Gene Symbol: Foxo1
Description: forkhead box O1
Alias: Fkhr, Foxo1a, forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, forkhead box O1A (rhabdomyosarcoma)
Species: rat
Products:     Foxo1

Top Publications

  1. Speckmann B, Walter P, Alili L, Reinehr R, Sies H, Klotz L, et al. Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors. Hepatology. 2008;48:1998-2006 pubmed publisher
    ..Recently, we reported stimulation of SeP promoter activity by the forkhead box transcription factor FoxO1a in hepatoma cells and its attenuation by insulin...
  2. Miao C, Luo Q, Wang W, Kang J, Shi G, Li H, et al. [Significance and expression of FKHR and AKT after subarachnoid hemorrhage in rat brain cortex]. Zhonghua Yi Xue Za Zhi. 2010;90:1507-9 pubmed
    To study the significance and expression of FKHR and AKT after subarachnoid hemorrhage (SAH) in rat brain cortex. Twenty-four rats were randomly divided into three groups: sham, SAH and SAH plus nimodipine (n=8 each)...
  3. Puthanveetil P, Wang Y, Zhang D, Wang F, Kim M, Innis S, et al. Cardiac triglyceride accumulation following acute lipid excess occurs through activation of a FoxO1-iNOS-CD36 pathway. Free Radic Biol Med. 2011;51:352-63 pubmed publisher
    ..Related to nutrient excess, FoxO1 has a role in regulating fatty acid uptake and oxidation and triglyceride (TG) storage by mechanisms that are ..
  4. Rena G, Prescott A, Guo S, Cohen P, Unterman T. Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting. Biochem J. 2001;354:605-12 pubmed
    The transcription factor, forkhead in rhabdomyosarcoma (FKHR), is phosphorylated at three amino acid residues (Thr-24, Ser-256 and Ser-319) by protein kinase B (PKB)alpha...
  5. Smith I, Alamdari N, O Neal P, Gonnella P, Aversa Z, Hasselgren P. Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism. Int J Biochem Cell Biol. 2010;42:701-11 pubmed publisher
    ..Sepsis in rats increased muscle FOXO1 and 3a mRNA and protein levels but did not influence FOXO4 expression...
  6. Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol. 2010;12:665-75 pubmed publisher
    ..Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy...
  7. Zhang X, Yong W, Lv J, Zhu Y, Zhang J, Chen F, et al. Inhibition of forkhead box O1 protects pancreatic beta-cells against dexamethasone-induced dysfunction. Endocrinology. 2009;150:4065-73 pubmed publisher
    Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types...
  8. Paik J, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun W, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009;5:540-53 pubmed publisher
    ..Here, we report the impact of combined FoxO1, 3, and 4 deficiencies on mammalian brain physiology with a particular emphasis on the study of the neural stem/..
  9. Ochi E, Hirose T, Hiranuma K, Min S, Ishii N, Nakazato K. Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle. J Appl Physiol (1985). 2010;108:306-13 pubmed publisher
    ..mTOR)(P), 70-kDa ribosomal protein S6 kinase (P70S6k), P70S6k(P), forkhead transcription factor 1 of the O class (FOXO1), FOXO1(P), FOXO3, FOXO3(P), myostatin, and activin receptor type IIB (ActRIIB) were measured...

More Information


  1. Nagatomo F, Fujino H, Kondo H, Suzuki H, Kouzaki M, Takeda I, et al. PGC-1? and FOXO1 mRNA levels and fiber characteristics of the soleus and plantaris muscles in rats after hindlimb unloading. Histol Histopathol. 2011;26:1545-53 pubmed publisher
    ..The peroxisome proliferator-activated receptor ? coactivator-1? (PGC-1?) and forkhead box-containing protein O1 (FOXO1) mRNA levels and fiber profiles of the soleus and plantaris muscles in rats subjected to unloading (unloaded group)..
  2. Guan X, Liu X, Hong X, Zhao N, Xiao Y, Wang L, et al. CD38 Deficiency Protects the Heart from Ischemia/Reperfusion Injury through Activating SIRT1/FOXOs-Mediated Antioxidative Stress Pathway. Oxid Med Cell Longev. 2016;2016:7410257 pubmed publisher
    ..The FOXO1 and FOXO3 expressions were significantly elevated by H/R injury in CD38 knockdown cells compared with normal H9c2 ..
