Fgfr3

Summary

Gene Symbol: Fgfr3
Description: fibroblast growth factor receptor 3
Alias: fibroblast growth factor receptor 3
Species: rat
Products:     Fgfr3

Top Publications

  1. Olsen S, Ibrahimi O, Raucci A, Zhang F, Eliseenkova A, Yayon A, et al. Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A. 2004;101:935-40 pubmed
    ..Importantly, comparison of the three FGF1-FGFR structures shows that the flexibility of the betaC'-betaE loop is a major determinant of ligand-binding specificity and promiscuity. ..
  2. Olsen S, Garbi M, Zampieri N, Eliseenkova A, Ornitz D, Goldfarb M, et al. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem. 2003;278:34226-36 pubmed
    ..Hence, FHFs and FGFs bear striking structural similarity but have diverged to direct related surfaces toward interaction with distinct protein targets. ..
  3. Rousseau F, Bonaventure J, Legeai Mallet L, Pelet A, Rozet J, Maroteaux P, et al. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature. 1994;371:252-4 pubmed
    ..8); the genetic interval encompassing the disease gene contains a member of the fibroblast-growth-factor receptor (FGFR3) family which is expressed in articular chondrocytes...
  4. Puligilla C, Feng F, Ishikawa K, Bertuzzi S, Dabdoub A, Griffith A, et al. Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn. 2007;236:1905-17 pubmed
    Deletion of fibroblast growth factor receptor 3 (Fgfr3) leads to hearing impairment in mice due to defects in the development of the organ of Corti, the sensory epithelium of the Cochlea...
  5. Pringle N, Yu W, Howell M, Colvin J, Ornitz D, Richardson W. Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Development. 2003;130:93-102 pubmed
    The postnatal central nervous system (CNS) contains many scattered cells that express fibroblast growth factor receptor 3 transcripts (Fgfr3)...
  6. Hayashi T, Cunningham D, Bermingham McDonogh O. Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2007;236:525-33 pubmed
    ..At late stages of cochlear development, Fgfr3 is necessary for the development of the tunnel of Corti...
  7. Friedmacher F, Doi T, Gosemann J, Fujiwara N, Kutasy B, Puri P. Upregulation of fibroblast growth factor receptor 2 and 3 in the late stages of fetal lung development in the nitrofen rat model. Pediatr Surg Int. 2012;28:195-9 pubmed publisher
    ..FGF signaling is mediated by a family of four single transmembrane receptors, FGFR1-4. FGFR2 and FGFR3 have been shown to be expressed predominantly in the late stages of developing lungs...
  8. Delezoide A, Lasselin Benoist C, Legeai Mallet L, Brice P, Senée V, Yayon A, et al. Abnormal FGFR 3 expression in cartilage of thanatophoric dysplasia fetuses. Hum Mol Genet. 1997;6:1899-906 pubmed
    ..the commonest lethal skeletal dysplasia in humans, is accounted for by recurrent mutations in the fibroblast growth factor receptor 3 gene (FGFR 3), causing its constitutive activation in vitro...
  9. Rieckmann T, Kotevic I, Trueb B. The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion. Exp Cell Res. 2008;314:1071-81 pubmed
    ..With its dimeric structure and its adhesion promoting properties, FGFRL1 resembles the nectins, a family of cell adhesion molecules found at cell-cell junctions. ..
  10. Jin C, Yang C, Wu X, Wang F, McKeehan W. FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression. In Vitro Cell Dev Biol Anim. 2011;47:500-5 pubmed publisher
    ..cells from two-compartment tumors are comprised of smooth muscle ?-actin-positive cells that express predominantly FGFR3 and fibroblast-like cells devoid of ?-actin and FGFR3...

Detail Information

Publications60

  1. Olsen S, Ibrahimi O, Raucci A, Zhang F, Eliseenkova A, Yayon A, et al. Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A. 2004;101:935-40 pubmed
    ..Importantly, comparison of the three FGF1-FGFR structures shows that the flexibility of the betaC'-betaE loop is a major determinant of ligand-binding specificity and promiscuity. ..
