Gabra5

Summary

Gene Symbol: Gabra5
Description: gamma-aminobutyric acid (GABA) A receptor, alpha 5
Alias: GABA(A) receptor subunit alpha-5, GABA-A receptor alpha-5 subunit, gamma-aminobutyric acid A receptor, alpha 5, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5, gamma-aminobutyric acid A receptor, alpha 5, gamma-aminobutyric acid receptor subunit alpha-5
Species: rat

Top Publications

  1. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992
  2. ncbi In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells
    Ivan Marchionni
    Neuroscience Programme, International School for Advanced Studies, Via Beirut 2 4, 34014 Trieste, Italy
    J Physiol 581:515-28. 2007
  3. ncbi Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brain
    David R Serwanski
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Comp Neurol 499:458-70. 2006
  4. ncbi Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte
    Mozibur Rahman
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Umea University, S 901 85 Umea, Sweden
    Eur J Pharmacol 547:37-44. 2006
  5. ncbi Expression of alpha 5 GABAA receptor subunit in developing rat hippocampus
    Blanca Ramos
    Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, c Prof Garcia Gonzalez, 41012, Spain
    Brain Res Dev Brain Res 151:87-98. 2004
  6. ncbi Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 7:201-7. 2002
  7. ncbi Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder
    G N Papadimitriou
    Department of Psychiatry, Eginition Hospital, Athens University Medical School, Greece
    Am J Med Genet 81:73-80. 1998
  8. ncbi Positive association between the GABRA5 gene and unipolar recurrent major depression
    L Oruc
    Flanders Interuniversity Institute for Biotechnology, Born Bunge Foundation, Department of Biochemistry, University of Antwerp, Belgium
    Neuropsychobiology 36:62-4. 1997
  9. ncbi A novel alpha subunit in rat brain GABAA receptors
    M Khrestchatisky
    Department of Biology, University of California, Los Angeles 90024
    Neuron 3:745-53. 1989
  10. ncbi Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology
    D B Pritchett
    Laboratory of Molecular Neuroendocrinology, Universitat Heidelberg, F R G
    J Neurochem 54:1802-4. 1990

Scientific Experts

  • I Massat
  • Miroslav M Savić
  • Ivan Marchionni
  • Mozibur Rahman
  • David R Serwanski
  • Blanca Ramos
  • Terry Clayton
  • Marija M Milinković
  • James M Cook
  • Sroan Joksimović
  • Sundari Rallapalli
  • Michael Van Linn
  • Enrico Cherubini
  • Azar Omrani
  • Inga-Maj Johansson
  • Sean B Christie
  • Angel L De Blas
  • Ming De Wang
  • Charlotte Lindblad
  • Inga Maj Johansson
  • Celia P Miralles
  • Xuejing Li
  • Torbjorn Backstrom
  • Ashok K Mehta
  • G N Papadimitriou
  • Ming-De Wang
  • David Baglietto-Vargas
  • Javier Vitorica
  • Jose Vela
  • L Oruc
  • Juan Felix Lopez-Tellez
  • Juan Carlos del Rio
  • Antonia Gutierrez
  • Diego Ruano
  • W Wisden
  • P H Seeburg
  • E G Daskalopoulou
  • G Karadima
  • D G Dikeos
  • D Vassilopoulos
  • C N Stefanis
  • D Avramopoulos
  • G R Verheyen
  • S Ivezic
  • C Van Broeckhoven
  • P Raeymaekers
  • I Furac
  • M Jakovljevic
  • D J Laurie
  • D B Pritchett
  • P Malherbe
  • M Khrestchatisky
  • H Monyer
  • T A Verdoorn
  • M Y Chiang
  • R Sprengel
  • B Sakmann
  • E Persohn
  • A Herb
  • N Brecha
  • R W Olsen
  • P Werner
  • C Sternini
  • E Sigel
  • W T Xu
  • A J MacLennan
  • J G Richards
  • A J Tobin
  • H Mohler
  • M B Jackson
  • R Baur

