Fez1

Summary

Gene Symbol: Fez1
Description: fasciculation and elongation protein zeta 1 (zygin I)
Alias: fasciculation and elongation protein zeta-1, protein kinase C-binding protein Zeta1, zygin I, zygin-1
Species: rat

Top Publications

  1. ncbi Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
  2. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes
    Jianghong He
    Cytoneurobiology Unit and Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, JS, 215123, People s Republic of China
    Mol Cell Biochem 325:159-67. 2009
  3. ncbi Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
    Toshitsugu Fujita
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 361:605-10. 2007
  4. ncbi Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility
    Junko Ikuta
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 353:127-32. 2007
  5. ncbi Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells
    Mojgan H Naghavi
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 19:1105-15. 2005
  6. ncbi Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation
    Tadaki Suzuki
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan
    J Biol Chem 280:24948-56. 2005
  7. ncbi Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis
    Fumihiko Okumura
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:53533-43. 2004
  8. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
    Akiko Honda
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 122:89-92. 2004
  9. ncbi Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
  10. ncbi The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection
    Juliane Haedicke
    Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 106:14040-5. 2009

Scientific Experts

  • S Kuroda
  • Toshitsugu Fujita
  • Junko Ikuta
  • Mojgan H Naghavi
  • Tadaki Suzuki
  • Jianghong He
  • Juliane Haedicke
  • Katsuyuki Tanizawa
  • Kenji Tatematsu
  • Toshihide Okajima
  • Hirofumi Sawa
  • Akiko Honda
  • Fumihiko Okumura
  • K Miyoshi
  • Chunlin Xia
  • Ting Zhu
  • Jun Liu
  • Craig Brown
  • Maomin Sun
  • ZhiJun Zhang
  • Juri Hamada
  • Marie W Wooten
  • Sebastien Walchli
  • Andres Maturana
  • AndrĂ©s D Maturana
  • Satoko Yamanouchi
  • Yasuko Orba
  • Shinya Tanaka
  • Shingo Semba
  • Stephen P Goff
  • Guangxia Gao
  • Kazuo Nagashima
  • Yuki Okada
  • Shuichi Endo
  • Theodora Hatziioannou
  • Taiichi Katayama
  • Keiichi I Nakayama
  • Shigetsugu Hatakeyama
  • Kousuke Baba
  • Masaya Tohyama
  • Masaki Matsumoto
  • Manabu Taniguchi
  • Takumi Kamura
  • Ko Miyoshi
  • Yoshihisa Koyama
  • M Tohyama
  • K Baba
  • K Oono
  • M Taniguchi
  • A Honda
  • T Fujita
  • T Katayama

Detail Information

Publications10

  1. ncbi Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein
    S Kuroda
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, 567 0047, Japan
    J Cell Biol 144:403-11. 1999
    ..The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content ..
  2. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in cultured rat neonatal astrocytes
    Jianghong He
    Cytoneurobiology Unit and Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, 199 Ren Ai Road, Suzhou Industrial Park, Suzhou, JS, 215123, People s Republic of China
    Mol Cell Biochem 325:159-67. 2009
    ..The fasciculation and elongation protein zeta-1 (FEZ1) gene was studied further because it has been suggested that it is not expressed by astrocytes...
  3. ncbi Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
    Toshitsugu Fujita
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 361:605-10. 2007
    Fasciculation and elongation protein zeta-1 (FEZ1) promotes efficiently the neurite elongation of rat phaeochromocytoma PC12 cells. We here characterized FEZ1 in PC12 cells...
  4. ncbi Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility
    Junko Ikuta
    Department of Structural Molecular Biology, Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka 567 0047, Japan
    Biochem Biophys Res Commun 353:127-32. 2007
    The fasciculation and elongation protein zeta-1 (FEZ1), a mammalian orthologue of Caenorhabditis elegans UNC-76 protein, is a 45-kDa protein with four coiled-coiled domains and efficiently promotes the neurite elongation in the rat ..
  5. ncbi Overexpression of fasciculation and elongation protein zeta-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells
    Mojgan H Naghavi
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 19:1105-15. 2005
    ..One of the candidate gene products, FEZ1 (fasciculation and elongation protein zeta-1), a protein kinase C (PKC)zeta-interacting protein homologous to the ..
  6. ncbi Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation
    Tadaki Suzuki
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan
    J Biol Chem 280:24948-56. 2005
    ..We have now identified fasciculation and elongation protein zeta 1 (FEZ1) as a protein that interacted with JCV agnoprotein in a yeast two-hybrid screen of a ..
  7. ncbi Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis
    Fumihiko Okumura
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:53533-43. 2004
    ..With a yeast two-hybrid screen, we have now identified FEZ1 (fasciculation and elongation protein zeta 1) as a protein that interacts with E4B...
  8. ncbi Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain
    Akiko Honda
    Department of Brain Science, Graduate School of Medicine and Dentistry, Okayama University, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 122:89-92. 2004
    Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth and fasciculation...
  9. ncbi Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
    K Miyoshi
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan
    Mol Psychiatry 8:685-94. 2003
    ..Here, we demonstrated the existence of DISC1 protein and identified fasciculation and elongation protein zeta-1 (FEZ1) as an interacting partner of DISC1 by a yeast two-hybrid study...
  10. ncbi The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection
    Juliane Haedicke
    Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 106:14040-5. 2009
    ..chemically mutagenized and selected for resistance to retroviral infection, we recently identified induction of rat FEZ1 (fasciculation and elongation protein zeta-1), a brain-specific protein, as the cause of this resistance...