Fdps

Summary

Gene Symbol: Fdps
Description: farnesyl diphosphate synthase
Alias: Ac2-125, FPS, farnesyl pyrophosphate synthase, (2E,6E)-farnesyl diphosphate synthase, CR 39, FPP synthase, FPP synthetase, cholesterol-regulated 39 kDa protein, dimethylallyltranstransferase, farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase), farnesyl diphosphate synthetase, farnesyl pyrophosphate synthetase, geranyltranstransferase, testis-specific farnesyl pyrophosphate synthetase
Species: rat

Top Publications

  1. doi Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells
    Chang Qing Du
    Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P R China
    Int J Mol Med 35:1767-72. 2015
  2. pmc Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro
    Z Li
    Department of Cardiology, Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, China
    Clin Exp Immunol 176:429-37. 2014
  3. ncbi Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes
    Werner J Kovacs
    Department of Biology, San Diego State University, San Diego, CA, USA
    Histochem Cell Biol 127:273-90. 2007
  4. ncbi An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains
    S V Dracheva
    The Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Genomics 63:202-26. 2000
  5. doi Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats
    Liang Li
    Institute of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, PR China
    Biochem Pharmacol 79:399-406. 2010
  6. doi Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway
    Yang Ye
    Institute of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qing Chun Road, Hangzhou 310003, PR China
    FEBS Lett 583:2997-3003. 2009
  7. ncbi Alendronate lowers cholesterol synthesis in the central nervous system of rats - a preliminary study
    L Cibickova
    Second Department of Medicine, University Hospital, Hradec Kralove, Czech Republic
    Physiol Res 58:455-8. 2009
  8. ncbi Defects of cholesterol biosynthesis
    Hans R Waterham
    Laboratory Genetic Metabolic Diseases, F0 224, Department of Pediatrics Emma Children s Hospital, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    FEBS Lett 580:5442-9. 2006
  9. pmc Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids
    Catherine Le Jossic-Corcos
    Laboratoire de Biologie Moleculaire et Cellulaire GDR CNRS no 2583, Universite de Bourgogne, 21000 Dijon, France
    Biochem J 385:787-94. 2005
  10. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents
    Catherine Le Jossic-Corcos
    Laboratoire de Biologie Moleculaire et Cellulaire GDR CNRS no 2583, Universite de Bourgogne, Dijon 21000, France
    J Steroid Biochem Mol Biol 88:203-11. 2004

Scientific Experts

  • Werner J Kovacs
  • Hans R Waterham
  • E F Remmers
  • Catherine Le Jossic-Corcos
  • Yang Ye
  • L Cibickova
  • Chang Qing Du
  • Z Li
  • Liang Li
  • Hannelore Heemers
  • Li Jiang Tang
  • Guang Zhong Zeng
  • Xiao Wei Liu
  • Hong Feng Jin
  • J Han
  • J Song
  • M Wang
  • J Zhang
  • G Fu
  • X Bi
  • X Shen
  • Shen Jiang Hu
  • S V Dracheva
  • Guo Ping Chen
  • Lei Yao
  • Yin Yang
  • S D Gupta
  • Ishaiahu Shechter
  • Frank Vanderhoydonc
  • Guido Verhoeven
  • Walter Heyns
  • Tania Roskams
  • Johannes V Swinnen
  • M M Griffiths
  • P S Gulko
  • J Shepard
  • T Furuya
  • L Chang
  • P A Edwards
  • Y Kawahito
  • L Ge
  • J Hoffman
  • S Chen
  • R L Wilder
  • J L Salstrom
  • J Wang
  • Y Du
  • B Joe
  • S Kotake
  • G W Cannon
  • R E Longman
  • I Goldberg
  • I Shechter
  • R S Mehan
  • H T Chen
  • T R Tansey
  • G Goping
  • J Ericsson
  • S K Krisans
  • M Runquist
  • D H Spear
  • A Thelin
  • G A Keller
  • G Dallner
  • C F Clarke
  • T Chojnacki
  • J H Teruya
  • S Y Kutsunai
  • S J Nazian
  • M N Ashby
  • C C Correll
  • G C Ness
  • A M Fogelman
  • R D Tanaka
  • L D Brewer
  • K Svenson
  • M Wamsley
  • E C Salido

