Gene Symbol: Fgf8
Description: fibroblast growth factor 8
Alias: fibroblast growth factor 8, fibroblast growth factor 8 (androgen-induced)
Species: rat
Products:     Fgf8

Top Publications

  1. Daphna Iken D, Shankar D, Lawshe A, Ornitz D, Shackleford G, MacArthur C. MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia. Oncogene. 1998;17:2711-7 pubmed
    Prior studies have identified Fibroblast Growth Factor-8 (Fgf8) as a possible proto-oncogene in mouse mammary tumorigenesis...
  2. Ghosh A, Shankar D, Shackleford G, Wu K, T Ang A, Miller G, et al. Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. Cell Growth Differ. 1996;7:1425-34 pubmed
    Three alternatively spliced mRNA isoforms of the human fibroblast growth factor-8 (FGF8) gene, expressed in a prostatic carcinoma cell line, have been isolated as cDNA clones and characterized by DNA sequencing...
  3. Valve E, Nevalainen M, Nurmi M, Laato M, Martikainen P, Harkonen P. Increased expression of FGF-8 isoforms and FGF receptors in human premalignant prostatic intraepithelial neoplasia lesions and prostate cancer. Lab Invest. 2001;81:815-26 pubmed
    b>Fibroblast growth factor 8 (FGF-8) is implicated in growth of prostate cancer. Alternative splicing of the human FGF-8 gene potentially allows coding for four protein isoforms (a, b, e, and f)...
  4. Vitelli F, Zhang Z, Huynh T, Sobotka A, Mupo A, Baldini A. Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol. 2006;295:559-70 pubmed
    b>Fgf8 and Tbx1 have been shown to interact in patterning the aortic arch, and both genes are required in formation and growth of the outflow tract of the heart. However, the nature of the interaction of the two genes is unclear...
  5. Xu X, Weinstein M, Li C, Naski M, Cohen R, Ornitz D, et al. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998;125:753-65 pubmed
    ..Consistent with this defect, the expression of Fgf8, an apical ectodermal factor, is absent in the mutant presumptive limb ectoderm, and the expression of Fgf10, a ..
  6. Storm E, Garel S, Borello U, Hebert J, Martinez S, McConnell S, et al. Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development. 2006;133:1831-44 pubmed
    Mouse embryos bearing hypomorphic and conditional null Fgf8 mutations have small and abnormally patterned telencephalons...
  7. Aggarwal V, Liao J, Bondarev A, Schimmang T, Lewandoski M, Locker J, et al. Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet. 2006;15:3219-28 pubmed
    ..Three murine Fgfs, Fgf3, Fgf8 and Fgf10 are coexpressed in different combinations with Tbx1...
  8. Kriangkrai R, Iseki S, Eto K, Chareonvit S. Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Anat Embryol (Berl). 2006;211:101-8 pubmed
    ..Thus, we conclude that maxillary incisor and mandibular molar share a similar signaling control of Fgf-8, Pitx-2, Shh, Msx-1, Pax-9 and Bmp-4 genes at the stage of oral epithelial thickening to the early bud stage of tooth development. ..
  9. Falardeau J, Chung W, Beenken A, Raivio T, Plummer L, Sidis Y, et al. Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest. 2008;118:2822-31 pubmed publisher
    ..Using a candidate gene approach, we identified 6 missense mutations in FGF8 in IHH probands with variable olfactory phenotypes...

More Information


  1. Sun X, Meyers E, Lewandoski M, Martin G. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 1999;13:1834-46 pubmed
    b>Fgf8 and Fgf4 encode FGF family members that are coexpressed in the primitive streak of the gastrulating mouse embryo. We have analyzed the phenotype of Fgf8(-/-) embryos and discovered that they fail to express Fgf4 in the streak...
  2. Zelarayan L, Vendrell V, Alvarez Y, Dominguez Frutos E, Theil T, Alonso M, et al. Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol. 2007;308:379-91 pubmed
    ..In this study we have looked to define the redundant and conserved roles of FGF3, FGF8 and FGF10 during the development of the murine and avian inner ear...
  3. Irving C, Malhas A, Guthrie S, Mason I. Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8. Development. 2002;129:5389-98 pubmed
    ..We demonstrate that both isthmic tissue and Fgf8 protein are attractants for trochlear axons in vitro, while ectopic Fgf8 causes turning of these axons away from ..
  4. Carev D, Saraga M, Saraga Babic M. Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol. 2008;23:853-62 pubmed publisher
    ..Due to VEGF involvement in vasculogenesis and angiogenesis, abnormal VEGF appearance might lead to impaired formation of the blood vessel network in the human permanent kidney. ..