  3. Kloting N, Bluher M, Kloting I. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Diabetes Metab Res Rev. 2006;22:146-54 pubmed
    ..dehydrogenase (11beta Hsd), peroxisome proliferator-activated receptor gamma (Ppar gamma), forkhead box O1 (Foxo1), glucose transporter 4 (Glut4), CCAAT/enhancer binding protein (C/ebp alpha), and fatty acid synthase (Fasn) were ..
  4. Li Y, Hu N, Yang D, Oxenkrug G, Yang Q. Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism. FEBS J. 2017;284:948-966 pubmed publisher
    ..Melatonin treatment up-regulated the expression of forkhead box protein O1 (FoxO1) and enhanced the binding of FoxO1 to the IDO1 promoter...
  5. Ropelle E, Pauli J, Prada P, Cintra D, Rocha G, Moraes J, et al. Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. J Physiol. 2009;587:2341-51 pubmed publisher
    Insulin signalling in the hypothalamus plays a role in maintaining body weight. The forkhead transcription factor Foxo1 is an important mediator of insulin signalling in the hypothalamus...
  6. Zareen N, Biswas S, Greene L. A feed-forward loop involving Trib3, Akt and FoxO mediates death of NGF-deprived neurons. Cell Death Differ. 2013;20:1719-30 pubmed publisher
    ..b>FoxO1a, a direct Akt substrate, is dephosphorylated upon NGF withdrawal and consequently undergoes nuclear translocation ..
  7. Wang F, Tong Q. SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell. 2009;20:801-8 pubmed publisher
    ..Mechanistically, SIRT2 suppresses adipogenesis by deacetylating FOXO1 to promote FOXO1's binding to PPARgamma and subsequent repression on PPARgamma transcriptional activity...
  8. Milkiewicz M, Roudier E, Doyle J, Trifonova A, Birot O, Haas T. Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle. Am J Pathol. 2011;178:935-44 pubmed publisher
    ..We studied the regulation of FoxO1 protein in ischemic rat skeletal muscle following iliac artery ligation and in cultured endothelial cells...
  9. Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens J, Ishihara O. Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Med Mol Morphol. 2009;42:216-21 pubmed publisher
    ..mechanism of follicular atresia, we also examined the expression and localization of forkhead transcription factor FOXO1, a major regulator of cell fate decisions such as differentiation, cell-cycle arrest, and cell death...
  10. Sheng F, Ren X, Dai X, Xu X, Dong M, Pei Q, et al. Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011;36:958-63 pubmed publisher
    ..and gene expressions of pancreatic and duodenal homeobox 1(PDX-1) and forkhead box-containing protein O-1 (FoxO1), which were important transcription factors for insulin secretion...
  11. Sengupta A, Kalinichenko V, Yutzey K. FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation. Circ Res. 2013;112:267-77 pubmed publisher
    ..transcription factors have been implicated as positive (forkhead box [Fox] transcription factor M1) and negative (FoxO1 and FoxO3) regulators of cardiomyocyte proliferation prenatally, but their regulatory interactions and functions ..
  12. Wang Y, Lin H, Hao N, Zhu Z, Wang D, Li Y, et al. Forkhead box O1 mediates defects in palmitate-induced insulin granule exocytosis by downregulation of calcium/calmodulin-dependent serine protein kinase expression in INS-1 cells. Diabetologia. 2015;58:1272-81 pubmed publisher
    The transcription factor forkhead box O1 (FOXO1) induces pancreatic islet beta cell endoplasmic reticulum stress and is involved in fatty-acid-induced insulin-secretion defects. Cask is a downstream target gene of FOXO1...
  13. Khan S, Kumar S, Jena G. Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat. Biochimie. 2016;125:42-52 pubmed publisher
    ..on the anti-diabetic role of VPA in type-2 diabetes mellitus by the modulation of insulin signaling and forkhead box protein O1 (FOXO1)-mediated gluconeogenesis...
  14. Housley M, Rodgers J, Udeshi N, Kelly T, Shabanowitz J, Hunt D, et al. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008;283:16283-92 pubmed publisher
    ..The transcription factor FoxO1 activates expression of gluconeogenic, including phosphoenolpyruvate carboxykinase and glucose-6-phosphatase, and ..
