Genomes and Genes
Gene Symbol: Gabrb2
Description: gamma-aminobutyric acid type A receptor beta 2 subunit
Alias: GARB2, gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2, Gamma-aminobutyric acid receptor beta 2, gamma-aminobutyric acid (GABA) A receptor, beta 2, gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
- Fu Z, Washbourne P, Ortinski P, Vicini S. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J Neurophysiol. 2003;90:3950-7 pubmed
- Schaerer M, Kannenberg K, Hunziker P, Baumann S, Sigel E. Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. J Biol Chem. 2001;276:26597-604 pubmed..Our observations therefore suggest a tight interaction between gC1q-R and the GABA(A) receptor which might be involved in receptor biosynthesis or modulation of the mature function. ..
- Ma X, Bao W, Wang X, Wang Z, Liu Q, Yao Z, et al. Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia. Exp Brain Res. 2014;232:3413-20 pubmed publisher..Taken together, the present data reveal that GABAA receptor ?2 and ?3 decrease following 1 h of acute restraint stress and may play a critical role in SIH. ..
- Ymer S, Schofield P, Draguhn A, Werner P, Kohler M, Seeburg P. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 1989;8:1665-70 pubmed..These results, together with the known alpha subunit heterogeneity, suggest that a variety of related but functionally distinct GABAA receptor subtypes are generated by different subunit combinations. ..
- Ma D, Whitehead P, Menold M, Martin E, Ashley Koch A, Mei H, et al. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet. 2005;77:377-88 pubmed..polymorphisms (SNPs) were screened in the following genes: GABRG1, GABRA2, GABRA4, and GABRB1 on chromosome 4p12; GABRB2, GABRA6, GABRA1, GABRG2, and GABRP on 5q34-q35...
- Shu H, Eisenman L, Jinadasa D, Covey D, Zorumski C, Mennerick S. Slow actions of neuroactive steroids at GABAA receptors. J Neurosci. 2004;24:6667-75 pubmed
- Newell J, McDevitt R, Czajkowski C. Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation. J Neurosci. 2004;24:11226-35 pubmed..Structural modeling suggests that the beta2 Ile154-Asp163 region is a protein hinge that forms a network of interconnections that couples binding site movements to the cascade of events leading to channel opening. ..
- Mercado J, Czajkowski C. Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. J Biol Chem. 2008;283:15250-7 pubmed publisher..Pentobarbital, however, triggers different movements in this region than GABA, suggesting their activation mechanisms differ. ..
- Kash T, Dizon M, Trudell J, Harrison N. Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem. 2004;279:4887-93 pubmed..The results suggest that interactions between an acidic residue in loop 7 (Asp146) and a basic residue in pre-transmembrane domain-1 (Lys215) are involved in coupling agonist binding to channel gating. ..
- Hong D, Kim C, Eom W, Choi K, Oh Y, Jung S, et al. Interactions of midazolam and propofol on ?1?2?2L and ?1?2?2S gamma aminobutyric acid type A receptors expressed in human embryonic kidney cells. Anesth Analg. 2011;112:1096-102 pubmed publisher..The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the ?(1)?(2)?(2)L receptor. ..
- Cai X, Flores Hernandez J, Feng J, Yan Z. Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. J Physiol. 2002;540:743-59 pubmed..This modulation provides a unique and flexible mechanism for 5-HT(4) receptors to dynamically regulate synaptic transmission and neuronal excitability in the PFC network...
- Li S, Park M, Kim M. Prenatal alteration and distribution of the GABA(B1) and GABA(B2) receptor subunit mRNAs during rat central nervous system development. Brain Res Dev Brain Res. 2004;150:141-50 pubmed
- Saras A, Gisselmann G, Vogt Eisele A, Erlkamp K, Kletke O, Pusch H, et al. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J Biol Chem. 2008;283:10470-5 pubmed publisher..We show here for the first time that histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site. ..
- Kowalczyk S, Winkelmann A, Smolinsky B, Förstera B, Neundorf I, Schwarz G, et al. Direct binding of GABAA receptor ?2 and ?3 subunits to gephyrin. Eur J Neurosci. 2013;37:544-54 pubmed publisher..These studies identify a novel gephyrin-binding motif in GABA(A) R ?2 and ?3 large cytoplasmic loops. ..
- Bali M, Akabas M. The location of a closed channel gate in the GABAA receptor channel. J Gen Physiol. 2007;129:145-59 pubmed..Given the homology with acetylcholine and 5-HT3 receptors there is probably a similar gate in those channels as well. This does not preclude the existence of an additional gate at a more cytoplasmic location. ..
- Hadley S, Amin J. Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. J Physiol. 2007;581:1001-18 pubmed..The possibility that the high affinity state of the alpha6beta2delta receptor modulates the granule neuron activity as well as potential mechanisms affecting its expression are discussed...
- Engblom A, Carlson B, Olsen R, Schousboe A, Kristiansen U. Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating. J Biol Chem. 2002;277:17438-47 pubmed..01). The present findings suggest that this TM1 glycine residue is critical for the rate at which desensitization occurs and that both GABA and intravenous anesthetics implement an analogous pathway for generating desensitization. ..
- Facciolo R, Alo R, Canonaco M, Franzoni M. Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon. Exp Brain Res. 2002;142:504-11 pubmed
- Bedford F, Kittler J, Muller E, Thomas P, Uren J, Merlo D, et al. GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat Neurosci. 2001;4:908-16 pubmed..Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes. ..
- Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, et al. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J Neurosci. 2002;22:1280-9 pubmed..The results indicate that tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses. ..
- Yang L, Sonner J. The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. Anesth Analg. 2008;106:838-45, table of contents pubmed publisher..Comparing the effect of drugs on anesthetic-sensitive wild-type receptors with relatively less sensitive mutant receptors may help identify compounds with anesthetic effects. ..
- Marchionni I, Omrani A, Cherubini E. In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells. J Physiol. 2007;581:515-28 pubmed..The increased cell excitability and synaptic activity following the activation of extrasynaptic GABA(A) receptors by ambient GABA would facilitate the induction of giant depolarizing potentials. ..
- Beck M, Brickley K, Wilkinson H, Sharma S, Smith M, Chazot P, et al. Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. J Biol Chem. 2002;277:30079-90 pubmed..The respective GABA(A) receptor beta 2 subunit/GRIF-1 binding domains were mapped using the yeast two-hybrid reporter gene assays. A possible role for GRIF-1 as a GABA(A) receptor beta 2 subunit trafficking factor is proposed. ..