  2. Olsen S, Garbi M, Zampieri N, Eliseenkova A, Ornitz D, Goldfarb M, et al. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem. 2003;278:34226-36 pubmed
    ..Hence, FHFs and FGFs bear striking structural similarity but have diverged to direct related surfaces toward interaction with distinct protein targets. ..
  3. Rousseau F, Bonaventure J, Legeai Mallet L, Pelet A, Rozet J, Maroteaux P, et al. Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature. 1994;371:252-4 pubmed
    ..8); the genetic interval encompassing the disease gene contains a member of the fibroblast-growth-factor receptor (FGFR3) family which is expressed in articular chondrocytes...
  4. Puligilla C, Feng F, Ishikawa K, Bertuzzi S, Dabdoub A, Griffith A, et al. Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn. 2007;236:1905-17 pubmed
    Deletion of fibroblast growth factor receptor 3 (Fgfr3) leads to hearing impairment in mice due to defects in the development of the organ of Corti, the sensory epithelium of the Cochlea...
  5. Pringle N, Yu W, Howell M, Colvin J, Ornitz D, Richardson W. Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Development. 2003;130:93-102 pubmed
    The postnatal central nervous system (CNS) contains many scattered cells that express fibroblast growth factor receptor 3 transcripts (Fgfr3)...
  6. Hayashi T, Cunningham D, Bermingham McDonogh O. Loss of Fgfr3 leads to excess hair cell development in the mouse organ of Corti. Dev Dyn. 2007;236:525-33 pubmed
    ..At late stages of cochlear development, Fgfr3 is necessary for the development of the tunnel of Corti...
  7. Friedmacher F, Doi T, Gosemann J, Fujiwara N, Kutasy B, Puri P. Upregulation of fibroblast growth factor receptor 2 and 3 in the late stages of fetal lung development in the nitrofen rat model. Pediatr Surg Int. 2012;28:195-9 pubmed publisher
    ..FGF signaling is mediated by a family of four single transmembrane receptors, FGFR1-4. FGFR2 and FGFR3 have been shown to be expressed predominantly in the late stages of developing lungs...
  8. Delezoide A, Lasselin Benoist C, Legeai Mallet L, Brice P, Senée V, Yayon A, et al. Abnormal FGFR 3 expression in cartilage of thanatophoric dysplasia fetuses. Hum Mol Genet. 1997;6:1899-906 pubmed
    ..the commonest lethal skeletal dysplasia in humans, is accounted for by recurrent mutations in the fibroblast growth factor receptor 3 gene (FGFR 3), causing its constitutive activation in vitro...
  9. Rieckmann T, Kotevic I, Trueb B. The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion. Exp Cell Res. 2008;314:1071-81 pubmed
    ..With its dimeric structure and its adhesion promoting properties, FGFRL1 resembles the nectins, a family of cell adhesion molecules found at cell-cell junctions. ..
  10. Jin C, Yang C, Wu X, Wang F, McKeehan W. FGFR3-expressing smooth muscle-like stromal cells differentiate in response to FGFR2IIIb-expressing prostate tumor cells and delay tumor progression. In Vitro Cell Dev Biol Anim. 2011;47:500-5 pubmed publisher
    ..cells from two-compartment tumors are comprised of smooth muscle ?-actin-positive cells that express predominantly FGFR3 and fibroblast-like cells devoid of ?-actin and FGFR3...
  11. Su N, Sun Q, Li C, Lu X, Qi H, Chen S, et al. Gain-of-function mutation in FGFR3 in mice leads to decreased bone mass by affecting both osteoblastogenesis and osteoclastogenesis. Hum Mol Genet. 2010;19:1199-210 pubmed publisher
    Achondroplasia (ACH) is a short-limbed dwarfism resulting from gain-of-function mutations in fibroblast growth factor receptor 3 (FGFR3)...
  12. Bocharov E, Lesovoy D, Goncharuk S, Goncharuk M, Hristova K, Arseniev A. Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies. Structure. 2013;21:2087-93 pubmed publisher
    b>Fibroblast growth factor receptor 3 (FGFR3) transduces biochemical signals via lateral dimerization in the plasma membrane, and plays an important role in human development and disease...
