Gene Symbol: Fth1
Description: ferritin heavy chain 1
Alias: Fth, ferritin heavy chain, Ferritin subunit H, ferritin H subunit, ferritin, heavy polypeptide 1
Species: rat
Products:     Fth1

Top Publications

  1. Han J, Seaman W, Di X, Wang W, Willingham M, Torti F, et al. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS ONE. 2011;6:e23800 pubmed publisher
    ..Iron delivered following binding of HFt to TIM-2 entered the cytosol and became metabolically available, resulting in increased levels of endogenous intracellular ferritin. We conclude that TIM-2 can function as an iron uptake pathway. ..
  2. Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, et al. Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection. Ann N Y Acad Sci. 2007;1119:216-26 pubmed
    ..protein kinase C beta subunit (PKCbeta), excitatory amino acid carrier 1 (EAAC1), and ferritin heavy polypeptide 1 (Fth1), that were upregulated after a 48-h fast compared to the fed status...
  3. Alekseenko A, Waseem T, Fedorovich S. Ferritin, a protein containing iron nanoparticles, induces reactive oxygen species formation and inhibits glutamate uptake in rat brain synaptosomes. Brain Res. 2008;1241:193-200 pubmed publisher
    ..These results indicate that iron-based nanoparticles can cause ROS and decreased glutamate uptake, potentially leading to neurodegeneration. ..
  4. Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee R, Rubin J, et al. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. J Neurosci. 2009;29:2534-44 pubmed publisher
    ..in neurons, leading to alterations of ligand-induced CXCR4 phosphorylation and upregulation of protein ferritin heavy chain (FHC), a negative intracellular regulator of CXCR4...
  5. Ursini M, de Franciscis V. TSH regulation of ferritin H chain messenger RNA levels in the rat thyroids. Biochem Biophys Res Commun. 1988;150:287-95 pubmed
    b>Ferritin heavy chain mRNA steady state levels are increased by thyrotropin both in vivo and in two independent thyroid derived permanent cell lines...
  6. Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
    ..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..
  7. Baillat G, Gaillard S, Castets F, Monneron A. Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. J Biol Chem. 2002;277:18961-6 pubmed
    ..Phocein thus appears to be a component of the complexes involved in some steps of the vesicular traffic machinery. ..
  8. Wu C, Groenink M, Bosma A, Reitsma P, van Deventer S, Chamuleau R. Rat ferritin-H: cDNA cloning, differential expression and localization during hepatocarcinogenesis. Carcinogenesis. 1997;18:47-52 pubmed
  9. Kato J, Fujikawa K, Kanda M, Fukuda N, Sasaki K, Takayama T, et al. A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Am J Hum Genet. 2001;69:191-7 pubmed

More Information


  1. Festa L, Gutoskey C, Graziano A, Waterhouse B, Meucci O. Induction of Interleukin-1β by Human Immunodeficiency Virus-1 Viral Proteins Leads to Increased Levels of Neuronal Ferritin Heavy Chain, Synaptic Injury, and Deficits in Flexible Attention. J Neurosci. 2015;35:10550-61 pubmed publisher
    ..Our studies in humans and nonhuman primates indicated that the protein ferritin heavy chain (FHC) is a critical player in neuronal changes and ensuing cognitive deficit observed in these patients...
  2. Finazzi D, Arosio P. Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Arch Toxicol. 2014;88:1787-802 pubmed publisher
    ..We will also discuss recent evidence connecting ferritins and the toxicity of iron in a set of neurodegenerative disorder characterized by focal cerebral siderosis. ..
  3. Tian Y, Zhao J, Zhao B, Gao Q, Xu J, Liu D. The ratio of sTfR/ferritin is associated with the expression level of TfR in rat bone marrow cells after endurance exercise. Biol Trace Elem Res. 2012;147:261-6 pubmed publisher
    ..01) and sTfR levels (r = 0.206; P < 0.05) in sedentary and exercised rats. In conclusion, we show that sTfR indices and the ratio of sTfR/ferritin could be useful indicators for monitoring iron deficiency during endurance training. ..
  4. Omiya S, Hikoso S, Imanishi Y, Saito A, Yamaguchi O, Takeda T, et al. Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes. J Mol Cell Cardiol. 2009;46:59-66 pubmed publisher
    b>Ferritin heavy chain (FHC) protein was significantly reduced in murine failing hearts following left coronary ligation or thoracic transverse aortic constriction...
  5. Ferreira C, Bucchini D, Martin M, Levi S, Arosio P, Grandchamp B, et al. Early embryonic lethality of H ferritin gene deletion in mice. J Biol Chem. 2000;275:3021-4 pubmed
    ..significance of the ferroxidase activity associated with the H subunit, we disrupted the H ferritin gene (Fth) in mice by homologous recombination...
  6. Leibold E, Aziz N, Brown A, Munro H. Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit. J Biol Chem. 1984;259:4327-34 pubmed
    ..The H-subunit sequence did not contain the octopeptide found as part of the L-subunit sequence. ..
  7. Murray M, White K, Munro H. Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression. Proc Natl Acad Sci U S A. 1987;84:7438-42 pubmed
  8. Thulluri S, Wu M, Blough E, Manne N, Litchfield A, Wang B. Regulation of iron-related molecules in the rat hippocampus: sex- and age-associated differences. Ann Clin Lab Sci. 2012;42:145-51 pubmed
    ..participate in regulating free iron levels (heme oxygenase 1 (HO1), iron-regulatory protein 1 (IRP1), and ferritin heavy chain (FTH)) and whether changes in the expression of these molecules are associated with differences in the ..
  9. Krawetz S, Connor W, Cannon P, Dixon G. A vector-primer-cloner-sequencer plasmid for the construction of cDNA libraries: evidence for a rat glyceraldehyde-3-phosphate dehydrogenase-like mRNA and a ferritin mRNA within testis. DNA. 1986;5:427-35 pubmed
    ..The utility of this VPCS has been demonstrated by isolating a rat ferritin and glyceraldehyde-3-phosphate dehydrogenase-like clone. ..
  10. Wu K, Polack A, Dalla Favera R. Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science. 1999;283:676-9 pubmed
    ..These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC. ..
  11. Li Y, He Y, Guan Q, Liu W, Han H, Nie Z. Disrupted iron metabolism and ensuing oxidative stress may mediate cognitive dysfunction induced by chronic cerebral hypoperfusion. Biol Trace Elem Res. 2012;150:242-8 pubmed publisher
    ..Western blotting revealed that the expression levels of ferritin heavy chain and the transferrin receptor were significantly elevated in hippocampus and cortex after CCH, whereas ..