  15. Shen B, Chao L, Chao J. Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress. Am J Physiol Heart Circ Physiol. 2010;298:H1048-54 pubmed publisher
    ..endothelial nitric oxide synthase expression through activation of the transcription factor forkhead box O 1 (FOXO1) in cultured endothelial cells...
  16. Wu L, Guo F, Wu Y, Wang Q, Ma X, Zhao Y, et al. The role of FoxO1 in interleukin-1β-induced autostimulation in retina endothelial cells and retinas of diabetic rats. Microvasc Res. 2017;112:93-100 pubmed publisher
    ..The present study aimed to investigate the effect of forkhead transcription factor O1 (FoxO1) expression on interleukin-1β (IL-1β)-induced autostimulation, both in vitro in human retina microvascular ..
  17. Xiong S, Salazar G, Patrushev N, Alexander R. FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J Biol Chem. 2011;286:5289-99 pubmed publisher
    Forkhead transcription factor FoxO1 and the NAD(+)-dependent histone deacetylase SIRT1 are evolutionarily conserved regulators of the development of aging, oxidative stress resistance, insulin resistance, and metabolism in species ..
  18. Dou C, Li N, Ding N, Liu C, Yang X, Kang F, et al. HDAC2 regulates FoxO1 during RANKL-induced osteoclastogenesis. Am J Physiol Cell Physiol. 2016;310:C780-7 pubmed publisher
    ..Mechanistically, upon RANKL activation, HDAC2 activated Akt; Akt directly phosphorylates and abrogates Forkhead box protein O1 (FoxO1), which is a negative regulator during osteoclastogenesis through reducing reactive oxygen species...
  19. Savai R, Al tamari H, Sedding D, Kojonazarov B, Muecke C, Teske R, et al. Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension. Nat Med. 2014;20:1289-300 pubmed publisher
    ..Here we show that in pulmonary vessels and PASMCs of human and experimental PH lungs, FoxO1 expression is downregulated and FoxO1 is inactivated via phosphorylation and nuclear exclusion...
  20. Alejandro E, Lim G, Mehran A, Hu X, Taghizadeh F, Pelipeychenko D, et al. Pancreatic ?-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription. FASEB J. 2011;25:3884-95 pubmed publisher
    ..Our data further indicate that Raf-1 specifically and acutely regulates insulin 2 mRNA via negative action on Foxo1, which has been shown to selectively control the insulin 2 gene...
  21. Puthanveetil P, Zhang D, Wang Y, Wang F, Wan A, Abrahani A, et al. Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1. J Mol Cell Cardiol. 2012;53:677-86 pubmed publisher
    ..We hypothesized that following diabetes, an increased nuclear presence of the Forkhead transcription factor, FoxO1, could turn on cardiac cell death through mediation of nitrosative stress...
  22. Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, et al. A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 2007;5:450-63 pubmed
    ..Thus, Bsx represents an essential factor for NPY/AgRP neuronal function and locomotory behavior in the control of energy balance. ..
  23. Wen Q, Duan X, Liao R, Little P, Gao G, Jiang H, et al. Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells. Neurosci Lett. 2011;498:31-6 pubmed publisher
    ..We examined the effects of nerve growth factor (NGF) on nuclear/cytoplasmic shuttling of FoxO1, FoxO3a and FoxO6 in PC12 cells and determined their translocation kinetics...
  24. Armoni M, Harel C, Karni S, Chen H, Bar Yoseph F, Ver M, et al. FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity. J Biol Chem. 2006;281:19881-91 pubmed
    b>FOXO1 and peroxisome proliferator-activated receptor-gamma (PPARgamma) are crucial transcription factors that regulate glucose metabolism and insulin responsiveness in insulin target tissues...
  25. Ni Y, Berenji K, Wang N, Oh M, Sachan N, Dey A, et al. Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation. 2006;114:1159-68 pubmed
    ..However, downstream molecular events are not yet well defined. Here, we report that expression of either Foxo1 or Foxo3 in cardiomyocytes attenuates calcineurin phosphatase activity and inhibits agonist-induced hypertrophic ..
