Gene Symbol: Fer
Description: FER tyrosine kinase
Alias: Fert2, Flk, Flk_retired, tyrosine-protein kinase Fer, c-FER, fer (fms/fps related) protein kinase, testis specific 2, fer (fps/fes related) tyrosine kinase, p94-FER, proto-oncogene c-Fer, proto-oncogene tyrosine-protein kinase FER, tyrosine protein kinase FLK
Species: rat
Products:     Fer

Top Publications

  1. Kogata N, Masuda M, Kamioka Y, Yamagishi A, Endo A, Okada M, et al. Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. Mol Biol Cell. 2003;14:3553-64 pubmed
    ..We sought to isolate tyrosine kinases responsible for PECAM-1 phosphorylation and identified Fer as a candidate, based on expression cloning...
  2. Iwanishi M, Czech M, Cherniack A. The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase. J Biol Chem. 2000;275:38995-9000 pubmed
    In a screen for 3T3-F442A adipocyte proteins that bind SH2 domains, we isolated a cDNA encoding Fer, a nonreceptor protein-tyrosine kinase of the Fes/Fps family that contains a functional SH2 domain...
  3. Letwin K, Yee S, Pawson T. Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody. Oncogene. 1988;3:621-7 pubmed
    ..These new protein-tyrosine kinases (elk and flk) are apparently members of subfamilies for which eph and fps/fes are prototypes...
  4. Nizard P, Ezan F, Bonnier D, Le Meur N, Langouët S, Baffet G, et al. Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells. BMC Genomics. 2014;15:1169 pubmed publisher
    ..Further analyses of the kinase interactomes revealed specific modules such as FER- and CRKL-containing modules that connect three members of the epidermal growth factor receptor (EGFR) family, ..
  5. Kierszenbaum A, Rivkin E, Tres L. Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome-acroplaxome-manchette complex in rat spermatids. Dev Dyn. 2008;237:3882-91 pubmed publisher
    We report the association of testicular Fer, a non-receptor tyrosine kinase, with acrosome development and remodeling of the acrosome-associated acroplaxome plate during spermatid head shaping...
  6. El Sayegh T, Arora P, Fan L, Laschinger C, Greer P, McCulloch C, et al. Phosphorylation of N-cadherin-associated cortactin by Fer kinase regulates N-cadherin mobility and intercellular adhesion strength. Mol Biol Cell. 2005;16:5514-27 pubmed
    ..We show that the nonreceptor tyrosine kinase Fer phosphorylates cadherin-associated cortactin and that this process is involved in mediating intercellular adhesion ..
  7. Craig A, Greer P. Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol. 2002;22:6363-74 pubmed
    ..Here, we report that in mouse bone marrow-derived mast cells, Fer kinase is activated downstream of activated Fc epsilon RI and activated Kit receptor, and this activation is ..
  8. Kim L, Wong T. Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. J Biol Chem. 1998;273:23542-8 pubmed
    Previous characterization of the nonreceptor tyrosine kinase FER identified a tight physical association with the catenin pp120 and led to the suggestion that FER may be involved in cell-cell signaling...
  9. Pasder O, Shpungin S, Salem Y, Makovsky A, Vilchick S, Michaeli S, et al. Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006;25:4194-206 pubmed
    b>Fer is a nuclear and cytoplasmic intracellular tyrosine kinase. Herein we show that Fer is required for cell-cycle progression in malignant cells...

More Information


  1. Kim L, Wong T. The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol Cell Biol. 1995;15:4553-61 pubmed
    The FER gene encodes a cytoplasmic tyrosine kinase with a single SH2 domain and an extensive amino terminus...
  2. Chen Y, Lee N, Mruk D, Lee W, Cheng C. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Biol Reprod. 2003;69:656-72 pubmed
    b>Fer kinase is a 94-kDa cytoplasmic cell-cell actin-based adherens junction (AJ)-associated nonreceptor protein tyrosine kinase (PTK) found in multiple epithelia including the testis, whereas FerT kinase (51 kDa) is the truncated testis-..
  3. Sangrar W, Gao Y, Scott M, Truesdell P, Greer P. Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Mol Cell Biol. 2007;27:6140-52 pubmed
    ..In this report, we show for the first time that Fer and Ctn are potently tyrosine phosphorylated in response to hydrogen peroxide (H2O2) in a variety of cell types...
  4. Zoubeidi A, Rocha J, Zouanat F, Hamel L, Scarlata E, Aprikian A, et al. The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. Mol Cancer Res. 2009;7:142-55 pubmed publisher
    ..We previously reported that Fer tyrosine kinase level correlates with the development of prostate cancer and aggressiveness of prostate cancer cell ..
  5. Makovski A, Yaffe E, Shpungin S, Nir U. Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells. J Biol Chem. 2012;287:6100-12 pubmed publisher
    b>Fer is an intracellular tyrosine kinase that accumulates in most mammalian tissues. A truncated variant of Fer, FerT, is uniquely detected in spermatogenic cells and is absent from normal somatic tissues...
  6. Hao Q, Ferris D, White G, Heisterkamp N, Groffen J. Nuclear and cytoplasmic location of the FER tyrosine kinase. Mol Cell Biol. 1991;11:1180-3 pubmed
    The location of the FER protein within the cell was investigated by using subcellular fractionation and immunofluorescence. FER was found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction...
  7. Udell C, Samayawardhena L, Kawakami Y, Kawakami T, Craig A. Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. J Biol Chem. 2006;281:20949-57 pubmed
    ..We previously showed that FcepsilonRI aggregation caused a rapid increase in phosphorylation of both Fer and Fps/Fes kinases in bone marrow-derived mast cells...
  8. Itoh T, Hasegawa J, Tsujita K, Kanaho Y, Takenawa T. The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal. 2009;2:ra52 pubmed publisher
    ..Here, we show that PA binds to the tyrosine kinase Fer and enhances its ability to phosphorylate cortactin, a protein that promotes actin polymerization...
  9. Guo C, Stark G. FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. Proc Natl Acad Sci U S A. 2011;108:7968-73 pubmed publisher
    ..to isolate a quinacrine-resistant cell line in which an inserted CMV promoter drives overexpression of the FER tyrosine kinase (FER)...
  10. Qi W, Ebbert K, Craig A, Greer P, McCafferty D. Absence of Fer protein tyrosine kinase exacerbates endotoxin induced intestinal epithelial barrier dysfunction in vivo. Gut. 2005;54:1091-7 pubmed
    b>Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation...
  11. Lee S, Peng I, Ng Y, Yanagisawa M, Bamji S, Elia L, et al. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin. J Cell Biol. 2008;183:893-908 pubmed publisher
    ..a pathway that promotes presynaptic development involving p120catenin (p120ctn), the cytoplasmic tyrosine kinase Fer, the protein phosphatase SHP-2, and beta-catenin...