Gene Symbol: Fgf2
Description: fibroblast growth factor 2
Alias: Fgf-2, bFGF, fibroblast growth factor 2, HBGF-2, angiogenesis promoting growth factor, basic fibroblast growth factor, heparin binding growth factor, heparin-binding growth factor 2
Species: rat
Products:     Fgf2

Top Publications

  1. Fujimoto K, Ichimori Y, Kakizoe T, Okajima E, Sakamoto H, Sugimura T, et al. Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma. Biochem Biophys Res Commun. 1991;180:386-92 pubmed
    ..The present results indicate that serum basic FGF level of patients with renal cell carcinoma is a useful diagnostic and prognostic marker for renal cell carcinoma. On the other hand, acidic FGF was not detectable in all sera and urine. ..
  2. Bland S, Tamlyn J, Barrientos R, Greenwood B, Watkins L, Campeau S, et al. Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress. Neuroscience. 2007;144:1219-28 pubmed
    Neurotrophic factors, including basic fibroblast growth factor (FGF-2) and brain-derived neurotrophic factor (BDNF) are known to be affected by exposure to stressful experiences...
  3. Schiera G, Proia P, Alberti C, Mineo M, Savettieri G, Di Liegro I. Neurons produce FGF2 and VEGF and secrete them at least in part by shedding extracellular vesicles. J Cell Mol Med. 2007;11:1384-94 pubmed publisher
    ..In the present paper, we report that neurons produce both vascular endothelial growth factor and fibroblast growth factor 2, two well-known angiogenic factors...
  4. Hellman U, Hellström M, Morner S, Engström Laurent A, Aberg A, Oliviero P, et al. Parallel up-regulation of FGF-2 and hyaluronan during development of cardiac hypertrophy in rat. Cell Tissue Res. 2008;332:49-56 pubmed publisher
  5. Chadi G, Silva C, Maximino J, Fuxe K, da Silva G. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain Res. 2008;1190:23-38 pubmed
    The present study investigated the effects of bilateral adrenalectomy (ADX) on the synthesis of basic fibroblast growth factor (bFGF, FGF-2) mRNA and on the expression of its FGF receptor subtype-2 (FGFR2) mRNA after a 6-hydroxydopamine (..
  6. Muller Ostermeyer F, Claus P, Grothe C. Distinctive effects of rat fibroblast growth factor-2 isoforms on PC12 and Schwann cells. Growth Factors. 2001;19:175-91 pubmed
  7. Timmer M, Muller Ostermeyer F, Kloth V, Winkler C, Grothe C, Nikkhah G. Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms. Exp Neurol. 2004;187:118-36 pubmed
    ..We propose that administration of HMW FGF-2 may be used to improve function in the rat Parkinson's disease model. ..
  8. Jungnickel J, Klutzny A, Guhr S, Meyer K, Grothe C. Regulation of neuronal death and calcitonin gene-related peptide by fibroblast growth factor-2 and FGFR3 after peripheral nerve injury: evidence from mouse mutants. Neuroscience. 2005;134:1343-50 pubmed
    The presence and regulation of basic fibroblast growth factor and its high-affinity tyrosine kinase receptor FGFR3 in sensory neurons during development and after peripheral nerve injury suggest a physiological role of the fibroblast ..
  9. Izikki M, Guignabert C, Fadel E, Humbert M, Tu L, Zadigue P, et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest. 2009;119:512-23 pubmed publisher
    ..Levels of FGF2 were increased in the medium of IPH P-ECs over controls, while there was no detectable difference in TGF-beta1, ..

More Information

Publications108 found, 100 shown here

  1. Poleshko A, Lobanok E, Mezhevikina L, Fesenko E, VolotkovskiÄ­ I. [The process of heme synthesis in bone marrow mesenchymal stem cells cultured under fibroblast growth factor bFGF and hypoxic conditions]. Biofizika. 2014;59:1125-30 pubmed
    It was demonstrated that fibroblast growth factor bFGF influences the process of heme synthesis, the proliferation activity and viability of bone marrow mesenchymal stem cells in culture under hypoxic conditions...
  2. Ishibashi T, Shinogami M, Ishimoto S, Yoshida K, Kaga K. Induction of KGF, basic FGF, and TGFalpha mRNA expression during healing of experimental TM perforations. Acta Otolaryngol. 1998;118:701-4 pubmed
    ..A related peptide, basic fibroblast growth factor (bFGF), has mitogenic properties for fibroblasts and endothelial cells...
  3. Chen R, Yu B, Hu L, Yan Z, Wang W, Liu M. [Changes of HSP70, bFGF and TGF-beta1 expression in rat brain after concussion]. Fa Yi Xue Za Zhi. 2009;25:249-53 pubmed
    ..directed against heat shock protein 70 (HSP70), transforming growth factor beta 1 (TGF-beta1) and basic fibroblast growth factor (bFGF)...
