Gene Symbol: Gabrb2
Description: gamma-aminobutyric acid type A receptor beta 2 subunit
Alias: GARB2, gamma-aminobutyric acid receptor subunit beta-2, GABA(A) receptor subunit beta-2, Gamma-aminobutyric acid receptor beta 2, gamma-aminobutyric acid (GABA) A receptor, beta 2, gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2
Species: rat
Products:     Gabrb2

Top Publications

  1. Kantamneni S, Holman D, Wilkinson K, CorrĂȘa S, Feligioni M, Ogden S, et al. GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation. J Neurochem. 2008;107:86-95 pubmed publisher
    ..These data suggest that GISP can function as a negative regulator of TSG101-dependent lysosomal degradation of transmembrane proteins in neurons to promote receptor stability. ..
  2. Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler J, Jovanovic J, et al. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibiti. J Biol Chem. 2006;281:22180-9 pubmed
    ..Together, the results suggest that PRIP plays an important role in BDNF-dependent regulation of GABA(A) receptors by mediating the specific association between beta subunits of these receptors with protein phosphatases. ..
  3. Saha S, Sieghart W, Fritschy J, McWilliam P, Batten T. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Mol Cell Neurosci. 2001;17:241-57 pubmed
    ..These results suggest that ionotropic receptors comprising the alpha1, alpha3, beta2/3, and gamma2 may mediate inhibitory GABA responses in the NTS. ..
  4. Wang Q, Pless S, Lynch J. Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors. J Biol Chem. 2010;285:40373-86 pubmed publisher
    ..This result implies unexpected conformational mobility in this crucial part of the gating machinery. Together, this information provides new insights into the activation mechanisms of Cys-loop receptors. ..
  5. Oscarsson A, Juhas M, Sjolander A, Eintrei C. The effect of propofol on actin, ERK-1/2 and GABAA receptor content in neurones. Acta Anaesthesiol Scand. 2007;51:1184-9 pubmed
    ..The increase in internal GABA(A)beta(2)-subunit content exhibits a close relationship to actin polymerization and to an increase in ERK-1/2 activation. Actin contributes to the internalization sequestering of the GABA(A)beta(2)-subunit. ..
  6. Maison S, Rosahl T, Homanics G, Liberman M. Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci. 2006;26:10315-26 pubmed
    ..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear. ..
  7. Sarto Jackson I, Milenkovic I, Smalla K, Gundelfinger E, Kaehne T, Herrera Molina R, et al. The cell adhesion molecule neuroplastin-65 is a novel interaction partner of ?-aminobutyric acid type A receptors. J Biol Chem. 2012;287:14201-14 pubmed publisher
  8. Graziane N, Yuen E, Yan Z. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Biol Chem. 2009;284:8329-36 pubmed publisher
  9. Chang C, Olcese R, Olsen R. A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. J Biol Chem. 2003;278:42821-8 pubmed