  26. Qin G, Zhou Y, Guo F, Ren L, Wu L, Zhang Y, et al. Overexpression of the FoxO1 Ameliorates Mesangial Cell Dysfunction in Male Diabetic Rats. Mol Endocrinol. 2015;29:1080-91 pubmed
    ..This study was designed to determine the function of forkhead box protein O1 (FoxO1), an important transcription factors in regulating cell metabolism and oxidative stress, in MCs in ..
  27. Ganopolsky J, Abid M, Aird W, Blostein M. GAS6-induced signaling in human endothelial cells is mediated by FOXO1a. J Thromb Haemost. 2008;6:1804-11 pubmed publisher
    ..vein endothelial cells (HUVECs) with gas6 induced time-dependent phosphorylation and nuclear exclusion of FOXO1a. This effect was suppressed by the PI3K inhibitor wortmannin, demonstrating that FOXO1a phosphorylation is PI3-..
  28. Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev. 2005;19:2783-810 pubmed
    ..Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior. ..
  29. Nozaki T, Ohura K. Regulation of miRNA during direct reprogramming of dental pulp cells to insulin-producing cells. Biochem Biophys Res Commun. 2014;444:195-8 pubmed publisher
    ..identified 242 conserved targets, including molecules crucial for the development of pancreatic beta-cells such as Foxo1. These findings indicate that dental pulp cells have potential for direct reprogramming to insulin-producing cells...
  30. Das F, Ghosh Choudhury N, Dey N, Bera A, Mariappan M, Kasinath B, et al. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. J Biol Chem. 2014;289:32703-16 pubmed publisher
    ..Here we show Akt-dependent phosphorylation of the transcription factor FoxO1 by high glucose...
  31. Gomez Crisostomo N, Rodríguez Martínez E, Rivas Arancibia S. Oxidative stress activates the transcription factors FoxO 1a and FoxO 3a in the hippocampus of rats exposed to low doses of ozone. Oxid Med Cell Longev. 2014;2014:805764 pubmed publisher
    ..The results indicate that ozone alters regulatory pathways related to both the antioxidant system and the cell cycle, inducing neuronal reentry into the cell cycle and apoptotic death. ..
  32. Al Mubarak B, Soriano F, Hardingham G. Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene. Channels (Austin). 2009;3:233-8 pubmed
    ..The predominant neuronal FOXOs, FOXO1 and FOXO3, promote the expression of pro-death genes, such as Fas Ligand, Bim and Txnip...
  33. Cui X, Wang C, Li L, Fan D, Zhou Y, Wu D, et al. Insulin decreases myocardial adiponectin receptor 1 expression via PI3K/Akt and FoxO1 pathway. Cardiovasc Res. 2012;93:69-78 pubmed publisher
    ..Insulin induced forkhead/winged helix box gene group O-1 (FoxO1) phosphorylation and translocation from the nucleus to the cytosol, and this was blocked by LY294002...
  34. Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren P. PPAR?/? regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS ONE. 2013;8:e59726 pubmed publisher
    b>FOXO1 is involved in glucocorticoid- and sepsis-induced muscle wasting, in part reflecting regulation of atrogin-1 and MuRF1. Mechanisms influencing FOXO1 expression in muscle wasting are poorly understood...
  35. Hannenhalli S, Putt M, Gilmore J, Wang J, Parmacek M, Epstein J, et al. Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation. 2006;114:1269-76 pubmed
    ..These findings provide a crucial link between animal models and human disease and suggest a specific role for FOX signaling in modulating the hypertrophic response of the heart to stress in humans. ..
  36. Hellwinkel O, Rogmann J, Asong L, Luebke A, Eichelberg C, Ahyai S, et al. A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer. BJU Int. 2008;101:1454-60 pubmed publisher
    ..Also, parts of the pathway are deviant in normal tumour-adjacent tissue; this might represent a reaction to neighbouring tumours or be a sign of pre-cancerous biological alterations. ..
  37. Jacobs F, van der Heide L, Wijchers P, Burbach J, Hoekman M, Smidt M. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. J Biol Chem. 2003;278:35959-67 pubmed
    ..localization after stimulation with growth factors, in contrast to the predominant cytosolic localization of FoxO1 and FoxO3...
  38. Woods Y, Rena G, Morrice N, Barthel A, Becker W, Guo S, et al. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. Biochem J. 2001;355:597-607 pubmed
    b>Forkhead in rhabdomyosarcoma (FKHR) is a transcription factor that has been implicated in the control of gene expression by insulin, as well as the regulation of apoptosis by survival factors...
