Gene Symbol: Fgf7
Description: fibroblast growth factor 7
Alias: KGF/FGF7, Kgf, fibroblast growth factor 7, FGF-7, HBGF-7, Keratinocyte Growth Factor Fgf-7, heparin-binding growth factor 7
Species: rat
Products:     Fgf7

Top Publications

  1. Pandey J, Wendell D. Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3. Mamm Genome. 2006;17:49-57 pubmed
    ..BN-Edpm3(BN) than F344. Thus, although there is greater angiogenic activity in the pituitary of estrogen-treated F344.BN-Edpm3(BN) rats, there is a deficiency in capillary maturation compared with F344. ..
  2. Luo Y, Lu W, Mohamedali K, Jang J, Jones R, Gabriel J, et al. The glycine box: a determinant of specificity for fibroblast growth factor. Biochemistry. 1998;37:16506-15 pubmed
    ..The results suggest that the combined sequence domain, which we call the FGF glycine box (G-box), is a major determinant for the specificity of the binding of FGF to heparan sulfate-FGFR duplexes. ..
  3. Uzan B, Figeac F, Portha B, Movassat J. Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation. PLoS ONE. 2009;4:e4734 pubmed publisher
    Keratinocyte growth factor (KGF; palifermin) is a growth factor with a high degree of specificity for epithelial cells. KGF is an important effector of epithelial growth and tissue homeostasis in various organs including the pancreas...
  4. Zhao H, Patra A, Yeh C, Tanaka Y, Oh B, Dahiya R. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Biochem Biophys Res Commun. 2002;292:482-91 pubmed
    ..To test this hypothesis, TGFbeta1, TGFbeta2 TGFbeta3, TGFbetaR-I, TGFbetaR-II, TGFalpha, EGF, EGFR, KGF and KGFR gene and protein expression were analyzed in dorsal and ventral lobes of aging rat prostates (1, 3, 6, 9, ..
  5. Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, Torrisi M, et al. Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes. Exp Cell Res. 2007;313:1758-77 pubmed
    Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR)...
  6. Burns R, Fairbanks T, Sala F, De Langhe S, Mailleux A, Thiery J, et al. Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev Biol. 2004;265:61-74 pubmed
    ..Thus, FGF10 signaling via FGFR2b appears to be critical in the extension of the epithelium into the mesenchyme during cecal development. ..
  7. Boget S, Leriche A, Revol A. Basic fibroblast growth factor and keratinocyte growth factor over-expression in benign prostatic hyperplasia. Farmaco. 2001;56:467-9 pubmed
    ..In this work, the expression of two FGFs: bFGF (or FGF2) and KGF (or FGF7), was studied in RT-PCR and semi-quantified in densitometry...
  8. Kitsberg D, Leder P. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene. 1996;13:2507-15 pubmed
    ..Using this approach we identified a member of the FGF family, kgf (fgf7), as a gene that is strongly upregulated in an int-2-containing mammary tumor...
  9. Park W, Miranda B, Lebeche D, Hashimoto G, Cardoso W. FGF-10 is a chemotactic factor for distal epithelial buds during lung development. Dev Biol. 1998;201:125-34 pubmed

More Information


  1. Santa Maria P, Redmond S, Atlas M, Ghassemifar R. Keratinocyte growth factor 1, fibroblast growth factor 2 and 10 in the healing tympanic membrane following perforation in rats. J Mol Histol. 2011;42:47-58 pubmed publisher
    The aim of this study was to provide a transcriptome profile of Keratinocyte Growth Factor (KGF)-1, Fibroblast Growth Factor (FGF) 2 and FGF10 (KGF2) in the healing rat tympanic membrane (TM) over 7 days and an immunohistochemical ..
  2. Riely G, Rachmilewitz J, Koo P, Tykocinski M. alpha2-macroglobulin modulates the immunoregulatory function of the lipocalin placental protein 14. Biochem J. 2000;351 Pt 2:503-8 pubmed
    ..Moreover, this represents the first documented interaction between the protein carrier alpha(2)M and a lipocalin protein. ..
  3. Ishiwata T, Naito Z, Lu Y, Kawahara K, Fujii T, Kawamoto Y, et al. Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Exp Mol Pathol. 2002;73:181-90 pubmed
    ..Fibroblast growth factor (FGF)-7, also known as keratinocyte growth factor (KGF), and FGF-10 are members of the FGF family and show high structural homology and similar biological characteristics...
  4. Mahlapuu M, Enerback S, Carlsson P. Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development. 2001;128:2397-406 pubmed
    ..Fibroblast growth factor (FGF) 10 and FGF7 both decrease Foxf1 expression and we speculate that this is mediated by transcriptional activation of epithelial ..
  5. Yan G, Fukabori Y, Nikolaropoulos S, Wang F, McKeehan W. Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin. Mol Endocrinol. 1992;6:2123-8 pubmed
    ..secreted member of the heparin-binding fibroblast growth factor family [keratinocyte growth factor (KGF)/fibroblast growth factor-7]. KGF was mitogenic for epithelial cells, but not for stromal cells...