Scientific Experts

More Information


  1. Fu Z, Washbourne P, Ortinski P, Vicini S. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J Neurophysiol. 2003;90:3950-7 pubmed
  2. Schaerer M, Kannenberg K, Hunziker P, Baumann S, Sigel E. Interaction between GABA(A) receptor beta subunits and the multifunctional protein gC1q-R. J Biol Chem. 2001;276:26597-604 pubmed
    ..Our observations therefore suggest a tight interaction between gC1q-R and the GABA(A) receptor which might be involved in receptor biosynthesis or modulation of the mature function. ..
  3. Ma X, Bao W, Wang X, Wang Z, Liu Q, Yao Z, et al. Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia. Exp Brain Res. 2014;232:3413-20 pubmed publisher
    ..Taken together, the present data reveal that GABAA receptor ?2 and ?3 decrease following 1 h of acute restraint stress and may play a critical role in SIH. ..
  4. Ymer S, Schofield P, Draguhn A, Werner P, Kohler M, Seeburg P. GABAA receptor beta subunit heterogeneity: functional expression of cloned cDNAs. EMBO J. 1989;8:1665-70 pubmed
    ..These results, together with the known alpha subunit heterogeneity, suggest that a variety of related but functionally distinct GABAA receptor subtypes are generated by different subunit combinations. ..
  5. Ma D, Whitehead P, Menold M, Martin E, Ashley Koch A, Mei H, et al. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet. 2005;77:377-88 pubmed
    ..polymorphisms (SNPs) were screened in the following genes: GABRG1, GABRA2, GABRA4, and GABRB1 on chromosome 4p12; GABRB2, GABRA6, GABRA1, GABRG2, and GABRP on 5q34-q35...
  6. Shu H, Eisenman L, Jinadasa D, Covey D, Zorumski C, Mennerick S. Slow actions of neuroactive steroids at GABAA receptors. J Neurosci. 2004;24:6667-75 pubmed
  7. Newell J, McDevitt R, Czajkowski C. Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation. J Neurosci. 2004;24:11226-35 pubmed
    ..Structural modeling suggests that the beta2 Ile154-Asp163 region is a protein hinge that forms a network of interconnections that couples binding site movements to the cascade of events leading to channel opening. ..
  8. Mercado J, Czajkowski C. Gamma-aminobutyric acid (GABA) and pentobarbital induce different conformational rearrangements in the GABA A receptor alpha1 and beta2 pre-M1 regions. J Biol Chem. 2008;283:15250-7 pubmed publisher
    ..Pentobarbital, however, triggers different movements in this region than GABA, suggesting their activation mechanisms differ. ..
  9. Kash T, Dizon M, Trudell J, Harrison N. Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem. 2004;279:4887-93 pubmed
    ..The results suggest that interactions between an acidic residue in loop 7 (Asp146) and a basic residue in pre-transmembrane domain-1 (Lys215) are involved in coupling agonist binding to channel gating. ..
  10. Hong D, Kim C, Eom W, Choi K, Oh Y, Jung S, et al. Interactions of midazolam and propofol on ?1?2?2L and ?1?2?2S gamma aminobutyric acid type A receptors expressed in human embryonic kidney cells. Anesth Analg. 2011;112:1096-102 pubmed publisher
    ..The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the ?(1)?(2)?(2)L receptor. ..
  11. Cai X, Flores Hernandez J, Feng J, Yan Z. Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. J Physiol. 2002;540:743-59 pubmed
    ..This modulation provides a unique and flexible mechanism for 5-HT(4) receptors to dynamically regulate synaptic transmission and neuronal excitability in the PFC network...
  12. Li S, Park M, Kim M. Prenatal alteration and distribution of the GABA(B1) and GABA(B2) receptor subunit mRNAs during rat central nervous system development. Brain Res Dev Brain Res. 2004;150:141-50 pubmed
  13. Saras A, Gisselmann G, Vogt Eisele A, Erlkamp K, Kletke O, Pusch H, et al. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J Biol Chem. 2008;283:10470-5 pubmed publisher
    ..We show here for the first time that histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site. ..
  14. Kowalczyk S, Winkelmann A, Smolinsky B, Förstera B, Neundorf I, Schwarz G, et al. Direct binding of GABAA receptor ?2 and ?3 subunits to gephyrin. Eur J Neurosci. 2013;37:544-54 pubmed publisher
    ..These studies identify a novel gephyrin-binding motif in GABA(A) R ?2 and ?3 large cytoplasmic loops. ..
  15. Williams C, Bell S, Jenkins A. A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor. J Biol Chem. 2010;285:7281-7 pubmed publisher
  16. Bali M, Akabas M. The location of a closed channel gate in the GABAA receptor channel. J Gen Physiol. 2007;129:145-59 pubmed
    ..Given the homology with acetylcholine and 5-HT3 receptors there is probably a similar gate in those channels as well. This does not preclude the existence of an additional gate at a more cytoplasmic location. ..
  17. Hadley S, Amin J. Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities. J Physiol. 2007;581:1001-18 pubmed
    ..The possibility that the high affinity state of the alpha6beta2delta receptor modulates the granule neuron activity as well as potential mechanisms affecting its expression are discussed...
  18. Engblom A, Carlson B, Olsen R, Schousboe A, Kristiansen U. Point mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gating. J Biol Chem. 2002;277:17438-47 pubmed
    ..01). The present findings suggest that this TM1 glycine residue is critical for the rate at which desensitization occurs and that both GABA and intravenous anesthetics implement an analogous pathway for generating desensitization. ..
  19. Facciolo R, Alo R, Canonaco M, Franzoni M. Early phylogenetic value of the major GABA(A) receptor subunit mRNAs in the telencephalon. Exp Brain Res. 2002;142:504-11 pubmed
  20. Wongsamitkul N, Baur R, Sigel E. Toward Understanding Functional Properties and Subunit Arrangement of ?4?2? ?-Aminobutyric Acid, Type A (GABAA) Receptors. J Biol Chem. 2016;291:18474-83 pubmed publisher
  21. Bedford F, Kittler J, Muller E, Thomas P, Uren J, Merlo D, et al. GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat Neurosci. 2001;4:908-16 pubmed
    ..Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes. ..
  22. Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, et al. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. J Neurosci. 2002;22:1280-9 pubmed
    ..The results indicate that tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses. ..
  23. Yang L, Sonner J. The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. Anesth Analg. 2008;106:838-45, table of contents pubmed publisher
    ..Comparing the effect of drugs on anesthetic-sensitive wild-type receptors with relatively less sensitive mutant receptors may help identify compounds with anesthetic effects. ..
  24. Marchionni I, Omrani A, Cherubini E. In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells. J Physiol. 2007;581:515-28 pubmed
    ..The increased cell excitability and synaptic activity following the activation of extrasynaptic GABA(A) receptors by ambient GABA would facilitate the induction of giant depolarizing potentials. ..
  25. Beck M, Brickley K, Wilkinson H, Sharma S, Smith M, Chazot P, et al. Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1. J Biol Chem. 2002;277:30079-90 pubmed
    ..The respective GABA(A) receptor beta 2 subunit/GRIF-1 binding domains were mapped using the yeast two-hybrid reporter gene assays. A possible role for GRIF-1 as a GABA(A) receptor beta 2 subunit trafficking factor is proposed. ..