Gabpa

Summary

Gene Symbol: Gabpa
Description: GA binding protein transcription factor, alpha subunit
Alias: Nrf-2alpha, Nrf2a, GA-binding protein alpha chain, GA binding protein transcription factor, alpha subunit 60kDa, GA repeat binding protein, alpha, nuclear respiratory factor 2 alpha
Species: rat
Products:     Gabpa

Top Publications

  1. Schweppe R, Melton A, Brodsky K, Aveline L, Resing K, Ahn N, et al. Purification and mass spectrometric identification of GA-binding protein (GABP) as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter. J Biol Chem. 2003;278:16863-72 pubmed
    ..Thus, we have identified GABPalpha/GABPbeta1 as a critical and functionally relevant Ets factor that regulates rPRL promoter activity via the BTE site. ..
  2. Izumi M, Yokoi M, Nishikawa N, Miyazawa H, Sugino A, Yamagishi M, et al. Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1. Biochim Biophys Acta. 2000;1492:341-52 pubmed
    ..These data indicate that E2F, GABP and Sp1 regulate the gene expression of this principal replication enzyme. ..
  3. Yang S, Liang H, Ning G, Wong Riley M. Ultrastructural study of depolarization-induced translocation of NRF-2 transcription factor in cultured rat visual cortical neurons. Eur J Neurosci. 2004;19:1153-62 pubmed
    ..Our results also indicate that the cytoplasmic to nuclear movement of transcription factors is a dynamic process induced by neuronal activity. ..
  4. Pang L, Xue H, Szalai G, Wang X, Wang Y, Watson D, et al. Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood. 2006;108:2198-206 pubmed
    ..In concert, these data reveal disparate, but overlapping, functions of Ets transcription factors at distinct stages of megakaryocyte maturation. ..
  5. Sidharthan N, Minchin R, Butcher N. Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J Biol Chem. 2013;288:34364-74 pubmed publisher
    ..Taken together, these results show that dopamine can induce its own metabolism and protect neuron-like cells from damage, suggesting that SULT1A3 activity may be a risk factor for dopamine-dependent neurodegenerative diseases. ..
  6. Zavattari P, Perra A, Menegon S, Kowalik M, Petrelli A, Angioni M, et al. Nrf2, but not β-catenin, mutation represents an early event in rat hepatocarcinogenesis. Hepatology. 2015;62:851-62 pubmed publisher
    ..Moreover, functional experiments demonstrate that Nrf2 is an oncogene critical for HCC progression and development. ..
  7. Demarest T, Schuh R, Waite E, Waddell J, McKenna M, Fiskum G. Sex dependent alterations in mitochondrial electron transport chain proteins following neonatal rat cerebral hypoxic-ischemia. J Bioenerg Biomembr. 2016;48:591-598 pubmed
    ..In conclusion, the female sex-selective increase in ETC proteins following HI may at least partially explain the relative female resilience to mitochondrial respiratory impairment and neuronal death that occur after HI. ..
  8. Pastorcic M, Das H. Ets transcription factors ER81 and Elk1 regulate the transcription of the human presenilin 1 gene promoter. Brain Res Mol Brain Res. 2003;113:57-66 pubmed
    ..However, GABPbeta alone activated PS1 transcription by two- to threefold. In contrast, the more distantly related Ets factor Elk1 repressed PS1 transcription very effectively. ..
  9. Xue H, Bollenbacher J, Rovella V, Tripuraneni R, Du Y, Liu C, et al. GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat Immunol. 2004;5:1036-44 pubmed

More Information

Publications14

  1. Reiff R, Ali B, Baron B, Yu T, Ben Salem S, Coulter M, et al. METTL23, a transcriptional partner of GABPA, is essential for human cognition. Hum Mol Genet. 2014;23:3456-66 pubmed publisher
    ..Overexpressed METTL23 protein localized to both nucleus and cytoplasm, and physically interacted with GABPA (GA-binding protein transcription factor, alpha subunit)...
  2. Du K, Leu J, Peng Y, Taub R. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. J Biol Chem. 1998;273:35208-15 pubmed
    ..The combined effect of small changes in the level of existing transcription factors and mitogenic signals may explain the transcriptional activation of the HRS gene during cell growth. ..
  3. Jaworski A, Smith C, Burden S. GA-binding protein is dispensable for neuromuscular synapse formation and synapse-specific gene expression. Mol Cell Biol. 2007;27:5040-6 pubmed
    ..These data indicate that GABP is dispensable for synapse-specific transcription and maintenance of normal AChR expression at synapses. ..
  4. Iida R, Ueki M, Yasuda T. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Free Radic Biol Med. 2012;52:1413-22 pubmed publisher
    ..These results suggest that M-LPH functions to protect cells from oxidative stress and/or initiation of the mitochondrial apoptotic cascade under stressed conditions. ..
  5. Venoji R, Amirtharaj G, Kini A, Vanaparthi S, Venkatraman A, Ramachandran A. Enteral glutamine differentially regulates Nrf 2 along the villus-crypt axis of the intestine to enhance glutathione levels. J Gastroenterol Hepatol. 2015;30:1740-7 pubmed publisher
    ..The protective effects of glutamine supplementation seem to be most pronounced in the crypt, where it upregulates proliferation, glutathione levels and alters actin dynamics. ..