  6. Pereira C, Herndon D, Rocker R, Jeschke M. Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression. J Surg Res. 2007;139:222-8 pubmed
    ..In the present study, we thought to determine the interaction between keratinocyte growth factor (KGF) administered as liposomal cDNA with other dermal and epidermal growth factors and collagen synthesis in an acute ..
  7. Beer H, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, et al. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene. 2005;24:5269-77 pubmed
  8. Adamson I, Bakowska J. KGF and HGF are growth factors for mesothelial cells in pleural lavage fluid after intratracheal asbestos. Exp Lung Res. 2001;27:605-16 pubmed
    ..The present study investigates whether the known mesothelial cell mitogens keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) are present in the lung and specifically in the pleural cavity during the phase ..
  9. Litovkin K, Ivanova O, Bauer A, Hoheisel J, Bubnov V, Zaporozhan V. Microarray study of gene expression in uterine leiomyoma. Exp Oncol. 2008;30:106-11 pubmed
    ..group comprises genes that to our knowledge have not been previously reported as deregulated in fibroids: CLDN1, FGF7 (KGF), HNRPM, ISOC1, MAGEC1 (CT7), MAPK12, RFC, TIE1, TNFRSF21 (DR6)...
  10. Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, et al. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008;283:23139-49 pubmed publisher
    ..The PDGF receptor inhibitor AG-17 inhibited PDGF-induced branching, whereas exogenous FGF7 and -10 fully recovered...
  11. Karvinen S, Pasonen Seppänen S, Hyttinen J, Pienimäki J, Törrönen K, Jokela T, et al. Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. J Biol Chem. 2003;278:49495-504 pubmed
    Keratinocyte growth factor (KGF) activates keratinocyte migration and stimulates wound healing...
  12. Leung H, Mehta P, Gray L, Collins A, Robson C, Neal D. Keratinocyte growth factor expression in hormone insensitive prostate cancer. Oncogene. 1997;15:1115-20 pubmed
    ..Keratinocyte Growth Factor (KGF or FGF7) has a differentiative and proliferative effect on the epithelium of the developing rat prostate...
  13. Kezele P, Nilsson E, Skinner M. Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition. Biol Reprod. 2005;73:967-73 pubmed
    ..The mesenchymal growth factor keratinocyte growth factor (KGF) (i.e...
  14. Parrott J, Kim G, Mosher R, Skinner M. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Mol Cell Endocrinol. 2000;167:77-87 pubmed
    The current study investigates the expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium (OSE) and ovarian cancer tissues. Ovarian tumors are primarily derived from the OSE...
  15. Galiacy S, Planus E, Lepetit H, Féréol S, Laurent V, Ware L, et al. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res. 2003;283:215-29 pubmed
    ..Cell spreading and migration are the first steps of reepithelialization. Keratinocyte growth factor (KGF) plays a key role in lung epithelial repair and protects against various injuries...
  16. Teramoto H, Yoneda A, Puri P. Gene expression of fibroblast growth factors 10 and 7 is downregulated in the lung of nitrofen-induced diaphragmatic hernia in rats. J Pediatr Surg. 2003;38:1021-4 pubmed
    ..093; P <.01). Decreased gene expression of FGF-10 and FGF-7 in the hypoplastic lung suggests that pulmonary hypoplasia in nitrofen-induced CDH rat may be caused by reduced synthesis of FGF-10 and FGF-7 during lung morphogenesis. ..
  17. Padela S, Yi M, Cabacungan J, Shek S, Belcastro R, Masood A, et al. A critical role for fibroblast growth factor-7 during early alveolar formation in the neonatal rat. Pediatr Res. 2008;63:232-8 pubmed
    ..We conclude that FGF-7, most likely through its effect on the vascular bed, is required for normal early postnatal alveolar formation from secondary crests. ..
  18. Liu C, Ha X, Jiang J, Lv T, Wu C. Keratinocyte growth factor (KGF) gene therapy mediated by an attenuated form of Salmonella typhimurium ameliorates radiation induced pulmonary injury in rats. J Radiat Res. 2011;52:176-84 pubmed
    The aim of this study is to investigate the effect of KGF (Keratinocyte growth factor) gene therapy mediated by the attenuated Salmonella typhimurium Ty21a on radiation-induced pulmonary injury in rats model...
  19. Metzger D, Xu Y, Shannon J. Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev Dyn. 2007;236:1175-92 pubmed
    ..We found that expression of Elf5 was induced by FGF7 and FGF10, ligands that primarily bind FGFR2b...
  20. Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, et al. Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway. Mol Med Rep. 2016;13:3755-62 pubmed publisher
    ..Keratinocyte growth factor (KGF) small interfering RNA (siRNA) was applied to knockdown the main cytoprotective factors in the MSCs...