  39. Hughes K, Meares G, Hansen P, Corbett J. FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. J Biol Chem. 2011;286:8338-48 pubmed publisher
    ..In this report, a role for FoxO1-dependent transcriptional activation and its regulation by SIRT1 in determining the cellular response to nitric ..
  40. Wu K, Cappel D, Martinez M, STAFFORD J. Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein. Endocrinology. 2010;151:3566-76 pubmed publisher
    ..Under low-insulin conditions, serum VLDL levels were increased 4.7-fold after hyperglycemia, and forkhead box O1 (FoxO1) was not excluded from the nucleus of liver cells...
  41. Perrot V, Rechler M. Characterization of insulin inhibition of transactivation by a C-terminal fragment of the forkhead transcription factor Foxo1 in rat hepatoma cells. J Biol Chem. 2003;278:26111-9 pubmed
    The transcription factor Foxo1 controls the expression of genes involved in fundamental cellular processes...
  42. Deng C, Wu D, Yang M, Chen Y, Wang C, Zhong Z, et al. Expression of tissue factor and forkhead box transcription factor O-1 in a rat model for chronic thromboembolic pulmonary hypertension. J Thromb Thrombolysis. 2016;42:520-8 pubmed publisher
    Few reports have examined tissue factor (TF) and forkhead box transcription factor O-1 (FoxO1) expression in chronic thromboembolic pulmonary hypertension (CTEPH) animal models...
  43. Yasui A, Nishizawa H, Okuno Y, Morita K, Kobayashi H, Kawai K, et al. Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor. Biochem Biophys Res Commun. 2007;364:358-65 pubmed
    ..3-kinase (PI3K) inhibitor, LY294002, and was abolished in C2C12 myocytes stably expressing a constitutively active Foxo1 (Foxo1-3A), suggesting the involvement of Foxo1 in the regulation of musclin mRNA...
  44. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs W, Wright C, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest. 2002;110:1839-47 pubmed
    ..We report that haploinsufficiency for the forkhead transcription factor Foxo1 reverses beta cell failure in Irs2(-/-) mice through partial restoration of beta cell proliferation and increased ..
  45. Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida Araki K, et al. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004;279:34741-9 pubmed
    Members of the Foxo family, Foxo1 (Fkhr), Foxo3 (Fkhrl1), and Foxo4 (Afx), are mammalian homologs of daf-16, which influences life span and energy metabolism in Caenorhabditis elegans...
  46. Margue C, Bernasconi M, Barr F, Schafer B. Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene. 2000;19:2921-9 pubmed
    The aberrant expression of the transcription factors PAX3 and PAX3/FKHR associated with rhabdomyosarcoma (RMS), solid tumors displaying muscle cell features, suggests that these proteins play an important role in the pathogenesis of RMS...
  47. Lee K, Ochi E, Song H, Nakazato K. Activation of AMP-activated protein kinase induce expression of FoxO1, FoxO3a, and myostatin after exercise-induced muscle damage. Biochem Biophys Res Commun. 2015;466:289-94 pubmed publisher
    ..We previously found that levels of Forkhead box proteins, FoxO1 and FoxO3a, and myostatin in rat gastrocnemius increased after exercise-induced muscle damage (EIMD)...
  48. Andreucci M, Michael A, Kramers C, Park K, Chen A, Matthaeus T, et al. Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1. Kidney Int. 2003;64:1189-98 pubmed
    ..We have found that none of the forkhead family of proteins, FKHR, is phosphorylated after ischemia/reperfusion in the rat kidney...
  49. Wang X, Chen L, Maures T, Herrington J, Carter Su C. SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. J Biol Chem. 2004;279:133-41 pubmed
    ..Akt effector proteins, glycogen synthase kinase-3, and forkhead transcription factors, FKHRL1/FOXO3 and FKHR/FOXO1. Immunolocalization studies indicated that, although ectopically expressed FKHR was primarily concentrated in the ..
  50. You H, Laychock S. Atrial natriuretic peptide promotes pancreatic islet beta-cell growth and Akt/Foxo1a/cyclin D2 signaling. Endocrinology. 2009;150:5455-65 pubmed publisher
    ..ANP and 8-Br-cGMP stimulated the phosphorylation of Akt and Foxo1a in INS-1E cells and islets, and LY294002 inhibited these responses...
