Fos

Summary

Gene Symbol: Fos
Description: Fos proto-oncogene, AP-1 transcription factor subunit
Alias: c-fos, proto-oncogene c-Fos, FBJ murine osteosarcoma viral oncogene homolog, FBJ osteosarcoma oncogene, c-fos oncogene, proto-oncogene cFOS, v-fos FBJ murine osteosarcoma viral oncogene homolog
Species: rat
Products:     Fos

Top Publications

  1. Olesen K, Auger A. Sex differences in Fos protein expression in the neonatal rat brain. J Neuroendocrinol. 2005;17:255-61 pubmed
    ..Although some studies report that steroid hormones regulate the expression of the inducible transcription factor, Fos, in developing brain, it is not known if there is a sex difference in Fos expression...
  2. Grippo A, Na E, Johnson R, Beltz T, Johnson A. Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats. Brain Res. 2004;1019:259-64 pubmed
    ..Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose...
  3. Pesic V, Popic J, Milanovic D, Loncarevic Vasiljkovic N, Rakic L, Kanazir S, et al. The effect of MK-801 on motor activity and c-Fos protein expression in the brain of adolescent Wistar rats. Brain Res. 2010;1321:96-104 pubmed publisher
    ..The involvement of the motor cortex and striatum in motor activity was assessed by analyzing changes in c-Fos protein levels that served as an indicator of neuronal activity...
  4. Chandramohan Y, Droste S, Arthur J, Reul J. The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and str. Eur J Neurosci. 2008;27:2701-13 pubmed publisher
    ..1/2 in mice completely abolished the forced swimming-induced increases in histone H3 phospho-acetylation and c-Fos induction in dentate granule neurons and the behavioural immobility response; (iv) blocking mineralocorticoid ..
  5. Moscarello J, Ben Shahar O, Ettenberg A. Effects of food deprivation on goal-directed behavior, spontaneous locomotion, and c-Fos immunoreactivity in the amygdala. Behav Brain Res. 2009;197:9-15 pubmed publisher
    ..shown that food deprivation and food presentation produce different patterns of neuronal activity (as measured by c-Fos immunoreactivity) in the medial prefrontal cortex and nucleus accumbens of rats...
  6. Valencia Torres L, Olarte Sanchez C, Body S, Fone K, Bradshaw C, Szabadi E. Fos expression in the prefrontal cortex and nucleus accumbens following exposure to retrospective timing tasks. Behav Neurosci. 2011;125:202-14 pubmed publisher
    ..of temporal discrimination tasks is associated with increased neuronal activation in these areas, as revealed by Fos expression, a marker for neuronal activation...
  7. Zhang J, Zhang D, McQuade J, Behbehani M, Tsien J, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet. 2002;30:416-20 pubmed
    ..The immediate early gene (IEG) c-fos encodes a transcription factor...
  8. Maturana A, Van Haasteren G, Piuz I, Castelbou C, Demaurex N, Schlegel W. Spontaneous calcium oscillations control c-fos transcription via the serum response element in neuroendocrine cells. J Biol Chem. 2002;277:39713-21 pubmed
    ..To study the effect of localized Ca2+ signals on the transcriptional activation of the c-fos oncogene, we stably expressed various c-fos beta-lactamase reporter constructs in pituitary AtT20 cells...
  9. Jovanović A, Babović S, Damjanovic A, Puskas L, Lazić D, Cvetić T, et al. The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia. Coll Antropol. 2013;37:847-52 pubmed
    The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia...
  10. Chometton S, Charrière K, Bayer L, Houdayer C, Franchi G, Poncet F, et al. The rostromedial zona incerta is involved in attentional processes while adjacent LHA responds to arousal: c-Fos and anatomical evidence. Brain Struct Funct. 2017;222:2507-2525 pubmed publisher
    ..We conclude that the rostromedial ZI is involved in attentional processes while the adjacent tuberal LHA is involved in arousal. ..