  4. Igelhorst B, Niederkinkhaus V, Karus C, Lange M, Dietzel I. Regulation of neuronal excitability by release of proteins from glial cells. Philos Trans R Soc Lond B Biol Sci. 2015;370: pubmed publisher
    ..As a first example, we show that basic fibroblast growth factor and neurotrophin-3, which are released from astrocytes by exposure to thyroid hormone, influence each ..
  5. Chen Q, Wang W. Expression of FGF-2 and IGF-1 in diabetic rats with fracture. Asian Pac J Trop Med. 2014;7:71-5 pubmed publisher
    ..There are some synergistic effects possibly between FGF-2 and IGF-1. ..
  6. Nakano S, Nakamura K, Teramoto N, Yamanouchi K, Nishihara M. Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells. Anim Sci J. 2016;87:99-108 pubmed publisher
    ..among the growth factors tested, which were known to be expressed in skeletal muscle, we found only basic fibroblast growth factor (bFGF) has a pro-adipogenic effect on skeletal muscle derived adipogenic progenitor clone, 2G11 cells...
  7. Hsiung R, Zhu W, Klein G, Qin W, Rosenberg A, Park P, et al. High basic fibroblast growth factor levels in nipple aspirate fluid are correlated with breast cancer. Cancer J. 2002;8:303-10 pubmed
    The angiogenic basic fibroblast growth factor (bFGF) and vascular endothelial growth factor are important in malignant breast epithelial growth...
  8. Li P, Oparil S, Sun J, Thompson J, Chen Y. Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells. J Appl Physiol (1985). 2003;95:643-51; discussion 863 pubmed
  9. Khalil N, Xu Y, O CONNOR R, Duronio V. Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK. J Biol Chem. 2005;280:43000-9 pubmed
  10. Sato T, Lee T, Takamatsu F, Fujikado T. Induction of fibroblast growth factor-2 by electrical stimulation in cultured retinal Mueller cells. Neuroreport. 2008;19:1617-21 pubmed publisher
    ..that retinal Mueller cells, the predominant glial cells, produce neurotrophic factors including basic fibroblast growth factor (FGF-2), and that electrical stimulation enhances the transcription of FGF-2 in the central nervous ..
  11. Liu H, Wang Q, Zhu F, Luo P, Liu T, Wei X. [Effect of fluorosis on the expression of basic fibroblast growth factor in rat incisors]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2007;42:242-4 pubmed
    To investigate the effects of overdose fluoride on the expression of basic fibroblast growth factor (bFGF) in rat incisors...
  12. Numakawa T, Nakajima S, Yamamoto N, Ooshima Y, Odaka H, Hashido K, et al. Basic fibroblast growth factor induces miR-134 upregulation in astrocyte for cell maturation. Biochem Biophys Res Commun. 2015;456:465-70 pubmed publisher
    ..Here, we report that basic fibroblast growth factor (bFGF) increased miR-134 expression in astrocyte...
  13. Su G, Meyer K, Nandini C, Qiao D, Salamat S, Friedl A. Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol. 2006;168:2014-26 pubmed
    Signaling by fibroblast growth factor 2 (FGF-2), an autocrine stimulator of glioma growth, is regulated by heparan sulfate proteoglycans (HSPGs) via a ternary complex with FGF-2 and the FGF receptor (FGFR)...
  14. Torres T, Lotfi C. Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2. Cell Tissue Res. 2007;329:443-55 pubmed
    ..The effects of adrenocorticotropic hormone (ACTH) and fibroblast growth factor 2 (FGF2) on Fos and Jun protein expression were investigated, and DNA synthesis was assessed by using ..
  15. Siddiqi S, Gude N, Hosoda T, Muraski J, Rubio M, Emmanuel G, et al. Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res. 2008;103:89-97 pubmed publisher
  16. Li X, Barkho B, Luo Y, Smrt R, Santistevan N, Liu C, et al. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008;283:27644-52 pubmed publisher
    ..Although exogenous basic fibroblast growth factor 2 (FGF-2/Fgf-2) is commonly used to expand adult neural stem/progenitor cells (NSPCs) in vitro, we do ..
  17. Kawaguchi H, Kurokawa T, Hanada K, Hiyama Y, Tamura M, Ogata E, et al. Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats. Endocrinology. 1994;135:774-81 pubmed
    The effect of local application of recombinant human basic fibroblast growth factor (rhbFGF) on fracture repair was examined using normal rats and streptozotocin-diabetic rats with impaired repairing ability...