  51. Ma Y, Wang X, Peng Y, Ding X. Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24. Mol Med Rep. 2016;13:2991-8 pubmed publisher
    ..In the present study, the role of forkhead box O1 (Foxo1) was investigated (which is a key regulatory factor in β‑cell function) in the apoptotic behavior of β..
  52. Herndon M, Law N, Donaubauer E, Kyriss B, Hunzicker Dunn M. Forkhead box O member FOXO1 regulates the majority of follicle-stimulating hormone responsive genes in ovarian granulosa cells. Mol Cell Endocrinol. 2016;434:116-26 pubmed publisher
    ..One pathway activated by FSH in granulosa cells (GCs) is phosphatidylinositol-3 kinase/AKT. The AKT target FOXO1 is reported to function primarily as a repressor of FSH genes, including Ccnd2 and Inha...
  53. Yuan Z, Lehtinen M, Merlo P, Villen J, Gygi S, Bonni A. Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem. 2009;284:11285-92 pubmed publisher
    ..Here, we show that MST1-induced phosphorylation of FOXO1 at serine 212, corresponding to serine 207 in FOXO3, disrupts the association of FOXO1 with 14-3-3 proteins...
  54. Biggs W, Cavenee W, Arden K. Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome. 2001;12:416-25 pubmed
    Genetic alterations of FKHR (FOXO1), AF6q21 (FOXO2), and AFX (FOXO4), closely related members of the forkhead family of DNA binding proteins, in human cancers has suggested they play a role in the regulation of cellular differentiation ..
  55. Kibbe C, Chen J, Xu G, Jing G, Shalev A. FOXO1 competes with carbohydrate response element-binding protein (ChREBP) and inhibits thioredoxin-interacting protein (TXNIP) transcription in pancreatic beta cells. J Biol Chem. 2013;288:23194-202 pubmed publisher
    ..The forkhead boxO1 transcription factor (FOXO1) has been reported to up-regulate TXNIP expression in neurons and endothelial cells but to down-regulate TXNIP in ..
  56. Jing E, Gesta S, Kahn C. SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 2007;6:105-14 pubmed
    ..The mechanism underlying the effects of reduced SIRT2 in 3T3-L1 adipocytes includes increased acetylation of FOXO1, with direct interaction between SIRT2 and FOXO1...
  57. Fritzius T, Moelling K. Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J. 2008;27:1399-410 pubmed publisher
    ..Furthermore, ProF overexpression leads to increased adipogenesis. ProF binds to the transcription factor Foxo1 (Forkhead box O1), a negative regulator of insulin action and adipogenesis, and facilitates the phosphorylation ..
  58. Park H, Carr J, Wang Z, Nogueira V, Hay N, Tyner A, et al. FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 2009;28:2908-18 pubmed publisher
    ..Together, our results identify FoxM1 as a key regulator of ROS in dividing cells, and provide insights into the mechanism how tumour cells use FoxM1 to control oxidative stress to escape premature senescence and apoptosis. ..
  59. Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung S, et al. Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am J Physiol Endocrinol Metab. 2003;285:E718-28 pubmed
    ..The forkhead transcription factor Foxo1 has been implicated as a mediator of insulin action in regulating hepatic gluconeogenesis, and a Foxo1 mutant (..
  60. Kamagate A, Qu S, Perdomo G, Su D, Kim D, Slusher S, et al. FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest. 2008;118:2347-64 pubmed publisher
    ..To characterize the underlying mechanism, we studied hepatic MTP regulation by forkhead box O1 (FoxO1), a transcription factor that plays a key role in hepatic insulin signaling...
  61. Ju S, Zhao Y, Chang X, Guo L. Orexin A protects cells from apoptosis by regulating FoxO1 and mTORC1 through the OX1R/PI3K/AKT signaling pathway in hepatocytes. Int J Mol Med. 2014;34:153-9 pubmed publisher
    ..Additionally, inhibition studies showed that orexin A induced forkhead box O1 (FoxO1) and mammalian target of rapamycin 1 (mTORC1) phosphorylation, while OX1R antagonist (SB334867, 10(-6) M), AKT ..
