisher
    ..mRNA levels of some common reference genes such as beta-actin, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), ubiquitin C, hypoxanthine phosphoribosyl-transferase and eukaryotic translation elongation factor (EF) were ..
  6. Maller C, Schröder E, Eaton P. Glyceraldehyde 3-phosphate dehydrogenase is unlikely to mediate hydrogen peroxide signaling: studies with a novel anti-dimedone sulfenic acid antibody. Antioxid Redox Signal. 2011;14:49-60 pubmed publisher
    ..Using this new antibody, we found that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is the predominant protein sulfenate present in isolated rat ventricular myocytes under basal conditions...
  7. Fort P, Marty L, Piechaczyk M, el Sabrouty S, Dani C, Jeanteur P, et al. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 1985;13:1431-42 pubmed
    We have isolated and sequenced a full-length cDNA clone encoding rat glyceraldehyde-3-phosphate-dehydrogenase (GAPDH, E.C.1.2.1.12)...
  8. Brand I, Heinickel A. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). J Biol Chem. 1991;266:20984-9 pubmed
    ..The behavior of glucose-6-phosphate dehydrogenase and glycerol-3-phosphate dehydrogenase from this tissue could not be followed. A possible function of ZnBP in supramolecular organization of carbohydrate metabolism is proposed. ..
  9. Cerella C, D Alessio M, Cristofanon S, De Nicola M, Radogna F, Dicato M, et al. Subapoptogenic oxidative stress strongly increases the activity of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase. Ann N Y Acad Sci. 2009;1171:583-90 pubmed publisher
    ..block of glycolytic flux via inactivation of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in U937 cells...
  10. Lee S, Kim C, Lee K, Ahn J. S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade. J Cell Biol. 2012;199:65-76 pubmed publisher
    ..a novel neuroprotective function of B23 through regulation of the SIAH1-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) death cascade...
  11. Ren G, Wang Y, Liu J. [The relationship between GAPDH mRNA multiple location degradation and advanced stage postmortem intervals]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009;40:848-52 pubmed
    To study the degradation regularity on different sites of housekeeping gene GAPDH in the same tissue in order to deduce advanced stage postmortem interval (PMI)...
  12. Su Y, Blake Palmer K, Fry A, Best A, Brown A, Hiemstra T, et al. Glyceraldehyde 3-phosphate dehydrogenase is required for band 3 (anion exchanger 1) membrane residency in the mammalian kidney. Am J Physiol Renal Physiol. 2011;300:F157-66 pubmed publisher
    ..It has previously been reported that the glycolytic enzyme GAPDH interacts only with erythrocyte AE1, by binding to the portion not found in the kidney isoform. (Chu H, Low PS...
  13. Hatle K, Gummadidala P, Navasa N, Bernardo E, Dodge J, Silverstrim B, et al. MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol Cell Biol. 2013;33:2302-14 pubmed publisher
    ..Impaired expression or loss of MCJ expression may therefore result in a "rapid" metabolism that mitigates the consequences of metabolic disorders. ..
  14. Tso J, Sun X, Kao T, Reece K, Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 1985;13:2485-502 pubmed
    Full length cDNAs encoding the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from rat and man have been isolated and sequenced...
  15. Chaudhry H, Dashoush N, Tang H, Zhang L, Wang X, Wu E, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004;279:35858-66 pubmed
    ..These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium. ..
  16. Kim J, Lee S, Park J, Lee S, Kim J, Ha S, et al. Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells. J Neurochem. 2003;85:1228-36 pubmed
    ..proteins, we immunoprecipitated PLD2 from PC12 cells and found that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) coimmunoprecipitated with PLD2 upon H2O2 treatment...
  17. Ivings L, Pennington S, Jenkins R, Weiss J, Burgoyne R. Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. Biochem J. 2002;363:599-608 pubmed
    ..These data suggest the possibility that neurocalcin delta functions in the control of clathrin-coated vesicle traffic. ..
