Gene Symbol: Fnbp1
Description: formin binding protein 1
Alias: formin-binding protein 1, formin-binding protein 1-like, formin-binding protein 17, rapostlin
Morin F, Vannier B, Houdart F, Regnacq M, Berges T, Voisin P. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Mol Vis. 2003;9:449-59 pubmed
..This effort should provide a rationale to understand how Pgamma-rod can affect receptor internalization-dependent MAP kinase activity. ..
Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M. Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. J Biol Chem. 2002;277:45428-34 pubmed
..We named it Rapostlin (apostle of Rnd2)...
Nakamura K, Yamashita Y, Tamamaki N, Katoh H, Kaneko T, Negishi M. In vivo function of Rnd2 in the development of neocortical pyramidal neurons. Neurosci Res. 2006;54:149-53 pubmed
..These results indicate that Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons. ..
Houdart F, Girard Nau N, Morin F, Voisin P, Vannier B. The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Mol Vis. 2005;11:1061-70 pubmed
..The description of this new function of PDE6gamma might help to understand the molecular mechanism of the severe retinal degeneration observed in PDE6gamma knock-out mice. ..
Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa Suetsugu K, et al
. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell. 2007;129:761-72 pubmed
..Furthermore, FBP17 is recruited to clathrin-coated pits in the late stage of CME, indicating its physiological role...
Wakita Y, Kakimoto T, Katoh H, Negishi M. The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons. J Biol Chem. 2011;286:32672-83 pubmed publisher
..Among them, Rapostlin/formin-binding protein 17 (FBP17) has attracted increasing attention as a critical coordinator of endocytosis...
Kakimoto T, Katoh H, Negishi M. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. J Biol Chem. 2004;279:14104-10 pubmed
..Of these GTPases, Rnd2 is specifically expressed in brain. We recently identified Rapostlin as a novel effector of Rnd2. Rapostlin induces neurite branching in response to Rnd2 in PC12 cells...
Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al
. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem. 2004;279:40091-9 pubmed
..These observations therefore indicate that FBP17 interacts with dynamin and regulates endocytosis by forming vesicotubular structures. ..