Fgfr1

Summary

Gene Symbol: Fgfr1
Description: Fibroblast growth factor receptor 1
Alias: fibroblast growth factor receptor 1, FGF receptor-1, FGFR-1, MFR, bFGF-R, bFGF-R-1, basic fibroblast growth factor receptor 1, c-fgr, proto-oncogene c-Fgr
Species: rat
Products:     Fgfr1

Top Publications

  1. Hu Y, Fang X, Dunham S, Prada C, Stachowiak E, Stachowiak M. 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. J Biol Chem. 2004;279:29325-35 pubmed
    b>Fibroblast growth factor receptor 1 (FGFR1) is a transmembrane protein capable of transducing stimulation by secreted FGFs...
  2. Roumiantsev S, Krause D, Neumann C, Dimitri C, Asiedu F, Cross N, et al. Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell. 2004;5:287-98 pubmed
    ..chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor-1 (FGFR1). However, patients with BCR-FGFR1 fusion present with typical chronic myeloid leukemia (CML)...
  3. Izikki M, Guignabert C, Fadel E, Humbert M, Tu L, Zadigue P, et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest. 2009;119:512-23 pubmed publisher
    ..No difference in FGF2-induced proliferation or FGF receptor type 1 (FGFR1) mRNA levels was detected between IPH and control PA-SMCs...
  4. Ren M, Li X, Cowell J. Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-fibroblast growth factor receptor-1 chimeric tyrosine kinase. Blood. 2009;114:1576-84 pubmed publisher
    A mouse model of human ZNF198-fibroblast growth factor receptor-1 (FGFR1) stem cell leukemia lymphoma has been developed to investigate mechanisms of oncogenesis and progression...
  5. Maric D, Fiorio Pla A, Chang Y, Barker J. Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors. J Neurosci. 2007;27:1836-52 pubmed
    ..NSCs residing in the dorsal telencephalon coexpressed FGFR1 and FGFR3, whereas those residing in the ventral telencephalon also expressed FGFR2...
  6. Chamorro Jorganes A, Araldi E, Penalva L, Sandhu D, Fernandez Hernando C, Suarez Y. MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol. 2011;31:2595-606 pubmed publisher
    ..Vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR2), and fibroblast growth factor receptor-1 (FGFR1) were identified by bioinformatic approaches and subsequently validated as targets of microRNA (miR)-16 and miR-..
  7. Fang X, Stachowiak E, Dunham Ems S, Klejbor I, Stachowiak M. Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. J Biol Chem. 2005;280:28451-62 pubmed
    In integrative nuclear fibroblast growth factor receptor-1 (FGFR1) signaling a newly synthesized FGFR1 translocates to the nucleus to stimulate cell differentiation and associated gene activities...
  8. Chen J, DeAngelo D, Kutok J, Williams I, Lee B, Wadleigh M, et al. PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004;101:14479-84 pubmed
    ..We hypothesized that small-molecule inhibitors of the ZNF198-FGFR1 fusion would have therapeutic efficacy...
  9. Wang P, Tang J, Yang J. [Effects of moxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32:97-101 pubmed
    ..Particularly it up-regulated the expression levels of key factors VEGF and flt-1, promoted the angiogenesis in the vital parts, and ultimately stimulated the repairing mechanisms of cerebral nerve injury. ..
  10. Borroto Escuela D, Corrales F, Narvaez M, Oflijan J, Agnati L, Palkovits M, et al. Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of ?-arrestin2. Biochem Biophys Res Commun. 2013;441:387-92 pubmed publisher
    ..5-HT in brain can, in part, be mediated by activation of the 5-HT1A receptor protomer in the hippocampal and raphe FGFR1-5-HT1A heteroreceptor complexes enhancing the FGFR1 signaling...

Detail Information

Publications95

  1. Hu Y, Fang X, Dunham S, Prada C, Stachowiak E, Stachowiak M. 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. J Biol Chem. 2004;279:29325-35 pubmed
    b>Fibroblast growth factor receptor 1 (FGFR1) is a transmembrane protein capable of transducing stimulation by secreted FGFs...
  2. Roumiantsev S, Krause D, Neumann C, Dimitri C, Asiedu F, Cross N, et al. Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell. 2004;5:287-98 pubmed
    ..chromosomal translocations fusing several genes, most commonly ZNF198, to fibroblast growth factor receptor-1 (FGFR1). However, patients with BCR-FGFR1 fusion present with typical chronic myeloid leukemia (CML)...
