Gabra1

Summary

Gene Symbol: Gabra1
Description: gamma-aminobutyric acid type A receptor alpha1 subunit
Alias: gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, gamma-aminobutyric acid A receptor, alpha 1, gamma-aminobutyric acid (GABA) A receptor, alpha 1, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1
Species: rat
Products:     Gabra1

Top Publications

  1. Hu Y, Lund I, Gravielle M, Farb D, Brooks Kayal A, Russek S. Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor. J Biol Chem. 2008;283:9328-40 pubmed publisher
    ..It is also associated with a variety of neurological diseases. Changes in GABA(A) receptor alpha1 subunit gene (GABRA1) expression have been reported in animal models of epilepsy, alcohol abuse, withdrawal, and stress...
  2. Hong D, Kim C, Eom W, Choi K, Oh Y, Jung S, et al. Interactions of midazolam and propofol on ?1?2?2L and ?1?2?2S gamma aminobutyric acid type A receptors expressed in human embryonic kidney cells. Anesth Analg. 2011;112:1096-102 pubmed publisher
    ..The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the ?(1)?(2)?(2)L receptor. ..
  3. Shu H, Eisenman L, Jinadasa D, Covey D, Zorumski C, Mennerick S. Slow actions of neuroactive steroids at GABAA receptors. J Neurosci. 2004;24:6667-75 pubmed
  4. Kanematsu T, Yasunaga A, Mizoguchi Y, Kuratani A, Kittler J, Jovanovic J, et al. Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibiti. J Biol Chem. 2006;281:22180-9 pubmed
    ..Together, the results suggest that PRIP plays an important role in BDNF-dependent regulation of GABA(A) receptors by mediating the specific association between beta subunits of these receptors with protein phosphatases. ..
  5. Laurie D, Seeburg P, Wisden W. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci. 1992;12:1063-76 pubmed
    ..The delta-subunit mRNA appears to codistribute with alpha-subunit mRNAs (alpha 4 and alpha 6) associated with GABAA subunits that fail to bind benzodiazepine agonists. ..
  6. Savić M, Milinković M, Rallapalli S, Clayton T, Joksimović S, Van Linn M, et al. The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats. Int J Neuropsychopharmacol. 2009;12:1179-93 pubmed publisher
    ..Combining a BZ with beta-CCt results in the near to control level of performance of a cognitive task, without sedation, and may be worth testing on human subjects. ..
  7. Majdi M, Ribeiro da Silva A, Cuello A. Variations in excitatory and inhibitory postsynaptic protein content in rat cerebral cortex with respect to aging and cognitive status. Neuroscience. 2009;159:896-907 pubmed publisher
    ..Finally, the excitatory, postsynaptic neuronal cell-adhesion receptor, neuroligin-1, was found to be significantly increased in both the prefrontal and parietal cortical areas of AI animals. ..
  8. Nair B, Johar K, Priya A, Wong Riley M. Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons. Biochim Biophys Acta. 2016;1863:1-9 pubmed publisher
    ..shRNA of Sp4, functional assays, and western blots, we found that Sp4 functionally regulates the transcription of Gabra1 (GABAA α1) and Gabra2 (GABAA α2), but not Gabra3 (GABAA α3) subunit genes...
  9. Newell J, Czajkowski C. The GABAA receptor alpha 1 subunit Pro174-Asp191 segment is involved in GABA binding and channel gating. J Biol Chem. 2003;278:13166-72 pubmed

More Information

Publications89

  1. Mazzuferi M, Palma E, Martinello K, Maiolino F, Roseti C, Fucile S, et al. Enhancement of GABA(A)-current run-down in the hippocampus occurs at the first spontaneous seizure in a model of temporal lobe epilepsy. Proc Natl Acad Sci U S A. 2010;107:3180-5 pubmed publisher
    ..These observations disclose research opportunities in the field of epileptogenesis that may lead to a better understanding of the mechanism whereby a previously normal tissue becomes epileptic. ..
