Gene Symbol: Fkbp4
Description: FK506 binding protein 4
Alias: FKBP-4, FKBP-52, p59, peptidyl-prolyl cis-trans isomerase FKBP4, 52 kDa FK506-binding protein, 52 kDa FKBP, 59 kDa immunophilin, FK506 binding protein 52, FKBP52 protein, FKBP59, HBI, HSP-binding immunophilin, PPIase FKBP4, immunophilin FKBP52, rotamase
Species: rat
Products:     Fkbp4

Top Publications

  1. Tai P, Albers M, Chang H, Faber L, Schreiber S. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science. 1992;256:1315-8 pubmed
    Immunophilins, a family of proteins that exhibit rotamase (peptidyl-prolyl cis-trans isomerase) activity in vitro, are expressed in many organisms and most tissues...
  2. Kuhner M, Goodenow R. DNA sequences of mouse H-2 and Qa genes. Immunogenetics. 1989;30:458-64 pubmed
  3. Yong W, Yang Z, Periyasamy S, Chen H, Yucel S, Li W, et al. Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem. 2007;282:5026-36 pubmed
    ..Our work demonstrates that Fkbp52 but not Fkbp51 is essential to AR-mediated signaling and provides evidence for an unprecedented Fkbp52 function, direct control of steroid receptor transcriptional activity. ..
  4. Schmitt J, Pohl J, Stunnenberg H. Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. Gene. 1993;132:267-71 pubmed
    A cDNA encoding the homologue of the rabbit immunophilin p59 was cloned from a mouse NIH-3T3 cell line library. Antibodies were generated against the N-terminal fragment of the protein produced in bacteria...
  5. Young J, Obermann W, Hartl F. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J Biol Chem. 1998;273:18007-10 pubmed
    ..In reticulocyte lysate, the C90 fusion protein recognized the TPR proteins p60, FKBP52, and Cyp40. Thus, our results identify the C90 domain as the specific binding site for a set of hsp90 cofactors having TPR domains. ..
  6. Sanokawa Akakura R, Dai H, Akakura S, Weinstein D, Fajardo J, Lang S, et al. A novel role for the immunophilin FKBP52 in copper transport. J Biol Chem. 2004;279:27845-8 pubmed
    ..Taken together, our present findings suggest that FKBP52 is a component of the copper efflux machinery, and in so, may also promote neuroprotection from copper toxicity. ..
  7. Chambraud B, Belabes H, Fontaine Lenoir V, Fellous A, Baulieu E. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation. FASEB J. 2007;21:2787-97 pubmed
    ..Collectively, our data define an unexpected property of FKBP52 as a novel regulator of microtubule dynamics. The possible role of microtubule formation and tubulin binding of other immunophilins such as FKBP12 and FKBP51 is discussed. ..
  8. Alnemri E, Fernandes Alnemri T, Nelki D, Dudley K, DuBois G, Litwack G. Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc Natl Acad Sci U S A. 1993;90:6839-43 pubmed
    ..Amino acid sequence analysis of this protein revealed that it is a phosphoprotein or kinase that is associated with the rFKBP-52. ..
  9. Pirkl F, Buchner J. Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J Mol Biol. 2001;308:795-806 pubmed

More Information


  1. Davies T, Ning Y, SANCHEZ E. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002;277:4597-600 pubmed
  2. Cheung Flynn J, Prapapanich V, Cox M, Riggs D, Suarez Quian C, Smith D. Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol Endocrinol. 2005;19:1654-66 pubmed
    ..We conclude that FKBP52 is an AR folding factor that has critically important physiological roles in some male reproductive tissues. ..
  3. Pratt W, Morishima Y, Murphy M, Harrell M. Chaperoning of glucocorticoid receptors. Handb Exp Pharmacol. 2006;:111-38 pubmed
  4. Smith D, Toft D. Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions. Mol Endocrinol. 2008;22:2229-40 pubmed publisher
    ..Here, we point out several areas in need of investigation to encourage new ideas and participants in this burgeoning field. ..
  5. Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M, et al. A role for FKBP52 in Tau protein function. Proc Natl Acad Sci U S A. 2010;107:2658-63 pubmed publisher
    ..Taken together, these findings indicate a role for FKBP52 in Tau function and may help to decipher and modulate the events involved in Tau-induced neurodegeneration. ..
  6. Quintá H, Maschi D, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem. 2010;115:716-34 pubmed publisher
  7. Yang J, Fuller P. Interactions of the mineralocorticoid receptor--within and without. Mol Cell Endocrinol. 2012;350:196-205 pubmed publisher
    ..This review will discuss the current understanding of interactions involving the MR and highlight their relevance to ligand- or tissue-specificity as well as their suitability as therapeutic targets. ..