  18. Hong M, Kefaloyianni E, Bao L, Malester B, Delaroche D, Neubert T, et al. Cardiac ATP-sensitive K+ channel associates with the glycolytic enzyme complex. FASEB J. 2011;25:2456-67 pubmed publisher
    ..domains as baits in a 2-hybrid screen against a rat cardiac cDNA library, we identified glycolytic enzymes (GAPDH and aldolase A) as putative interacting proteins...
  19. Sakai A, Shimizu H, Kono K, Furuya E. Monochloroacetic acid inhibits liver gluconeogenesis by inactivating glyceraldehyde-3-phosphate dehydrogenase. Chem Res Toxicol. 2005;18:277-82 pubmed
    ..gluconeogenesis from glycerol, which can be converted to glucose without glyceraldehyde-3-phosphate dehydrogenase (GAPDH), was not inhibited by MCA...
  20. Baba T, Kobayashi H, Kawasaki H, Mineki R, Naito H, Ohmori D. Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle. FEBS Lett. 2010;584:2796-800 pubmed publisher
    ..Mass spectrometry analysis revealed that this protein was glyceraldehyde-3-phosphate dehydrogenase (GAPDH)...
  21. Tomokuni Y, Goryo K, Katsura A, Torii S, Yasumoto K, Kemnitz K, et al. Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy in living cells. FEBS J. 2010;277:1310-8 pubmed publisher
    Loose interaction between the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoglycerate kinase (PGK) was visualized in living CHO-K1 cells by fluorescence resonance energy transfer (FRET), using time-domain ..
  22. Charles D, Pretsch W. Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987;176:81-91 pubmed
    ..The recovered mouse mutants might be used as animal models to study corresponding genetic diseases in humans. ..
  23. Huo J, Zhu X, Ma R, Dong H, Su B. GAPDH/Siah1 cascade is involved in traumatic spinal cord injury and could be attenuated by sivelestat sodium. Neuroscience. 2016;330:171-80 pubmed publisher
    The glyceraldehyde-3-phosphate dehydrogenase (GAPDH)/Siah1 signaling pathway has been recognized as a sensor of nitric oxide (NO)...
  24. Qvit N, Joshi A, Cunningham A, Ferreira J, Mochly Rosen D. Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death. J Biol Chem. 2016;291:13608-21 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), an important glycolytic enzyme, has a non-catalytic (thus a non-canonical) role in inducing mitochondrial elimination under oxidative stress...
  25. Wagener J, Schneider J, Baxmann S, Kalbacher H, Borelli C, Nuding S, et al. A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation. J Invest Dermatol. 2013;133:144-53 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has an important role not only in glycolysis but also in nonmetabolic processes, including transcription activation and apoptosis...
  26. Zhuang J, Wang P, Huang X, Chen X, Kang J, Hwang P. Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A. 2013;110:17356-61 pubmed publisher
    ..Thus, the mitochondrial disulfide relay system allows p53 to regulate two spatially segregated genomes depending on oxidative metabolic activity. ..
  27. Meng Y, Liu X, Ma X, Shen Y, Fan L, Leng J, et al. The protein profile of mouse mature cumulus-oocyte complex. Biochim Biophys Acta. 2007;1774:1477-90 pubmed
    ..These data provide valuable information for future studies to identify proteins involved in ovarian follicular development and related reproductive abnormalities. ..
  28. Sampath P, Mazumder B, Seshadri V, Gerber C, Chavatte L, Kinter M, et al. Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. Cell. 2004;119:195-208 pubmed
  29. Hao G, Derakhshan B, Shi L, Campagne F, Gross S. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A. 2006;103:1012-7 pubmed
    ..revealed endogenous SNO-Cys modification sites on cerebellum proteins, including alpha-tubulin, beta-tubulin, GAPDH, and dihydropyrimidinase-related protein-2...