  5. Mark R, Fuson K, Keane Lazar K, May P. Fibroblast growth factor-8 protects cultured rat hippocampal neurons from oxidative insult. Brain Res. 1999;830:88-93 pubmed
    ..From these studies, we conclude that FGF-8b is another member of the FGF family which may show in vivo efficacy for the treatment of oxidative insults, such as stroke. ..
  6. Zhu Y, Jiang J, Ma L, Zhang J, Hong Y, Liao K, et al. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Toxicology. 2009;260:120-5 pubmed publisher
    ..1), bone morphogenetic proteins signaling molecules (Bmp4 and Bmp7), fibroblast growth factor signaling molecules (Fgf8, Fgf10 and Fgfr2), and the transforming growth factor-beta superfamily signaling molecules (TGF-beta1 and TGF-beta ..
  7. Meyers E, Martin G. Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science. 1999;285:403-6 pubmed
    A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant...
  8. Byrd N, Meyers E. Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol. 2005;284:233-45 pubmed
    ..Recently, Fgf8 has been proposed as a candidate modifier for 22q11 deletion syndromes...
  9. Wang Q, Stamp G, Powell S, Abel P, Laniado M, Mahony C, et al. Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy. J Clin Pathol. 1999;52:29-34 pubmed
    To investigate the correlation between androgen receptor expression and fibroblast growth factor 8 (FGF8) mRNA levels...
  10. Liu S, Ma Z, Sun W, Sun X, Hong Y, Ma L, et al. The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate. Toxicology. 2012;293:53-8 pubmed publisher
    b>Fibroblast growth factor 8 (FGF8) is an androgen-induced growth factor (AIGF) that is crucial for embryonic development...
  11. Miyoshi T, Otsuka F, Yamashita M, Inagaki K, Nakamura E, Tsukamoto N, et al. Functional relationship between fibroblast growth factor-8 and bone morphogenetic proteins in regulating steroidogenesis by rat granulosa cells. Mol Cell Endocrinol. 2010;325:84-92 pubmed publisher
    ..This interaction between FGF-8 and BMPs may play a key role in regulating steroidogenesis through oocyte-granulosa cell communication. ..
  12. Morgan E, Nguyen S, Scott V, Stadler H. Loss of Bmp7 and Fgf8 signaling in Hoxa13-mutant mice causes hypospadia. Development. 2003;130:3095-109 pubmed
    ..early signaling in the developing mouse genital tubercle, we show that Hoxa13 is essential for normal expression of Fgf8 and Bmp7 in the urethral plate epithelium...
  13. Vitelli F, Lania G, Huynh T, Baldini A. Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol. 2010;49:836-40 pubmed publisher
    ..Tbx1 regulates Fgf8 expression hence the hypothesis that the proliferation impairment may contribute to the heart phenotype of mutants...
  14. Sherman L, Wainwright D, Ponta H, Herrlich P. A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. Genes Dev. 1998;12:1058-71 pubmed
  15. Ilagan R, Abu Issa R, Brown D, Yang Y, Jiao K, Schwartz R, et al. Fgf8 is required for anterior heart field development. Development. 2006;133:2435-45 pubmed
    ..Here, we have used an Fgf8lacZ allele to demonstrate that Fgf8 is expressed within the developing AHF...
  16. Lancman J, Caruccio N, Harfe B, Pasquinelli A, Schageman J, Pertsemlidis A, et al. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev Dyn. 2005;234:948-60 pubmed
    ..elegans let-7 and lin-4. Finally, we show that these miRNAs and others are expressed in the chick limb consistent with the hypothesis that they regulate chicken Lin-41 activity in vivo. ..
  17. Olsen S, Li J, Bromleigh C, Eliseenkova A, Ibrahimi O, Lao Z, et al. Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. Genes Dev. 2006;20:185-98 pubmed
    Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-hindbrain region during development...
  18. Otsuji M, Takahara M, Naruse T, Guan D, Harada M, Zhe P, et al. Developmental abnormalities in rat embryos leading to tibial ray deficiencies induced by busulfan. Birth Defects Res A Clin Mol Teratol. 2005;73:461-7 pubmed
    ..We performed Nile blue staining, whole mount in situ hybridization for fibroblast growth factor 8 (Fgf8), bone morphogenetic protein 4 (Bmp4) and Sonic hedgehog (Shh), terminal deoxynucleotidyl ..
  19. Wang X, Li X, Wang K, Zhou H, Xue B, Li L, et al. Forskolin cooperating with growth factor on generation of dopaminergic neurons from human fetal mesencephalic neural progenitor cells. Neurosci Lett. 2004;362:117-21 pubmed
    ..When NPCs were treated with FGF8 alone, the DAergic phenotype was expressed lightly...
  20. High F, Jain R, Stoller J, Antonucci N, Lu M, Loomes K, et al. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009;119:1986-96 pubmed publisher
    ..In mid-gestation, these mutants displayed decreased Fgf8 and Bmp4 expression. Notch inhibition within the second heart field affected the development of neighboring tissues...