  2. Brar R, Singh J, Kaur T, Arora S, Singh A. Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. Naunyn Schmiedebergs Arch Pharmacol. 2014;387:143-51 pubmed publisher
    ..Hence, it is concluded that regulation of GABAA receptors is important for management of AKI. Moreover, the GABAergic activity of SVP is important for its renoprotective effect. ..
  3. Ni H, Jiang Y, Bo T, Wang J, Pan H, Wu X. Long-term effects of neonatal seizures on subsequent N-methyl-D-aspartate receptor-1 and gamma-aminobutyric acid receptor A-alpha 1 receptor expression in hippocampus of the Wistar rat. Neurosci Lett. 2004;368:254-7 pubmed
    ..Our results suggest that recurrent or single prolonged seizures during the neonatal period may have long-term effects on the balance between excitatory NMDA system and inhibitory GABA system in hippocampus of rats. ..
  4. Kharlamov E, Lepsveridze E, Meparishvili M, Solomonia R, Lu B, Miller E, et al. Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy. Epilepsy Res. 2011;95:20-34 pubmed publisher
    ..014, and p=0.005, respectively); no changes were found in HSP90 expression. These results provide for the first time evidence of long-term alterations of GABA(A) and glutamate receptor subunits and a HSP following CCI. ..
  5. Chintagari N, Jin N, Gao L, Wang Y, Xi D, Liu L. Role of GABA receptors in fetal lung development in rats. PLoS ONE. 2010;5:e14171 pubmed publisher
    ..In conclusion, our results indicate that GABAA receptors accelerate fetal lung development, likely through an enhanced cell proliferation and/or fluid secretion. ..
  6. Klausberger T, Roberts J, Somogyi P. Cell type- and input-specific differences in the number and subtypes of synaptic GABA(A) receptors in the hippocampus. J Neurosci. 2002;22:2513-21 pubmed
    ..The high number of GABA(A) receptors in synapses on basket cells might contribute to the precisely timed phasing of basket cell activity. ..
  7. Akk G, Li P, Bracamontes J, Reichert D, Covey D, Steinbach J. Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol. 2008;74:614-27 pubmed publisher
    ..The findings are consistent with a model in which the alpha1Ser240 and alpha1Gln241 residues shape the surface to which steroid molecules bind. ..
  8. Khrestchatisky M, MacLennan A, Chiang M, Xu W, Jackson M, Brecha N, et al. A novel alpha subunit in rat brain GABAA receptors. Neuron. 1989;3:745-53 pubmed
    ..Picrotoxin alone, applied to oocytes producing the alpha and beta polypeptides, elicited an outward current. We suggest that these polypeptides together produce GABA-gated ion channels that can also open spontaneously. ..
  9. Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, et al. Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling. PLoS ONE. 2014;9:e113610 pubmed publisher
  10. Liu Q, Wong Riley M. Developmental changes in the expression of GABAA receptor subunits alpha1, alpha2, and alpha3 in the rat pre-Botzinger complex. J Appl Physiol (1985). 2004;96:1825-31 pubmed
    ..This mechanism may contribute partially to the dramatic reduction in cytochrome oxidase activity within the PBC at P12, as shown previously. ..
  11. Raol Y, Lund I, Bandyopadhyay S, Zhang G, Roberts D, Wolfe J, et al. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci. 2006;26:11342-6 pubmed
    ..These findings provide the first direct evidence that altering GABR subunit expression can affect the development of epilepsy and suggest that alpha1 subunit levels are important determinants of inhibitory function in hippocampus. ..
  12. Kang J, Shen W, Macdonald R. Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X. J Neurosci. 2009;29:2833-44 pubmed publisher
    ..dominant mutation associated with childhood absence epilepsy that generates a PTC in exon 8 of the 9 exon GABRA1 gene that is 74 bp upstream of intron 8...
  13. Argence M, Vassias I, Kerhuel L, Vidal P, de Waele C. Stimulation by cochlear implant in unilaterally deaf rats reverses the decrease of inhibitory transmission in the inferior colliculus. Eur J Neurosci. 2008;28:1589-602 pubmed publisher
    ..Electrical stimulation of the deafferented auditory nerve in patients may be a potential new approach for treating tinnitus with unilateral hearing loss. ..