Detail Information

Publications62

  1. Olesen K, Auger A. Sex differences in Fos protein expression in the neonatal rat brain. J Neuroendocrinol. 2005;17:255-61 pubmed
    ..Although some studies report that steroid hormones regulate the expression of the inducible transcription factor, Fos, in developing brain, it is not known if there is a sex difference in Fos expression...
  2. Grippo A, Na E, Johnson R, Beltz T, Johnson A. Sucrose ingestion elicits reduced Fos expression in the nucleus accumbens of anhedonic rats. Brain Res. 2004;1019:259-64 pubmed
    ..Following 4 weeks of CMS in rats, NAc Fos-immunoreactivity was measured after ingestion of a fixed volume of sucrose...
  3. Pesic V, Popic J, Milanovic D, Loncarevic Vasiljkovic N, Rakic L, Kanazir S, et al. The effect of MK-801 on motor activity and c-Fos protein expression in the brain of adolescent Wistar rats. Brain Res. 2010;1321:96-104 pubmed publisher
    ..The involvement of the motor cortex and striatum in motor activity was assessed by analyzing changes in c-Fos protein levels that served as an indicator of neuronal activity...
  4. Chandramohan Y, Droste S, Arthur J, Reul J. The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D-aspartate/extracellular signal-regulated kinase/mitogen- and str. Eur J Neurosci. 2008;27:2701-13 pubmed publisher
    ..1/2 in mice completely abolished the forced swimming-induced increases in histone H3 phospho-acetylation and c-Fos induction in dentate granule neurons and the behavioural immobility response; (iv) blocking mineralocorticoid ..
  5. Moscarello J, Ben Shahar O, Ettenberg A. Effects of food deprivation on goal-directed behavior, spontaneous locomotion, and c-Fos immunoreactivity in the amygdala. Behav Brain Res. 2009;197:9-15 pubmed publisher
    ..shown that food deprivation and food presentation produce different patterns of neuronal activity (as measured by c-Fos immunoreactivity) in the medial prefrontal cortex and nucleus accumbens of rats...
  6. Valencia Torres L, Olarte Sanchez C, Body S, Fone K, Bradshaw C, Szabadi E. Fos expression in the prefrontal cortex and nucleus accumbens following exposure to retrospective timing tasks. Behav Neurosci. 2011;125:202-14 pubmed publisher
    ..of temporal discrimination tasks is associated with increased neuronal activation in these areas, as revealed by Fos expression, a marker for neuronal activation...
  7. Zhang J, Zhang D, McQuade J, Behbehani M, Tsien J, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet. 2002;30:416-20 pubmed
    ..The immediate early gene (IEG) c-fos encodes a transcription factor...
  8. Maturana A, Van Haasteren G, Piuz I, Castelbou C, Demaurex N, Schlegel W. Spontaneous calcium oscillations control c-fos transcription via the serum response element in neuroendocrine cells. J Biol Chem. 2002;277:39713-21 pubmed
    ..To study the effect of localized Ca2+ signals on the transcriptional activation of the c-fos oncogene, we stably expressed various c-fos beta-lactamase reporter constructs in pituitary AtT20 cells...
  9. Jovanović A, Babović S, Damjanovic A, Puskas L, Lazić D, Cvetić T, et al. The role of C-Fos protein, somatostatin and neuropeptide Y in the pathogenesis of ischemic brain injuries based on animal model of cerebral ischemia. Coll Antropol. 2013;37:847-52 pubmed
    The aim of this study was to define all the areas of changes in expression of nuclear c-Fos protein (c-Fos), cytoplasmic somatostatin (SS) and neuropeptide Y (NPY) in rat brain during experimental ischemia...
  10. Chometton S, Charrière K, Bayer L, Houdayer C, Franchi G, Poncet F, et al. The rostromedial zona incerta is involved in attentional processes while adjacent LHA responds to arousal: c-Fos and anatomical evidence. Brain Struct Funct. 2017;222:2507-2525 pubmed publisher
    ..We conclude that the rostromedial ZI is involved in attentional processes while the adjacent tuberal LHA is involved in arousal. ..
  11. McGregor I, Hargreaves G, Apfelbach R, Hunt G. Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam. J Neurosci. 2004;24:4134-44 pubmed
    ..The neural correlates of this phenomenon were investigated here using Fos immunohistochemistry. Rats received either midazolam (0.75 mg/kg, s.c...