  3. Izikki M, Guignabert C, Fadel E, Humbert M, Tu L, Zadigue P, et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest. 2009;119:512-23 pubmed publisher
    ..No difference in FGF2-induced proliferation or FGF receptor type 1 (FGFR1) mRNA levels was detected between IPH and control PA-SMCs...
  4. Ren M, Li X, Cowell J. Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-fibroblast growth factor receptor-1 chimeric tyrosine kinase. Blood. 2009;114:1576-84 pubmed publisher
    A mouse model of human ZNF198-fibroblast growth factor receptor-1 (FGFR1) stem cell leukemia lymphoma has been developed to investigate mechanisms of oncogenesis and progression...
  5. Maric D, Fiorio Pla A, Chang Y, Barker J. Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors. J Neurosci. 2007;27:1836-52 pubmed
    ..NSCs residing in the dorsal telencephalon coexpressed FGFR1 and FGFR3, whereas those residing in the ventral telencephalon also expressed FGFR2...
  6. Chamorro Jorganes A, Araldi E, Penalva L, Sandhu D, Fernandez Hernando C, Suarez Y. MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol. 2011;31:2595-606 pubmed publisher
    ..Vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR2), and fibroblast growth factor receptor-1 (FGFR1) were identified by bioinformatic approaches and subsequently validated as targets of microRNA (miR)-16 and miR-..
  7. Fang X, Stachowiak E, Dunham Ems S, Klejbor I, Stachowiak M. Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulation. J Biol Chem. 2005;280:28451-62 pubmed
    In integrative nuclear fibroblast growth factor receptor-1 (FGFR1) signaling a newly synthesized FGFR1 translocates to the nucleus to stimulate cell differentiation and associated gene activities...
  8. Chen J, DeAngelo D, Kutok J, Williams I, Lee B, Wadleigh M, et al. PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci U S A. 2004;101:14479-84 pubmed
    ..We hypothesized that small-molecule inhibitors of the ZNF198-FGFR1 fusion would have therapeutic efficacy...
  9. Wang P, Tang J, Yang J. [Effects of moxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012;32:97-101 pubmed
    ..Particularly it up-regulated the expression levels of key factors VEGF and flt-1, promoted the angiogenesis in the vital parts, and ultimately stimulated the repairing mechanisms of cerebral nerve injury. ..
  10. Borroto Escuela D, Corrales F, Narvaez M, Oflijan J, Agnati L, Palkovits M, et al. Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of ?-arrestin2. Biochem Biophys Res Commun. 2013;441:387-92 pubmed publisher
    ..5-HT in brain can, in part, be mediated by activation of the 5-HT1A receptor protomer in the hippocampal and raphe FGFR1-5-HT1A heteroreceptor complexes enhancing the FGFR1 signaling...
  11. Haenzi B, Gers Barlag K, Akhoundzadeh H, Hutson T, Menezes S, Bunge M, et al. Overexpression of the Fibroblast Growth Factor Receptor 1 (FGFR1) in a Model of Spinal Cord Injury in Rats. PLoS ONE. 2016;11:e0150541 pubmed publisher
    ..Therefore, it is essential to find new targets for treatment. The fibroblast growth factor receptor 1 (FGFR1) signalling pathway has a history of being explored for SCI treatment...
  12. Nakano S, Nakamura K, Teramoto N, Yamanouchi K, Nishihara M. Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells. Anim Sci J. 2016;87:99-108 pubmed publisher
    ..In addition, the effect of bFGF is mediated via two types of FGF receptor (FGFR) isoforms: FGFR1 and FGFR2 IIIc, and both receptors are prerequisite for bFGF to express its pro-adipogenic effect...
  13. Andres C, Hasenauer J, Ahn H, Joseph E, Isensee J, Theis F, et al. Wound-healing growth factor, basic FGF, induces Erk1/2-dependent mechanical hyperalgesia. Pain. 2013;154:2216-26 pubmed publisher
    ..Reverse transcription polymerase chain reaction showed that the receptor of bFGF, FGFR1, is expressed in lumbar rat dorsal root ganglia (DRG)...
  14. Zhou Y, Xu X, Chen L, Li C, Brodie S, Deng C. A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet. 2000;9:2001-8 pubmed
    ..that is caused by a proline-->arginine substitution at amino acid 252 (Pro252Arg) in fibroblast growth factor receptor 1 (FGFR1)...
