Gene Symbol: Fgf12
Description: fibroblast growth factor 12
Alias: Fhf1, Fhf1b, fibroblast growth factor 12, FGF-12, FHF-1, fibroblast growth factor homologous factor 1, fibroblast growth factor homologous factor 1b
Liu C, Dib Hajj S, Renganathan M, Cummins T, Waxman S. Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B. J Biol Chem. 2003;278:1029-36 pubmed
We have previously shown that fibroblast growth factor homologous factor 1B (FHF1B), a cytosolic member of the fibroblast growth factor family, associates with the sensory neuron-specific channel Na(v)1...
Olsen S, Garbi M, Zampieri N, Eliseenkova A, Ornitz D, Goldfarb M, et al
. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. J Biol Chem. 2003;278:34226-36 pubmed
..the molecular basis for this differential target binding specificity, we elucidated the crystal structure of FHF1b to 1.7-A resolution...
Siekierska A, Isrie M, Liu Y, Scheldeman C, Vanthillo N, Lagae L, et al
. Gain-of-function FHF1 mutation causes early-onset epileptic encephalopathy with cerebellar atrophy. Neurology. 2016;86:2162-70 pubmed publisher
..Transgenic overexpression of mutant FHF1B in zebrafish larvae enhanced epileptiform discharges, demonstrating the epileptic potential of this FHF1 mutation ..
Smallwood P, Munoz Sanjuan I, Tong P, Macke J, Hendry S, Gilbert D, et al
. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996;93:9850-7 pubmed
..Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function. ..
Liu Cj -, Dib Hajj S, Waxman S. Fibroblast growth factor homologous factor 1B binds to the C terminus of the tetrodotoxin-resistant sodium channel rNav1.9a (NaN). J Biol Chem. 2001;276:18925-33 pubmed
..9a (NaN) led to the identification of fibroblast growth factor homologous factor 1B (FHF1B), a member of the fibroblast growth factor family, as an interacting partner of rNa(v)1...
Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, et al
. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron. 2007;55:449-63 pubmed
..b>Fhf1-/-Fhf4-/- mice suffer from severe ataxia and other neurological deficits...
Wildburger N, Ali S, Hsu W, Shavkunov A, Nenov M, Lichti C, et al
. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. Mol Cell Proteomics. 2015;14:1288-300 pubmed publisher
..2 protein interactors. Of the identified putative protein interactors, fibroblast growth factor 12 (FGF12), a member of the nonsecreted intracellular FGF family, exhibited 30-fold enrichment in Nav1...
Song S, Kim K, Jo E, Kim Y, Kwon J, Bae S, et al
. Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth Muscle Cell Plasticity and Fate. Arterioscler Thromb Vasc Biol. 2016;36:1928-36 pubmed publisher
..Here, we identified fibroblast growth factor 12 (FGF12) as a novel key regulator of the VSMC phenotype switch...