  18. Cao W, Wen R, Li F, LaVail M, Steinberg R. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp Eye Res. 1997;65:241-8 pubmed
    ..response of the normal mouse retina to mechanical injury by examining the expression of mRNAs for basic fibroblast growth factor (bFGF), ciliary neurotrophic factor (CNTF), and their receptors, FGF receptor-1 (FGFR-1) and CNTF ..
  19. Wang H, Ruan H, Huang G. [A preliminary study on the changes of expression of PDGF-beta, PDGFR-beta, TGF-beta 1, TGFR, bFGF and its relationship with the wound age in wound healing]. Fa Yi Xue Za Zhi. 2001;17:198-201, 204 pubmed
    ..5-6 h pm). The expression of the cytokines PDGF-beta, PDGFR-beta, TGF-beta 1, and bFGF in the epithelial cells was already enhanced since 0...
  20. Yoon K, Nery S, Rutlin M, Radtke F, Fishell G, Gaiano N. Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci. 2004;24:9497-506 pubmed
    ..5 (E14.5) ganglionic eminence (GE) progenitors that grew into neurospheres in FGF2. Constitutive activation of C-promoter binding factor (CBF1), a Notch pathway effector, also increased neurosphere ..
  21. Serls A, Doherty S, Parvatiyar P, Wells J, Deutsch G. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development. 2005;132:35-47 pubmed
    ..of cardiac mesoderm, ventral foregut endoderm explants respond to exogenous fibroblast growth factor (FGF) 1 and FGF2 in a dose-dependent manner, with lower concentrations activating liver specific genes and higher concentrations ..
  22. Imamura M, Kanematsu A, Yamamoto S, Kimura Y, Kanatani I, Ito N, et al. Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. Am J Physiol Renal Physiol. 2007;293:F1007-17 pubmed
    ..In this report, the role of basic fibroblast growth factor (bFGF) was investigated using a rat bladder smooth muscle cell (BSMC) culture system and an original ..
  23. Mao X, Zeng Q, Wang X, Cao L. [Mechanism of the angiogenic effect of bone marrow stromal cells implantation on acute myocardial infarction]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005;21:311-4 pubmed
    ..The infarction regions were examined to identify the angiogenesis and the expression of the VEGF and bFGF. In experiment group, the hearts were examined on the day 42 and 56 after AMI (the day 14 and 28 after cells ..
  24. Messersmith D, Murtie J, Le T, Frost E, Armstrong R. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. J Neurosci Res. 2000;62:241-56 pubmed
    b>Fibroblast growth factor 2 (FGF2) is an excellent candidate to regulate remyelination based on its proposed actions in oligodendrocyte lineage cell development in conjunction with its involvement in CNS regeneration...
  25. Kondratyev A, Ved R, Gale K. The effects of repeated minimal electroconvulsive shock exposure on levels of mRNA encoding fibroblast growth factor-2 and nerve growth factor in limbic regions. Neuroscience. 2002;114:411-6 pubmed
    ..The sustained increases in mRNAs for these trophic factors may contribute to the neuroprotective actions of chronic ECS treatment. ..
  26. Monfils M, Driscoll I, Melvin N, Kolb B. Differential expression of basic fibroblast growth factor-2 in the developing rat brain. Neuroscience. 2006;141:213-21 pubmed
    b>Basic fibroblast growth factor-2 is a trophic molecule involved in a number of functions within the CNS, including the regulation of CNS responses to injury...
  27. Fu X, Sun T, Gu X. [Expression of basic fibroblast growth factor (bFGF) in rat and mouse skin and its biological significance]. Zhonghua Yi Xue Za Zhi. 2001;81:609-12 pubmed
    To explore the expression of basic fibroblast growth factor (bFGF) in rat and mouse skin and to explore its potential biological singificance...
  28. Thomas Mudge R, Okada Ban M, Vandenbroucke F, Vincent Salomon A, Girault J, Thiery J, et al. Nuclear FGF-2 facilitates cell survival in vitro and during establishment of metastases. Oncogene. 2004;23:4771-9 pubmed
    Nuclear-targeted high molecular weight 24 kDa fibroblast growth factor 2 (FGF-2) may induce specific cell functions through intracrine mechanisms...
  29. Rose K, Kriha D, Pallast S, Junker V, Klumpp S, Krieglstein J. Basic fibroblast growth factor: lysine 134 is essential for its neuroprotective activity. Neurochem Int. 2007;51:25-31 pubmed
    b>Basic fibroblast growth factor (bFGF) is a heparin-binding growth factor known to cause cell proliferation, angiogenesis and neuroprotection...
  30. Gomez M, Manzano A, Figueras A, Vinals F, Ventura F, Rosa J, et al. Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway. Am J Physiol Endocrinol Metab. 2012;303:E695-707 pubmed publisher
    ..Pulldown assays showed the binding of the CREB transcription factor to this site. Altogether, these results show how the paracrine regulation orchestrated by Sertoli cells in response to testosterone controls glycolysis in germ cells. ..