  21. van Tuyl M, Groenman F, Wang J, Kuliszewski M, Liu J, Tibboel D, et al. Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev Biol. 2007;303:514-26 pubmed
    ..Stimulation of vascularization with angiogenic factors such as Fgf2 and Ang1 partially restored tubular growth and branching in Shh-deficient lungs, suggesting that vascularization is required for branching morphogenesis. ..
  22. Graeff R, Wang G, McCray P. KGF and FGF-10 stimulate liquid secretion in human fetal lung. Pediatr Res. 1999;46:523-9 pubmed
    ..secretion are poorly understood; however, recent studies in murine models show that keratinocyte growth factor (KGF, FGF-7) and fibroblast growth factor 10 (FGF-10) stimulate liquid secretion...
  23. Ye F, Duvillie B, Scharfmann R. Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells. Diabetologia. 2005;48:277-81 pubmed
    ..The expression of FGFs was analysed by RT-PCR. To investigate the cell types expressing FGF7 and FGF10, we separated epithelial from mesenchymal cells using immunomagnetic beads linked to E-cadherin ..
  24. Qiao R, Yan W, Clavijo C, Mehrian Shai R, Zhong Q, Kim K, et al. Effects of KGF on alveolar epithelial cell transdifferentiation are mediated by JNK signaling. Am J Respir Cell Mol Biol. 2008;38:239-46 pubmed
    ..type I (AT1) cell-like phenotype, a process that can be both prevented and reversed by keratinocyte growth factor (KGF)...
  25. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, et al. Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J Biochem. 2000;128:923-32 pubmed
    ..These results suggest that the product of this gene might be involved in the development of sensory neurons as well as the regeneration of motor neurons. ..
  26. Siegfried S, Pekonen F, Nyman T, Ammälä M, Rutanen E. Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma. Cancer. 1997;79:1166-71 pubmed
    Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor (FGF) family. KGF is a stromally derived, paracrine growth factor specifically mitogenic for a variety of epithelial cells...
  27. Tillie Leblond I, Gosset P, Le Berre R, Janin A, Prangere T, Tonnel A, et al. Keratinocyte growth factor improves alterations of lung permeability and bronchial epithelium in allergic rats. Eur Respir J. 2007;30:31-9 pubmed
    ..Keratinocyte growth factor (KGF) has been shown to induce epithelial cell proliferation and to protect from acute lung injuries...
  28. Mason R, Pan T, Edeen K, Nielsen L, Zhang F, Longphre M, et al. Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. J Clin Invest. 2003;112:244-55 pubmed
    ..We developed culture conditions in which keratinocyte growth factor (KGF) stimulates fatty acid and phospholipid synthesis...
  29. Chelly N, Henrion A, Pinteur C, Chailley Heu B, Bourbon J. Role of keratinocyte growth factor in the control of surfactant synthesis by fetal lung mesenchyme. Endocrinology. 2001;142:1814-9 pubmed
    ..We have recently shown that keratinocyte growth factor (KGF), also called fibroblast growth factor-7, enhances the maturation of fetal alveolar epithelial type II cells...
  30. Zhang T, Guan H, Yang K. Keratinocyte growth factor promotes preadipocyte proliferation via an autocrine mechanism. J Cell Biochem. 2010;109:737-46 pubmed publisher
    Keratinocyte growth factor (KGF; also known as FGF-7) is a well-characterized paracrine growth factor for tissue growth and regeneration...
  31. Manavi M, Hudelist G, Fink Retter A, Gschwandtler Kaulich D, Pischinger K, Czerwenka K. Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Gynecol Oncol. 2007;105:418-26 pubmed
    ..c-erbB-2), cyclin-dependent kinase inhibitor 4 (CDKN2A, p16INK4A), cytokeratin 8 (KRT8), KRAS (K-ras), FLT1, KGF (FGF7), BCL2-like 2 protein (BCL2L2), ERBB4, MYCN (N-myc), cyclin D1 (CCND1), KIT (c-kit), secreted phosphoprotein 1 (..
  32. Al Hamilly N, Radwan L, Abdul Rahman M, Mourad M, Grawish M. Biological roles of KGF, CTGF and TGF-β in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. Arch Oral Biol. 2016;66:38-43 pubmed publisher
    To identify the possible biological roles of keratinocyte growth factor (KGF), connective tissue growth factor (CTGF) and transforming growth factor-β (TGF-β) in cyclosporine-A (CsA) and phenytoin (PNT)-induced gingival overgrowth (..
  33. Yan G, Nikolaropoulos S, Wang F, McKeehan W. Sequence of rat keratinocyte growth factor (heparin-binding growth factor type 7). In Vitro Cell Dev Biol. 1991;27A:437-8 pubmed
  34. Beyer T, Werner S, Dickson C, Grose R. Fibroblast growth factor 22 and its potential role during skin development and repair. Exp Cell Res. 2003;287:228-36 pubmed
    ..5 embryos, as well as in adult skin and keratinocytes of the hyperthickened wound epithelium. This expression pattern suggests a potential role for FGF-22 in cutaneous development and repair. ..