  15. Lonic A, Powell J, Kong Y, Thomas D, Holien J, Truong N, et al. Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation. J Biol Chem. 2013;288:14874-85 pubmed publisher
    ..models for growth factor-regulated neuronal differentiation, we show that Ser(779) in the cytoplasmic domains of FGFR1 and FGFR2 is required for the sustained activation of Ras and ERK but not for other FGFR phosphotyrosine pathways...
  16. Kulahin N, Li S, Kiselyov V, Bock E, Berezin V. Identification of neural cell adhesion molecule L1-derived neuritogenic ligands of the fibroblast growth factor receptor. J Neurosci Res. 2009;87:1806-12 pubmed publisher
    ..Thus, the identified peptides act as L1 mimetics with regard to activation of FGFR and induction of neurite outgrowth. ..
  17. Muenke M, Schell U, Hehr A, Robin N, Losken H, Schinzel A, et al. A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome. Nat Genet. 1994;8:269-74 pubmed
    ..Here we present evidence that mutations in the fibroblast growth factor receptor-1 (FGFR1) gene, which maps to 8p, cause one form of familial Pfeiffer syndrome...
  18. Haugsten E, Malecki J, Bjørklund S, Olsnes S, Wesche J. Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Mol Biol Cell. 2008;19:3390-403 pubmed publisher
    ..in internalization and sorting of fibroblast growth factor receptor (FGFR), we constructed several mutants of FGFR1 in which lysines, potential ubiquitination sites, were substituted for arginines...
  19. Li C, Xu X, Nelson D, Williams T, Kuehn M, Deng C. FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development. 2005;132:4755-64 pubmed
    ..However, because of early post-implantation lethality associated with fibroblast growth factor receptor 1 (FGFR1) deficiency, the role of this receptor in limb development remains elusive...
  20. Jiao J, Greendorfer J, Zhang P, Zinn K, Diglio C, Thompson J. Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite. Arch Biochem Biophys. 2003;410:187-200 pubmed
  21. Borroto Escuela D, Pérez Alea M, Narvaez M, Tarakanov A, Mudó G, Jiménez Beristain A, et al. Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression. Biochem Biophys Res Commun. 2015;463:180-6 pubmed publisher
    New findings show existence of FGFR1-5-HT1A heteroreceptor complexes in 5-HT nerve cells of the dorsal and median raphe nuclei of the rat midbrain and hippocampus...
  22. Gattineni J, Alphonse P, Zhang Q, Mathews N, Bates C, Baum M. Regulation of renal phosphate transport by FGF23 is mediated by FGFR1 and FGFR4. Am J Physiol Renal Physiol. 2014;306:F351-8 pubmed publisher
    ..b>FGFR1, 3, and 4 are expressed in the mouse proximal tubule, and deletion of any one receptor did not affect serum ..
  23. Ren M, Qin H, Ren R, Cowell J. Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities. Leukemia. 2013;27:32-40 pubmed publisher
    Myeloid and lymphoid malignancies associated with fibroblast growth factor receptor-1 (FGFR1) abnormalities are characterized by constitutively activated FGFR1 kinase and rapid transformation to acute myeloid leukemia and lymphoblastic ..
  24. Trokovic N, Trokovic R, Partanen J. Fibroblast growth factor signalling and regional specification of the pharyngeal ectoderm. Int J Dev Biol. 2005;49:797-805 pubmed
    ..In mice homozygous for a hypomorphic allele of Fgfr1, neural crest cells migrating from the hindbrain mostly fail to enter the second branchial arch...
  25. Gu Y, Xue C, Zhu J, Sun H, Ding F, Cao Z, et al. Basic fibroblast growth factor (bFGF) facilitates differentiation of adult dorsal root ganglia-derived neural stem cells toward Schwann cells by binding to FGFR-1 through MAPK/ERK activation. J Mol Neurosci. 2014;52:538-51 pubmed publisher
    ..Furthermore, we noted that bFGF-induced differentiation of DRG-NSCs toward Schwann cells might be mediated by binding to fibroblast growth factor receptor-1 (FGFR-1) through activation of MAPK/ERK signal pathway. ..
  26. Hausott B, Rietzler A, Vallant N, Auer M, Haller I, Perkhofer S, et al. Inhibition of fibroblast growth factor receptor 1 endocytosis promotes axonal branching of adult sensory neurons. Neuroscience. 2011;188:13-22 pubmed publisher
    ..Among the four types of FGF receptors (FGFRs), FGFR1 is expressed in adult sensory neurons of dorsal root ganglia (DRG), and overexpression of FGFR1 promotes FGF-2-..
