Gene Symbol: Fpgs
Description: folylpolyglutamate synthase
Alias: folylpolyglutamate synthase, mitochondrial
Bolanowska W, Russell C, McGuire J. Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate. Arch Biochem Biophys. 1990;281:198-203 pubmed
NaHCO3 activated the folylpolyglutamate synthetase (FPGS) from rat liver and the human leukemia cell lines K562 and CCRF-CEM by 1.7- to 2.0-fold...
Galivan J, Ryan T, Chave K, Rhee M, Yao R, Yin D. Glutamyl hydrolase. pharmacological role and enzymatic characterization. Pharmacol Ther. 2000;85:207-15 pubmed
..GH is being evaluated as an intracellular target for inhibition in order to enhance the therapeutic activity of antifolates and fluorouracil. ..
Lawrence S, Titus S, Ferguson J, Heineman A, Taylor S, Moran R. Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates. J Biol Chem. 2014;289:29386-96 pubmed publisher
Folylpoly-Î³-glutamate synthetase (FPGS) catalyze the addition of multiple glutamates to tetrahydrofolate derivatives. Two mRNAs for the fpgs gene direct isoforms of FPGS to the cytosol and to mitochondria in mouse and human tissues...
Tolomelli B, Marchi Marchetti M, Laffi R, Marchetti M. Folylpolyglutamate synthetase activity in regenerating rat liver. Int J Vitam Nutr Res. 1987;57:169-72 pubmed
McGuire J, Hsieh P, Coward J, Bertino J. In vitro methotrexate polyglutamate synthesis by rat liver folylpolyglutamate synthetase and inhibition by bromosulfophthalein. Adv Exp Med Biol. 1983;163:199-214 pubmed
..Since BSP is transported into mammalian cells, it is the first inhibitor of polyglutamate biosynthesis which has potential for use in in vivo studies. ..
Schneider E, Ryan T. Gamma-glutamyl hydrolase and drug resistance. Clin Chim Acta. 2006;374:25-32 pubmed
..Finally, there have been reports suggesting that gamma-glutamyl hydrolase plays a role as a tumor marker in breast and lung cancer. ..
Barredo J, Moran R. Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. Mol Pharmacol. 1992;42:687-94 pubmed
..range of folate antimetabolites to polyglutamate derivatives by the enzyme folylpoly-gamma-glutamate synthetase (FPGS)...
McGuire J, Hsieh P, Coward J, Bertino J. Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products. J Biol Chem. 1980;255:5776-88 pubmed
..Inhibition by the specificity of the rat liver synthetase. Inhibition by the pentaglutamate derivative offers a means by which folylpolyglutamates could regulate their own synthesis. ..
Clarke L, Waxman D. Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. Arch Biochem Biophys. 1987;256:585-96 pubmed
Folylpolyglutamate synthetase (FPGS) was isolated from human liver cytosol by 0-30% (w/v) ammonium sulfate fractionation and characterized biochemically...