  31. Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E. Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells. Biol Pharm Bull. 2014;37:688-93 pubmed
    ..The aim of the present study was to clarify the effect of one of these factors, basic fibroblast growth factor (bFGF) on differentiation of EPC...
  32. Hayashi A, Kim H, de Juan E. Alterations in protein tyrosine kinase pathways following retinal vein occlusion in the rat. Curr Eye Res. 1999;18:231-9 pubmed
    ..western blot analysis of tyrosine-phosphorylated proteins, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and 3 signal proteins in the tyrosine kinase pathways: phospholipase Cgamma (PLCgamma), ..
  33. Shin E, Lee C, Cho T, Kim Y, Song S, Juhnn Y, et al. betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth. J Biol Chem. 2006;281:35954-64 pubmed
    ..that betaPak-interacting exchange factor (betaPIX) guanine nucleotide exchange factor (GEF) mediates basic fibroblast growth factor (bFGF)-stimulated Rac1 activation through phosphorylation of Ser-525 and Thr-526 at the GIT-binding ..
  34. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, et al. Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors. Stem Cells. 2009;27:3021-31 pubmed publisher
    ..Taken together, these data support the premise that genetic modification of MSCs before transplantation could be salutary for treating myocardial infarction. ..
  35. Shurygin M, Shurygina I. [Influence of FGF2 level on the inflammation phase dynamics at the postinfarction cardiosclerosis]. Patol Fiziol Eksp Ter. 2010;:34-7 pubmed
    ..inflammatory stage and take effect on the early collagen synthesis in infarction regions (from 3 days in group with FGF2 injection vs. 7 days in control group)...
  36. Yang J, Wang X, Shi B, Huang F. The angiogenic peptide vascular endothelial growth factor-basic fibroblast growth factor signaling is up-regulated in a rat pressure ulcer model. Anat Rec (Hoboken). 2013;296:1161-8 pubmed publisher
    ..to investigate the mRNA and protein expression levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in pressure ulcers, and to elucidate the molecular mechanism by which VEGF and bFGF are ..
  37. Madiai F, Goettl V, Hussain S, Clairmont A, Stephens R, Hackshaw K. Anti-fibroblast growth factor-2 antibodies attenuate mechanical allodynia in a rat model of neuropathic pain. J Mol Neurosci. 2005;27:315-24 pubmed
    ..These results suggest that endogenous astroglial FGF-2 contributes to maintaining NP tactile allodynia associated with reactivity of spinal cord astrocytes and that inhibition of spinal FGF-2 ameliorates NP pain signs. ..
  38. Maffucci T, Raimondi C, Abu Hayyeh S, Dominguez V, Sala G, Zachary I, et al. A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation. PLoS ONE. 2009;4:e8285 pubmed publisher
    ..Furthermore these data unveil a novel role for PLCgamma1 as a mediator of PI3K-dependent Akt activation and as a novel key regulator of different Akt-dependent processes. ..
  39. Zimering M, Katsumata N, Sato Y, Brandi M, Aurbach G, Marx S, et al. Increased basic fibroblast growth factor in plasma from multiple endocrine neoplasia type 1: relation to pituitary tumor. J Clin Endocrinol Metab. 1993;76:1182-7 pubmed
    ..We previously reported a basic fibroblast growth factor (bFGF)-like substance in the plasma of subjects with MEN1...
  40. Kaneko K, Yonemitsu Y, Fujii T, Onimaru M, Jin C, Inoue M, et al. A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia. Am J Physiol Heart Circ Physiol. 2006;290:H1484-92 pubmed
    ..These results suggest the distinct mechanism of MNMS from critical limb ischemia without reperfusion. Therefore, radical scavenging should be paid more attention than therapeutic angiogenesis when arterial circulation is reconstructed. ..
  41. Liu Y, Liu Y, Liu X, Chen J, Zhang K, Huang F, et al. Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition. J Am Heart Assoc. 2015;4: pubmed publisher
    ..Our study added evidence to the beneficial effect of apocynin in type 4 CRS. ..
  42. Chen G, Chen Y, Yang X, Li Z. Nano-microcapsule basic fibroblast growth factor combined with hypoxia-inducible factor-1 improves random skin flap survival in rats. Mol Med Rep. 2016;13:1661-6 pubmed publisher
    The present study aimed to investigate the effect of nano-microcapsule-basic fibroblast growth factor (bFGF) combined with hypoxia-inducible factor-1 (HIF-1) on the random skin flap survival of rats...
  43. Ben Ami R, Albert N, Lewis R, Kontoyiannis D. Proangiogenic growth factors potentiate in situ angiogenesis and enhance antifungal drug activity in murine invasive aspergillosis. J Infect Dis. 2013;207:1066-74 pubmed publisher
    ..We assessed the effects of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on survival rates, fungal burden, and in situ ..