  21. Schneider B, Seehus C, Capowski E, Aebischer P, Zhang S, Svendsen C. Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation. Hum Mol Genet. 2007;16:651-66 pubmed
    ..of ventral midbrain dopaminergic neurons, alpha-synuclein cytotoxicity appeared most pronounced following FGF8/SHH specification and was decreased by inhibition of dopamine synthesis...
  22. Lin D, Huang Y, He F, Gu S, Zhang G, Chen Y, et al. Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev Dyn. 2007;236:1307-12 pubmed
    ..human tooth morphogenesis, we examined the expression patterns of several regulatory genes, including BMP4, FGF8, MSX1, PAX9, PITX2, and SHOX2, and compared them with that found in mice...
  23. Guo C, Sun Y, Zhou B, Adam R, Li X, Pu W, et al. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011;121:1585-95 pubmed publisher
    ..The mutant phenotypes were attributable in part to a reduction of fibroblast growth factor 8 (Fgf8), which was shown to be a direct downstream effector of Six1 and Eya1...
  24. Singla R, Wang J, Singla D. Fibroblast growth factor-8 inhibits oxidative stress-induced apoptosis in H9c2 cells. Mol Cell Biochem. 2017;425:77-84 pubmed publisher
    ..Furthermore, our data demonstrate that apoptotic inhibition by FGF-8 is consequent to FoxO-1 oxidative detoxification as well as augmentation to the PI3K/AKT cell survival pathway. ..
  25. Shim K, Minowada G, Coling D, Martin G. Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell. 2005;8:553-64 pubmed
    ..Both this cell fate change and hearing loss can be partially rescued by reducing Fgf8 gene dosage in Spry2 null mutant mice...
  26. Roussa E, Farkas L, Krieglstein K. TGF-beta promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8. Neurobiol Dis. 2004;16:300-10 pubmed
    ..Treatment with TGF-beta, sonic hedgehog (Shh), or fibroblast growth factor-8 (FGF8) significantly increased number of tyrosine hydroxylase (TH)-immunoreactive neurons after 7 days, whereas ..
  27. Park E, Ogden L, Talbot A, Evans S, Cai C, Black B, et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006;133:2419-33 pubmed
    b>Fibroblast growth factor 8 (Fgf8) is a secreted signaling protein expressed in numerous temporospatial domains that are potentially relevant to cardiovascular development...
  28. Uchii M, Tamura T, Suda T, Kakuni M, Tanaka A, Miki I. Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. Arthritis Res Ther. 2008;10:R90 pubmed publisher
    b>Fibroblast growth factor 8 (FGF8) is isolated as an androgen-induced growth factor, and has recently been shown to contribute to limb morphogenesis...
  29. Macatee T, Hammond B, Arenkiel B, Francis L, Frank D, Moon A. Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development. 2003;130:6361-74 pubmed
    b>Fibroblast growth factor 8 (Fgf8) is expressed in many domains of the developing embryo...
  30. Xu J, Lawshe A, MacArthur C, Ornitz D. Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev. 1999;83:165-78 pubmed
    ..It exhibits 60% amino acid identity with Fgf8 and 50% identity with Fgf8...
  31. Valve E, Martikainen P, Seppänen J, Oksjoki S, Hinkka S, Anttila L, et al. Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors. Int J Cancer. 2000;88:718-25 pubmed
    ..This suggests that FGF-8 has an important role in ovarian tumorigenesis. ..
  32. Boulet A, Moon A, Arenkiel B, Capecchi M. The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol. 2004;273:361-72 pubmed
    ..Based on experiments in the chick, Fgf8 expression in the intermediate mesoderm (IM) has been proposed to play a critical role in the initiation of limb ..
  33. Omoteyama K, Takagi M. FGF8 regulates myogenesis and induces Runx2 expression and osteoblast differentiation in cultured cells. J Cell Biochem. 2009;106:546-52 pubmed publisher
    In the current study, treatment of the rat osteogenic cell line ROB-C26 cells with fibroblast growth factor 8 (FGF8) stimulated alkaline phosphatase (ALP) activity, and also induced the expression of the Runx2 transcription factor, and ..
  34. Gnanapragasam V, Robinson M, Marsh C, Robson C, Hamdy F, Leung H. FGF8 isoform b expression in human prostate cancer. Br J Cancer. 2003;88:1432-8 pubmed
    Overexpression of fibroblast growth factor 8 (FGF8) mRNA has been previously described in prostate cancer. Of its four isoforms, FGF8b is thought to be the most important in carcinogenesis...