  30. Tsuchiya Y, Okada G, Kobayashi S, Chikuma T, Hojo H. 4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase is degraded by cathepsin G in rat neutrophils. Oxid Med Cell Longev. 2011;2011:213686 pubmed publisher
    ..Moreover, the degradation activity was inhibited by cathepsin G inhibitors. These results suggest that cathepsin G plays a crucial role in the degradation of 4-hydroxy-2-nonenal-modified glyceraldehyde-3-phosphate dehydrogenase. ..
  31. Lazarev V, Nikotina A, Semenyuk P, Evstafyeva D, Mikhaylova E, Muronetz V, et al. Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress. Free Radic Biol Med. 2016;92:29-38 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the most abundant targets of the oxidative stress...
  32. Beyret E, Lin H. Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Dev Biol. 2011;355:215-26 pubmed publisher
    ..These results pinpoint a function of the PIWI protein subfamily to meiosis during spermatogenesis. ..
  33. Hosokawa K, Hamada Y, Fujiya A, Murase M, Maekawa R, Niwa Y, et al. S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells. Am J Physiol Endocrinol Metab. 2017;312:E471-E481 pubmed publisher
    ..and enzyme activity, insulin signaling, and poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH)...
  34. Maehara Y, Fujiyoshi T, Takahashi K, Yamamoto M, Endo H. 1.5 kb mRNA abundantly expressed in rat tumors encodes a 37 kilodalton protein in vitro. Biochem Biophys Res Commun. 1985;131:800-5 pubmed
  35. Li Y, Nowotny P, Holmans P, Smemo S, Kauwe J, Hinrichs A, et al. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A. 2004;101:15688-93 pubmed
    ..and 1,196 control subjects and report association with SNPs in the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene. Subsequent analysis of GAPD paralogs on other chromosomes demonstrated association with two other paralogs...
  36. Mustafa A, Gadalla M, Sen N, Kim S, Mu W, Gazi S, et al. H2S signals through protein S-sulfhydration. Sci Signal. 2009;2:ra72 pubmed publisher
    ..About 10 to 25% of many liver proteins, including actin, tubulin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are sulfhydrated under physiological conditions...
  37. Tummala H, Kirwan M, Walne A, Hossain U, Jackson N, Pondarre C, et al. ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function. Am J Hum Genet. 2014;94:246-56 pubmed publisher
    ..Collectively, these observations identify a distinct bone-marrow-failure syndrome due to mutations in ERCC6L2, a gene implicated in DNA repair and mitochondrial function...
  38. Dhar Chowdhury P, Harrell M, Han S, Jankowska D, Parachuru L, Morrissey A, et al. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. J Biol Chem. 2005;280:38464-70 pubmed
    ..two potential interacting proteins to be the glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and triose-phosphate isomerase...
  39. Rajamohan S, Pillai V, Gupta M, Sundaresan N, Birukov K, Samant S, et al. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol. 2009;29:4116-29 pubmed publisher
    ..These data demonstrate that the activity of PARP1 is under the control of SIRT1, which is necessary for survival of cells under stress conditions. ..
  40. Voskresenskiy A, Sun L. The housekeeping gene (GA3PDH) and the long interspersed nuclear element (LINE) in the blood and organs of rats treated with cocaine. Ann N Y Acad Sci. 2008;1137:309-15 pubmed publisher
    ..Apparently, a recruitment phenomenon of housekeeping genes and transposons is possible in the pathogenesis of drug addiction. ..
  41. Barbini L, Rodriguez J, Dominguez F, Vega F. Glyceraldehyde-3-phosphate dehydrogenase exerts different biologic activities in apoptotic and proliferating hepatocytes according to its subcellular localization. Mol Cell Biochem. 2007;300:19-28 pubmed
    Recent evidences indicate new roles for the glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in essential mammalian cell processes, such as apoptosis and proliferation...