  44. Mansukhani A, Moscatelli D, Talarico D, Levytska V, Basilico C. A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF. Proc Natl Acad Sci U S A. 1990;87:4378-82 pubmed
    ..Thus this receptor can functionally interact with two growth factors of the FGF family. ..
  45. Leadbeater W, Gonzalez A, Logaras N, Berry M, Turnbull J, Logan A. Intracellular trafficking in neurones and glia of fibroblast growth factor-2, fibroblast growth factor receptor 1 and heparan sulphate proteoglycans in the injured adult rat cerebral cortex. J Neurochem. 2006;96:1189-200 pubmed
    ..The spatiotemporal dynamics of FGF-2-FGFR1-HSPG complex formation implies a role for individual HSPGs in regulating FGF-2 storage, nuclear trafficking and cell-specific injury responses in CNS wounds. ..
  46. Gu Y, Xue C, Zhu J, Sun H, Ding F, Cao Z, et al. Basic fibroblast growth factor (bFGF) facilitates differentiation of adult dorsal root ganglia-derived neural stem cells toward Schwann cells by binding to FGFR-1 through MAPK/ERK activation. J Mol Neurosci. 2014;52:538-51 pubmed publisher
    ..We found that among these three growth factors, bFGF was the strongest inducer for the glial differentiation of DRG-NSCs, and bFGF induced the generation of an ..
  47. Cho J, Kholodilov N, Burke R. Patterns of developmental mRNA expression of neurturin and GFRalpha2 in the rat striatum and substantia nigra do not suggest a role in the regulation of natural cell death in dopamine neurons. Brain Res Dev Brain Res. 2004;148:143-9 pubmed
    ..Thus these studies are not strongly supportive of a role for NTN in regulating natural cell death (NCD) in DA neurons, either as a target-derived or as a local paracrine factor. ..
  48. Liu W, Wang Z, Huang Z. Bone marrow-derived mesenchymal stem cells expressing the bFGF transgene promote axon regeneration and functional recovery after spinal cord injury in rats. Neurol Res. 2011;33:686-93 pubmed publisher
    ..effects of transplanting bone marrow-derived mesenchymal stem cells (BMSCs) transfected with the basic fibroblast growth factor (bFGF) gene in spinal cord-injured rats...
  49. Li P, Bai Y, Yin G, Pu X, Huang Z, Liao X, et al. Synergistic and sequential effects of BMP-2, bFGF and VEGF on osteogenic differentiation of rat osteoblasts. J Bone Miner Metab. 2014;32:627-35 pubmed publisher
    ..the effects of bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) on regulation of rat osteoblast (ROB) maturation in vitro were investigated...
  50. Zhang L, Chen Y, Li G, Chen M, Huang W, Liu Y, et al. TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts. Lipids Health Dis. 2016;15:2 pubmed publisher
    ..The above results suggest that p38/Egr-1 pathway-mediated FGF-2 is involved in 15-HETE-induced differentiation of PAFs into myofibroblasts and cell proliferation. ..
  51. Uranishi R, Nakase H, Sakaki T. Expression of angiogenic growth factors in dural arteriovenous fistula. J Neurosurg. 1999;91:781-6 pubmed
    ..the existence of sinus thrombosis in dural AVF and the expression of angiogenic growth factors (basic fibroblast growth factor [bFGF] and vascular endothelial growth factor [VEGF]) in nine patients with dural AVFs that were ..
  52. Salik E, Ercan F, Sirvanci S, Cetinel S, Onat F, San T. Effect of aging on the distribution of basic fibroblast growth factor immunoreactive cells in the rat hippocampus. Brain Res Bull. 2005;64:409-15 pubmed
    ..b>Basic fibroblast growth factor (bFGF) plays an important role in the stimulation of mitogenesis in glial cells, the support of ..
  53. Shetty A, Hattiangady B, Shetty G. Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes. Glia. 2005;51:173-86 pubmed
    ..Additionally, the results demonstrate that decreased FGF-2 concentration during aging is a consequence of age-related impairment in FGF-2 synthesis by astrocytes. ..
  54. Xiao Y, Zhao B, Gao Z, Pan Q. Overaccumulation of transforming growth factor-beta1 and basic fibroblast growth factor in lens epithelial cells of congenital cataract. Can J Ophthalmol. 2009;44:189-92 pubmed publisher
    The aim of this study was to evaluate the accumulation of transforming growth factor (TGF)-beta1 and basic fibroblast growth factor (bFGF) at gene and protein levels in lens epithelial cells of anterior subcapsular congenital cataracts (..