  62. Schmoll D, Walker K, Alessi D, Grempler R, Burchell A, Guo S, et al. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. J Biol Chem. 2000;275:36324-33 pubmed
    ..Coexpression of the Forkhead transcription factor FKHR stimulates the glucose-6-phosphatase promoter activity via interaction with an insulin response unit (IRU), and ..
  63. Essers M, de Vries Smits L, Barker N, Polderman P, Burgering B, Korswagen H. Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science. 2005;308:1181-4 pubmed
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress. ..
  64. Hosaka T, Biggs W, Tieu D, Boyer A, Varki N, Cavenee W, et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A. 2004;101:2975-80 pubmed
    ..The mammalian orthologs of DAF-16, the closely-related FOXO subclass of forkhead transcription factors (FKHR/FOXO1, FKHRL1/FOXO3a, and AFX/FOXO4), also have important roles in cell cycle arrest, apoptosis and stress responses in ..
  65. Zhang X, Gan L, Pan H, Guo S, He X, Olson S, et al. Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J Biol Chem. 2002;277:45276-84 pubmed
    b>FKHR is a member of the FOXO subfamily of Forkhead transcription factors, which are important targets for insulin and growth factor signaling...
  66. Walter P, Steinbrenner H, Barthel A, Klotz L. Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor. Biochem Biophys Res Commun. 2008;365:316-21 pubmed
    ..We here demonstrate that the human SeP promoter responds to overexpression of FoxO1a as well as of a constitutively active form of FoxO1a...
  67. Huang Z, Kataoka M, Chen J, Wu G, Ding J, Nie M, et al. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015;125:4122-34 pubmed publisher
    ..Transcriptome analyses of CIP-deficient hearts revealed that the p53- and FOXO1-mediated gene networks related to homeostasis are disturbed upon pressure overload stress...
  68. Chen F, Zhu Y, Tang X, Sun Y, Jia W, Sun Y, et al. Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic ?-cells dysfunction. Endocrinology. 2011;152:1779-88 pubmed publisher
    ..However, the molecular mechanism underlying the regulation of FoxO1 and PDX-1 expression in ?-cells treated with DEX is not fully understood...
  69. Perilhou A, Tourrel Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, et al. The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1- and ChREBP-controlled pathways. Mol Cell Biol. 2008;28:6568-79 pubmed publisher
    ..pancreatic beta cells, COUP-TFII gene expression is repressed by secreted insulin in response to glucose through Foxo1 signaling. Ex vivo COUP-TFII reduces insulin production and secretion...
  70. Kato S, Ding J, Pisck E, Jhala U, Du K. COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression. J Biol Chem. 2008;283:35464-73 pubmed publisher
    ..Here we report that COP1, whose expression is enhanced by insulin, regulates FoxO1 protein stability...
  71. Tsai W, Bhattacharyya N, Han L, Hanover J, Rechler M. Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Endocrinology. 2003;144:5615-22 pubmed
    ..In the present study we mutated Leu375 to alanine in the nuclear export signal of Foxo1 (mouse FOXO1), so that it would remain in the nucleus of H4IIE rat hepatoma cells after insulin treatment, and ..
  72. Chen B, Xiong Z, Zhang C, Ma Y, Meng R, Chen G, et al. [Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:2419-22 pubmed
    To investigate the effects of AICAR on the activity of transcription factor FOXO1 and expression of ubiquitin ligase MuRF1 in rat cardiomyocytes, and explore the possible role of AMP-activated protein kinase (AMPK) in proteolysis ..
  73. Philip Couderc P, Tavares N, Roatti A, Lerch R, Montessuit C, Baertschi A. Forkhead transcription factors coordinate expression of myocardial KATP channel subunits and energy metabolism. Circ Res. 2008;102:e20-35 pubmed publisher
    ..In electrophoretic mobility-shift assays, FoxO1 binds to the FoxO concensus site of the KATP channel subunit KIR6.1 promoter...
  74. Portal Nuñez S, Cruces J, Gutiérrez Rojas I, Lozano D, Ardura J, Villanueva Peñacarrillo M, et al. The vertebrae of prematurely aging mice as a skeletal model of involutional osteoporosis. Histol Histopathol. 2013;28:1473-81 pubmed publisher
    ..5 in NPAM vs 1.9±0.2 in PAM; p?0.01). This was associated with increased expression of oxidative stress markers, Foxo1 and GADD45, in PAM vertebrae...