  35. Marsh S, Bansal G, Zammit C, Barnard R, Coope R, Roberts Clarke D, et al. Increased expression of fibroblast growth factor 8 in human breast cancer. Oncogene. 1999;18:1053-60 pubmed
    b>Fibroblast growth factor 8 (FGF8) is an important developmental protein which is oncogenic and able to cooperate with wnt-1 to produce mouse mammary carcinoma...
  36. Lania G, Zhang Z, Huynh T, Caprio C, Moon A, Vitelli F, et al. Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol. 2009;328:109-17 pubmed publisher
    ..Because Tbx1 regulates the expression of Fgf8 in the mesoderm, we postulated that Fgf8 mediates critical Tbx1-dependent interactions between mesodermal cells and ..
  37. Tirosh Finkel L, Zeisel A, Brodt Ivenshitz M, Shamai A, Yao Z, Seger R, et al. BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors. Development. 2010;137:2989-3000 pubmed publisher
    ..Hence, BMP and FGF signaling pathways act via inter- and intra-regulatory loops in multiple tissues, to coordinate the balance between proliferation and differentiation of cardiac progenitors. ..
  38. Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P, et al. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn. 2004;229:722-32 pubmed
    ..Exogenous FGF8 peptide supplementation in vitro rescues the abnormal SMG phenotype seen in cyclopamine-treated explants, ..
  39. Potula H, Kathuria S, Ghosh A, Maiti T, Dey S. Transient expression, purification and characterization of bioactive human fibroblast growth factor 8b in tobacco plants. Transgenic Res. 2008;17:19-32 pubmed
    cDNA of human fibroblast growth factor 8 isoform b (FGF8b) was cloned for the first time into a plant expression vector with or without endoplasmic reticulum retention signal (KDEL) and was transiently expressed as His tagged fusion ..
  40. Ye W, Shimamura K, Rubenstein J, Hynes M, Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell. 1998;93:755-66 pubmed
    ..We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary and in the rostral forebrain, create induction sites for ..
  41. Ladher R, Wright T, Moon A, Mansour S, Schoenwolf G. FGF8 initiates inner ear induction in chick and mouse. Genes Dev. 2005;19:603-13 pubmed
    ..We show that endoderm is necessary for otic induction in the chick and that Fgf8, expressed in the chick endoderm subjacent to Fgf19, is both sufficient and necessary for the expression of Fgf19 ..
  42. Perantoni A, Timofeeva O, Naillat F, Richman C, Pajni Underwood S, Wilson C, et al. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development. 2005;132:3859-71 pubmed
    To bypass the essential gastrulation function of Fgf8 and study its role in lineages of the primitive streak, we have used a new mouse line, T-Cre, to generate mouse embryos with pan-mesodermal loss of Fgf8 expression...
  43. Tucker A, Al Khamis A, Ferguson C, Bach I, Rosenfeld M, Sharpe P. Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development. 1999;126:221-8 pubmed
    ..in combination with CD44, a cell surface binding protein, and that blocking CD44 binding results in inhibition of Fgf8-induced expression of Clim-2 and Lhx-6...
  44. Suzuki K, Tokue A, Kamiakito T, Kuriki K, Saito K, Tanaka A. Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. Virchows Arch. 2001;439:616-21 pubmed
    ..1 are required for the growth of early postimplantational embryonic tissues, we investigated the expressions of FGF8, FGF4, and FGFRI in surgically resected specimens of primary testicular germ cell tumors using an ..
  45. Song Z, Wu X, Powell W, Cardiff R, Cohen M, Tin R, et al. Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res. 2002;62:5096-105 pubmed
    b>Fibroblast growth factor 8 isoform b (FGF8b), a mitogenic and transforming polypeptide, was demonstrated to be naturally up-regulated in prostatic premalignant and malignant lesions in men...
  46. Jaskoll T, Witcher D, Toreno L, Bringas P, Moon A, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004;268:457-69 pubmed
    b>FGF8 has been shown to play important morphoregulatory roles during embryonic development...
  47. Kawauchi S, Shou J, Santos R, Hebert J, McConnell S, Mason I, et al. Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development. 2005;132:5211-23 pubmed
    ..We used a genetic approach to test the hypothesis that Fgf8 plays such a role in developing OE...
  48. Ericson J, Norlin S, Jessell T, Edlund T. Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development. 1998;125:1005-15 pubmed
    ..infundibulum appears to have a dual signaling function, serving initially as a source of BMP4 and subsequently of FGF8. The ventral juxtapituitary mesenchyme appears to serve as a later source of BMP2 and BMP7...
  49. Neubüser A, Peters H, Balling R, Martin G. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell. 1997;90:247-55 pubmed
    ..the sites of Pax9 expression in the mandibular arch are positioned by the combined activity of two signals, one (FGF8) that induces Pax9 expression and the other (BMP2 and BMP4) that prevents this induction...