  55. Cho K, Lee D, Shin D, Park Y, Chon K. The importance of vascular endothelial growth factor in the healing of acute tympanic membrane perforation. Am J Otolaryngol. 2010;31:309-14 pubmed publisher
    The purpose of this study was to determine the more important growth factor expression between basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in the healing of acute tympanic membrane (TM) perforation...
  56. Yang Y, Xia T, Zhi W, Wei L, Weng J, Zhang C, et al. Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials. 2011;32:4243-54 pubmed publisher
    ..Emulsion electrospinning was adopted to imbed basic fibroblast growth factor (bFGF) into ultrafine fibers with a core-sheath structure to promote the wound healing process...
  57. Xu W, Wang X, Xu G, Guo J. Basic fibroblast growth factor expression is implicated in mesenchymal stem cells response to light-induced retinal injury. Cell Mol Neurobiol. 2013;33:1171-9 pubmed publisher
    ..b>Basic fibroblast growth factor (bFGF) in MSCs was knockdown by lentivirus-mediated mRNA interference...
  58. Kamemura N, Murakami S, Komatsu H, Sawanoi M, Miyamoto K, Ishidoh K, et al. Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells. Biochem Biophys Res Commun. 2017;483:82-87 pubmed publisher
    ..Although FGF2 stimulation induced the phosphorylation of ERK1/2, MEK1/2, and Raf-1 at Ser-338 in rat chondrosarcoma cells, ..
  59. Woodman S, Ashton A, Schubert W, Lee H, Williams T, Medina F, et al. Caveolin-1 knockout mice show an impaired angiogenic response to exogenous stimuli. Am J Pathol. 2003;162:2059-68 pubmed
    ..A primary mediator of angiogenesis is basic fibroblast growth factor (bFGF)...
  60. Nilsson E, Skinner M. Kit ligand and basic fibroblast growth factor interactions in the induction of ovarian primordial to primary follicle transition. Mol Cell Endocrinol. 2004;214:19-25 pubmed
    ..e. stem cell factor) and basic fibroblast growth factor (bFGF) that promote the primordial to primary follicle transition in rat ovaries...
  61. He Z, Ding J, Zhang J, Liu Y, Gong C, Sun S, et al. Fibroblast growth factor-2 counteracts the effect of ciliary neurotrophic factor on spontaneous differentiation in adult hippocampal progenitor cells. J Huazhong Univ Sci Technolog Med Sci. 2012;32:867-871 pubmed publisher
    ..These results suggested that FGF-2 could inhibit the spontaneous differentiation of cultured AHPs by negatively regulating the expression of endogenous CNTF in AHPs. ..
  62. Zittermann S, Issekutz A. Endothelial growth factors VEGF and bFGF differentially enhance monocyte and neutrophil recruitment to inflammation. J Leukoc Biol. 2006;80:247-57 pubmed
    Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are produced at sites of inflammation...
  63. Urbich C, Rossig L, Kaluza D, Potente M, Boeckel J, Knau A, et al. HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood. 2009;113:5669-79 pubmed publisher
    ..Silencing of HDAC5 increased the expression of fibroblast growth factor 2 (FGF2) and angiogenic guidance factors, including Slit2...
  64. de Oliveira G, Duobles T, Castelucci P, Chadi G. Differential regulation of FGF-2 in neurons and reactive astrocytes of axotomized rat hypoglossal nucleus. A possible therapeutic target for neuroprotection in peripheral nerve pathology. Acta Histochem. 2010;112:604-17 pubmed publisher
    ..In many cases, suitable treatment is problematic as the therapeutic target remains unknown. Basic fibroblast growth factor (bFGF, FGF-2) is involved in neuronal maintenance and wound repair following nervous system lesions...
  65. Carreras I, Rich C, Panchenko M, Foster J. Basic fibroblast growth factor decreases elastin gene transcription in aortic smooth muscle cells. J Cell Biochem. 2002;85:592-600 pubmed
    ..In this study, we examined the effect of basic fibroblast growth factor (bFGF) on the expression of elastin in aortic smooth muscle cells (SMC) to gain insight into events ..
  66. Cowan C, Quarto N, Warren S, Salim A, Longaker M. Age-related changes in the biomolecular mechanisms of calvarial osteoblast biology affect fibroblast growth factor-2 signaling and osteogenesis. J Biol Chem. 2003;278:32005-13 pubmed
    ..Collectively, these findings begin to explain why juvenile, but not adult, osteoblasts successfully heal calvarial defects. ..
  67. Neubauer M, Fischbach C, Bauer Kreisel P, Lieb E, Hacker M, Tessmar J, et al. Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. FEBS Lett. 2004;577:277-83 pubmed
    ..It is widely acknowledged that basic fibroblast growth factor (bFGF) modulates chondrogenic and osteogenic differentiation of MSCs, but thorough investigations of ..