  13. Govindarajan V, Overbeek P. Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Development. 2001;128:1617-27 pubmed
    ..we have generated transgenic mice with ocular expression of secreted self-dimerizing versions of FGFR1 (FR1) and FGFR3 (FR3)...
  14. Harada D, Yamanaka Y, Ueda K, Nishimura R, Morishima T, Seino Y, et al. Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1. Bone. 2007;41:273-81 pubmed
    The most frequent type of rhizomelic dwarfism, achondroplasia (ACH), is caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene...
  15. Papadopoulou A, Papachristou D, Chatzopoulos S, Pirttiniemi P, Papavassiliou A, Basdra E. Load application induces changes in the expression levels of Sox-9, FGFR-3 and VEGF in condylar chondrocytes. FEBS Lett. 2007;581:2041-6 pubmed
  16. Sibley K, Cuthbert Heavens D, Knowles M. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Oncogene. 2001;20:686-91 pubmed
    ..One candidate within this region is fibroblast growth factor receptor 3 (FGFR3)...
  17. Burger M, van der Aa M, van Oers J, Brinkmann A, van der Kwast T, Steyerberg E, et al. Prediction of progression of non-muscle-invasive bladder cancer by WHO 1973 and 2004 grading and by FGFR3 mutation status: a prospective study. Eur Urol. 2008;54:835-43 pubmed publisher
    ..Aim of this study was to investigate the prognostic value of the WHO 1973 and 2004 grading systems and biomarkers FGFR3, CK20 and Ki-67...
  18. Claus P, Grothe C. Molecular cloning and developmental expression of rat fibroblast growth factor receptor 3. Histochem Cell Biol. 2001;115:147-55 pubmed
    ..The temporal and spatial pattern of FGFR-3 expression suggests specific functions in several tissues during development. ..
  19. Moko S, Blandin de Chalain T. New Zealand Maori family with the pro250arg fibroblast growth factor receptor 3 mutation associated with craniosynostosis. J Craniomaxillofac Surg. 2001;29:22-4 pubmed
    ..The aim of the study is to determine whether the family has the pro250arg mutation in the gene for fibroblast growth factor receptor 3 (FGFR3), a mutation found in patients with various types of craniosynostosis...
  20. Lievens P, Mutinelli C, Baynes D, Liboi E. The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling. J Biol Chem. 2004;279:43254-60 pubmed
    Amino acid substitutions at the Lys-650 codon within the activation loop kinase domain of fibroblast growth factor receptor 3 (FGFR3) result in graded constitutive phosphorylation of the receptor...
  21. Meyers G, Orlow S, Munro I, Przylepa K, Jabs E. Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation in Crouzon syndrome with acanthosis nigricans. Nat Genet. 1995;11:462-4 pubmed
    ..In contrast, only FGFR3 mutations have been reported in dwarfing conditions--achondroplasia, thanatophoric dysplasia, and ..
  22. Sibley K, Stern P, Knowles M. Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. Oncogene. 2001;20:4416-8 pubmed
    Mutations in FGFR3 have been identified in several tumour types including bladder carcinoma, cervical carcinoma, and multiple myeloma...
  23. Weinstein M, Xu X, Ohyama K, Deng C. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 1998;125:3615-23 pubmed
    ..These data revealed a cooperative function of FGFR-3 and FGFR-4 to promote the formation of alveoli during postnatal lung development. ..
  24. Timmer M, Cesnulevicius K, Winkler C, Kolb J, Lipokatic Takacs E, Jungnickel J, et al. Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. J Neurosci. 2007;27:459-71 pubmed
    ..system, we analyzed the nigrostriatal system of mice lacking FGF-2, mice overexpressing FGF-2, and FGF-receptor-3 (FGFR3)-deficient mice both after development and after 6-hydroxydopamine lesion...
  25. Inglis Broadgate S, Thomson R, Pellicano F, Tartaglia M, Pontikis C, Cooper J, et al. FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. Dev Biol. 2005;279:73-85 pubmed
    Mice with the K644E kinase domain mutation in fibroblast growth factor receptor 3 (Fgfr3) (EIIa;Fgfr3(+/K644E)) exhibited a marked enlargement of the brain. The brain size was increased as early as E11...