  14. Sallam M, El Gowilly S, Abdel Galil A, El Mas M. Central GABAA receptors are involved in inflammatory and cardiovascular consequences of endotoxemia in conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:279-88 pubmed publisher
    ..c. tiagabine (GABA reuptake inhibitor) or vigabatrin (GABA transaminase inhibitor). These data suggest a major role for central GABAA receptors in the inflammatory and cardiovascular effects of endotoxemia. ..
  15. Eaton M, Lim Y, Bracamontes J, Steinbach J, Akk G. Agonist-specific conformational changes in the ?1-?2 subunit interface of the GABA A receptor. Mol Pharmacol. 2012;82:255-63 pubmed publisher
    ..We infer from the data that the structure of the ?1-?2 subunit interface undergoes agonist-specific conformational changes. ..
  16. Bali M, Akabas M. The location of a closed channel gate in the GABAA receptor channel. J Gen Physiol. 2007;129:145-59 pubmed
    ..Given the homology with acetylcholine and 5-HT3 receptors there is probably a similar gate in those channels as well. This does not preclude the existence of an additional gate at a more cytoplasmic location. ..
  17. Hoekzema E, Rojas S, Herance R, Pareto D, Abad S, Jimenez X, et al. In vivo molecular imaging of the GABA/benzodiazepine receptor complex in the aged rat brain. Neurobiol Aging. 2012;33:1457-65 pubmed publisher
    ..Moreover, these findings indicate that the aging process involves declines in neural BDZ recognition site availability, proposed to reflect alterations in GABA(A) receptor subunit polypeptide expression. ..
  18. Wang Q, Pless S, Lynch J. Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors. J Biol Chem. 2010;285:40373-86 pubmed publisher
    ..This result implies unexpected conformational mobility in this crucial part of the gating machinery. Together, this information provides new insights into the activation mechanisms of Cys-loop receptors. ..
  19. Gross A, Sims R, Swinny J, Sieghart W, Bolam J, Stanford I. Differential localization of GABA(A) receptor subunits in relation to rat striatopallidal and pallidopallidal synapses. Eur J Neurosci. 2011;33:868-78 pubmed publisher
    ..Due to the kinetic properties which each GABA(A) ? subunit confers, this distribution is likely to contribute differentially to both physiological and pathological patterns of activity. ..
  20. Bosman L, Rosahl T, Brussaard A. Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunits. J Physiol. 2002;545:169-81 pubmed
    ..Thus, distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex. ..
  21. Ravizza T, Friedman L, Moshe S, VELISKOVA J. Sex differences in GABA(A)ergic system in rat substantia nigra pars reticulata. Int J Dev Neurosci. 2003;21:245-54 pubmed
  22. Kim N, Cha S, Kong I. Excitatory GABAA receptor in autonomic pelvic ganglion neurons innervating bladder. Biochem Biophys Res Commun. 2014;447:205-9 pubmed publisher
    ..These results provide useful information about the autonomic function of bladder in physiological and pathological conditions. ..
  23. Andrade S, Arbo B, Batista B, Neves A, Branchini G, Brum I, et al. Effect of progesterone on the expression of GABA(A) receptor subunits in the prefrontal cortex of rats: implications of sex differences and brain hemisphere. Cell Biochem Funct. 2012;30:696-700 pubmed publisher
  24. Shin D, Yu W, Sutton A, Calos M, Carlen P. Elevated potassium elicits recurrent surges of large GABAA-receptor-mediated post-synaptic currents in hippocampal CA3 pyramidal neurons. J Neurophysiol. 2011;105:1185-98 pubmed publisher
    ..In conclusion, these cyclic large IPSC events observable in CA3 pyramidal neurons in 10 mM KCl may be due to transient GABA depletion from continuously active interneuronal afferents. ..
  25. Bianchi M, Macdonald R. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. J Physiol. 2002;544:3-18 pubmed
    ..These results may indicate a previously unrecognized role for the slow phases of desensitization for synaptic function under conditions of repeated GABA(A) receptor activation. ..