  12. Sukhareva E, Dygalo N, Kalinina T. [Influence of dexamethasone on the expression of immediate early genes c-fos and c-jun in different regions of the neonatal brain]. Mol Biol (Mosk). 2016;50:266-71 pubmed publisher
    The ratio of the expression levels of the immediate early genes c-jun and c-fos that encode components of the AP-1 transcription complex determines the direction of changes in the expression of genes controlled by the complex, including ..
  13. Zhang Y, Feng X, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998;394:909-13 pubmed
    ..AP-1 transcription factors, composed of c-Jun and c-Fos, bind to and direct transcription from TREs, which are therefore known as AP1-binding sites...
  14. Yochiy A, Britto L, Hunziker M. Novelty, but not operant aversive learning, enhances Fos and Egr-1 expression in the medial prefrontal cortex and hippocampal areas of rats. Behav Neurosci. 2012;126:826-34 pubmed publisher
    ..This study examined whether a previous experience with shocks changes the pattern of Fos and Egr-1 expression in the medial prefrontal cortex (mPFC), the hippocampal cornus ammonis 1 (CA1), and dentate ..
  15. Hollis J, Lemus M, Evetts M, Oldfield B. Central interleukin-10 attenuates lipopolysaccharide-induced changes in food intake, energy expenditure and hypothalamic Fos expression. Neuropharmacology. 2010;58:730-8 pubmed publisher
    ..c.v.) to attenuate the changes in food intake, energy substrate partitioning, and central Fos expression within the hypothalamus to peripheral LPS (100 microg/kg, i.p...
  16. Usenko T, Kukushkin A, Pospelova T, Pospelov V. Transient expression of E1A and Ras oncogenes causes downregulation of c-fos gene transcription in nontransformed REF52 cells. Oncogene. 2003;22:7661-6 pubmed
    ..transformation of rat embryo fibroblast (REF) cells with E1A and cHa-ras oncogenes leads to downmodulation of c-fos gene transcription...
  17. Lue J, Leong S, Day A, Tsai Y, Shieh J, Wen C. Changes in c-Fos protein expression in the rat cuneate nucleus after electric stimulation of the transected median nerve. J Neurotrauma. 2002;19:897-907 pubmed
    In this study we investigate temporal changes in Fos expression in cuneate neurons after a high-threshold electrical stimulation of the transected median nerve in rats...
  18. Zouhairi N, Ba M hamed S, Bennis M. Maternal prenatal stress in rats influences c-fos expression in the spinal cord of the offspring. Acta Histochem. 2012;114:525-33 pubmed publisher
    ..The activation of spinal cord neurons showing c-fos expression was examined following vaginocervical mechanical stimulation in adult rats, which were the offspring of ..
  19. Ahlgren J, Porter K, Hayward L. Hemodynamic responses and c-Fos changes associated with hypotensive hemorrhage: standardizing a protocol for severe hemorrhage in conscious rats. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1862-71 pubmed
    ..This study assessed the cardiovascular response and Fos-like immunoreactivity (FLI) in specific brain regions following severe HEM at three rates (2, 1, or 0.5 ml.kg(-1)...
  20. Lin C, Wang H, Tsai Y, Huang C, Chen S, Lue J. Pre-treatment with lidocaine suppresses ectopic discharges and attenuates neuropeptide Y and c-Fos expressions in the rat cuneate nucleus following median nerve transection. J Chem Neuroanat. 2009;38:47-56 pubmed publisher
    ..the effects of pre-treatment with lidocaine on injury discharges of the nerve, and neuropeptide Y (NPY) and c-Fos expression in the cuneate nucleus (CN) after median nerve transection (MNT)...
  21. Ellsworth B, Burns A, Escudero K, Duval D, Nelson S, Clay C. The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein. Mol Cell Endocrinol. 2003;206:93-111 pubmed
    ..We suggest that GRAS is a composite regulatory element whose functional activity is dependent on the organization of a multi-protein complex consisting of Smads, AP-1 and a member of the forkhead family of DNA binding proteins. ..
  22. Killick R, Ribe E, Al Shawi R, Malik B, Hooper C, Fernandes C, et al. Clusterin regulates ?-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry. 2014;19:88-98 pubmed publisher
  23. Gong P, Stewart D, Hu B, Vinson C, Alam J. Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch Biochem Biophys. 2002;405:265-74 pubmed