  26. Vairaktaris E, Goutzanis L, Nkenke E, Spyridonidou S, Vassiliou S, Derka S, et al. Diabetes does not influence oral oncogenesis through fibroblast growth factor receptors. In Vivo. 2007;21:623-8 pubmed
    ..In the last stages of oral oncogenesis, the expression of both proteins remained relatively stable. It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis. ..
  27. Cappellen D, De Oliveira C, Ricol D, de Medina S, Bourdin J, Sastre Garau X, et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet. 1999;23:18-20 pubmed
  28. Murashima Suginami A, Takahashi K, Kawabata T, Sakata T, Tsukamoto H, Sugai M, et al. Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun. 2007;359:549-55 pubmed
    ..USAG-1 abrogation rescued apoptotic elimination of odontogenic mesenchymal cells. Based upon these results, we conclude that USAG-1 controls the number of teeth in the maxillary incisor region by regulating apoptosis. ..
  29. Matsushita M, Hasegawa S, Kitoh H, Mori K, Ohkawara B, Yasoda A, et al. Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene. Endocrinology. 2015;156:548-54 pubmed publisher
    ..causing short stature owing to a gain-of-function mutation in the FGFR3 gene, which encodes the fibroblast growth factor receptor 3. We found that meclozine, an over-the-counter drug for motion sickness, inhibited elevated FGFR3 ..
  30. Huang Z, Chen H, Blais S, Neubert T, Li X, Mohammadi M. Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation. Structure. 2013;21:1889-96 pubmed publisher
    The K650E gain-of-function mutation in the tyrosine kinase domain of FGF receptor 3 (FGFR3) causes Thanatophoric Dysplasia type II, a neonatal lethal congenital dwarfism syndrome, and when acquired somatically, it contributes to ..
  31. Krejci P, Prochazkova J, Smutny J, Chlebova K, Lin P, Aklian A, et al. FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence. Bone. 2010;47:102-10 pubmed publisher
    ..In FGFR3-related skeletal dyplasias, oncogenic mutations in the FGFR3 receptor tyrosine kinase cause profound inhibition of ..
  32. Mueller K, Jacques B, Kelley M. Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci. 2002;22:9368-77 pubmed
    ..cell development have not been determined; however, previous results suggested a key role for fibroblast growth factor receptor 3 (FGFR3)...
  33. Martinez Torrecuadrada J, Cheung L, López Serra P, Barderas R, Canamero M, Ferreiro S, et al. Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Mol Cancer Ther. 2008;7:862-73 pubmed publisher
    Human single-chain Fv directed against fibroblast growth factor receptor 3 (FGFR3) have been shown to block proliferation of RT112 bladder carcinoma cells in vitro...
  34. Shin J, Min M, Larrieu Lahargue F, Canron X, Kunstfeld R, Nguyen L, et al. Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. Mol Biol Cell. 2006;17:576-84 pubmed
    ..Together, these results indicate that FGFR-3 is an initial target of Prox1 during the lymphatic cell fate specification and that FGF signaling may play an important role in lymphatic vessel development...
  35. Davidson D, Blanc A, Filion D, Wang H, Plut P, Pfeffer G, et al. Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis. J Biol Chem. 2005;280:20509-15 pubmed
    Signaling by fibroblast growth factor (FGF) 18 and FGF receptor 3 (FGFR3) have been shown to regulate proliferation, differentiation, and matrix production of articular and growth plate chondrocytes in vivo and in vitro...
  36. Vidrich A, Buzan J, Brodrick B, Ilo C, Bradley L, Fendig K, et al. Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal development. Am J Physiol Gastrointest Liver Physiol. 2009;297:G168-78 pubmed publisher
    b>Fibroblast growth factor receptor 3 (FGFR-3) is expressed in the lower crypt epithelium, where stem cells of the intestine reside...
  37. Zhao H, Yang T, Madakashira B, Thiels C, Bechtle C, Garcia C, et al. Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Dev Biol. 2008;318:276-88 pubmed publisher
    ..FGF receptors (Fgfr1-3) early in lens development demonstrated that expression of only a single allele of Fgfr2 or Fgfr3 was sufficient for grossly normal lens development, while mice possessing only a single Fgfr1 allele developed ..