  26. Picard N, Guénin S, Perrin Y, Hilaire G, Larnicol N. Prenatal diazepam exposure alters respiratory control system and GABAA and adenosine receptor gene expression in newborn rats. Pediatr Res. 2008;64:44-9 pubmed publisher
    ..These mRNA changes, which are region-specific, suggest that prenatal diazepam exposure interferes with developmental events whose impact on the respiratory system maturation deserves further studies. ..
  27. Kumar S, Suryanarayanan A, Boyd K, Comerford C, Lai M, Ren Q, et al. Ethanol reduces GABAA alpha1 subunit receptor surface expression by a protein kinase Cgamma-dependent mechanism in cultured cerebral cortical neurons. Mol Pharmacol. 2010;77:793-803 pubmed publisher
    ..These findings suggest that ethanol exposure selectively alters PKCgamma translocation to GABA(A) receptors and PKCgamma regulates GABA(A) alpha1 receptor trafficking after ethanol exposure. ..
  28. Fleming R, Li Q, Risher M, Sexton H, Moore S, Wilson W, et al. Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells. Alcohol Clin Exp Res. 2013;37:1154-60 pubmed publisher
  29. Saha S, Sieghart W, Fritschy J, McWilliam P, Batten T. Gamma-aminobutyric acid receptor (GABA(A)) subunits in rat nucleus tractus solitarii (NTS) revealed by polymerase chain reaction (PCR) and immunohistochemistry. Mol Cell Neurosci. 2001;17:241-57 pubmed
    ..These results suggest that ionotropic receptors comprising the alpha1, alpha3, beta2/3, and gamma2 may mediate inhibitory GABA responses in the NTS. ..
  30. Pérez González D, Hernandez O, Covey E, Malmierca M. GABA(A)-mediated inhibition modulates stimulus-specific adaptation in the inferior colliculus. PLoS ONE. 2012;7:e34297 pubmed publisher
    ..Together, these findings suggest that GABA(A)-mediated inhibition acts as a gain control mechanism that enhances SSA by modifying the responsiveness of the neuron. ..
  31. Zhao C, Hwang S, Buchholz B, Carpenter T, Lightstone F, Lightstone F, et al. GABAA receptor target of tetramethylenedisulfotetramine. Proc Natl Acad Sci U S A. 2014;111:8607-12 pubmed publisher
  32. Vanini G, Baghdoyan H. Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness. Sleep. 2013;36:337-43 pubmed publisher
    ..Vanini G; Baghdoyan HA. Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness. SLEEP 2013;36(3):337-343. ..
  33. Zheng G, Zhang X, Chen Y, Zhang Y, Luo W, Chen J. Evidence for a role of GABAA receptor in the acute restraint stress-induced enhancement of spatial memory. Brain Res. 2007;1181:61-73 pubmed
    ..These results demonstrated that the changes in ERK phosphorylation in hippocampus and PFC were regulated by GABAA receptor in a learning and memory paradigm under acute restraint stress conditions. ..
  34. Urstadt K, Kally P, Zaidi S, Stanley B. Ipsilateral feeding-specific circuits between the nucleus accumbens shell and the lateral hypothalamus: regulation by glutamate and GABA receptor subtypes. Neuropharmacology. 2013;67:176-82 pubmed publisher
  35. Li X, Dong L, Liu Z, Luo J. Expression of gamma-aminobutyric acid A receptor subunits alpha1, beta1, gamma2 mRNA in rats with hepatic encephalopathy. World J Gastroenterol. 2005;11:3319-22 pubmed
  36. Marks G, Sachs O, Birabil C. Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system. Neuroscience. 2008;156:1-10 pubmed publisher
    ..GABAergic control of REM sleep in the PnO requires the cholinergic system and may be acting through presynaptic modulation of acetylcholine release. ..
  37. Pham Le N, Cockburn C, Nowell K, Brown J. Activation of GABAA or 5HT1A receptors in the raphé pallidus abolish the cardiovascular responses to exogenous stress in conscious rats. Brain Res Bull. 2011;86:360-6 pubmed publisher
    ..Impairment in 5HT(1A) receptor function in the NRP likely impairs the normal cardioprotective responses to stress and may contribute to the etiology of SIDS. ..