Detail Information

Publications15

  1. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    W Wisden
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1040-62. 1992
    ..Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation...
  2. ncbi In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells
    Ivan Marchionni
    Neuroscience Programme, International School for Advanced Studies, Via Beirut 2 4, 34014 Trieste, Italy
    J Physiol 581:515-28. 2007
    ..The increased cell excitability and synaptic activity following the activation of extrasynaptic GABA(A) receptors by ambient GABA would facilitate the induction of giant depolarizing potentials...
  3. ncbi Synaptic and nonsynaptic localization of GABAA receptors containing the alpha5 subunit in the rat brain
    David R Serwanski
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut 06269, USA
    J Comp Neurol 499:458-70. 2006
    ..The results suggest that the synaptic alpha5-GABA(A)Rs might play a role in the phasic GABAergic inhibition of pyramidal neurons in hippocampus and cerebral cortex...
  4. ncbi Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte
    Mozibur Rahman
    Umea Neurosteroid Research Center, Department of Clinical Science, Obstetrics and Gynecology, Umea University, S 901 85 Umea, Sweden
    Eur J Pharmacol 547:37-44. 2006
    ..Results from the current study revealed a different modulation pattern by neurosteroids between the alpha(1)beta(2)gamma(2L) and alpha(5)beta(2)gamma(2L) receptor...
  5. ncbi Expression of alpha 5 GABAA receptor subunit in developing rat hippocampus
    Blanca Ramos
    Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, c Prof Garcia Gonzalez, 41012, Spain
    Brain Res Dev Brain Res 151:87-98. 2004
    ..This developmental pattern is similar to that reported for the Na(+)-K(+)-2Cl(-) system and it might be correlated with the transition from excitatory to inhibitory GABAergic activity...
  6. ncbi Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 7:201-7. 2002
    ..00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD...
  7. ncbi Association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) and bipolar affective disorder
    G N Papadimitriou
    Department of Psychiatry, Eginition Hospital, Athens University Medical School, Greece
    Am J Med Genet 81:73-80. 1998
    ..We examined the possible genetic association between the GABA(A) receptor alpha5 subunit gene locus (GABRA5) on chromosome 15 and affective disorder, in 48 bipolar patients (BP), 40 unipolar patients (UP), and 50 healthy ..
  8. ncbi Positive association between the GABRA5 gene and unipolar recurrent major depression
    L Oruc
    Flanders Interuniversity Institute for Biotechnology, Born Bunge Foundation, Department of Biochemistry, University of Antwerp, Belgium
    Neuropsychobiology 36:62-4. 1997
    ..Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder...
  9. ncbi A novel alpha subunit in rat brain GABAA receptors
    M Khrestchatisky
    Department of Biology, University of California, Los Angeles 90024
    Neuron 3:745-53. 1989
    ..Picrotoxin alone, applied to oocytes producing the alpha and beta polypeptides, elicited an outward current. We suggest that these polypeptides together produce GABA-gated ion channels that can also open spontaneously...
  10. ncbi Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology
    D B Pritchett
    Laboratory of Molecular Neuroendocrinology, Universitat Heidelberg, F R G
    J Neurochem 54:1802-4. 1990
    ..Based on these findings, a reclassification of the GABAA/benzodiazepine receptors is warranted...
  11. ncbi Functional expression and sites of gene transcription of a novel alpha subunit of the GABAA receptor in rat brain
    P Malherbe
    Research Department, Hoffmann La Roche, Basle, Switzerland
    FEBS Lett 260:261-5. 1990
    ....
  12. ncbi The GABAA receptor family: molecular and functional diversity
    P H Seeburg
    Laboratory of Molecular Neuroendocrinology, University of Heidelberg, Federal Republic of Germany
    Cold Spring Harb Symp Quant Biol 55:29-40. 1990
  13. ncbi GABAA receptor channels: from subunits to functional entities
    W Wisden
    University of Heidelberg, Germany
    Curr Opin Neurobiol 2:263-9. 1992
    ..In addition, molecular determinants underlying the differential binding properties of allosteric ligands to receptor subtypes have been identified...
  14. ncbi The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum
    D J Laurie
    Laboratory of Molecular Neuroendocrinology, Zentrum fur Molekulare Biologie, University of Heidelberg, Germany
    J Neurosci 12:1063-76. 1992
    ..The delta-subunit mRNA appears to codistribute with alpha-subunit mRNAs (alpha 4 and alpha 6) associated with GABAA subunits that fail to bind benzodiazepine agonists...
  15. ncbi The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats
    Miroslav M Savić
    Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia
    Int J Neuropsychopharmacol 12:1179-93. 2009
    ..Combining a BZ with beta-CCt results in the near to control level of performance of a cognitive task, without sedation, and may be worth testing on human subjects...