Gene Symbol: Fmod
Description: fibromodulin
Alias: fibromodulin, KSPG fibromodulin, collagen-binding 59 kDa protein, keratan sulfate proteoglycan fibromodulin
Species: rat
Products:     Fmod

Top Publications

  1. Soo C, Hu F, Zhang X, Wang Y, Beanes S, Lorenz H, et al. Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair. Am J Pathol. 2000;157:423-33 pubmed
    ..however, TGF-beta modulators such as latent TGF-beta binding protein-1 (LTBP-1), decorin, biglycan, and fibromodulin can bind and potentially inhibit TGF-beta activity...
  2. Jeansson M, Granqvist A, Nyström J, Haraldsson B. Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice. Diabetologia. 2006;49:2200-9 pubmed
    ..Also, glomerular components such as versican, decorin and fibromodulin were found to be downregulated after 40 weeks of diabetes.
  3. Schaefer L, Raslik I, Grone H, Schonherr E, Macakova K, Ugorcakova J, et al. Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin. FASEB J. 2001;15:559-61 pubmed
    Small leucine-rich proteoglycans (SLRPs), for example, decorin, biglycan, fibromodulin, and lumican, are extracellular matrix organizers and binding partners of TGF-b. Decorin is also involved in growth control and angiogenesis...
  4. Matias M, Li H, Young W, Bartold P. Immunohistochemical localization of fibromodulin in the periodontium during cementogenesis and root formation in the rat molar. J Periodontal Res. 2003;38:502-7 pubmed
    ..Recently, the small leucine-rich proteoglycan, fibromodulin, has been isolated from bovine periodontal ligament and localized in bovine cementum, as well as in human ..
  5. Qian H, Xiao Y, Bartold P. Immunohistochemical localization and expression of fibromodulin in adult rat periodontium and inflamed human gingiva. Oral Dis. 2004;10:233-9 pubmed
    The aim of this study was to determine the distribution and expression of fibromodulin in adult rat periodontal tissues and inflamed human gingiva.
  6. Lui P, Chan L, Lee Y, Fu S, Chan K. Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model. Rheumatology (Oxford). 2010;49:231-9 pubmed publisher
    ..The expression of biglycan, fibromodulin and aggrecan increased with time, whereas the expression of decorin was sustained from Week 2 to Week 12...
  7. Mormone E, Lu Y, Ge X, Fiel M, Nieto N. Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. Gastroenterology. 2012;142:612-621.e5 pubmed publisher
    ..b>Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli...
  8. Hoffman M, Flister M, Núñez L, Xiao B, Greene A, Jacob H, et al. Female-specific hypertension loci on rat chromosome 13. Hypertension. 2013;62:557-63 pubmed publisher
    ..The congenic interval of the protective line 9F strain contains 3 genes (Optc, Prelp, and Fmod), and the hypertensive line 9E contains 1 additional gene (Btg2)...
  9. Syaidah R, Horiguchi K, Fujiwara K, Tsukada T, Kikuchi M, Yashiro T. Laminin and collagen modulate expression of the small leucine-rich proteoglycan fibromodulin in rat anterior pituitary gland. Cell Tissue Res. 2013;354:633-8 pubmed
    ..We have previously shown that FS cells and pericytes produce fibromodulin, a small leucine-rich proteoglycan (SLRP)...

More Information


  1. Delalande A, Gosselin M, Suwalski A, Guilmain W, Leduc C, Berchel M, et al. Enhanced Achilles tendon healing by fibromodulin gene transfer. Nanomedicine. 2015;11:1735-44 pubmed publisher
    ..Gene delivery of fibromodulin, a proteoglycan involved in collagen assembly was found to promote rat Achilles tendon repair in vivo and in ..
  2. Zheng Z, Zhang X, Dang C, Beanes S, Chang G, Chen Y, et al. Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing. Am J Pathol. 2016;186:2824-2832 pubmed publisher
    ..In this study, using loss- and gain-of-function rodent fetal wound models, we identified that fibromodulin (Fm) is essential for fetal-type scarless wound healing...