  27. Hu Y, Guimond S, Travers P, Cadman S, Hohenester E, Turnbull J, et al. Novel mechanisms of fibroblast growth factor receptor 1 regulation by extracellular matrix protein anosmin-1. J Biol Chem. 2009;284:29905-20 pubmed publisher
    ..We have previously demonstrated that anosmin-1, a glycosylated extracellular matrix protein, interacts with the FGFR1 signaling complex and enhances its activity in an IIIc isoform-specific and HS-dependent manner...
  28. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006;444:770-4 pubmed
    ..to be incapable of intracellular signalling, we searched for other components of the FGF23 receptor and found FGFR1(IIIc), which was directly converted by Klotho into the FGF23 receptor...
  29. Huang Z, Tan Y, Gu J, Liu Y, Song L, Niu J, et al. Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability. Cell Rep. 2017;20:1717-1728 pubmed publisher
    ..In addition to providing a physical basis for the diverse activities of FGF1, our findings will impact ongoing drug discoveries targeting FGF1 and related FGFs for the treatment of a variety of human diseases. ..
  30. Poladia D, Kish K, Kutay B, Hains D, Kegg H, Zhao H, et al. Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol. 2006;291:325-39 pubmed
    ..b>Fgfr1(Mes-/-) and fgfr2(Mes-/-) mice develop normal-appearing kidneys...
  31. Villanueva C, Jacobson Dickman E, Xu C, Manouvrier S, Dwyer A, Sykiotis G, et al. Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations. Genet Med. 2015;17:651-9 pubmed publisher
    ..Probands and available family members underwent phenotyping and screening for FGFR1 mutations...
  32. Hassan A, Durlacher K, Silver J, Naveh Many T, Levi R. The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia. Am J Physiol Renal Physiol. 2016;310:F217-21 pubmed publisher
    ..FGF23 expression is increased by activation of the FGF receptor 1 (FGFR1) in rats with normal renal function and in vitro in bone-derived osteoblast-like cells...
  33. Li G, Oparil S, Kelpke S, Chen Y, Thompson J. Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro. Circulation. 2002;106:854-9 pubmed
  34. Turner C, Flagel S, Clinton S, Akil H, Watson S. Cocaine interacts with the novelty-seeking trait to modulate FGFR1 gene expression in the rat. Neurosci Lett. 2008;446:105-7 pubmed publisher
    ..Specifically, we assessed the regulation of FGFR1 in response to cocaine in animals that were selectively bred on the basis of their locomotor response to a novel ..
  35. Miura S, Davis S, Klingensmith J, Mishina Y. BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 2006;133:3767-75 pubmed
    ..This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development. ..
  36. Laitinen E, Tommiska J, Dunkel L, Sankilampi U, Vaaralahti K, Raivio T. Idiopathic hypogonadotropic hypogonadism in a mother and her monozygotic twins born after a single embryo transfer. Fertil Steril. 2010;93:2074.e13-6 pubmed publisher
    ..IHH) and her monozygotic (MZ) twin boys who all have the same heterozygous fibroblast growth factor receptor-1 (FGFR1) gene mutation. Case report. University hospital...
  37. West D, Rees C, Duchesne L, Patey S, Terry C, Turnbull J, et al. Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. J Biol Chem. 2005;280:13457-64 pubmed
    ..The results show that fibroblast growth factor (FGF) 1, 2, 4, and 7, FGF receptor 1, hepatocyte growth factor/scatter factor (HGF/SF), FGF-binding protein, normal protease sensitive form of ..
  38. Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn D, Rossant J, et al. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 2003;22:1811-23 pubmed
    ..Tissue-specific inactivation of one of the FGF receptor (FGFR) genes, Fgfr1, in the midbrain and rhombomere 1 of the hindbrain of mouse embryos results in deletion of the inferior colliculi ..
  39. Leadbeater W, Gonzalez A, Logaras N, Berry M, Turnbull J, Logan A. Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex. J Neurochem. 2006;96:1189-200 pubmed
    ..We examined the intracellular dynamics of FGF-2, FGFR1 and the HSPGs syndecan-2 and -3, glypican-1 and -2, and perlecan in neurones and glia in and around adult rat ..
