Fit 1


Gene Symbol: Fit 1
Description: interleukin 1 receptor-like 1
Alias: FIT1, Fit-1, St2, interleukin-1 receptor-like 1, fos-responsive gene 1 protein
Species: rat
Products:     Fit 1

Top Publications

  1. Seki K, Sanada S, Kudinova A, Steinhauser M, Handa V, Gannon J, et al. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ Heart Fail. 2009;2:684-91 pubmed publisher
    b>ST2 is an interleukin (IL)-1 receptor family member with membrane-bound (ST2L) and soluble (sST2) isoforms, and sST2 is a biomarker for poor outcome in patients with myocardial infarction (MI)...
  2. Miller A, Xu D, Asquith D, Denby L, Li Y, Sattar N, et al. IL-33 reduces the development of atherosclerosis. J Exp Med. 2008;205:339-46 pubmed publisher
    ..We show that IL-33, which is a novel IL-1-like cytokine that signals via ST2, can reduce atherosclerosis development in ApoE(-/-) mice on a high-fat diet...
  3. Sanada S, Hakuno D, Higgins L, Schreiter E, McKenzie A, Lee R. IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J Clin Invest. 2007;117:1538-49 pubmed
    b>ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms...
  4. Rössler U, Thomassen E, Hültner L, Baier S, Danescu J, Werenskiold A. Secreted and membrane-bound isoforms of T1, an orphan receptor related to IL-1-binding proteins, are differently expressed in vivo. Dev Biol. 1995;168:86-97 pubmed
    ..Thus, T1-M likely represents a novel orphan receptor of selected hemopoietic cells. The matrix-associated T1-S variant might act to create a reservoir of the putative T1 ligand in some differentiating tissues. ..
  5. Kurowska Stolarska M, Stolarski B, Kewin P, Murphy G, Corrigan C, Ying S, et al. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol. 2009;183:6469-77 pubmed publisher
    Alternatively activated macrophages (AAM) play a crucial role in type 2 immunity. Mice deficient in ST2, a receptor for the latest member of the IL-1 family, IL-33, have impaired type 2 immune responses...
  6. Gudbjartsson D, Bjornsdottir U, Halapi E, Helgadottir A, Sulem P, Jonsdottir G, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet. 2009;41:342-7 pubmed publisher
    ..2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls). ..
  7. Savenije O, Kerkhof M, Reijmerink N, Brunekreef B, de Jongste J, Smit H, et al. Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 2011;127:750-6.e1-5 pubmed publisher
    ..IL1RL1-a levels were not associated with eosinophil counts. We demonstrate that IL1RL1 polymorphisms are associated with serum IL1RL1-a, blood eosinophils, and asthma in childhood. ..
  8. Shelburne C, McCoy M, Piekorz R, Sexl V, Roh K, Jacobs Helber S, et al. Stat5 expression is critical for mast cell development and survival. Blood. 2003;102:1290-7 pubmed
    ..These results indicate that Stat5A and Stat5B are critical regulators of in vitro and in vivo mast cell development and survival. ..
  9. Hoogerwerf J, Leendertse M, Wieland C, de Vos A, de Boer J, Florquin S, et al. Loss of suppression of tumorigenicity 2 (ST2) gene reverses sepsis-induced inhibition of lung host defense in mice. Am J Respir Crit Care Med. 2011;183:932-40 pubmed publisher
    ..Suppression of tumorigenicity 2 (ST2) is a negative regulator of Toll-like receptor signaling implicated in endotoxin tolerance...