  42. Park J, Han D, Kim K, Kang Y, Kim Y. O-GlcNAcylation disrupts glyceraldehyde-3-phosphate dehydrogenase homo-tetramer formation and mediates its nuclear translocation. Biochim Biophys Acta. 2009;1794:254-62 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a typical glycolytic enzyme comprised of four identical 37 kDa subunits...
  43. Ohya S, Asakura K, Muraki K, Watanabe M, Imaizumi Y. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2002;282:G277-87 pubmed
    ..The membrane depolarization by 1 microM E-4031 indicates the contribution of K(+) channels encoded by ERG1/KCNE2 to the resting membrane potential in stomach SMCs...
  44. Nakamura T, Hinagata J, Tanaka T, Imanishi T, Wada Y, Kodama T, et al. HSP90, HSP70, and GAPDH directly interact with the cytoplasmic domain of macrophage scavenger receptors. Biochem Biophys Res Commun. 2002;290:858-64 pubmed
    ..70 (HSP70), leucine aminopeptidase (LAP), adenocylhomocysteinase, and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) were included...
  45. Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, et al. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. J Biol Chem. 2015;290:14493-503 pubmed publisher
    ..Here we report that PARP-1 interacts with a pool of glyceradehyde-3-phosphate dehydrogenase (GAPDH) that translocates into the nucleus under oxidative/nitrosative stress both in vitro and in vivo...
  46. Adams L, Lemire J, Schwartz S. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells a. Arterioscler Thromb Vasc Biol. 1999;19:2600-8 pubmed
  47. Heinz F, Freimüller B. Glyceraldehyde-3-phosphate dehydrogenase from human tissues. Methods Enzymol. 1982;89 Pt D:301-5 pubmed
  48. Ercolani L, Florence B, Denaro M, Alexander M. Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene. J Biol Chem. 1988;263:15335-41 pubmed
    Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.2.12) (GAPDH) mRNA levels, protein, and enzymatic activity increase in 3T3-F442A adipocytes after exposure to physiological concentrations of insulin (Alexander, M., Curtis, G., Avruch, J...
  49. Martins de Souza D, Alsaif M, Ernst A, Harris L, Aerts N, Lenaerts I, et al. The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia. BMC Res Notes. 2012;5:146 pubmed publisher
    ..1 (Hk1), aldolase C (Aldoc), triosephosphate isomerase (Tpi1), glyceraldehyde-3-phosphate dehydrogenase (Gapdh), phosphoglycerate mutase 1 (Pgam1), phosphoglycerate kinase 1 (Pgk1) and enolase 2 (Eno2)...
  50. You B, Huang S, Qin Q, Yi B, Yuan Y, Xu Z, et al. Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis. PLoS ONE. 2013;8:e58697 pubmed publisher
    ..yeast two-hybrid screen of a human heart cDNA library with Mst1 as bait, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified as an Mst1-interacting protein...
  51. Mathiyalagan P, Okabe J, Chang L, Su Y, Du X, El Osta A. The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. Nucleic Acids Res. 2014;42:790-803 pubmed publisher
    ..These studies provide a framework for MHC expression and regulation of genes implicated in pathological remodeling of ventricular hypertrophy. ..
  52. Zhao C, Zha Y, Wu X, Chen L, Shi J, Cui L. The quantification of ADAMTS4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction. Biomed Pharmacother. 2011;65:555-9 pubmed publisher
    ..The expressions of glyseraldehyde-3-phosphate dehydrogenase (GAPDH), beta-actin (ACTB), acidic ribosomal phosphoprotein P0 (ARBP), and ribosomal protein L13A (RPL13A) were examined ..
  53. Ratnakumari L, Murthy C. Response of rat cerebral glycolytic enzymes to hyperammonemic states. Neurosci Lett. 1993;161:37-40 pubmed
    ..The results suggests an enhanced rate of glycolysis in brain in hyperammonemic states and strengthens the role of ammonium ion in stimulating certain enzymes of the glycolytic pathway. ..