  40. Bae J, Lew E, Yuzawa S, Tomé F, Lax I, Schlessinger J. The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site. Cell. 2009;138:514-24 pubmed publisher
    ..Here we describe the crystal structure of the activated tyrosine kinase domain of FGFR1 in complex with a phospholipase Cgamma fragment...
  41. Irshad S, Bansal M, Castillo Martin M, Zheng T, Aytes A, Wenske S, et al. A molecular signature predictive of indolent prostate cancer. Sci Transl Med. 2013;5:202ra122 pubmed publisher
    ..We then further classified this signature with a decision tree learning model to identify three genes--FGFR1, PMP22, and CDKN1A--that together accurately predicted outcome of low Gleason score tumors...
  42. van der Wal E, Gomez Pinilla F, Cotman C. Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain. Neuroscience. 1994;60:311-23 pubmed
    ..In addition, our results suggest that the fibroblast growth factor system may have a role in plasticity events triggered by physiological activity. ..
  43. Cheng M, Chen L, Wang M, Hsu C, Cheng J. Decrease of FGF receptor (FGFR) and interstitial fibrosis in the kidney of streptozotocin-induced diabetic rats. Horm Metab Res. 2014;46:1-7 pubmed publisher
    ..Also, klotho has no effect on expression of FGFR. Thus, decrease of oxidative stress is useful for the recovery of FGFR expression and improvement of renal fibrosis in type-1 like diabetic rats. ..
  44. Huber K, Meisinger C, Grothe C. Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury. J Comp Neurol. 1997;382:189-98 pubmed
    We have studied the expression of basic fibroblast growth factor 2 (FGF-2) and FGF receptor 1 (FGFR1) in the hypoglossal motor system during degeneration and regeneration by using an RNase protection assay, in situ hybridization, and ..
  45. Tucker E, Segall S, Gopalakrishna D, Wu Y, Vernon M, Polleux F, et al. Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J Neurosci. 2008;28:9504-18 pubmed publisher
    ..Thus, extrinsic and intrinsic forebrain patterning mechanisms cooperate to establish LGE and MGE progenitor identity, and presumably their capacities to generate distinct classes of neuronal progeny. ..
  46. Yang F, Zhang Y, Ressler S, Ittmann M, Ayala G, Dang T, et al. FGFR1 is essential for prostate cancer progression and metastasis. Cancer Res. 2013;73:3716-24 pubmed publisher
    The fibroblast growth factor receptor 1 (FGFR1) is ectopically expressed in prostate carcinoma cells, but its functional contributions are undefined...
  47. Bae J, Boggon T, Tomé F, Mandiyan V, Lax I, Schlessinger J. Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells. Proc Natl Acad Sci U S A. 2010;107:2866-71 pubmed publisher
    ..structural and biochemical experiments demonstrating that formation of an asymmetric dimer between activated FGFR1 kinase domains is required for transphosphorylation of FGFR1 in FGF-stimulated cells...
  48. Luo W, Liu A, Chen Y, Lim H, Marshall Neff J, Black J, et al. Inhibition of accelerated graft arteriosclerosis by gene transfer of soluble fibroblast growth factor receptor-1 in rat aortic transplants. Arterioscler Thromb Vasc Biol. 2004;24:1081-6 pubmed
    ..Targeted interruption of FGF function could potentially reduce neointima formation in patients with heart and kidney transplants. ..
  49. Lee J, Kim J, Cho K, Lee M, Cho S, Kwak S, et al. Wnt11/Fgfr1b cross-talk modulates the fate of cells in palate development. Dev Biol. 2008;314:341-50 pubmed publisher
    ..Wnt-11 overexpression and beads soaked in SU5402 (an Fgfr1 inhibitor) were employed in in vitro organ cultures...
  50. Ting S, Whitelock J, Tomic R, Gunawan C, Teoh W, Amal R, et al. Cellular uptake and activity of heparin functionalised cerium oxide nanoparticles in monocytes. Biomaterials. 2013;34:4377-86 pubmed publisher
    ..found to be biologically active due to their ability to bind fibroblast growth factor 2 and signal through FGF receptor 1. Additionally, the heparin-coupled nanoceria, once internalised by the cells, were found to be degraded by 48 ..
  51. Novoyatleva T, Sajjad A, Pogoryelov D, Patra C, Schermuly R, Engel F. FGF1-mediated cardiomyocyte cell cycle reentry depends on the interaction of FGFR-1 and Fn14. FASEB J. 2014;28:2492-503 pubmed publisher
    ..Taken together, our data suggest that FGFR-1/Fn14 interaction may represent a novel endogenous mechanism to modulate the action of these receptors and their ligands and to control cardiomyocyte cell cycle reentry. ..