  38. Maric H, Mukherjee J, Tretter V, Moss S, Schindelin H. Gephyrin-mediated ?-aminobutyric acid type A and glycine receptor clustering relies on a common binding site. J Biol Chem. 2011;286:42105-14 pubmed publisher
  39. Eyre M, Renzi M, Farrant M, Nusser Z. Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor α subunit isoforms. J Neurosci. 2012;32:5853-67 pubmed publisher
  40. Wieland H, Lüddens H, Seeburg P. A single histidine in GABAA receptors is essential for benzodiazepine agonist binding. J Biol Chem. 1992;267:1426-9 pubmed
    ..Hence, this histidine present in the alpha 1, alpha 2, alpha 3, and alpha 5 subunits appears to be a key residue for the action of clinically used BZ ligands. ..
  41. Horii A, Kitahara T, Smith P, Darlington C, Masumura C, Kubo T. Effects of unilateral labyrinthectomy on GAD, GAT1 and GABA receptor gene expression in the rat vestibular nucleus. Neuroreport. 2003;14:2359-63 pubmed
  42. Sigel E, Baur R, Kellenberger S, Malherbe P. Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels. EMBO J. 1992;11:2017-23 pubmed
  43. Shan Q, Haddrill J, Lynch J. Comparative surface accessibility of a pore-lining threonine residue (T6') in the glycine and GABA(A) receptors. J Biol Chem. 2002;277:44845-53 pubmed
    ..The results also indicate that the GABA(A)R pore structure at the 6' level may vary between different expression systems. ..
  44. Evans M, Cady C, Disney K, Yang L, Laguardia J. Three brief epileptic seizures reduce inhibitory synaptic currents, GABA(A) currents, and GABA(A)-receptor subunits. Epilepsia. 2006;47:1655-64 pubmed
    ..Seizure-induced reductions in GABA-mediated inhibition could exacerbate epilepsy. ..
  45. Fisher J. The alpha 1 and alpha 6 subunit subtypes of the mammalian GABA(A) receptor confer distinct channel gating kinetics. J Physiol. 2004;561:433-48 pubmed
    ..Structural heterogeneity within these transmembrane and intracellular regions can therefore influence the characteristics of the postsynaptic response of GABA(A) receptors with different subunit composition. ..
  46. Lund I, Hu Y, Raol Y, Benham R, Faris R, Russek S, et al. BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. Sci Signal. 2008;1:ra9 pubmed publisher
    ..protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site...
  47. Kraushaar U, Backus K. Characterization of GABA(A) and glycine receptors in neurons of the developing rat inferior colliculus. Pflugers Arch. 2002;445:279-88 pubmed
    ..The different properties of GABA(A)Rs and GlyRs expressed in the same IC neuron suggest a distinct functional contribution to the development of inhibitory synapses in the IC. ..
  48. Jacobson Pick S, Richter Levin G. Short- and long-term effects of juvenile stressor exposure on the expression of GABAA receptor subunits in rats. Stress. 2012;15:416-24 pubmed publisher
    ..Thus, age- and region-specific alterations of the ? subunits may contribute to the age-specific behavioral alterations observed following juvenile stress exposure. ..
  49. Davies P, Hanna M, Hales T, Kirkness E. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature. 1997;385:820-3 pubmed
    ..The expression pattern of this subunit in the brain suggests a new target for manipulation of neuronal pathways within the basal ganglia. ..
  50. Lolait S, O Carroll A, Kusano K, Muller J, Brownstein M, Mahan L. Cloning and expression of a novel rat GABAA receptor. FEBS Lett. 1989;246:145-8 pubmed
    ..GABAA alpha- and beta-subunit mRNA is detectable in the cortex, cerebellum and hippocampus. ..
  51. Costa J, Mele M, Baptista M, Gomes J, Ruscher K, Nobre R, et al. Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death. Mol Neurobiol. 2016;53:3513-3527 pubmed publisher
    ..Our results show that excitotoxicity and brain ischemia downregulate full-length gephyrin with a concomitant generation of truncated products, which affect synaptic clustering of GABAAR and cell death. ..