  38. Messersmith D, Murtie J, Le T, Frost E, Armstrong R. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. J Neurosci Res. 2000;62:241-56 pubmed
    ..cells, including progenitors and mature cells, were found to express multiple FGFR types (FGFR1, FGFR2, and/or FGFR3). In addition, in lesion areas, astrocytes expressed FGFR1, FGFR2, and FGFR3...
  39. Sawai H, Komori S, Ida A, Henmi T, Bessho T, Koyama K. Prenatal diagnosis of thanatophoric dysplasia by mutational analysis of the fibroblast growth factor receptor 3 gene and a proposed correction of previously published PCR results. Prenat Diagn. 1999;19:21-4 pubmed
    ..Recently. mutations in the fibroblast growth factor receptor 3 (FGFR3) gene that cause two subtypes of this disorder, type I (TDI) and type II (TDII), have been ..
  40. Zammit C, Barnard R, Gomm J, Coope R, Shousha S, Coombes C, et al. Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancer. J Pathol. 2001;194:27-34 pubmed
    Immunohistochemical staining of human breast tissues, using an antibody against fibroblast growth factor receptor 3 [FGFR-3], showed differences in cellular distribution...
  41. Junker K, van Oers J, Zwarthoff E, Kania I, Schubert J, Hartmann A. Fibroblast growth factor receptor 3 mutations in bladder tumors correlate with low frequency of chromosome alterations. Neoplasia. 2008;10:1-7 pubmed
    The aim of this study was to analyze the distribution of FGFR3 mutations in bladder tumors of different grade and stage and determine the relation of mutations to chromosomal alterations detected by comparative genomic hybridization (CGH)..
  42. Bellus G, Bamshad M, Przylepa K, Dorst J, Lee R, Hurko O, et al. Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3. Am J Med Genet. 1999;85:53-65 pubmed
    We previously discovered a novel missense mutation (Lys650Met) in the tyrosine kinase domain of the fibroblast growth factor receptor 3 (FGFR3) gene in four unrelated individuals with a condition we called "severe achondroplasia ..
  43. Jacky B, Garay P, Dupuy J, Nelson J, Cai B, Molina Y, et al. Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A). PLoS Pathog. 2013;9:e1003369 pubmed publisher
    ..Here we present data supporting the identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a high affinity receptor for BoNT/A in neuronal cells...
  44. Li M, Seki Y, Freitas P, Nagata M, Kojima T, Sultana S, et al. FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line. J Electron Microsc (Tokyo). 2010;59:227-36 pubmed publisher
    ..comprising the parathyroid hormone (PTH)-related peptide (PTHrP), the PTH/PTHrP receptor and the fibroblast growth factor receptor 3 (FGFR3) plays a central role in chondrocyte proliferation...
  45. Cho J, Guo C, Torello M, Lunstrum G, Iwata T, Deng C, et al. Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci U S A. 2004;101:609-14 pubmed
    Mutations of fibroblast growth factor receptor 3 (FGFR3) are responsible for achondroplasia (ACH) and related dwarfing conditions in humans...
  46. Jungnickel J, Klutzny A, Guhr S, Meyer K, Grothe C. Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. Neuroscience. 2005;134:1343-50 pubmed
    The presence and regulation of basic fibroblast growth factor and its high-affinity tyrosine kinase receptor FGFR3 in sensory neurons during development and after peripheral nerve injury suggest a physiological role of the fibroblast ..
  47. Suzuki M, Uehara Y, Motomura Matsuzaka K, Oki J, Koyama Y, Kimura M, et al. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008;22:1006-14 pubmed publisher
    ..It is thus suggested that betaKlotho expression is a crucial determinant of the FGF21 specificity of the target cells upon which it acts in an endocrine fashion. ..
  48. Castro Feijoo L, Loidi L, Vidal A, Parajes S, Roson E, Alvarez A, et al. Hypochondroplasia and Acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?. Eur J Endocrinol. 2008;159:243-9 pubmed publisher
    ..dysplasia inherited in an autosomal dominant manner due, in most cases, to mutations in the fibroblast growth factor receptor 3 (FGFR3)...