  75. Zimmer J, Takahashi T, Hofmann A, Puri P. Downregulation of Forkhead box F1 gene expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Pediatr Surg Int. 2016;32:1121-1126 pubmed
    ..In human and experimental models of arterial PH, the Fox protein FoxO1 was found to be downregulated...
  76. Zhou Y, Lee J, Reno C, Sun C, Park S, Chung J, et al. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011;17:356-65 pubmed publisher
    ..Here we show that XBP-1s interacts with the Forkhead box O1 (FoxO1) transcription factor and directs it toward proteasome-mediated degradation...
  77. Deng X, Zhang W, O Sullivan I, Williams J, Dong Q, Park E, et al. FoxO1 inhibits sterol regulatory element-binding protein-1c (SREBP-1c) gene expression via transcription factors Sp1 and SREBP-1c. J Biol Chem. 2012;287:20132-43 pubmed publisher
    ..b>FoxO1, a forkhead box class-O transcription factor, is an important mediator of insulin action, but its role in the ..
  78. Guo F, Zhang Y, Wang Q, Ren L, Zhou Y, Ma X, et al. Effects of FoxO1 on podocyte injury in diabetic rats. Biochem Biophys Res Commun. 2015;466:260-6 pubmed publisher
    This study was designed to investigate the protective effect of forkhead transcription factor O1 (FoxO1) on podocyte injury in rats with diabetic nephropathy...
  79. Yan L, Guo S, Brault M, Harmon J, Robertson R, Hamid R, et al. The B55?-containing PP2A holoenzyme dephosphorylates FOXO1 in islet ?-cells under oxidative stress. Biochem J. 2012;444:239-47 pubmed publisher
    The FOXO1 (forkhead box O1) transcription factor influences many key cellular processes, including those important in metabolism, proliferation and cell death...
  80. Nagashima T, Shigematsu N, Maruki R, Urano Y, Tanaka H, Shimaya A, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010;78:961-70 pubmed publisher
    ..The forkhead transcription factor forkhead box O1 (Foxo1) plays a crucial role in mediating the effect of insulin on hepatic gluconeogenesis...
  81. Orth H, Krüger K, Schmoll D, Grempler R, Scherbaum W, Joost H, et al. Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a). Regul Pept. 2004;121:19-24 pubmed
    The transcription factor FKHR (FOXO1a) is regulated by protein kinase B (PKB) and insulin controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins...
  82. Li F, Xie P, Fan Y, Zhang H, Zheng L, Gu D, et al. C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1. J Biol Chem. 2009;284:20090-8 pubmed publisher
    ..However, the ubiquitin ligases responsible for the degradation of FoxO1 and the relevance of this regulation to smooth muscle cell (SMC) proliferation and survival have not been fully ..
  83. Ropelle E, Pauli J, Cintra D, Frederico M, De Pinho R, Velloso L, et al. Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats. J Physiol. 2009;587:2069-76 pubmed publisher
    ..PGC-1alpha and Foxo1 can physically interact with one another and represent an important signal transduction pathway that governs the ..
  84. Fredericks W, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr F, et al. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol. 1995;15:1522-35 pubmed
    ..chromosome involved in this translocation have been identified as the transcription factor-encoding genes PAX3 and FKHR. The NH2-terminal paired box and homeodomain DNA-binding domains of PAX3 are fused in frame to COOH-terminal ..
  85. Gao J, Ruan J, Gao L. Excessive fluoride reduces Foxo1 expression in dental epithelial cells of the rat incisor. Eur J Oral Sci. 2014;122:317-23 pubmed publisher
    Enamel fluorosis is characterized by hypomineralization, and forkhead box O1 (Foxo1) is essential for mouse enamel biomineralization...
  86. Richards J, Sharma S, Falender A, Lo Y. Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins. Mol Endocrinol. 2002;16:580-99 pubmed
    ..mouse and rat models, we show 1) that FKHR [Forkhead homolog of rhabdomysarcoma = Forkhead box binding protein (Foxo1), FKHRL1 (Forkhead-like protein-1 = Foxo3), and AFX (a Forkhead transcription factor = Foxo4); all defined ..