Detail Information

Publications21

  1. doi Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells
    Chang Qing Du
    Department of Cardiology, Zhejiang Hospital, Hangzhou, Zhejiang 310013, P R China
    Int J Mol Med 35:1767-72. 2015
    ..b>Farnesyl pyrophosphate synthase (FPPS) plays an important role in cardiovascular remodeling through the modulation of the above-..
  2. pmc Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro
    Z Li
    Department of Cardiology, Sir Run Run Shaw Hospital, Hangzhou, Zhejiang Province, China
    Clin Exp Immunol 176:429-37. 2014
    b>Farnesyl pyrophosphate synthase (FPPS)-catalysed isoprenoid intermediates are important for the activation of Ras homologue gene family, member A (RhoA) in angiotensin (Ang) II-induced cardiac fibrosis...
  3. ncbi Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes
    Werner J Kovacs
    Department of Biology, San Diego State University, San Diego, CA, USA
    Histochem Cell Biol 127:273-90. 2007
    ....
  4. ncbi An integrated genetic linkage map with 1,137 markers constructed from five F2 crosses of autoimmune disease-prone and -resistant inbred rat strains
    S V Dracheva
    The Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Genomics 63:202-26. 2000
    ..Two hundred forty genes are incorporated in the map. This integrated map should allow comparison of rat genetic maps from different groups and thereby facilitate genetic studies of rat autoimmune and related disease models...
  5. doi Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats
    Liang Li
    Institute of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, PR China
    Biochem Pharmacol 79:399-406. 2010
    b>Farnesyl pyrophosphate synthase (FPPS), an essential enzyme in the mevalonate pathway, was reported to be upregulated in young spontaneously hypertensive rats (SHR) when compared with Wistar-Kyoto (WKY) rats, and this was accompanied by ..
  6. doi Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway
    Yang Ye
    Institute of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qing Chun Road, Hangzhou 310003, PR China
    FEBS Lett 583:2997-3003. 2009
    ..The anti-hypertrophic effects of inhibition of FPP synthase with alendronate in Ang II-cultured neonatal cardiomyocytes were partially reversed by geranylgeranyol (GGOH) ..
  7. ncbi Alendronate lowers cholesterol synthesis in the central nervous system of rats - a preliminary study
    L Cibickova
    Second Department of Medicine, University Hospital, Hradec Kralove, Czech Republic
    Physiol Res 58:455-8. 2009
    ..In conclusion, this study brings the first experimental evidence of the inhibition of cholesterol biosynthesis with alendronate in central nervous system...
  8. ncbi Defects of cholesterol biosynthesis
    Hans R Waterham
    Laboratory Genetic Metabolic Diseases, F0 224, Department of Pediatrics Emma Children s Hospital, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    FEBS Lett 580:5442-9. 2006
    ..The etiology of the underlying pathophysiology may involve multiple affected processes due to lowered cholesterol and/or the elevated, teratogenic levels of the intermediate sterol precursors...
  9. pmc Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids
    Catherine Le Jossic-Corcos
    Laboratoire de Biologie Moleculaire et Cellulaire GDR CNRS no 2583, Universite de Bourgogne, 21000 Dijon, France
    Biochem J 385:787-94. 2005
    ..involved, we examined how tuna fish oil and individual n-3 and n-6 PUFA affect the expression of hepatic FPP synthase (farnesyl diphosphate synthase), a SREBP (sterol regulatory element-binding protein) target enzyme that is ..
  10. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents
    Catherine Le Jossic-Corcos
    Laboratoire de Biologie Moleculaire et Cellulaire GDR CNRS no 2583, Universite de Bourgogne, Dijon 21000, France
    J Steroid Biochem Mol Biol 88:203-11. 2004
    ..cholesterol synthesis, we analysed the effect of fibrates on expression of the farnesyl diphosphate synthase (FPP synthase) gene, known to be regulated by sterol regulatory element-binding proteins (SREBPs), in conjunction with HMG-..