  52. Li H, Huguenard J, Fisher R. Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol Dis. 2007;25:623-30 pubmed
    ..The findings suggest a mechanism for the higher prevalence of absence epilepsy in female patients. ..
  53. Mukherjee J, Kretschmannova K, Gouzer G, Maric H, Ramsden S, Tretter V, et al. The residence time of GABA(A)Rs at inhibitory synapses is determined by direct binding of the receptor ?1 subunit to gephyrin. J Neurosci. 2011;31:14677-87 pubmed publisher
  54. Qian H, Feng Y, He X, Yang Y, Sung J, Xia Y. Effects of inhibitory amino acids on expression of GABAA R? and glycine R?1 in hypoxic rat cortical neurons during development. Brain Res. 2011;1425:1-12 pubmed publisher
  55. Wang W, Ju Y, Zhou Q, Tang J, Li M, Zhang L, et al. The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC. J Neurosci. 2017;37:7096-7110 pubmed publisher
  56. Kamran M, Bahrami A, Soltani N, Keshavarz M, Farsi L. GABA-induced vasorelaxation mediated by nitric oxide and GABAA receptor in non diabetic and streptozotocin-induced diabetic rat vessels. Gen Physiol Biophys. 2013;32:101-6 pubmed publisher
    ..From the results of this study it may be concluded that the vasorelaxatory effect of GABA is mediated by the GABAA receptor and nitric oxide in both STZ diabetic and non-diabetic vessels. ..
  57. Waldvogel H, Baer K, Gai W, Gilbert R, Rees M, Mohler H, et al. Differential localization of GABAA receptor subunits within the substantia nigra of the human brain: an immunohistochemical study. J Comp Neurol. 2008;506:912-29 pubmed
  58. Wang H, Yin G, Rogers K, Miralles C, De Blas A, Rubio M. Monaural conductive hearing loss alters the expression of the GluA3 AMPA and glycine receptor ?1 subunits in bushy and fusiform cells of the cochlear nucleus. Neuroscience. 2011;199:438-51 pubmed publisher
  59. Fu Z, Washbourne P, Ortinski P, Vicini S. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. J Neurophysiol. 2003;90:3950-7 pubmed
  60. Foley C, Stanton J, Price E, Cunningham J, Hasser E, Heesch C. GABA(A) alpha1 and alpha2 receptor subunit expression in rostral ventrolateral medulla in nonpregnant and pregnant rats. Brain Res. 2003;975:196-206 pubmed
  61. Desrues L, Lefebvre T, Lecointre C, Schouft M, Leprince J, Compère V, et al. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PLoS ONE. 2012;7:e36319 pubmed publisher
    ..This UII-induced disappearance of the repressor activity of GABA(A)R, may play a key role in the initiation of astrocyte proliferation. ..
  62. McIntyre D, Hutcheon B, Schwabe K, Poulter M. Divergent GABA(A) receptor-mediated synaptic transmission in genetically seizure-prone and seizure-resistant rats. J Neurosci. 2002;22:9922-31 pubmed
    ..This suggests that the timing of inhibition, particularly slow inhibitory neurotransmission between nonpyramidal neurons, may be a contributing factor in seizure genesis. ..
  63. You Z, Xia Q, Liang F, Tang Y, Xu C, Huang J, et al. Effects on the expression of GABAA receptor subunits by jujuboside A treatment in rat hippocampal neurons. J Ethnopharmacol. 2010;128:419-23 pubmed publisher
    ..Differences in alterations in GABA(A) receptor subunit mRNAs expression following JuA and DZP treatments could help to explain the differences in the pharmacological action of the two drugs. ..
  64. Jung S, Akabas M, Harris R. Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation. J Biol Chem. 2005;280:308-16 pubmed
    ..Our data show that GABA(A) receptor is a dynamic protein during alcohol modulation and channel gating. ..
  65. Wang J, Li H, Chen X, Mo F, Qi R, Guo J, et al. Temporal change in NMDA receptor signaling and GABAA receptor expression in rat caudal vestibular nucleus during motion sickness habituation. Brain Res. 2012;1461:30-40 pubmed publisher
    ..It suggested that GABA(A) receptor level might be negatively regulated by Arc protein in caudal vestibular nucleus neurons. ..