  68. Yao H, Liu T, Meng X, Han Q, Zhang M, Wang L. Effect of basic fibroblast growth factor on the myocardial expression of hypoxia-inducible factor-1? and vascular endothelial growth factor following acute myocardial infarction. Heart Lung Circ. 2013;22:946-51 pubmed publisher
    To investigate the effect of basic fibroblast growth factor (bFGF) on myocardial expression of hypoxia-inducible factor-1? (HIF-1?) and vascular endothelial growth factor (VEGF) following acute myocardial infarction (AMI) in rats...
  69. Prokosch Willing V, Meyer Zu Hoerste M, Mertsch S, Stupp T, Thanos S. Postnatal visual deprivation in rats regulates several retinal genes and proteins, including differentiation-associated fibroblast growth factor-2. Dev Neurosci. 2015;37:14-28 pubmed publisher
    ..At the retinomic level, several transcripts associated with retinal differentiation, such as fibroblast growth factor 2 (FGF-2), were either up- or downregulated. Most of the transcripts could be verified at the mRNA level...
  70. Santana R, Trackman P. Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus. Int J Oral Maxillofac Implants. 2006;21:711-8 pubmed
    ..The present study investigated whether controlled local release of fibroblast growth factor 2 (FGF-2) stimulates bone defect healing in this model of diabetes...
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    ..In addition, the presence of basic fibroblast growth factor (bFGF) enhances this AEC function...
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    ..Lastly, ChIP analyses revealed that Sp1 binds to the FGF-2 promoter region in vivo. These results indicate that expression of FGF-2 in neonatal rat cardiomyocytes is associated with Sp1 binding to the FGF-2 promoter. ..
  73. Jang E, Albadawi H, Watkins M, Edelman E, Baker A. Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle. Proc Natl Acad Sci U S A. 2012;109:1679-84 pubmed publisher
    ..Taken together, these results support liposomal delivery of syndecan-4 as an effective means to improving the potential of using growth factors to achieve therapeutic neovascularization of ischemic tissue. ..
  74. Srisakuldee W, Makazan Z, Nickel B, Zhang F, Thliveris J, Pasumarthi K, et al. The FGF-2-triggered protection of cardiac subsarcolemmal mitochondria from calcium overload is mitochondrial connexin 43-dependent. Cardiovasc Res. 2014;103:72-80 pubmed publisher
    b>Fibroblast growth factor 2 (FGF-2) protects the heart from ischaemia- and reperfusion-induced cell death by a mechanism linked to protein kinase C (PKC)?-mediated connexin 43 (Cx43) phosphorylation...
  75. Satoh H, Asano S, Maeda R, Murakami I, Inada I, Sato F, et al. Prevention of gastric ulcer relapse induced by indomethacin in rats by a mutein of basic fibroblast growth factor. Jpn J Pharmacol. 1997;73:229-41 pubmed
    ..In the present study, we examined the effects of human basic fibroblast growth factor (bFGF) mutein CS23 (TGP-580) and histamine H2-receptor antagonists (H2-RAs) on ulcer relapse in this ..
  76. Follesa P, Biggio F, Gorini G, Caria S, Talani G, Dazzi L, et al. Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain. Brain Res. 2007;1179:28-34 pubmed
    ..These new findings contribute to the elucidation of the molecular mechanisms underlying the therapeutic actions of vagus nerve stimulation in both treatment-resistant depression and epilepsy. ..
  77. Rose K, Litterscheid S, Klumpp S, Krieglstein J. Fibroblast growth factor 2 requires complex formation with ATP for neuroprotective activity. Neuroscience. 2009;164:1695-700 pubmed publisher
    The neurotrophic and neuroprotective activity of fibroblast growth factor (FGF2) is well documented. In this study, we attempted to demonstrate that binding of ATP to FGF2 is essential for its neuroprotective effect...
  78. Won S, Xie L, Kim S, Tang H, Wang Y, Mao X, et al. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res. 2006;1123:237-44 pubmed
    b>Basic fibroblast growth factor (FGF-2) has been reported to protect against ischemic injury in the brains of young adult rodents. However, little is known about whether FGF-2 retains this capability in the aged ischemic brain...
  79. Fayazzadeh E, Ahmadi S, Rabbani S, Boroumand M, Salavati A, Anvari M. A comparative study of recombinant human basic fibroblast growth factor (bFGF) and erythropoietin (EPO) in prevention of skin flap ischemic necrosis in rats. Arch Iran Med. 2012;15:553-6 pubmed publisher
    ..In present experimental study, we investigated the effects of fibroblast growth factor-2 (FGF-2 or bFGF) and erythropoietin (EPO) in prevention of skin flap necrosis in rats...