  49. Oh L, Denninger A, Colvin J, Vyas A, Tole S, Ornitz D, et al. Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. J Neurosci. 2003;23:883-94 pubmed
    ..We have shown that, in the normal postnatal brain, the spatial and temporal expression pattern of FGFR3 parallels the appearance of differentiated oligodendrocytes and that in culture FGFR3 is expressed maximally at ..
  50. Naski M, Colvin J, Coffin J, Ornitz D. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development. 1998;125:4977-88 pubmed
    b>Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of skeletal growth and activating mutations in Fgfr3 cause achondroplasia, the most common genetic form of dwarfism in humans...
  51. Miyake A, Hattori Y, Ohta M, Itoh N. Rat oligodendrocytes and astrocytes preferentially express fibroblast growth factor receptor-2 and -3 mRNAs. J Neurosci Res. 1996;45:534-41 pubmed
    ..The expression of FGFR-2 IIIc and FGFR-3 IIIc with different ligand specificities might play important roles in the various effects of FGFs on oligodendrocytes and astrocytes. ..
  52. Jin C, Wang F, Wu X, Yu C, Luo Y, McKeehan W. Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. Cancer Res. 2004;64:4555-62 pubmed
    ..of stromal cells in vivo depends on epithelial cells, we show that signaling from epithelial FGF9 to stromal FGFR3 potentially mediates epithelial-to-stromal communication that also is directionally specific...
  53. Arnaud Dabernat S, Kritzik M, Kayali A, Zhang Y, Liu G, Ungles C, et al. FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. Diabetes. 2007;56:96-106 pubmed
    ..Although FGFR3 is a crucial developmental gene, acting as a negative regulator of bone formation, its participation remains ..
  54. Tang J, Su N, Zhou S, Xie Y, Huang J, Wen X, et al. Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice. Arthritis Rheumatol. 2016;68:2432-43 pubmed publisher
    ..The effect of inhibiting Indian hedgehog (IHH) signaling in Fgfr3-deficient explants was analyzed. Conditional Fgfr3 deletion in mice aggravated DMM-induced cartilage degeneration...
  55. Barbisan F, Santinelli A, Mazzucchelli R, Lopez Beltran A, Cheng L, Scarpelli M, et al. Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur. Cancer. 2008;112:636-44 pubmed
    ..The objective of the current study was to evaluate immunohistochemically tissue expression of fibroblast growth factor receptor 3 (FGFR3), cytokeratin 20 (CK20), and MIB-1 in nonrecurrent and recurrent PUNLMP...
  56. Oji G, Gomez P, Kurriger G, Stevens J, Morcuende J. Indian hedgehog signaling pathway differences between swarm rat chondrosarcoma and native rat chondrocytes. Iowa Orthop J. 2007;27:9-16 pubmed
    ..b>Fibroblast Growth Factor Receptor 3 (FGFR3) conversely decreases proliferation and hastens differentiation with an agonist...
  57. Chen L, Li C, Qiao W, Xu X, Deng C. A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Hum Mol Genet. 2001;10:457-65 pubmed
    Missense mutations in fibroblast growth factor receptor 3 (FGFR3) result in several types of human skeletal dysplasia, including the neonatally lethal dwarfism known as thanatophoric dysplasia...
  58. Cinaroglu A, Ozmen Y, Ozdemir A, Ozcan F, Ergorul C, Cayirlioglu P, et al. Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. J Neurosci Res. 2005;79:329-39 pubmed
    ..FGFR2 and FGFR3 antibodies showed prominent labeling in the inner retina, especially in proliferating cultured Muller glia...
  59. Su N, Xu X, Li C, He Q, Zhao L, Li C, et al. Generation of Fgfr3 conditional knockout mice. Int J Biol Sci. 2010;6:327-32 pubmed
    b>Fibroblast growth factor receptor 3 (FGFR3), highly conserved in both humans and murine, is one of key tyrosine kinase receptors for FGF...
  60. Drummond A, Tellbach M, Dyson M, Findlay J. Fibroblast growth factor-9, a local regulator of ovarian function. Endocrinology. 2007;148:3711-21 pubmed
    ..The FGF9 receptors FGFR2 and FGFR3 mRNAs were present in postnatal and immature rat ovary and appeared to be constitutively expressed...