More Information


  1. Yang S, Lin J, Wu S, Huang K, Jung F, Ma M, et al. Membrane translocation of IL-33 receptor in ventilator induced lung injury. PLoS ONE. 2015;10:e0121391 pubmed publisher
    ..The objective of this study was to discover the role of IL-33 and its ST2 receptor in acute lung injury induced by mechanical ventilator (ventilator-induced lung injury; VILI)...
  2. Cullingford T, Butler M, Marshall A, Tham E, Sugden P, Clerk A. Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochim Biophys Acta. 2008;1783:1229-36 pubmed publisher
    ..The dynamic regulation of expression of multiple Klf family members in cardiac myocytes suggests that, as a family, they are actively involved in regulating phenotypic responses (hypertrophy and apoptosis) to extracellular stimuli. ..
  3. Kearley J, Buckland K, Mathie S, Lloyd C. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med. 2009;179:772-81 pubmed publisher
    ..The role of Th2 cells in maintaining AHR was confirmed using blocking antibodies against T1/ST2, IL-4, and IL-13 during the resolution period...
  4. Yin H, Li X, Yuan B, Zhang B, Hu S, Gu H, et al. Adenovirus-mediated overexpression of soluble ST2 provides a protective effect on lipopolysaccharide-induced acute lung injury in mice. Clin Exp Immunol. 2011;164:248-55 pubmed publisher
    ..Previously, we have reported that soluble ST2 (sST2), a member of the Toll-interleukin (IL)-1 receptor (TIR) superfamily, represses proinflammatory cytokine ..
  5. Ferreira M, McRae A, Medland S, Nyholt D, Gordon S, Wright M, et al. Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. Eur J Hum Genet. 2011;19:458-64 pubmed publisher
    ..In conclusion, we confirm the association between asthma risk and variants in ORMDL3 and identify a novel risk variant in IL1RL1. Follow-up of the 17q21 deletion in larger cohorts is warranted. ..
  6. Allan D, Fairlie Clarke K, Elliott C, Schuh C, Barnett S, Lassmann H, et al. Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system. Acta Neuropathol Commun. 2016;4:75 pubmed publisher
    ..In this study, we have mapped cellular expression of IL-33 and its receptor ST2 by immunohistochemistry in the brain tissues of MS patients and appropriate controls; and investigated the ..
  7. Tsapaki A, Zaravinos A, Apostolakis S, Voudris K, Vogiatzi K, Kochiadakis G, et al. Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of coronary artery disease. J Thromb Thrombolysis. 2010;30:365-71 pubmed publisher
    Genetic polymorphy of the distal promoter region of the ST2 gene influences transcriptional activity and susceptibility to atopic dermatitis and asthma...
  8. Ragusa R, Cabiati M, Guzzardi M, D Amico A, Giannessi D, Del Ry S, et al. Effects of obesity on IL-33/ST2 system in heart, adipose tissue and liver: study in the experimental model of Zucker rats. Exp Mol Pathol. 2017;102:354-359 pubmed publisher
    Suppression of tumorigenicity 2 (ST2) mediates the effect of Interleukin-33 (IL-33). Few data are reported on the relationship between IL-33/ST2 and obesity...
  9. Hacker S, Lambers C, Pollreisz A, Hoetzenecker K, Lichtenauer M, Mangold A, et al. Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD. J Clin Lab Anal. 2009;23:372-9 pubmed publisher
    ..and histone-associated-DNA-fragments were increased in patients with COPD, whereas anti-inflammatory soluble ST2 showed a peak in patients with COPD I&II (P=0.031) compared to healthy smokers...
  10. Mangan N, Dasvarma A, McKenzie A, Fallon P. T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Eur J Immunol. 2007;37:1302-12 pubmed
    The transmembrane form of T1/ST2 (ST2) is a specific marker on murine Th2 cells that have been generated in vitro, or isolated from sites of allergic type 2 inflammation...
  11. Tajima S, Oshikawa K, Tominaga S, Sugiyama Y. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Chest. 2003;124:1206-14 pubmed
    The human ST2 gene can be specifically induced by growth stimulation in fibroblastic cells, and the soluble ST2 protein (ST2) is expressed preferentially in T-helper type 2 (Th2) cells...
  12. Oshikawa K, Kuroiwa K, Tago K, Iwahana H, Yanagisawa K, Ohno S, et al. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med. 2001;164:277-81 pubmed
    Previous studies have reported that ST2 is preferentially expressed on Th2 cells and plays a critical part in controlling airway inflammation in murine models of asthma...
  13. Bosse Y, Lemire M, Poon A, Daley D, He J, Sandford A, et al. Asthma and genes encoding components of the vitamin D pathway. Respir Res. 2009;10:98 pubmed publisher
    ..Multilocus models testing genes in the same pathway are potentially more effective to evaluate the risk of asthma, but the effects are not uniform across populations. ..
  14. Stastna M, Chimenti I, Marban E, Van Eyk J. Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics. 2010;10:245-53 pubmed publisher
    ..factor (ANP) and connective tissue growth factor, and CSC-specific protein interleukin-1 receptor-like 1 (ST2) were found to affect rat CSC proliferation...
  15. Castano R, Bosse Y, Endam L, Desrosiers M. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Am J Rhinol Allergy. 2009;23:377-84 pubmed publisher
    ..Pending replication of these results, this study suggests that polymorphisms within the IL1RL1 gene may be associated with CRS, conferring a protective effect, particularly among those with severe disease. ..
  16. Socrates T, Defilippi C, Reichlin T, Twerenbold R, Breidhardt T, Noveanu M, et al. Interleukin family member ST2 and mortality in acute dyspnoea. J Intern Med. 2010;268:493-500 pubmed publisher
    The study objective was to investigate the prognostic utility and patient-specific characteristics of ST2 (suppression of tumorigenicity 2), assessed with a novel sensitive assay...
  17. Hayakawa H, Hayakawa M, Kume A, Tominaga S. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem. 2007;282:26369-80 pubmed
    The ST2 gene produces a soluble secreted form and a transmembrane form, referred to as soluble ST2 and ST2L, respectively...
  18. Bithell A, Alberta J, Hornby F, Stiles C, Williams B. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Res Dev Brain Res. 2003;146:107-18 pubmed
    ..These observations suggest that mr-gef encodes a protein that is part of a signaling pathway involved in telencephalic neurogenesis; particularly in the development of GABAergic interneurons. ..
  19. Martínez Martínez E, Miana M, Jurado López R, Rousseau E, Rossignol P, Zannad F, et al. A role for soluble ST2 in vascular remodeling associated with obesity in rats. PLoS ONE. 2013;8:e79176 pubmed publisher
    The function of the Interleukin-33 (IL-33)/ST2 system has been mainly investigated on immunological aspects, but recent data suggest that this pathway plays also an important role in cardiovascular system and adipose tissue...
  20. Walzl G, Matthews S, Kendall S, Gutierrez Ramos J, Coyle A, Openshaw P, et al. Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. J Exp Med. 2001;193:785-92 pubmed
    ..T1/ST2 is a surface ligand of the IL-1 receptor family, expressed on Th2- but not on interferon (IFN)-gamma-producing Th1 ..
  21. Bergers G, Reikerstorfer A, Braselmann S, Graninger P, Busslinger M. Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J. 1994;13:1176-88 pubmed
    ..The orthologous gene of the mouse (known as T1 or ST2) is expressed during ontogeny first in the fetal liver of the embryo and then in lung and hematopoietic tissues of ..