    ..luciferase gene by arsenite was inhibited to varying degrees by dominant-negative mutants of Nrf2, MafK, c-Fos, and CREB but most strongly with the latter...
  24. Tae H, Park S, Cho J, Kim I, Ahn J, Park J, et al. Differential activation of c?Fos in the paraventricular nuclei of the hypothalamus and thalamus following myocardial infarction in rats. Mol Med Rep. 2016;14:3503-8 pubmed publisher
    Proto-oncogene c?Fos (c?Fos) is frequently used to detect a pathogenesis in central nervous system disorders...
  25. Meech R, Makarenkova H, Edelman D, Jones F. The homeodomain protein Barx2 promotes myogenic differentiation and is regulated by myogenic regulatory factors. J Biol Chem. 2003;278:8269-78 pubmed
    ..Taken together, these studies indicate that Barx2 is a key regulator of myogenic differentiation that acts downstream of muscle regulatory factors. ..
  26. Harris J. Using c-fos as a neural marker of pain. Brain Res Bull. 1998;45:1-8 pubmed
    Just over a decade has past since Hunt et al. reported that the gene c-fos and its protein product Fos are expressed in the spinal cord of rats subjected to peripheral noxious stimulation...
  27. Zheng W, Li Z, Huang X, Wang Z, Xu W, Song Z. [Expression of C-fos, C-jun in hippocampus under the model of transmitting epileptic discharge from brain tissue to muscular tissue on its own skull]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011;28:1014-8 pubmed
    The objective of this study was to investigate the changes of the behaviors, EEG and expression of c-fos, c-jun on induced seizure in rats by injecting penicillin after transmitting epileptic discharge from brain tissue to muscular ..
  28. Scicli A, Petrovich G, Swanson L, Thompson R. Contextual fear conditioning is associated with lateralized expression of the immediate early gene c-fos in the central and basolateral amygdalar nuclei. Behav Neurosci. 2004;118:5-14 pubmed
    b>Fos, the protein product of the immediate early gene c-fos, was used to map functional circuitry underlying contextual conditioned fear...
  29. Modirrousta M, Mainville L, Jones B. Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci. 2005;21:2807-16 pubmed
    ..In the present study in rats, we tested whether they express c-Fos differently after total sleep deprivation (SD) vs. sleep recovery (SR)...
  30. Hasegawa M, Kondo M, Suzuki I, Shimizu N, Sessle B, Iwata K. ERK is involved in tooth-pressure-induced Fos expression in Vc neurons. J Dent Res. 2012;91:1141-6 pubmed publisher
    ..In addition, the tooth mechanical pressure led to Fos expression in the pERK-positive Vc neurons that would be suppressed by intrathecal administration of an MEK1/2 ..
  31. Malnou C, Salem T, Brockly F, Wodrich H, Piechaczyk M, Jariel Encontre I. Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic. J Biol Chem. 2007;282:31046-59 pubmed
    c-Fos proto-oncoprotein forms AP-1 transcription complexes with heterodimerization partners such as c-Jun, JunB, and JunD. Thereby, it controls essential cell functions and exerts tumorigenic actions...
  32. Varlinskaya E, Vogt B, Spear L. Social context induces two unique patterns of c-Fos expression in adolescent and adult rats. Dev Psychobiol. 2013;55:684-97 pubmed publisher
    ..c-Fos protein immunoreactivity was used to index neuronal activation in 15 regions of interest...
  33. Morales T, Aguilar L, Ramos E, Mena F, Morgan C. Fos expression induced by milk ingestion in the caudal brainstem of neonatal rats. Brain Res. 2008;1241:76-83 pubmed publisher
    Prominent Fos expression in the nucleus of the solitary tract (NTS) related to feeding has been reported in the brainstem of adult animals...
  34. Kim H, Kim T, Jeong B, Cho I, Han D, Takegahara N, et al. Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 2013;17:249-60 pubmed publisher
    ..These data demonstrate that Tmem64 is a positive modulator of osteoclast differentiation via SERCA2-dependent Ca(2+) signaling. ..
  35. Pompeiano O. Contribution of REM sleep to Fos and FRA expression in the vestibular nuclei of rat leading to vestibular adaptation during the STS-90 Neurolab Mission. Arch Ital Biol. 2007;145:55-85 pubmed
    ..also Pompeiano, 1967, 1970, 1974 for ref.). 2. In a previous study (Pompeiano et al., 2002) changes in Fos and FRA expression were used to identify the short-term (Fos) and the long-term (FRA) molecular changes which ..