  52. Turner C, Gula E, Taylor L, Watson S, Akil H. Antidepressant-like effects of intracerebroventricular FGF2 in rats. Brain Res. 2008;1224:63-8 pubmed publisher
    ..Finally, the FGF system itself was altered after FGF2 administration. Specifically, there was an increase in FGFR1 mRNA in the dentate gyrus 24 h post-FGF2, suggesting the potential for self-amplification of the initial signal...
  53. Seyed M, DiMario J. Fibroblast growth factor receptor 1 gene expression is required for cardiomyocyte proliferation and is repressed by Sp3. J Mol Cell Cardiol. 2008;44:510-9 pubmed publisher
    b>Fibroblast growth factor receptor 1 (FGFR1) is the only high-affinity FGFR in the vertebrate myocardium...
  54. Ozaki S, Radeke M, Anderson D. Rapid upregulation of fibroblast growth factor receptor 1 (flg) by rat photoreceptor cells after injury. Invest Ophthalmol Vis Sci. 2000;41:568-79 pubmed
    ..Confocal immunofluorescence microscopy was used to identify sites of bFGF and FGF receptor 1 (FGFR1) expression after focal injury or experimental retinal detachment in adult rats...
  55. Ballaz S, Perez J, Waselus M, Akil H, Watson S. Interaction between cholecystokinin and the fibroblast growth factor system in the ventral tegmental area of selectively bred high- and low-responder rats. Neuroscience. 2013;255:68-75 pubmed publisher
  56. Stevens H, Smith K, Maragnoli M, Fagel D, Borok E, Shanabrough M, et al. Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. J Neurosci. 2010;30:5590-602 pubmed publisher
    ..fibroblast growth factor receptors (FGFRs) in cortical development, we conditionally inactivated Fgfr2 or both Fgfr1 and Fgfr2 [Fgfr2 conditional knock-out (cKO) or double knock-out mice, respectively] in radial glial cells of the ..
  57. Sato N, Hasegawa T, Hori N, Fukami M, Yoshimura Y, Ogata T. Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: report of three families: case report. Hum Reprod. 2005;20:2173-8 pubmed
    ..We studied the effects and the consequences of GT in autosomal dominant KS caused by heterozygous FGFR1 mutations. Three Japanese families were examined. In family A, an adult male received GT and had two sons...
  58. Serls A, Doherty S, Parvatiyar P, Wells J, Deutsch G. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development. 2005;132:35-47 pubmed
    ..Together, the findings suggest that a concentration threshold of FGFs emanating from the cardiac mesoderm are involved in patterning the foregut endoderm. ..
  59. Wu A, Kolumam G, Stawicki S, Chen Y, Li J, Zavala Solorio J, et al. Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med. 2011;3:113ra126 pubmed publisher
    ..Here, we describe an alternative antidiabetic strategy using agonistic anti-FGFR1 (FGF receptor 1) antibodies (R1MAbs) that mimic the metabolic effects of FGF21...
  60. Suzuki M, Uehara Y, Motomura Matsuzaka K, Oki J, Koyama Y, Kimura M, et al. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008;22:1006-14 pubmed publisher
    ..It is thus suggested that betaKlotho expression is a crucial determinant of the FGF21 specificity of the target cells upon which it acts in an endocrine fashion. ..
  61. Frinchi M, Di Liberto V, Olivieri M, Fuxe K, Belluardo N, Mudo G. FGF-2/FGFR1 neurotrophic system expression level and its basal activation do not account for the age-dependent decline of precursor cell proliferation in the subventricular zone of rat brain. Brain Res. 2010;1358:39-45 pubmed publisher
    ..we focused our attention on the neurotrophic system fibroblast growth factor-2 (FGF-2) and its receptor FGFR1, a potent modulator of precursor cell proliferation...
  62. Lalonde R, Strazielle C. Behavioral effects of neonatal lesions on the cerebellar system. Int J Dev Neurosci. 2015;43:58-65 pubmed publisher
    ..Deficits are also evident in murine null mutants such as Zic1, Fgfr1/FgFr2, and Xpa/Ercc8...
  63. Pitteloud N, Acierno J, Meysing A, Eliseenkova A, Ma J, Ibrahimi O, et al. Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A. 2006;103:6281-6 pubmed
    Mutations in KAL1 and FGFR1 cause Kallmann syndrome (KS), whereas mutations in the GNRHR and GPR54 genes cause idiopathic hypogonadotropic hypogonadism with normal olfaction (nIHH)...
