Gene Symbol: Fgf14
Description: fibroblast growth factor 14
Alias: Fhf4, fibroblast growth factor 14, FGF homologus factor 4b, FGF-14, fibroblast growth factor homologous factor 4
Shavkunov A, Wildburger N, Nenov M, James T, Buzhdygan T, Panova Elektronova N, et al
. The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3). J Biol Chem. 2013;288:19370-85 pubmed publisher
The FGF14 protein controls biophysical properties and subcellular distribution of neuronal voltage-gated Na(+) (Nav) channels through direct binding to the channel C terminus...
Munoz Sanjuan I, Smallwood P, Nathans J. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. J Biol Chem. 2000;275:2589-97 pubmed
Olsen S, Garbi M, Zampieri N, Eliseenkova A, Ornitz D, Goldfarb M, et al
. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem. 2003;278:34226-36 pubmed
..FGF homologous factors (FHF1-FHF4; also known as FGF11-FGF14) are related to FGFs by substantial sequence homology, yet their only documented interactions are with an ..
Miyagawa K, Kimura S, Yoshida T, Sakamoto H, Takaku F, Sugimura T, et al
. Structural analysis of a mature hst-1 protein with transforming growth factor activity. Biochem Biophys Res Commun. 1991;174:404-10 pubmed
..These results indicated that the mature hst-1 protein consisting of 148 amino acids had transforming growth factor activity. ..
Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, et al
. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron. 2007;55:449-63 pubmed
..Fhf1-/-Fhf4-/- mice suffer from severe ataxia and other neurological deficits...
Hsu W, Nenov M, Shavkunov A, Panova N, Zhan M, Laezza F. Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation. PLoS ONE. 2015;10:e0117246 pubmed publisher
..potential in neurons and mediates synaptic transmission, and its multivalent accessory protein, the fibroblast growth factor 14 (FGF14)...
Yamamoto S, Mikami T, Ohbayashi N, Ohta M, Itoh N. Structure and expression of a novel isoform of mouse FGF homologous factor (FHF)-4. Biochim Biophys Acta. 1998;1398:38-41 pubmed
Yan H, Pablo J, Pitt G. FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. Cell Rep. 2013;4:66-75 pubmed publisher
..Mutations in FGF14, an FHF that is the locus for spinocerebellar ataxia 27 (SCA27), are believed to be pathogenic because of a ..