  80. Pasumarthi K, Kardami E, Cattini P. High and low molecular weight fibroblast growth factor-2 increase proliferation of neonatal rat cardiac myocytes but have differential effects on binucleation and nuclear morphology. Evidence for both paracrine and intracrine actions of fibroblast gr. Circ Res. 1996;78:126-36 pubmed
    b>Basic fibroblast growth factor (FGF-2) plays a vital role in the growth and differentiation of cardiac myocytes. It exists in high and low molecular weight forms because of the use of alternative initiation codons in the same mRNA...
  81. Hakuba N, Taniguchi M, Shimizu Y, Sugimoto A, Shinomori Y, Gyo K. A new method for closing tympanic membrane perforations using basic fibroblast growth factor. Laryngoscope. 2003;113:1352-5 pubmed
    To present a new method for closing tympanic membrane perforations using basic fibroblast growth factor (bFGF) combined with an atelocollagen/silicone bilayer membrane as a patch material...
  82. Li B, Dicicco Bloom E. Basic fibroblast growth factor exhibits dual and rapid regulation of cyclin D1 and p27 to stimulate proliferation of rat cerebral cortical precursors. Dev Neurosci. 2004;26:197-207 pubmed
    ..Here we define the mechanisms by which basic fibroblast growth factor (bFGF) stimulates cortical precursors, with particular attention to the responses of cell cycle ..
  83. Petrovic M, Krkovic M, Osredkar J, Hawlina M, Petrovic D. Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes. Clin Exp Ophthalmol. 2008;36:168-72 pubmed publisher
    b>Basic fibroblast growth factor (bFGF) expression is implicated in proliferative diabetic retinopathy (PDR)...
  84. Do M, Sato Y, Shimizu N, Suzuki T, Shono J, Mizunoya W, et al. Growth factor regulation of neural chemorepellent Sema3A expression in satellite cell cultures. Am J Physiol Cell Physiol. 2011;301:C1270-9 pubmed publisher
    ..Am J Physiol Cell Physiol 297: C238-C252, 2009]. Here, we address regulatory effects of basic fibroblast growth factor (FGF2) and transforming growth factor (TGF)-?s on Sema3A expression in satellite cell cultures...
  85. Clarke W, Berry M, Smith C, Kent A, Logan A. Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats. Mol Cell Neurosci. 2001;17:17-30 pubmed
    ..However, the precise contribution of nuclear FGF-2/FGFR1 to the pathophysiological response of astrocytes after injury is undetermined. ..
  86. Yoshida E, Atkinson T, Chakravarthy B. Neuroprotective gene expression profiles in ischemic cortical cultures preconditioned with IGF-1 or bFGF. Brain Res Mol Brain Res. 2004;131:33-50 pubmed
    ..transcriptional profiles of cells preconditioned either with insulin-like growth factor I (IGF-1) or basic fibroblast growth factor (bFGF), to identify differentially regulated genes that may function in growth factor signaling, ..
  87. Haga H, Saito T, Okumoto K, Ugajin S, Sato C, Ishii R, et al. Enhanced expression of fibroblast growth factor 2 in bone marrow cells and its potential role in the differentiation of hepatic epithelial stem-like cells into the hepatocyte lineage. Cell Tissue Res. 2011;343:371-8 pubmed publisher
    ..DNA microarray analysis showed the upregulated expression of fibroblast growth factor 2 (FGF2) mRNA in BMCs co-cultured with HSLCs, and the expression of mRNAs for both albumin and tyrosine ..
  88. Kuniyasu H, Abbruzzese J, Cleary K, Fidler I. Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. Int J Oncol. 2001;19:681-5 pubmed
    ..0041) and significant upregulation of basic fibroblast growth factor (bFGF) mRNA expression in adjacent tumor cells (p=0.0213)...
  89. Munchhof A, Li F, White H, Mead L, Krier T, Fenoglio A, et al. Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells. Hum Mol Genet. 2006;15:1858-69 pubmed
    ..Thus, these studies identify a unique biochemical pathway in Nf1+/- ECs as a potential therapeutic target in the neurofibroma microenvironment...
  90. Tripathi R, McTigue D. Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats. J Comp Neurol. 2008;510:129-44 pubmed publisher
    ..Thus, both CNTF and FGF-2 are present in regions of elevated OPC proliferation and oligodendrocyte generation after SCI and therefore may play a role in injury-induced gliogenesis. ..
  91. Neubüser A, Peters H, Balling R, Martin G. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell. 1997;90:247-55 pubmed
    ..We suggest that a similar mechanism may be used for specifying the sites of development of other organs. ..
  92. Ishida K, Yoshimura N, Mandai M, Honda Y. Inhibitory effect of TNP-470 on experimental choroidal neovascularization in a rat model. Invest Ophthalmol Vis Sci. 1999;40:1512-9 pubmed
    ..and semiquantitative polymerase chain reaction (PCR) analyses for the expression of mRNA of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) were carried out...