  64. Pitteloud N, Quinton R, Pearce S, Raivio T, Acierno J, Dwyer A, et al. Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism. J Clin Invest. 2007;117:457-63 pubmed
    ..and anosmia) and another with normosmic IHH, in which a single-gene defect had been identified: a heterozygous FGF receptor 1 (FGFR1) mutation in pedigree 1 and a compound heterozygous gonadotropin-releasing hormone receptor (GNRHR) ..
  65. O Reilly B, Kishore A, Crowther J, Smith C. Correlation of growth factor receptor expression with clinical growth in vestibular schwannomas. Otol Neurotol. 2004;25:791-6 pubmed
    ..Overexpression of fibroblastic growth factor receptor 1 has a positive correlation with the incidence and the rate of growth of sporadic vestibular schwannomas. ..
  66. Borroto Escuela D, Narvaez M, Perez Alea M, Tarakanov A, Jimenez Beristain A, Mudo G, et al. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochem Biophys Res Commun. 2015;456:489-93 pubmed publisher
    ..With in situ proximity ligation assay (PLA) and supported by co-location of the FGFR1 and 5-HT1A immunoreactivities in midbrain raphe 5-HT cells, evidence for the existence of FGFR1-5-HT1A ..
  67. Grothe C, Meisinger C, Hertenstein A, Kurz H, Wewetzer K. Expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 messenger RNAs in spinal ganglia and sciatic nerve: regulation after peripheral nerve lesion. Neuroscience. 1997;76:123-35 pubmed
    ..fibroblast growth factor (FGF-2) in the peripheral nervous system we have analysed the expression of FGF-2 and FGF receptor 1 (FGFR1) in spinal ganglia and the sciatic nerve under normal conditions and after nerve crush using RNAse ..
  68. Jyo Oshiro Y, Sasaki T, Kawakami Y, Nohno T, Itoh N, Osawa G, et al. Expression of the fibroblast growth factor receptor 1-4 genes in glomeruli in anti-Thy1.1 mesangial proliferative glomerulonephritis. Virchows Arch. 1999;435:501-8 pubmed
    ..1 GN, so we used in situ hybridization to determine whether cells expressing FGFR1-4 mRNAs could be detected...
  69. Chernyshova Y, Leshchyns ka I, Hsu S, Schachner M, Sytnyk V. The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones. J Neurosci. 2011;31:3522-35 pubmed publisher
    ..Thus, we reveal a novel role for a cell adhesion molecule in that it regulates addition of the new membrane to the cell surface of growth cones in developing neurons. ..
  70. Liu X, Zhu X. Increased expression and nuclear accumulation of basic fibroblast growth factor in primary cultured astrocytes following ischemic-like insults. Brain Res Mol Brain Res. 1999;71:171-7 pubmed
  71. Messersmith D, Murtie J, Le T, Frost E, Armstrong R. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. J Neurosci Res. 2000;62:241-56 pubmed
    ..oligodendrocyte lineage cells, including progenitors and mature cells, were found to express multiple FGFR types (FGFR1, FGFR2, and/or FGFR3). In addition, in lesion areas, astrocytes expressed FGFR1, FGFR2, and FGFR3...
  72. Hadziselimovic N, De Geyter C, Demougin P, Oakeley E, Hadziselimovic F. Decreased expression of FGFR1, SOS1, RAF1 genes in cryptorchidism. Urol Int. 2010;84:353-61 pubmed publisher
    ..A novel observation in our study was that the fibroblast growth factor receptor 1 gene (FGFR1) and its mediators SOS1 and RAF1 were expressed less in undescended testes...
  73. Yamada H, Akishita M, Ito M, Tamura K, Daviet L, Lehtonen J, et al. AT2 receptor and vascular smooth muscle cell differentiation in vascular development. Hypertension. 1999;33:1414-9 pubmed
    ..Taken together, our results suggest that the AT2 receptor promotes vascular differentiation and contributes to vasculogenesis. ..
  74. Takami K, Matsuo A, Terai K, Walker D, McGeer E, McGeer P. Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease. Brain Res. 1998;802:89-97 pubmed
    ..Immunoreactivity using a monoclonal antibody demonstrated a similar distribution pattern. The localization of FGFR-1 is consistent with previous reports on the involvement of FGF-1 and FGF-2 in AD. ..