  66. Pávai Z, Pap Z, Orbán Kis K, Szilagyi T. Quantitative characterization of regional differences in the GABAA-receptor alpha1-subunit mRNA expression in the rat brain. Rom J Morphol Embryol. 2010;51:43-7 pubmed
  67. Feng H, Macdonald R. Proton modulation of alpha 1 beta 3 delta GABAA receptor channel gating and desensitization. J Neurophysiol. 2004;92:1577-85 pubmed
  68. Seeburg P, Wisden W, Verdoorn T, Pritchett D, Werner P, Herb A, et al. The GABAA receptor family: molecular and functional diversity. Cold Spring Harb Symp Quant Biol. 1990;55:29-40 pubmed
  69. Wisden W, Seeburg P. GABAA receptor channels: from subunits to functional entities. Curr Opin Neurobiol. 1992;2:263-9 pubmed
    ..In addition, molecular determinants underlying the differential binding properties of allosteric ligands to receptor subtypes have been identified. ..
  70. Wang J, Cheng W, Xu T, Yang Z. Propofol induces apoptosis and inhibits the proliferation of rat embryonic neural stem cells via gamma-aminobutyric acid type A receptor. Genet Mol Res. 2015;14:14920-8 pubmed publisher
    ..The GABAA receptor mediates propofol-induced apoptosis and proliferation inhibition of rENSCs, possibly by modulating the Chk1/p53 signaling pathway. ..
  71. McDonald A, Mascagni F. Parvalbumin-containing interneurons in the basolateral amygdala express high levels of the alpha1 subunit of the GABAA receptor. J Comp Neurol. 2004;473:137-46 pubmed
    ..The activation of alpha1-containing GABA(A) receptors in the ABL by benzodiazepines may disrupt rhythmic oscillations critical for memory consolidation. ..
  72. Bedford F, Kittler J, Muller E, Thomas P, Uren J, Merlo D, et al. GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat Neurosci. 2001;4:908-16 pubmed
    ..Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes. ..
  73. Vetiska S, Ahmadian G, Ju W, Liu L, Wymann M, Wang Y. GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors. Neuropharmacology. 2007;52:146-55 pubmed
    ..Our results imply a mechanism whereby insulin can regulate changes in synaptic transmission through its downstream actions on the GABAA receptor. ..
  74. Saras A, Gisselmann G, Vogt Eisele A, Erlkamp K, Kletke O, Pusch H, et al. Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. J Biol Chem. 2008;283:10470-5 pubmed publisher
    ..We show here for the first time that histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site. ..
  75. Sengupta J, Pochiraju S, Pochiraju S, Kannampalli P, Bruckert M, Addya S, et al. MicroRNA-mediated GABA A?-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats. Pain. 2013;154:59-70 pubmed publisher
    ..These results support an integral role for miRNA-mediated transcriptional deregulation of the GABAergic system in neonatal cystitis-induced chronic pelvic pain. ..
  76. Rodriguez Pallares J, Caruncho H, Lopez Real A, Wojcik S, Guerra M, Labandeira Garcia J. Rat brain cholinergic, dopaminergic, noradrenergic and serotonergic neurons express GABAA receptors derived from the alpha3 subunit. Receptors Channels. 2001;7:471-8 pubmed
  77. Korol S, Jin Z, Babateen O, Birnir B. GLP-1 and exendin-4 transiently enhance GABAA receptor-mediated synaptic and tonic currents in rat hippocampal CA3 pyramidal neurons. Diabetes. 2015;64:79-89 pubmed publisher
    ..The results demonstrate GLP-1 receptor regulation of hippocampal function and are consistent with GLP-1 receptor agonists enhancing GABAA signaling by pre- and postsynaptic mechanisms. ..
  78. Draguhn A, Verdorn T, Ewert M, Seeburg P, Sakmann B. Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+. Neuron. 1990;5:781-8 pubmed
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    ..Therefore, we have shown that HFS induces significant plasticity in the motor cortex, and has the potential to disrupt performance on a skilled motor task. ..