  11. ncbi Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo
    Hannelore Heemers
    Faculty of Medicine, LEGENDO, Onderwijs en Navorsing 9, Gasthuisberg, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Mol Cell Endocrinol 205:21-31. 2003
    ..Taken together, these findings provide evidence for a coordinate regulation of lipogenic gene expression not only in prostate cancer cell lines in culture but also in non-cancerous androgen-responsive tissues in vivo...
  12. ncbi Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene
    D H Spear
    Department of Biologicl Chemistry, UCLA School of Medicine 90024
    J Biol Chem 267:14462-9. 1992
    ..Further mutational and deletion analysis of the FPP synthase promoter-CAT constructs followed by stable transfection and primer extension of the CAT mRNA levels indicated ..
  13. ncbi Differential binding of proteins to peroxisomes in rat hepatoma cells: unique association of enzymes involved in isoprenoid metabolism
    S D Gupta
    Department of Biochemistry and Molecular Biology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    J Lipid Res 40:1572-84. 1999
    ..Based on these observations, the significance and a possible regulatory model in the formation of isoprenoid end-products are discussed...
  14. ncbi An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    Transplant Proc 31:1549-54. 1999
  15. ncbi Farnesyl-diphosphate synthase is localized in peroxisomes
    S K Krisans
    Department of Biology, San Diego State University, California 92182
    J Biol Chem 269:14165-9. 1994
    In this study, we have investigated the subcellular localization of farnesyl-diphosphate synthase (FPP synthase)...
  16. ncbi Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase
    M Runquist
    Department of Biochemistry, Arrhenius Laboratories for the Natural Sciences, Stockholm University, Sweden
    J Biol Chem 269:5804-9. 1994
    ..In this reaction sequence intermediate formation of farnesyl pyrophosphate (FPP) predominates, and the FPP synthase activity was studied in more detail...
  17. pmc Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway
    C F Clarke
    Department of Medicine, School of Medicine, University of California, Los Angeles 90024
    Mol Cell Biol 7:3138-46. 1987
    ..Thus, alterations in the rate of cholesterogenesis resulted in the coordinate regulation of three mRNAs encoding HMG-CoA reductase, HMG-CoA synthase, and CR39, the latter being tentatively identified as prenyltransferase...
  18. ncbi Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase
    M N Ashby
    Department of Biological Chemistry, School of Medicine, University of California, Los Angeles 90024
    J Biol Chem 264:635-40. 1989
    ..We conclude that CR39 encodes the prenyltransferase of cholesterol biosynthesis, farnesyl pyrophosphate synthetase. Furthermore, in the liver this enzyme shows coordinate regulation with two other enzymes, 3-hydroxy-..
  19. pmc Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA
    J H Teruya
    Division of Cardiology, University of California, Los Angeles School of Medicine 90024 1736
    Mol Cell Biol 10:2315-26. 1990
    ..In testis, an FPP synthetase-related RNA was detected that was larger than the liver FPP synthetase mRNA and was present at very high ..
  20. ncbi Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells
    J H Teruya
    Division of Cardiology, University of California Los Angeles School of Medicine 90024
    Biol Reprod 44:663-71. 1991
    A rat farnesyl pyrophosphate (FPP) synthetase cDNA was used to study the expression of FPP synthetase mRNA levels during spermatogenesis in the rat...
  21. ncbi Pituitary regulation of the expression of the farnesyl pyrophosphate synthetase gene in the testes of the sexually maturing rat
    S J Nazian
    Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa 33612
    J Androl 12:264-72. 1991
    ..the coordinate regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and farnesyl pyrophosphate synthetase, the authors observed that rat testes contained high levels of a farnesyl pyrophosphate synthetase ..