  75. Masumura M, Murayama N, Inoue T, Ohno T. Selective induction of fibroblast growth factor receptor-1 mRNA after transient focal ischemia in the cerebral cortex of rats. Neurosci Lett. 1996;213:119-22 pubmed
    ..In view of the neuroprotective activity of basic FGF reported so far, the present results suggest that FGFR-1 induction may subserve to self-protect neurons in the ischemic penumbral field of the cerebral cortex. ..
  76. Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, et al. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008;283:23139-49 pubmed publisher
    ..Thus, PDGF signaling is a possible mechanism involved in the interaction between epithelial and neural crest-derived mesenchyme. ..
  77. Smith C, Berry M, Clarke W, Logan A. Differential expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 in a scarring and nonscarring model of CNS injury in the rat. Eur J Neurosci. 2001;13:443-56 pubmed
    ..We have investigated the expression of FGF-2 and fibroblast growth factor receptor 1 (FGFR1) after penetrating lesions to the cerebral cortex of 5 days post partum (dpp) (nonscarring) ..
  78. Ren M, Qin H, Kitamura E, Cowell J. Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models. Blood. 2013;122:1007-16 pubmed publisher
    Myeloid and lymphoid neoplasm associated with FGFR1 is an aggressive disease, and resistant to all the current chemotherapies...
  79. Meisinger C, Hertenstein A, Grothe C. Fibroblast growth factor receptor 1 in the adrenal gland and PC12 cells: developmental expression and regulation by extrinsic molecules. Brain Res Mol Brain Res. 1996;36:70-8 pubmed
    In the present study we have analyzed the expression of fibroblast growth factor receptor 1 (FGFR-1) mRNA in the developing and adult rat adrenal gland and in PC12 cells under different culture conditions...
  80. García González D, Clemente D, Coelho M, Esteban P, Soussi Yanicostas N, De Castro F. Dynamic roles of FGF-2 and Anosmin-1 in the migration of neuronal precursors from the subventricular zone during pre- and postnatal development. Exp Neurol. 2010;222:285-95 pubmed publisher
    ..At all these stages, FGF-2 exerts a FGFR1-mediated motogenic effect on NPs and induces the proliferation of SVZ astrocytes (putatively type B cells from ..
  81. Plotnikov A, Hubbard S, Schlessinger J, Mohammadi M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell. 2000;101:413-24 pubmed
    ..of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively...
  82. Molina Hernández A, Rodríguez Martínez G, Escobedo Ávila I, Velasco I. Histamine up-regulates fibroblast growth factor receptor 1 and increases FOXP2 neurons in cultured neural precursors by histamine type 1 receptor activation: conceivable role of histamine in neurogenesis during cortical development in vivo. Neural Dev. 2013;8:4 pubmed publisher
  83. Xu N, Qin Y, Reindollar R, Tho S, McDonough P, Layman L. A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2007;92:1155-8 pubmed
    ..Currently, the fibroblast growth factor receptor 1 (FGFR1) gene is the only known autosomal dominant cause of KS, which is also associated with ..
  84. Lu R, Ito J, Iwamoto N, Nishimaki Mogami T, Yokoyama S. FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res. 2009;50:1156-64 pubmed publisher
    ..We concluded that FGF-1-induced apoE expression in astrocytes depends on LXRalpha being mediated by both LXRalpha expression and an LXRalpha ligand biosynthesis. ..
  85. Ho T, Liu X, Huang Y, Warneke C, Johnson M, Hoang A, et al. The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma. BMC Cancer. 2015;15:304 pubmed publisher
    ..gov Identifier NCT00126594). Fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor receptor substrate 2 alpha (FRS2α) expression was assessed ..
  86. Ren M, Qin H, Wu Q, Savage N, George T, Cowell J. Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice. Int J Cancer. 2016;139:836-40 pubmed publisher
    ..leukemia/lymphoma syndrome, translocations involving 8p11 lead to constitutive activation of the fibroblast growth factor receptor 1 (FGFR1) kinase...
  87. Jiao H, Arner P, Dickson S, Vidal H, Mejhert N, Henegar C, et al. Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity. J Clin Endocrinol Metab. 2011;96:E962-6 pubmed publisher
    Previous studies suggest a role for fibroblast growth factor receptor 1 (FGFR1) in the regulation of energy balance. Our objective was to investigate whether FGFR1 is an obesity gene by genetic association and functional studies...